First look: USC at Notre Dame odds and lines

Looking at Saturday’s USC at Notre Dame college football odds, lines and trends. Here’s what you need to know.

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The USC Trojans (6-0) meet the Notre Dame Fighting Irish (5-2) on Saturday at Notre Dame Stadium in South Bend, Ind. Kickoff is scheduled for 7:30 p.m. ET (NBC/Peacock). Below, we look at USC vs. Notre Dame odds from FanDuel Sportsbook. Also see: SportsbookWire’s college football picks and predictions.

The Trojans had a close shave in a home game against Arizona on Saturday. USC narrowly escaped with a 43-41 win in triple overtime, as the Trojans failed to cover for a 3rd straight game. The defense also allowed 41 points for the 2nd straight game, and the Over has cashed in 3 consecutive outings, and 5 of 6 contests overall.

The Fighting Irish suffered a 33-20 loss at Louisville on Saturday night, its 2nd loss in 3 games, sandwiching a 21-14 win at Duke on Sept. 30. It was just the 2nd time that Notre Dame failed to cover the spread this season. The Under has cashed in 3 consecutive contests for the Irish.

USC is No. 9 and Notre Dame is No. 21 in the US LBM Coaches Poll powered by USA TODAY Sports.

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USC at Notre Dame odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 7:01 a.m. ET.

  • Moneyline (ML): USC +108 (bet $100 to win $108) | Notre Dame -130 (bet $130 to win $100)
  • Against the spread (ATS): USC +2.5 (-110) | Notre Dame -2.5 (-110)
  • Over/Under (O/U): 63.5 (O: -105 | U: -115)

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2023 betting stats

  • ML: USC 6-0 | Notre Dame 5-2
  • ATS: USC 2-4 | Notre Dame 5-2
  • O/U: USC 5-1 | Notre Dame 3-4

USC at Notre Dame head-to-head

The Fighting Irish lead the all-time series 48-37-5, with the Trojans winning last season’s meeting in Los Angeles 38-27. Prior to that Notre Dame had won the past 4 meetings, including the 2021 battle in South Bend 31-16.

While Notre Dame is 4-1 straight up (SU) in the past 5 games overall, USC is 3-1 against the spread (ATS) in the previous 4 in the series. The Under has cashed in 3 of the past 4 meetings in this rivalry, too.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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