USC at Notre Dame odds, picks and predictions

Analyzing Saturday’s USC at Notre Dame odds and lines, with college football expert picks, predictions and best bets.

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The USC Trojans (6-0) and the Notre Dame Fighting Irish (5-2) meet Saturday at Notre Dame Stadium in South Bend, Ind. Kickoff is scheduled for 7:30 p.m. ET (NBC/Peacock). Below, we analyze BetMGM Sportsbook’s lines around the USC vs. Notre Dame odds, and make our expert college football picks and predictions.

The Trojans fought off an upset bid from Arizona last Saturday night at Los Angeles Memorial Coliseum, winning 43-41 in 3 OT to stay unbeaten. However, it failed to cover for the 3rd straight outing, while cashing the Over in each of the games. That’s because USC has allowed 41 points in consecutive outings, and 28 or more points in 3 in a row.

The Fighting Irish lost that gut-wrenching game to Ohio State on the final play on Sept. 23, before going down to Duke and winning in the final minute. It hit the road for a 2nd straight game inside the ACC last week and fell to Louisville 33-20.

The Under has cashed in 3 in a row for the Irish, mainly because the offense has disappeared. After going for 41 or more points in the first 4 games, the Irish offense has averaged just 18.3 PPG, while allowing 21.3 PPG.

USC slapped the brakes on a 4-game series losing streak last season, winning 38-27 in Los Angeles. The Trojans haven’t won in South Bend since a 31-17 win on Oct. 22, 2011.

USC is No. 9 and Notre Dame is No. 21 in the US LBM Coaches Poll powered by USA TODAY Sports.

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USC at Notre Dame odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 12:06 a.m. ET.

  • Moneyline (ML): USC +120 (bet $100 to win $120) | Notre Dame -145 (bet $145 to win $100)
  • Against the spread (ATS): USC +2.5 (-105) | Notre Dame -2.5 (-115)
  • Over/Under (O/U): 60.5 (O: -105 | U: -115)

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USC at Notre Dame picks and predictions

Prediction

USC 38, Notre Dame 31

Moneyline

It’s hard to believe USC (+120) is actually the underdog here. Yes, Notre Dame (-145) has had its way with the Trojans in this rivalry game in recent seasons, but USC’s offense has been on fire lately, while Notre Dame’s offense has been rather stagnant.

Yes, the Trojans cannot stop anybody, as they allowed Arizona to walk all over them at the Coliseum, and nearly come away with the upset. But USC’s offense can run with anybody, and if this turns into a track meet, I am not sure Notre Dame has the tools to make it to the finish line first.

Against the spread

While I much prefer the Trojans straight up, playing USC +2.5 (-105) isn’t a terrible play, either. I mean, Notre Dame does have a tendency to play close games lately, and it lost on the final play in regulation at home in the most recent home game. And Notre Dame did snatch a victory from Duke in the final minute of regulation, so we could see another close game with a razor-thin difference.

Over/Under

OVER 60.5 (-105) is worth a look, mainly because USC hasn’t offered up very much resistance on defense lately. Even Notre Dame’s moribund offense should come alive somewhat against the very giving Men of Troy.

And we know QB Caleb Williams and the Trojans are going to score. USC has registered 42 or more points in all 6 games to date.

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First look: USC at Notre Dame odds and lines

Looking at Saturday’s USC at Notre Dame college football odds, lines and trends. Here’s what you need to know.

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The USC Trojans (6-0) meet the Notre Dame Fighting Irish (5-2) on Saturday at Notre Dame Stadium in South Bend, Ind. Kickoff is scheduled for 7:30 p.m. ET (NBC/Peacock). Below, we look at USC vs. Notre Dame odds from FanDuel Sportsbook. Also see: SportsbookWire’s college football picks and predictions.

The Trojans had a close shave in a home game against Arizona on Saturday. USC narrowly escaped with a 43-41 win in triple overtime, as the Trojans failed to cover for a 3rd straight game. The defense also allowed 41 points for the 2nd straight game, and the Over has cashed in 3 consecutive outings, and 5 of 6 contests overall.

The Fighting Irish suffered a 33-20 loss at Louisville on Saturday night, its 2nd loss in 3 games, sandwiching a 21-14 win at Duke on Sept. 30. It was just the 2nd time that Notre Dame failed to cover the spread this season. The Under has cashed in 3 consecutive contests for the Irish.

USC is No. 9 and Notre Dame is No. 21 in the US LBM Coaches Poll powered by USA TODAY Sports.

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USC at Notre Dame odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 7:01 a.m. ET.

  • Moneyline (ML): USC +108 (bet $100 to win $108) | Notre Dame -130 (bet $130 to win $100)
  • Against the spread (ATS): USC +2.5 (-110) | Notre Dame -2.5 (-110)
  • Over/Under (O/U): 63.5 (O: -105 | U: -115)

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2023 betting stats

  • ML: USC 6-0 | Notre Dame 5-2
  • ATS: USC 2-4 | Notre Dame 5-2
  • O/U: USC 5-1 | Notre Dame 3-4

USC at Notre Dame head-to-head

The Fighting Irish lead the all-time series 48-37-5, with the Trojans winning last season’s meeting in Los Angeles 38-27. Prior to that Notre Dame had won the past 4 meetings, including the 2021 battle in South Bend 31-16.

While Notre Dame is 4-1 straight up (SU) in the past 5 games overall, USC is 3-1 against the spread (ATS) in the previous 4 in the series. The Under has cashed in 3 of the past 4 meetings in this rivalry, too.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Kevin J. Erickson on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:
Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / Recruiting / Transfer portal / College Football Playoffs / College Sports Wire

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First look: USC at Notre Dame odds and lines

Previewing the USC at Notre Dame Week 8 matchup, with college football odds, trends and head-to-head records.

The USC Trojans (3-3) visit the Notre Dame Fighting Irish (5-1) Saturday in South Bend, Ind. The game at Notre Dame Stadium is scheduled for 7:30 p.m. ET. Below, we look at the USC vs. Notre Dame odds and lines; check back for our college football picks and predictions.

USC comes in off a bye week. The Trojans have struggled on defense over the season’s first half. Southern Cal has coughed up 40-plus points in each of its three losses. Overall, USC ranks an average-sounding 69th in FBS in total defense (382.2 yards per game). But two of the team’s three victories have come against foes (Colorado, San Jose State) that rank among the bottom-15 offensive teams.

The Fighting Irish bounced back with an Oct. 9 win over Virginia Tech after falling to the Cincinnati Bearcats Oct. 2. Notre Dame has inexplicably averaged just 2.8 yards per carry in the ground game. Its 96.2 rushing yards per game rank 96th in the nation. But being in South Bend ought to help: UND had won 26 straight at Notre Dame Stadium until the 24-13 setback to UC.

USC at Notre Dame odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 4:35 p.m. ET.

  • Money line: USC +205 (bet $100 to win $205) | Notre Dame -260 (bet $260 to win $100)
  • Against the spread (ATS): USC +6.5, -103 (bet $103 to win $100) | Notre Dame -6.5, -117 (bet $117 to win $100)
  • Over/Under (O/U): 58.5, O: -103 (bet $103 to win $100) | U: -117 (bet $117 to win $100)

Also see: Betting 101

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2021 betting stats:

  • ML: USC 3-3 | Notre Dame 5-1
  • ATS: USC 3-3 | Notre Dame 3-3
  • O/U: USC 4-2 | Notre Dame 4-2

USC at Notre Dame head-to-head

Notre Dame is 47-36-5 in this series that dates back to 1926. The Irish have won three straight in the series.

The last two games (2018, 2019) were decided by one-score margins. The 2020 game was a casualty of COVID-19 protocols.

The home side has beaten the spread in six of the last seven meetings.

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