Fantasy Football: 5 important handcuff running backs for 2022

Alexander Mattison is the clear choice to top this list of running back handcuffs to target in fantasy football.

There are some NFL backfields with two fantasy-relevant running backs who have standalone value in fantasy football even if both RBs stay healthy.

And there are other backfields that feature a backup who doesn’t offer much standalone value but is still a must-roster player due to the workload he’d assume if the starter went down. That’s a handcuff running back, or an insurance running back, and these are five of the top candidates you should consider this season.