San Francisco Giants at Los Angeles Dodgers odds, picks and predictions

Analyzing Wednesday’s San Francisco Giants at Los Angeles Dodgers odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (2-4) and Los Angeles Dodgers (6-2) meet Wednesday as they close out a 3-game series at Dodger Stadium. First pitch is slated for 10:10 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Dodgers odds and make our expert MLB picks and predictions for the best bets.

Season series: Dodgers lead 2-0

San Francisco dropped Tuesday’s game 5-4 to log its 3rd straight setback. The Giants have lost 6 of their last 7 games against Los Angeles.

The Dodgers are thus far 5-1 at Dodger Stadium (L.A. also had 1 home game in Seoul, South Korea). Los Angeles pitching owns a 2.78 ERA, 1.04 over those games in their home yard.

Giants at Dodgers projected starters

LHP Kyle Harrison vs. RHP Tyler Glasnow

Harrison (1-0, 3.00 ERA) is tabbed for his 2nd start this season. He allowed 2 ER on 6 H and 0 BB with 5 K in 6 IP in his debut at the San Diego Padres Friday.

  • Posted a 4.15 ERA, 1.15 WHIP in a 7-start 2023 rookie season
  • Career vs. Dodgers: 0-0, 1.74 ERA (10 1/3 IP, 2 ER), 3 H, 3 BB, 6 K in 2 starts

Glasnow (1-0, 2.45 ERA) makes his 3rd start. He has a 0.82 WHIP, 4.1 BB/9 and 6.6 K/9 in 11 innings.

  • Owns a 3.86 ERA, 1.20 WHIP across 129 career games; logged a 3.53 ERA for the Tampa Bay Rays in 2023
  • Makes this start on 5-day rest, which figures as his preferred interval (.623 OPS allowed)
  • Last outing: Win, 6 IP, 1 ER, 2 H, 1 BB, 5 K in 7-1 win vs. St. Louis Cardinals
  • Career vs. Giants: 2-0, 0.64 ERA (14 IP, 1 ER), 8 H, 5 BB, 16 K in 2 starts and 1 relief appearance

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Giants at Dodgers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:45 a.m. ET.

  • Moneyline: Giants +180 (bet $100 to win $180) | Dodgers -225 (bet $225 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-105) | Dodgers -1.5 (-115)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

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Giants at Dodgers picks and predictions

Prediction

Dodgers 4, Giants 2

Moneyline

Lots of juice clouding profit potential here. PASS.

Run line/Against the spread

Harrison was aided by a .236 batting average on balls in play last season. Glasnow’s early-season stuff has often been dominant over his career (.584 OPS allowed).

Peg a moderate lean on the DODGERS -1.5 (-115).

Over/Under

The Over is 4-0-1 across L.A.’s last 4 games and is undefeated across the Giants’ 6 games this season.

But there is some lean toward a pushback in Wednesday’s series finale. Most of that comes from the L.A. side of the equation, with Glasnow being a pick to click and on the Dodgers’ offensive numbers being a bit overcooked by a .358 batting average on balls in play (.379 BABIP with runners in scoring position) and a 17.1% of fly balls landing as home runs.

The back ends of both bullpens figure as mostly available.

Consider a partial-unit play on the UNDER 8.5 (-115).

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San Francisco Giants at Los Angeles Dodgers odds, picks and predictions

Analyzing Tuesday’s San Francisco Giants at Los Angeles Dodgers odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (2-3) and Los Angeles Dodgers (5-2) continue a 3-game NL West series Tuesday night. First pitch at Dodger Stadium is slated for 10:10 p.m. ET (TBS). Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Dodgers odds and make our expert MLB picks and predictions for the best bets.

Season series: Dodgers lead 1-0

San Francisco went 1-for-7 with runners in scoring position in dropping Monday’s series opener 8-3. The Giants are 1 for their last 14 in such situations.

The Dodgers are thus far 5-1 at Dodger Stadium (they also had 1 home game in Seoul, South Korea). Los Angeles pitching has been sharp at home, logging a 2.54 ERA and 0.98 WHIP.

Giants at Dodgers projected starters

RHP Logan Webb vs. Undecided

Webb (0-0, 3.00 ERA) makes his 2nd start of the season. He has a 1.17 WHIP, 3.0 BB/9 and 7.5 K/9 through 6 IP.

  • Owns a 3.07 ERA over the last 3 seasons
  • Last outing: Loss, 6 IP, 2 ER, 5 H, 2 BB, 5 K in 6-4 loss at San Diego Padres
  • Career vs. Dodgers: 3-5, 3.96 ERA (63 2/3 IP, 28 ER), 63 H, 18 BB, 51 K
  • Per ESPN, current Dodger bats own an aggregate .895 OPS against him

The Dodgers are expected to go with bullpen options to make their way through Tuesday’s game.

  • RHP Michael Grove and LHP Ryan Yarbrough figure as likely sources of bulk innings

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Giants at Dodgers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:49 a.m. ET.

  • Moneyline: Giants +120 (bet $100 to win $120) | Dodgers -145 (bet $145 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-165) | Dodgers -1.5 (+140)
  • Over/Under (O/U): 8.5 (O: +100 | U: -120)

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Giants at Dodgers picks and predictions

Prediction

Giants 5, Dodgers 4

Moneyline

San Francisco is a respectable 4-4 over its last 8 games at Dodger Stadium. The Giants were a solid preseason futures play and figure to be a tad undervalued here.

But bullpen games, especially early-season ones, draw a caution flag in this corner. Consider a pass and going with just the stronger Over bet or going in small — like half of a half of a unit small — on the visiting GIANTS +120.

Run line/Against the spread

PASS: Better relative value can be found elsewhere.

Over/Under

The Over hit Monday and is 3-0-1 across the Dodgers’ last 4 games and is undefeated across the Giants’ 5 games this season.

Los Angeles has had few problems against Webb in the past. The San Francisco right-hander is durable and can usually get fairly deep into games, but this is start No. 2 and he did register 97 pitches in his debut effort. What’s behind him are the Over-worthy numbers thus far posted by the Giants bullpen. Through 16 innings, San Francisco relievers own a 10.12 ERA.

On what is expected to be a breeze-blowing-out night at Chavez Ravine, BACK THE OVER 8.5 (+100).

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San Francisco Giants at Los Angeles Dodgers odds, picks and predictions

Analyzing Monday’s San Francisco Giants at Los Angeles Dodgers odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (2-2) and Los Angeles Dodgers (4-2) open a 3-game NL West rivalry set Monday night. First pitch at Dodger Stadium is slated for 10:10 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Dodgers odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Los Angeles won last year’s series 7-6

San Francisco took 2 of 4 games in a season-opening series at the San Diego Padres. Giants pitching was touched up for a 6.35 ERA in the 4 games.

The Dodgers remain at home after taking 3 of 4 games against the St. Louis Cardinals. L.A. pitching filed a 2.68 ERA and 10.8 strikeouts per 9 IP in the  quartet of games in Chavez Ravine.

Giants at Dodgers projected starters

RHP Keaton Winn vs. LHP James Paxton

Winn makes his season debut. In his rookie 2023 campaign, he went 1-3 with a 4.68 ERA, 1.04 WHIP, 1.7 BB/9 and 7.4 K/9 in 42 1.3 IP.

  • Did not make his Cactus League debut until March 17 after experiencing elbow soreness in late-February.
  • Will likely be on a relatively limited pitch count (threw 42 pitches in his 2nd of just 2 spring-training outings)
  • Career vs. Dodgers: 0-1, 10.13 ERA (5 1/3 IP, 6 ER), 6 H, 0 BB, 5 K in 1 start

Paxton is making his season debut. Pitching 19 games for the Boston Red Sox in 2023, the veteran lefty went 7-5 with a 4.50 ERA, 1.31 WHIP, 3.1 BB/9 and 9.5 K/9 in 96 IP.

  • Limited to just 6 starts from 2020-22 due to injuries and was shut down with a knee injury in early September last season
  • Struggled after the All-Star break, notching a 6.98 ERA
  • Career vs. Giants: 1-0, 3.38 ERA (10 2/3 IP, 4 ER), 13 H, 4 BB, 13 K in 2 starts

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Giants at Dodgers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:13 a.m. ET.

  • Moneyline: Giants +185 (bet $100 to win $185) | Dodgers -225 (bet $225 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-110) | Dodgers -1.5 (-110)
  • Over/Under (O/U): 9 (O: +100 | U: -120)

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Giants at Dodgers picks and predictions

Prediction

Dodgers 6, Giants 4

Moneyline

PASS: The run line in this one offers up drier (less juice) tags.

Run line/Against the spread

San Francisco’s 2 losses have been by multiple runs; 3 of the Dodgers’ 4 wins have been by multi-run margins.

Los Angeles has taken 4 of the last 5 meetings against their Northern California rivals. Three of those wins were by 3 runs or more. Over 2022-23, the Dodgers played .679 (110-52) baseball in Chavez Ravine, and regardless of the many home parks he has toiled in, Paxton has usually been a much better pitcher in home environs.

Winn faced the Dodgers once last season (Sept. 29) and was rocked, allowing 6 runs (3 home runs) in 5 1/3 IP.

FanDuel Sportsbook has a better value on the Dodgers RL play. Back the DODGERS -1.5 (-102).

Over/Under

The San Francisco offense figures to be solid in 2024, and the Dodgers are loaded up and down the lineup.

Both starters have question marks. With the season getting underway in earnest Thursday, both bullpens are 4 days more tangled than they were in the freshness of Opening Day air.

The Los Angeles weather report is calling for a double-digit wind blowing out, and that could mean an extra run or more on the odd potential wall-scraper or would-be long fly landing for extra bases.

FanDuel’s price here makes for extra leverage. TAKE THE OVER 8.5 (-110).

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Sunday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (2-1) and San Diego Padres (2-3) close out a 4-game series Sunday at Petco Park. First pitch is scheduled for 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 2-1

San Francisco went 4 for 7 with runners in scoring position in a 9-6 win over San Diego Saturday. Over their 2 wins in this series, the Giants gave gone 9 of 18 in such situations.

The Padres had 3 extra-base hits Saturday. A San Diego club that last year tallied a league-average .413 slugging percentage has banged out 14 extra-base hits over its last 4 games.

Giants at Padres projected starters

RHP Daulton Jefferies vs. RHP Michael King

Jefferies has not pitched in the Majors since 2022; he missed last season recovering from his 2nd Tommy John surgery.

  • Owns a 5.75 ERA over 14 career games (10 starts)
  • Pitched 14 innings in spring training, logging a 2.57 ERA with 16 K against 3 BB
  • Has never faced the Padres

King (4-8, 2.75 ERA with the New York Yankees in 2023) is making his 1st home start with the Padres after being acquired in the Juan Soto trade. Last season, he had a 1.15 WHIP, 2.8 BB/9 and 10.9 K/9 in 104 2/3 innings.

  • Last outing: Win, 3 1/3 IP, 3 ER, 4 H, 3 BB, 5 K in 15-11 win vs. Los Angeles Dodgers March 21 (in South Korea)
  • Has faced the Giants once, tossing 1 2/3 innings against them last April 1 (2 R allowed on 4 H and 1 BB; struck out 3)
  • This game marks his 20th career start; he owns a 3.44 career ERA across 116 games overall

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Giants at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:35 a.m. ET.

  • Moneyline: Giants +115 (bet $100 to win $115) | Padres -135 (bet $135 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-175) | Padres -1.5 (+145)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

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Giants at Padres picks and predictions

Prediction

Padres 5, Giants 4

Moneyline

There are too many questions on the Giants side of the ledger, especially with Jefferies getting the nod for the 1st time since May 18, 2022.

King will likely see a hefty contingent of left-handed batters in the San Francisco order, but the former Yankee relief standout has an excellent history against batters of the opposite hand (.656 OPS allowed career, .542 OPSA in 2023).

The Padres went 9-3 at home last September; they are 13-7 across their last 20 home games against San Francisco.

FanDuel Sportsbook has the best value price here: BET THE PADRES (-132).

Run line/Against the spread

PASS: Peg the ML as having the best leverage in this matchup.

Over/Under

The Over has cashed in all 3 games of this series.

Both offenses are clicking so far this season, and there are mound questions on both sides in this series finale. Last September, the Padres got on a roll at home. Over those last 12 games referenced above, they cranked out an .854 OPS while scoring 5.58 runs per game.

San Francisco banged out an .817 OPS in spring training, and batters on both sides get the likely benefit of a significant outward breeze, which is in the forecast. The game could also be in jeopardy due to expected heavy rain.

FanDuel Sportsbook has better leverage: BACK THE OVER 8.5 (-110).

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Saturday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (2-2) welcome the San Francisco Giants (1-1) to Petco Park for the 3rd of a 4-game series Saturday. First pitch is set for 7:15 p.m. ET (FOX). Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 1-1.

The Padres lost their season-opening game 5-2 to the Los Angeles Dodgers but won the following 2, scoring at least 6 in both games. In its 4th game of the season, San Diego lost to the Giants 8-3. It has yet to hold a team to under 4 runs. The Padres finished 3rd in the National League West last season with an 82-80 record. They were 44-37 at home.

The Giants lost to the Padres 6-4 on Opening Day as a slight underdog then took down the Padres 8-3 Friday, closing +124 on the moneyline. The Giants have the league’s 10th-highest payroll, so expectations are high for them this season. San Fran finished last season 79-83 and was 34-47 on the road. They are 1-1 against the spread (ATS) this season and 2-0 O/U.

Giants at Padres projected starters

RHP Jordan Hicks vs. RHP Dylan Cease

Hicks (3-9, 3.29 ERA) made 65 appearances and 0 starts in 2023. He owned a 1.35 WHIP, 4.4 BB/9 and 11.1 K/9 through 65 2/3 IP.

  • 2023 road splits: 2-3, 0.87 ERA (31 IP, 3 ER — 2 HR), 9 BB, 42 K in 31 appearances.
  • Hasn’t pitched against San Diego since April 7, 2019
  • Spent last season split between the Cardinals and Blue Jays

Cease (7-9, 4.58 ERA) made 33 starts last season for the White Sox. He finished with a 1.42 WHIP, 4.0 BB/9 and 10.9 K/9 through 177 IP.

  • 2023 home splits: 3-7, 4.20 ERA (94 1/3 IP, 44 ER — 8 HR), 48 BB, 104 K in 17 starts
  • White Sox were 16-17 in the 33 games Cease started last season
  • 2023 vs. San Francisco: Win, 5 IP, 1 ER (1 HR), 5 BB, 1 H in a 7-3 home victory

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Giants at Padres odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11 a.m. ET.

  • Moneyline (ML): Giants +110 (bet $100 to win $110) | Padres -130 (bet $130 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-194) | Padres -1.5 (+160)
  • Over/Under (O/U): 7.5 (O: -112 | U: -108)

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Giants at Padres picks and predictions

Prediction

Padres 5, Giants 3

Moneyline

BET PADRES (-130).

The Giants will likely play most of their game from the bullpen with Hicks transitioning to the rotation. San Fran didn’t have a terrific set or relievers last season, finishing 14th in the MLB in reliever ERA.

San Diego was solid at home last season, ending 44-37. It was also 43-37 following a loss last season. The Padres should have the pitching edge and have tallied at least 6 runs in 2 of their last 3 games.

Take the home side here and back PADRES (-130).

Run line/Against the spread

PASS.

There’s no real value here. The Giants are too expensive to play as a run-line underdog while the Padres are too risky to take as a run-line favorite. Ultimately, the moneyline has the best team-specific value.

Over/Under

LEAN OVER 7.5 (-112).

If there’s one thing both teams have done well this season, it is hit the Over. The Padres are averaging 8 runs per game over their last 3 games and are 3-1 O/U on the season.

The Giants are 2-0 O/U and have scored at least 4 per game while allowing 4.5 per game in their 2 performances this season. Neither team has an ace taking the mound.

With that in mind, expect the offenses to stay hot and take OVER 7.5 (-112).

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Friday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (0-1) and San Diego Padres (2-1) play the 2nd game of a 4-game set Friday at Petco Park. First pitch is scheduled for 9:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 1-0

San Francisco dropped Thursday’s series opener 6-4. With the setback, the Giants are now 2-5 across their last 7 season openers. Dating back to last September, San Francisco is 1-6 in their last 7 games against San Diego.

San Diego plated 4 runs in the bottom of the 7th inning, pulling off a comeback from a 3-2 deficit in Thursday’s contest. The Padres went 4 of 12 with runners in scoring position.

Giants at Padres projected starters

LHP Kyle Harrison vs. RHP Joe Musgrove

Harrison (1-1, 4.15 ERA in 2023) makes his 1st start this season and 8th of his career. He had a 1.15 WHIP, 2.9 BB/9 and 9.1 K/9 in 34 2/3 innings last season.

  • 2023 with Sacramento (AAA): 1-3, 4.66 ERA (65 2/3 IP, 34 ER), 48 BB in 20 starts
  • 2023 road stats: 0-1, 6.28 ERA (14 1/3 IP, 10 ER) in 3 starts
  • Career vs. Padres: Loss, 5 2/3 IP, 6 ER, 6 H, 2 BB, 5 K in 1 start, a 6-1 road loss Sept. 2, 2023

Musgrove (0-0, 16.88 ERA) makes his 2nd start. He allowed 5 ER on 7 H and 2 BB with 2 K in 2 2/3 IP in his debut vs. the Los Angeles Dodgers in Seoul, South Korea March 21.

  • Missed last 3 months of 2023 with a shoulder injury
  • Per ESPN, has held current Giants batters to a collective .627 OPS
  • 2023 stats: 10-3, 3.05 ERA (97 1/3 IP, 33 ER) in 17 starts
  • 2023 home stats: 6-1, 3.04 ERA (56 1/3 IP, 19 ER) in 10 starts
  • 2023 vs. Giants: No-decision, 3 1/3 IP, 7 ER, 6 H, 1 BB, 3 K in 1 start, a 16-11 home win April 29
  • Career vs. Giants: 4-3, 3.86 ERA (74 2/3 IP, 32 ER) in 13 starts

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Giants at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:50 a.m. ET.

  • Moneyline: Giants +125 (bet $100 to win $125) | Padres -150 (bet $150 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-165) | Padres -1.5 (+140)
  • Over/Under (O/U): 8 (O: +100 | U: -120)

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Giants at Padres picks and predictions

Prediction

Padres 5, Giants 4

Moneyline

The San Diego weather report calls for an outward breeze, and Harrison figures as a fly-ball pitcher. There are questions on both sides of this mound match-up, but Musgrove figures as the more projectable and dependable hurler.

The Friars (-150) do have a left-leaning lineup and one that struggled against port-siders in 2023 (.683 OPS), but in his rookie-season small sample, Harrison did not exactly mow down lefty batters (1.068 OPS allowed).

Dating back to last August, San Diego is 11-4 across its last 15 games at Petco Park.

BET PADRES (-150).

Run line/Against the spread

PASS: Peg the ML as having the best leverage in this matchup.

Over/Under

The last 9 games of this series have seen the winning club score at least 5 runs. Peg the Padre bats as having some confidence after Thursday’s comeback. San Francisco had a robust .817 OPS in spring training, and batters on both sides get the likely benefit of a breeze blowing out.

FanDuel Sportsbook has the best value price here: BACK THE OVER 7.5 (-112).

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Thursday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (0-0) open the season against the San Diego Padres (1-1) on Thursday. The NL West rivals meet at Petco Park with 1st pitch scheduled for a 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Padres won last year’s series 8-5

By many accounts, San Diego underplayed its talent level in going 82-80 a year ago. The Padres, now several pieces lighter after shedding salary, placed 3rd in the NL West, 3 games ahead of San Francisco.

The Giants went 79-83 last season. They were quite good May-June, going 35-20 with a run differential to match. But San Francisco faded down the stretch, especially late. They went just 9-19 after Sept. 1.

Thursday’s game marks the Giants’ season opener. The Friars split 2 feature games against the Los Angeles Dodgers on March 20-21 in Seoul, South Korea.

Giants at Padres projected starters

Logan Webb vs Yu Darvish

Webb went 11-13 with a 3.25 ERA last season. He logged a 1.07 WHIP, 1.3 BB/9 and 8.1 K/9 in 216 IP last season.

  • Owns a tidy 3.07 ERA across the last 3 seasons (92 games)
  • Faced San Diego just once last season, allowing 1 run in 9 IP
  • Struggled in spring training, allowing 37 hits and 26 ER in 21 1/13 IP

Darvish went 8-10 with a 4.56 ERA last season. He notched a 1.3 WHIP, 2.8 BB/9 and 9.3 K/9 across 136 1/3 IP.

  • Started March 20 game vs. Dodgers in South Korea: went 3 2/3 IP, allowing 1 unearned run on 2 H with 3 BB and 3 K
  • Pitched 12 IP against the Giants in 2023: allowed 8 R on 12 H

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Giants at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 10:45 9.m. ET.

  • Moneyline: Giants -105 (bet $105 to win $100) | Padres -115 (bet $100 to win $115)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+210) | Padres +1.5 (-170)
  • Over/Under (O/U): 7.5 (O: -110 | U: -110)

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Giants at Padres picks and predictions

Prediction

Giants 4, Padres 3

Moneyline

The Giants are a decent futures play in 2024, and Webb on the mound puts a good foot forward for the visitors. Plus the Giants banged the ball around pretty good in Cactus League play. Their .817 OPS ranked 3rd in MLB batting.

San Diego has to deal with the baseball rarity of multi-day travel and extra off days.

BET SAN FRANCISCO (-105).

Run line/Against the spread

PASS: Peg the ML as having the best leverage in this matchup.

Over/Under

The Under has cashed in 5 straight San Francisco-San Diego meetings and is the slight lean here.

The pitching starts at (mostly) square one for both sides. Rotations are at the top and bullpens are fresh. Mix in a weather report that calls for a double-digit win blowing in from left, and the low side is the way to go.

BACK THE UNDER 7.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on Twitter/X and like us on Facebook.

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (78-80) and San Francisco Giants (78-80) meet for the final time this season on Wednesday. First pitch from Oracle Park is 9:45 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 7-5

The Padres lost the opener 2-1, but bounced back Tuesday night with a 4-0  win. They have won 10 of their last 12 games, but are 1 game from being eliminated from Wild Card contention.

The Giants are 3-9 in their last 12 games. They also are 1 game from being eliminated.

Padres at Giants projected starters

RHP Matt Waldron vs. LHP Sean Manaea

Waldron (1-3, 4.58 ERA) makes his 6th start and 8th appearance. He has a 1.25 WHIP, 2.5 BB/9 and 7.4 K/9 in 35 1/3 innings.

  • Last start: No-decision, 5 2/3 IP, 1 ER, 3 H, 2 BB, 9 K in 4-2 home win over St. Louis Cardinals on Friday
  • Allowed 1 ER in 5 IP in a no-decision vs. Giants Aug. 31

Manaea (7-6, 4.51 ERA) makes his 10th start and 37th appearance. He has a 1.25 WHIP, 3.4 BB/9 and 9.7 K/9 in 111 2/3 innings.

  • Last start: Win, 7 IP, 0 R, 3 H, 0 BB, 2 K in 5-1 victory at the Los Angeles Dodgers on Friday
  • Is 2-1 with 2.00 ERA in 3 starts since rejoining the rotation

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Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:21 p.m. ET.

  • Moneyline (ML): Padres -110 (bet $110 to win $100) | Giants -110 (bet $110 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+150) | Giants +1.5 (-185)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 2

Moneyline

The Padres have won 10 of their last 12 games and, while they are only 34-43 on the road this season, they have won 5 of their last 6 road games. Also, Waldron has only allowed 3 runs in his last 2 starts (11 IP).

You can take Padres straight up and it isn’t a bad play but you have win more on the spread, based on their recent play.

PASS.

Run line/Against the spread

Thirty of the Padres’ last 31 wins have been by 2 or more runs. They have covered the spread in 9 of their last 12 games. Meanwhile, 7 of the Giants’ last 8 losses have been by 2 or more runs.

BET PADRES -1.5 (+150).

Over/Under

Half of the 12 games between the  teams have not reached 9 runs. The last 4 meetings have had fewer than 9. And 6 of the Padres’ last 7 games have not reached 9 runs.

BET UNDER 8.5 (-115).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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Additional MLB coverage:
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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Tuesday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (77-80) and San Francisco Giants (78-79) play the 2nd game of a 3-game set Tuesday at Oracle Park. First pitch is scheduled for 9:45 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 6-5

The Padres lost 2-1 as -114 favorites as the Under (7) hit in the series opener Monday. San Diego has lost 2 of 3 and has fallen to 5½ games back of the Arizona Diamondbacks and the Chicago Cubs, who are tied for the final 2 NL Wild Cards.

Giants LF Michael Conforto batted in both runs for San Francisco with a 2-run single in the 8th inning. The Giants have won just 3 of their last 11 outings and are 4½ games out of the final NL Wild Card spot.

Padres at Giants projected starters

RHP Seth Lugo vs. LHP Kyle Harrison

Lugo (7-7, 3.79 ERA) makes his 26th start. He has a 1.24 WHIP, 2.2 BB/9 and 8.7 K/9 in 137 2/3 innings.

  • Last start: No-decision, 6 IP, 2 ER, 7 H, 2 BB, 7 K in 3-2 home victory vs. Colorado Rockies Wednesday
  • 2023 road stats: 3-3, 3.91 ERA (73 2/3 IP, 32 ER) in 13 starts
  • 2023 vs. Giants: 1-0, 0.82 ERA (11 IP, 1 ER) in 2 starts — Most recent: Win, 6 IP, 0 ER, 3 H, 1 BB, 4 K in 4-0 home victory Sept. 3
  • Career vs. Giants: 3-2, 2.52 ERA (35 2/3 IP, 10 ER) across 4 starts and 11 relief appearances

Harrison (1-1, 4.85 ERA) makes his 7th start. The rookie has a 1.28 WHIP, 2.7 BB/9 and 9.4 K/9 in 29 2/3 innings.

  • Last start: No-decision, 5 1/3 IP, 2 ER, 3 H, 1 BB, 2 K in 7-2 loss at Los Angeles Dodgers Thursday
  • 2023 home stats: 1-0, 3.52 ERA (15 1/3 IP, 6 ER) in 3 starts
  • Career vs. Padres: Loss, 5 2/3 IP, 6 ER, 6 H, 2 BB, 5 K in 1 start, a 6-1 road loss Sept. 2

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Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:21 a.m. ET.

  • Moneyline (ML): Padres -125 (bet $125 to win $100) | Giants +105 (bet $100 to win $105)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+135) | Giants +1.5 (-160)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 4

Moneyline

The PADRES (-125) will get eliminated with 1 more loss this season. They would also get eliminated by 1 more win for the Diamondbacks and Cubs, but that is out of their control. San Diego scored 6 runs on Harrison the 1st time they saw him, and I expect it to have a similar performance Tuesday in a must-win scenario.

BET PADRES (-125).

Run line/Against the spread

The Giants are 19-7 on the run line this season as home underdogs. San Francisco +1.5 (-160) will probably hit, but there’s no need to pay the higher price on the run line when San Diego ML is the better play.

PASS. Bet the moneyline and/or the total instead.

Over/Under

The Over is 22-19-4 (53.7%) this season when the Padres are road favorites. San Diego scored just 1 run Monday, and I expect it to bounce back vs. the rookie Harrison.

The Under has hit in 4 straight games for San Francisco, but its last Over cashed in Harrison’s most recent start.

BET OVER 8.5 (-105).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Monday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (77-79) and San Francisco Giants (77-79) open a 3-game set Monday at Oracle Park. First pitch is scheduled for 9:45 p.m. ET (FS1). Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 6-4

The Padres won 12-2 as -189 home favorites vs. the St. Louis Cardinals as the Over (8) hit Sunday. San Diego has won 9 of its last 10 games and is tied with San Francisco in the NL Wild Card standings, 5 games back of the Chicago Cubs for the final spot.

The Giants lost 3-2 as +149 underdogs at the Los Angeles Dodgers as the Under (9) cashed Sunday. San Francisco is 2-8 in its last 10 games.

Padres at Giants projected starters

LHP Blake Snell vs. RHP Logan Webb

Snell (14-9, 2.33 ERA) makes his 32nd start. He has a 1.20 WHIP, 5.0 BB/9 and 11.7 K/9 in 174 innings.

  • Last start: No-decision, 7 IP, 0 ER, 0 H, 4 BB, 10 K in 2-0 home victory vs. Colorado Rockies Tuesday
  • 2023 road stats: 5-4, 2.13 ERA (84 2/3 IP, 20 ER) in 15 starts
  • 2023 vs. Giants: 2-0, 0.00 ERA (12 IP) across 2 starts
  • Career vs. Giants: 5-1, 1.83 ERA (44 1/3 IP, 9 ER) over 8 starts

Webb (10-13, 3.35 ERA) makes his 33rd start. He has a 1.08 WHIP, 1.3 BB/9 and 8.1 K/9 in 207 innings.

  • Last start: Loss, 6 IP, 3 ER, 9 H, 2 BB, 4 K in 7-1 loss at Arizona Diamondbacks Wednesday
  • 2023 home stats: 6-6, 2.37 ERA (102 2/3 IP, 27 ER) in 15 starts
  • Career vs. Padres: 2-2, 2.77 ERA (48 2/3 IP, 15 ER) in 8 starts and 1 relief appearance — last faced San Diego in 2022

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Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:46 a.m. ET.

  • Moneyline (ML): Padres -115 (bet $115 to win $100) | Giants -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+155) | Giants +1.5 (-190)
  • Over/Under (O/U): 7 (O: +100 | U: -120)

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Padres at Giants picks and predictions

Prediction

Padres 3, Giants 2

Moneyline

The PADRES (-115) are one of the hottest teams in MLB right now as they continue on their very unlikely postseason push. Snell has been dominant in 2 starts this season vs. the Giants, who have been struggling to win games lately. It may be too little, too late for San Diego’s playoff aspirations, but I’ll still take the hotter team with the better pitcher.

BET PADRES (-115).

Run line/Against the spread

The Giants are 18-7 on the run line this season as home underdogs, according to TeamRankings.com. San Francisco +1.5 (-190) will likely hit, but there’s no need to pay the higher price on the run line when San Diego ML is the better play.

PASS. Bet the moneyline and/or the total instead.

Over/Under

The Under is 43-30-2 (58.9%) in Giants home games this season and has hit in 4 of the Padres’ last 5 overall. With Snell and Webb on the mound in a must-win game for both teams, I like UNDER 7 (-120) to cash Monday at Oracle Park.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Corey Scott on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Additional MLB coverage:
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