First look: Clemson at Notre Dame odds and lines

Looking at Saturday’s Clemson at Notre Dame college football odds, lines and trends. Here’s what you need to know.

The No. 5 Clemson Tigers (8-0) and Notre Dame Fighting Irish (5-3) clash in an early November showdown Saturday at Notre Dame Stadium in South Bend. Kickoff is scheduled for 7:30 p.m. ET (NBC). Below, we look at Clemson vs. Notre Dame from Tipico Sportsbook; check back for all our college football picks and predictions.

Clemson enters this game off back-to-back, 1-score victories followed by a Week 9 bye. The Tigers survived a somewhat shaky defensive effort in an Oct. 15 win (34-28) over Florida State. They overcame 4 turnovers in an Oct. 22 victory (27-21) over Syracuse.

The Fighting Irish took down Syracuse Saturday (a week after the Orange fell to Clemson). Notre Dame easily covered a 1.5-point spread in a 41-24 triumph that saw the Irish held an opposing offense under 300 total yards (286) for a 2nd straight week and a 3rd time in 4 weeks.

Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.

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Clemson at Notre Dame odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 10:27 p.m. ET.

  • Moneyline: Clemson -190 (bet $190 to win $100) | Notre Dame +155 (bet $100 to win $155)
  • Against the spread (ATS): Clemson -3.5 (-107) | Notre Dame +3.5 (-115)
  • Over/Under (O/U): 44.5 (O: -107 | U: -115)

2022 betting stats

  • ML: Clemson 8-0 | Notre Dame 5-3
  • ATS: Clemson 4-4 | Notre Dame 4-4
  • O/U: Clemson 4-4 | Notre Dame 3-5

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Clemson vs. Notre Dame head-to-head

Clemson and Notre Dame did not play last season. They did, however, meet twice the year before – once in the regular season (Notre Dame win on Nov. 7, 2020) and once in the ACC Championship Game (Clemson win on Dec. 20, 2020).

The Tigers are 3-1 over 4 games against UND in the last 6 years. All-time – launched in 1977 – includes 6 games (4 CU wins, 2 UND wins).

Since 2015, both teams own a pair of ATS wins in 4 games; the Under is 3-1.

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