First look: Notre Dame at USC odds and lines

Looking at Saturday’s Notre Dame at USC NCAA Football odds, lines and trends. Here’s what you need to know.

The No. 15 Notre Dame Fighting Irish (8-3) and No. 5 USC Trojans (10-1) clash in a rivalry battle Saturday evening. Kickoff at Los Angeles Memorial Coliseum is scheduled for 7:30 p.m. ET (ABC). Below, we look at Notre Dame vs. USC from Tipico Sportsbook; check back for all our college football picks and predictions.

Notre Dame covered a 19.5-point spread in blanking Boston College 44-0 Saturday. Junior RB Logan Diggs had 122 rushing yards to pace an Irish ground game that pounded out 281 yards, its 2nd-most this season. The win marked UND’s 5th in a row.

The 7th-ranked (CFP) Trojans topped current No. 18 UCLA 48-45 (covering a 2-point spread) Saturday night. QB Caleb Williams threw for a season-high 470 yards in leading Southern Cal to its 4th-straight conquest. USC had 649 total yards in the game and was buoyed by a plus-3 in turnovers.

Rankings courtesy the AFCA Coaches Poll powered by USA TODAY Sports.

Stream select live college football games and full replays: Get ESPN+

Notre Dame at USC odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 1:50 p.m. ET.

  • Moneyline: Off the board
  • Against the spread (ATS): Notre Dame +5.5 (-110) | USC -5.5 (-110)
  • Over/Under (O/U): 62.5 (O: -110 | U: -110)

2022 betting stats

  • ML: Notre Dame 8-3 | USC 10-1
  • ATS: Notre Dame 6-5 | USC 7-4
  • O/U: Notre Dame 6-5 | USC 8-3

Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!

Notre Dame vs. USC head-to-head

UND won last year’s meeting 31-6 (Oct. 23, 2021) and has won 4 in a row in this series, which dates back to 1926. In 89 all-time meetings, the Fighting Irish lead 48-36-5.

Saturday’s contest will be the 1st series game in Los Angeles since 2018. The rivals have split the last 6 games in Southern California.

Since 2011, each side is 5-5 against the number. The Under has hit in 3 straight meetings and is 6-4 since 2011.

Play our free daily Pick’em Challenge and win! Play now!

Want action on this game or any other NCAA football matchup? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

Follow SportsbookWire on Twitter and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:

Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / College Football News

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1622]