First look: Notre Dame Fighting Irish at Clemson Tigers odds and lines

Looking at Saturday’s Notre Dame Fighting Irish at Clemson Tigers college football odds, lines and trends. Here’s what you need to know.

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The Notre Dame Fighting Irish (7-2) visit the Clemson Tigers (4-4) on Saturday. Kickoff from Memorial Stadium is set for noon ET (NBC). Below, we look at Notre Dame vs. Clemson odds from BetMGM Sportsbook. Also see: SportsbookWire’s college football picks and predictions.

Notre Dame throttled Pitt 58-7 on Saturday covering as a 21-point home favorite. QB Sam Hartman went 18 of 25 for 288 yards and 2 INTs while QB Steve Angeli went 6 of 7 for 92 yards and a TD. The Fighting Irish scored in a multitude of ways with a passing TD, 4 rushing TDs, a Pick Six, and a punt return TD.

Clemson fell 24-17 against North Carolina State on Saturday but covered as a 9.5-point road underdog. QB Cade Klubnik went 33 of 50 for 263 yards and 2 INT and RB Phil Mafah carried the ball 16 times for 84 yards and 2 TDs in the loss.

Notre Dame is No. 12 in the US LBM Coaches Poll powered by USA TODAY Sports

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Notre Dame at Clemson odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:42 a.m. ET,

  • Moneyline (ML): Notre Dame -150 (bet $150 to win $100) | Clemson +120 (bet $100 to win $120)
  • Against the spread (ATS): Notre Dame -2.5 (-110) | Clemson +2.5 (-110)
  • Over/Under (O/U): 46 (O: -110 | U: -110)

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2023 betting stats

  • ML: Notre Dame 7-2 | Clemson 4-4
  • ATS: Notre Dame 7-2 | Clemson 2-6
  • O/U: Notre Dame 5-4 | Clemson 3-5

Notre Dame vs. Clemson head-to-head

Notre Dame last faced Clemson in November of 2022 when it won 35-14 to cover as a 4-point home underdog. The Over of 43.5 hit in that game.

These programs have faced off 5 times since 2015 with Clemson going 3-2 in that span. Notre Dame is 3-2 ATS in the matchups while the Over is 2-3. Notre Dame covered as the underdog in each of its 2 series wins while Clemson covered as a double-digit favorite in each of its 3 series wins.

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First look: Pitt at Notre Dame odds and lines

Looking at Saturday’s Pitt at Notre Dame college football odds, lines and trends. Here’s what you need to know.

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The No. 14 Notre Dame Fighting Irish (6-2) welcome the Pitt Panthers (2-5) to Notre Dame Stadium Saturday. Kickoff is set for 3:30 p.m. ET (NBC). Below, we look at Pitt vs. Notre Dame odds from FanDuel Sportsbook’s. Also see: SportsbookWire’s college football picks and predictions.

Notre Dame destroyed the No. 22 USC Trojans 48-20 on Oct. 14, covering as a 3-point home favorite. The Fighting Irish have covered 6 of 8 games this season and are 3-1 against the spread (ATS) at home. Notre Dame’s defense has allowed 20 or fewer points over 4 of its last 5 games. Notre Dame is No. 14 in the US LBM Coaches Poll powered by USA TODAY Sports.

Pitt lost to the Wake Forest Demon Deacons 21-17 Saturday, failing to cover as a 2.5-point road favorite. The Panthers are just 1-5-1 ATS this season with their lone cover a 38-21 win over the Louisville Cardinals as a 7-point home underdog. The Panthers are led by QB Phil Jurkovec, who has 818 passing yards and 7 TDs.

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Pitt at Notre Dame odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 12:08 p.m. ET.

  • Moneyline (ML): Pitt +720 (bet $100 to win $720) | Notre Dame -1200 (bet $1,200 to win $100)
  • Against the spread (ATS): Pitt +19.5 (-110) | Notre Dame -19.5 (-110)
  • Over/Under (O/U): 45.5 (O: -115 | U: -105)

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2023 betting stats

  • ML: Notre Dame 6-2 | Pitt 2-5
  • ATS: Notre Dame 6-2 | Pitt 1-5-1
  • O/U: Notre Dame 4-4 | Pitt 5-2

Pitt at Notre Dame head-to-head

Notre Dame leads the all-time series 49-21-1 and is on a 3-game win streak.  The Irish won the last matchup 45-3 in Pittsburgh during the 2020 season.

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First look: USC at Notre Dame odds and lines

Looking at Saturday’s USC at Notre Dame college football odds, lines and trends. Here’s what you need to know.

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The USC Trojans (6-0) meet the Notre Dame Fighting Irish (5-2) on Saturday at Notre Dame Stadium in South Bend, Ind. Kickoff is scheduled for 7:30 p.m. ET (NBC/Peacock). Below, we look at USC vs. Notre Dame odds from FanDuel Sportsbook. Also see: SportsbookWire’s college football picks and predictions.

The Trojans had a close shave in a home game against Arizona on Saturday. USC narrowly escaped with a 43-41 win in triple overtime, as the Trojans failed to cover for a 3rd straight game. The defense also allowed 41 points for the 2nd straight game, and the Over has cashed in 3 consecutive outings, and 5 of 6 contests overall.

The Fighting Irish suffered a 33-20 loss at Louisville on Saturday night, its 2nd loss in 3 games, sandwiching a 21-14 win at Duke on Sept. 30. It was just the 2nd time that Notre Dame failed to cover the spread this season. The Under has cashed in 3 consecutive contests for the Irish.

USC is No. 9 and Notre Dame is No. 21 in the US LBM Coaches Poll powered by USA TODAY Sports.

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USC at Notre Dame odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 7:01 a.m. ET.

  • Moneyline (ML): USC +108 (bet $100 to win $108) | Notre Dame -130 (bet $130 to win $100)
  • Against the spread (ATS): USC +2.5 (-110) | Notre Dame -2.5 (-110)
  • Over/Under (O/U): 63.5 (O: -105 | U: -115)

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2023 betting stats

  • ML: USC 6-0 | Notre Dame 5-2
  • ATS: USC 2-4 | Notre Dame 5-2
  • O/U: USC 5-1 | Notre Dame 3-4

USC at Notre Dame head-to-head

The Fighting Irish lead the all-time series 48-37-5, with the Trojans winning last season’s meeting in Los Angeles 38-27. Prior to that Notre Dame had won the past 4 meetings, including the 2021 battle in South Bend 31-16.

While Notre Dame is 4-1 straight up (SU) in the past 5 games overall, USC is 3-1 against the spread (ATS) in the previous 4 in the series. The Under has cashed in 3 of the past 4 meetings in this rivalry, too.

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First look: Notre Dame at Duke odds and lines

Looking at Saturday’s Notre Dame at Duke college football odds, lines and trends. Here’s what you need to know.

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The Notre Dame Fighting Irish (4-1) travel to meet the Duke Blue Devils (4-0) on Saturday at Wallace Wade Stadium in Durham, N.C. Kickoff is scheduled for 7:30 p.m. ET (ABC). Below, we look at Notre Dame vs. Duke odds from FanDuel Sportsbook. Also see: SportsbookWire’s college football picks and predictions.

The Fighting Irish will be fighting mad after losing a marquee matchup against Ohio State on the final play of regulation. Notre Dame led 14-10 with :03 left in regulation, but the Buckeyes punched in a 1-yard touchdown to stun the Fighting Irish in their place. Notre Dame still covered, and it is 4-1 against the spread (ATS) this season.

The Blue Devils routed the UConn Huskies in East Hartford by a 41-7 score, with the only drama coming for total bettors. Duke led 41-0 with a total of 45.5, but Under bettors saw UConn break the shutout, and flip the total to an Over result, with just 12 ticks remaining in the game. Duke is now 3-0 ATS in 3 games against FBS opponents.

Notre Dame is No. 13 and Duke is No. 16 in the US LBM Coaches Poll powered by USA TODAY Sports.

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Notre Dame at Duke odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 12:39 p.m. ET.

  • Moneyline (ML): Notre Dame -205 (bet $205 to win $100) | Duke +168 (bet $100 to win $168)
  • Against the spread (ATS): Notre Dame -5.5 (-110) | Duke +5.5 (-110)
  • Over/Under (O/U): 50.5 (O: -110 | U: -110)

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2023 betting stats

  • ML: Notre Dame 4-1 | Duke 4-0
  • ATS: Notre Dame 4-1 | Duke 3-1
  • O/U: Notre Dame 3-2 | Duke 2-1-1

Notre Dame at Duke head-to-head

The Fighting Irish lead the all-time series 5-2. Notre Dame earned a 27-13 victory in South Bend in the most recent meeting during the COVID season in front of no fans on Sept. 12, 2020. The most recent meeting in front of fans was at Wallace Wade on Nov. 9, 2019, a 38-7 victory by the Fighting Irish.

Duke’s last win in the series was a 38-35 win on Sept. 24, 2016, in South Bend. The teams have split the 2 all-time meetings in Durham, with the Blue Devils last winning 37-13 at home against the Irish back on Dec. 2, 1961.

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First look: Ohio State at Notre Dame odds and lines

Looking at Saturday’s Ohio State at Notre Dame college football odds, lines and trends. Here’s what you need to know.

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The Ohio State Buckeyes (3-0) travel to meet the Notre Dame Fighting Irish (4-0) on Saturday at Notre Dame Stadium. Kickoff is scheduled for 7:30 p.m. ET (NBC). Below, we look at Ohio State vs. Notre Dame odds from FanDuel Sportsbook. Also see: SportsbookWire’s college football picks and predictions.

The Buckeyes struggled and failed to cover in their 1st 2 games — winning 23-3 at Indiana, but coming nowhere near a cover as 30-point favorites, and beating Youngstown State 35-7 win as a 40-point favorite. However, Ohio State had its finest game of the season, whipping Western Kentucky 63-10 as a 30-point favorite to nearly take care of the Over (64.5) on its own.

The Fighting Irish are coming off a 41-17 win against Central Michigan Saturday, snapping a 3-0 against the spread (ATS) run. The Over has cashed in each of the past 3 games after opening with an Under result in the opener against Navy in Ireland.

Ohio State is No. 4 and Notre Dame is No. 9 in the US LBM Coaches Poll powered by USA TODAY Sports.

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Ohio State at Notre Dame odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 5:46 a.m. ET.

  • Moneyline (ML): Ohio State -162 (bet $162 to win $100) | Notre Dame +134 (bet $100 to win $134)
  • Against the spread (ATS): Ohio State -3.5 (-105) | Notre Dame +3.5 (-115)
  • Over/Under (O/U): 54.5 (O: -110 | U: -110)

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2023 betting stats

  • ML: Ohio State 3-0 | Notre Dame 4-0
  • ATS: Ohio State 1-2 | Notre Dame 3-1
  • O/U: Ohio State 1-2 | Notre Dame 3-1

Ohio State at Notre Dame head-to-head

The Buckeyes lead the all-time series 5-2, including wins in each of the past 5 battles dating back to Sept. 30, 1995. Ohio State picked up a 21-10 win at “The Horseshoe” in Columbus last season on Sept. 3. The last time these teams met in South Bend was Sept. 28, 1996, a 29-16 victory by Ohio State.

Notre Dame’s last victory in this series came on Oct. 31, 1936, a 7-2 victory at home with Irish coach Elmer Layden outdueling Buckeyes coach Francis Schmidt.

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First look: Central Michigan at Notre Dame odds and lines

Looking at Saturday’s Central Michigan at Notre Dame college football odds, lines and trends. Here’s what you need to know.

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The Central Michigan Chippewas (1-1) and the Notre Dame Fighting Irish (3-0) meet Saturday at Notre Dame Stadium. Kickoff is scheduled for 2:30 p.m. ET (Peacock). Below, we look at Central Michigan vs. Notre Dame odds from FanDuel Sportsbook. Also see: SportsbookWire’s college football picks and predictions.

Central Michigan opened the season with a 31-7 loss at Michigan State in the season opener on Sept. 1, failing to come close to covering a 14-point number as the Under (44.5) cashed. The Chips fired up against New Hampshire of the FCS at Kelly/Shorts, posting a wild 45-42 win Saturday, although again they failed to cover as the Over (48.5) easily hit this time.

Notre Dame has had an odyssey to start the season. It won 42-3 in Dublin, Ireland, over Navy, it pounded Tennessee State of the FCS by a 56-3 count at home and then it outlasted NC State and Mother Nature in stormy Raleigh for a 45-24 win Saturday. The Irish are not only 3-0 straight up (SU), but 3-0 against the spread (ATS), too, and the Over has cashed in the last 2 outings.

Notre Dame is No. 11 in the USA TODAY Sports AFCA Coaches Poll.

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Central Michigan at Notre Dame odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 2:11 p.m. ET.

  • Moneyline (ML): Off the board (OTB)
  • Against the spread (ATS): Central Michigan +33.5 (-110) | Notre Dame -33.5 (-110)
  • Over/Under (O/U): 55.5 (O: -110 | U: -110)

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2023 betting stats

  • ML: Central Michigan 1-1 | Notre Dame 3-0
  • ATS: Central Michigan 0-2 | Notre Dame 3-0
  • O/U: Central Michigan 1-1 | Notre Dame 2-1

Central Michigan at Notre Dame head-to-head

This is the 1st matchup between these institutions on the gridiron.

Central Michigan has lost 3 in a row against Power 5 teams, with its last win against Washington State in the Sun Bowl on Dec. 31, 2021.

Notre Dame is playing against a MAC team for the 1st time since Sept. 11, 2021, a 32-29 win over Toledo as a 16.5-point favorite as the Over (55) cashed that afternoon.

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First look: Navy vs. Notre Dame odds and lines

Looking at Saturday’s Navy vs. Notre Dame college football odds, lines and trends. Here’s what you need to know.

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The Navy Midshipmen and the Notre Dame Fighting Irish open the regular season on Saturday at Aviva Stadium in Dublin, Ireland. Kickoff is scheduled for 2:30 p.m. ET (NBC). Below, we look at Navy vs. Notre Dame odds from BetMGM Sportsbook. Also see: SportsbookWire’s college football picks and predictions.

Navy begins a new era with new head coach Brian Newberry steering the ship, taking over for the fired Ken Niumatalolo. Newberry and new offensive coordinator Grant Chesnut will still try and run the ball, but there will be a little more passing than we’ve seen in previous seasons.

Notre Dame had a close shave against Navy last season, hanging on for a 35-32 victory but falling well short of covering the 17-point spread. The linebackers will be tasked with stopping the run, and they’re one of the strengths of the Irish D. The secondary is also strong, but they’re unlikely to see many tests.

Wake Forest transfer QB Sam Hartman takes the reins of the offense for the Irish. He has plenty of help at the skill positions, and the run game will be just as potent, led by RB Audric Estime.

Notre Dame is No. 13 in the USA TODAY Sports AFCA Coaches Poll.

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Navy vs. Notre Dame odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 6:33 a.m. ET.

  • Moneyline (ML): Navy +800 (bet $100 to win $800) | Notre Dame -1400 (bet $1,400 to win $100)
  • Against the spread (ATS): Navy +20.5 (-110) | Notre Dame -20.5 (-110)
  • Over/Under (O/U): 50.5 (O: -110 | U: -110)

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2022 betting stats

  • ML: Navy 4-8 | Notre Dame 9-4
  • ATS: Navy 7-5 | Notre Dame 7-6
  • O/U: Navy 7-5 | Notre Dame 8-5

Navy vs. Notre Dame head-to-head

Notre Dame leads the all-time series by a 79-13-1 count. The Irish also have 2 vacated wins in the series.

The last time Navy topped the Irish came on Nov. 5, 2016, in Jacksonville, Fla., with the Middies winning 28-27. Notre Dame is 3-1 against the spread (ATS) in the past 4 meetings, with the Over going 3-1. However, the Midshipmen hold a 5-4 ATS advantage over the last 9 meetings, and the Over is 9-3 in the past 12 meetings.

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College sports coverage from USA TODAY Sports Media Group:
Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / Recruiting / Transfer portal / College Football Playoffs / College Sports Wire

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First look: Notre Dame at USC odds and lines

Looking at Saturday’s Notre Dame at USC NCAA Football odds, lines and trends. Here’s what you need to know.

The No. 15 Notre Dame Fighting Irish (8-3) and No. 5 USC Trojans (10-1) clash in a rivalry battle Saturday evening. Kickoff at Los Angeles Memorial Coliseum is scheduled for 7:30 p.m. ET (ABC). Below, we look at Notre Dame vs. USC from Tipico Sportsbook; check back for all our college football picks and predictions.

Notre Dame covered a 19.5-point spread in blanking Boston College 44-0 Saturday. Junior RB Logan Diggs had 122 rushing yards to pace an Irish ground game that pounded out 281 yards, its 2nd-most this season. The win marked UND’s 5th in a row.

The 7th-ranked (CFP) Trojans topped current No. 18 UCLA 48-45 (covering a 2-point spread) Saturday night. QB Caleb Williams threw for a season-high 470 yards in leading Southern Cal to its 4th-straight conquest. USC had 649 total yards in the game and was buoyed by a plus-3 in turnovers.

Rankings courtesy the AFCA Coaches Poll powered by USA TODAY Sports.

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Notre Dame at USC odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 1:50 p.m. ET.

  • Moneyline: Off the board
  • Against the spread (ATS): Notre Dame +5.5 (-110) | USC -5.5 (-110)
  • Over/Under (O/U): 62.5 (O: -110 | U: -110)

2022 betting stats

  • ML: Notre Dame 8-3 | USC 10-1
  • ATS: Notre Dame 6-5 | USC 7-4
  • O/U: Notre Dame 6-5 | USC 8-3

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Notre Dame vs. USC head-to-head

UND won last year’s meeting 31-6 (Oct. 23, 2021) and has won 4 in a row in this series, which dates back to 1926. In 89 all-time meetings, the Fighting Irish lead 48-36-5.

Saturday’s contest will be the 1st series game in Los Angeles since 2018. The rivals have split the last 6 games in Southern California.

Since 2011, each side is 5-5 against the number. The Under has hit in 3 straight meetings and is 6-4 since 2011.

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Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / College Football News

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First look: Boston College at Notre Dame Fighting Irish odds and lines

Looking at Saturday’s Boston College at Notre Dame NCAA Football odds, lines and trends. Here’s what you need to know.

The Boston College Eagles (3-7) and No. 19 Notre Dame Fighting Irish (7-3) meet in South Bend Saturday afternoon. Kickoff at Notre Dame Stadium is scheduled for 2:30 p.m. ET (NBC). Below, we look at Boston College vs. Notre Dame from Tipico Sportsbook; check back for all our college football picks and predictions.

Boston College is fresh off an unexpected 21-20 win at No. 25 NC State. The 17-point underdog Eagles snapped a 4-game losing streak despite logging minus-1 yard in the rushing department. QB Emmett Morehead threw for 330 yards and 3 TDs, as BC won for the 1st time since Oct. 1.

The Irish — tabbed 20th in the College Football Playoff rankings — failed to cover a 17-point spread when they squeaked by Navy 35-32 Saturday. Notre Dame was held scoreless in the 2nd half, but still managed its 4th consecutive victory.

Rankings courtesy the AFCA Coaches Poll powered by USA TODAY Sports.

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Boston College at Notre Dame odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:08 p.m. ET.

  • Moneyline: Boston College +850 (bet $100 to win $850) | Notre Dame -1800 (bet $1,800 to win $100)
  • Against the spread (ATS): Boston College +20.5 (-103) | Notre Dame -20.5 (-117)
  • Over/Under (O/U): 44.5 (O: -115 | U: -105)

2022 betting stats

  • ML: Boston College 3-7 | Notre Dame 7-3
  • ATS: Boston College 3-7 | Notre Dame 5-5
  • O/U: Boston College 5-5 | Notre Dame 5-5

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Boston College vs. Notre Dame head-to-head

The Irish have held sway in recent battles of the Holy War, having won 8 in a row since BC’s last triumph in the series in 2008. Notre Dame is 16-9 overall against the Eagles since 1st meeting in 1975.

Against the number, Notre Dame is on a 3-game win streak. The Irish were favored by 13 when they downed the Eagles 45-31 in the last meeting on  Nov. 14, 2020.

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Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / College Football News

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First look: Clemson at Notre Dame odds and lines

Looking at Saturday’s Clemson at Notre Dame college football odds, lines and trends. Here’s what you need to know.

The No. 5 Clemson Tigers (8-0) and Notre Dame Fighting Irish (5-3) clash in an early November showdown Saturday at Notre Dame Stadium in South Bend. Kickoff is scheduled for 7:30 p.m. ET (NBC). Below, we look at Clemson vs. Notre Dame from Tipico Sportsbook; check back for all our college football picks and predictions.

Clemson enters this game off back-to-back, 1-score victories followed by a Week 9 bye. The Tigers survived a somewhat shaky defensive effort in an Oct. 15 win (34-28) over Florida State. They overcame 4 turnovers in an Oct. 22 victory (27-21) over Syracuse.

The Fighting Irish took down Syracuse Saturday (a week after the Orange fell to Clemson). Notre Dame easily covered a 1.5-point spread in a 41-24 triumph that saw the Irish held an opposing offense under 300 total yards (286) for a 2nd straight week and a 3rd time in 4 weeks.

Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.

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Clemson at Notre Dame odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 10:27 p.m. ET.

  • Moneyline: Clemson -190 (bet $190 to win $100) | Notre Dame +155 (bet $100 to win $155)
  • Against the spread (ATS): Clemson -3.5 (-107) | Notre Dame +3.5 (-115)
  • Over/Under (O/U): 44.5 (O: -107 | U: -115)

2022 betting stats

  • ML: Clemson 8-0 | Notre Dame 5-3
  • ATS: Clemson 4-4 | Notre Dame 4-4
  • O/U: Clemson 4-4 | Notre Dame 3-5

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Clemson vs. Notre Dame head-to-head

Clemson and Notre Dame did not play last season. They did, however, meet twice the year before – once in the regular season (Notre Dame win on Nov. 7, 2020) and once in the ACC Championship Game (Clemson win on Dec. 20, 2020).

The Tigers are 3-1 over 4 games against UND in the last 6 years. All-time – launched in 1977 – includes 6 games (4 CU wins, 2 UND wins).

Since 2015, both teams own a pair of ATS wins in 4 games; the Under is 3-1.

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