San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Sunday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (2-1) and San Diego Padres (2-3) close out a 4-game series Sunday at Petco Park. First pitch is scheduled for 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 2-1

San Francisco went 4 for 7 with runners in scoring position in a 9-6 win over San Diego Saturday. Over their 2 wins in this series, the Giants gave gone 9 of 18 in such situations.

The Padres had 3 extra-base hits Saturday. A San Diego club that last year tallied a league-average .413 slugging percentage has banged out 14 extra-base hits over its last 4 games.

Giants at Padres projected starters

RHP Daulton Jefferies vs. RHP Michael King

Jefferies has not pitched in the Majors since 2022; he missed last season recovering from his 2nd Tommy John surgery.

  • Owns a 5.75 ERA over 14 career games (10 starts)
  • Pitched 14 innings in spring training, logging a 2.57 ERA with 16 K against 3 BB
  • Has never faced the Padres

King (4-8, 2.75 ERA with the New York Yankees in 2023) is making his 1st home start with the Padres after being acquired in the Juan Soto trade. Last season, he had a 1.15 WHIP, 2.8 BB/9 and 10.9 K/9 in 104 2/3 innings.

  • Last outing: Win, 3 1/3 IP, 3 ER, 4 H, 3 BB, 5 K in 15-11 win vs. Los Angeles Dodgers March 21 (in South Korea)
  • Has faced the Giants once, tossing 1 2/3 innings against them last April 1 (2 R allowed on 4 H and 1 BB; struck out 3)
  • This game marks his 20th career start; he owns a 3.44 career ERA across 116 games overall

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Giants at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:35 a.m. ET.

  • Moneyline: Giants +115 (bet $100 to win $115) | Padres -135 (bet $135 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-175) | Padres -1.5 (+145)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

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Giants at Padres picks and predictions

Prediction

Padres 5, Giants 4

Moneyline

There are too many questions on the Giants side of the ledger, especially with Jefferies getting the nod for the 1st time since May 18, 2022.

King will likely see a hefty contingent of left-handed batters in the San Francisco order, but the former Yankee relief standout has an excellent history against batters of the opposite hand (.656 OPS allowed career, .542 OPSA in 2023).

The Padres went 9-3 at home last September; they are 13-7 across their last 20 home games against San Francisco.

FanDuel Sportsbook has the best value price here: BET THE PADRES (-132).

Run line/Against the spread

PASS: Peg the ML as having the best leverage in this matchup.

Over/Under

The Over has cashed in all 3 games of this series.

Both offenses are clicking so far this season, and there are mound questions on both sides in this series finale. Last September, the Padres got on a roll at home. Over those last 12 games referenced above, they cranked out an .854 OPS while scoring 5.58 runs per game.

San Francisco banged out an .817 OPS in spring training, and batters on both sides get the likely benefit of a significant outward breeze, which is in the forecast. The game could also be in jeopardy due to expected heavy rain.

FanDuel Sportsbook has better leverage: BACK THE OVER 8.5 (-110).

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Saturday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (2-2) welcome the San Francisco Giants (1-1) to Petco Park for the 3rd of a 4-game series Saturday. First pitch is set for 7:15 p.m. ET (FOX). Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 1-1.

The Padres lost their season-opening game 5-2 to the Los Angeles Dodgers but won the following 2, scoring at least 6 in both games. In its 4th game of the season, San Diego lost to the Giants 8-3. It has yet to hold a team to under 4 runs. The Padres finished 3rd in the National League West last season with an 82-80 record. They were 44-37 at home.

The Giants lost to the Padres 6-4 on Opening Day as a slight underdog then took down the Padres 8-3 Friday, closing +124 on the moneyline. The Giants have the league’s 10th-highest payroll, so expectations are high for them this season. San Fran finished last season 79-83 and was 34-47 on the road. They are 1-1 against the spread (ATS) this season and 2-0 O/U.

Giants at Padres projected starters

RHP Jordan Hicks vs. RHP Dylan Cease

Hicks (3-9, 3.29 ERA) made 65 appearances and 0 starts in 2023. He owned a 1.35 WHIP, 4.4 BB/9 and 11.1 K/9 through 65 2/3 IP.

  • 2023 road splits: 2-3, 0.87 ERA (31 IP, 3 ER — 2 HR), 9 BB, 42 K in 31 appearances.
  • Hasn’t pitched against San Diego since April 7, 2019
  • Spent last season split between the Cardinals and Blue Jays

Cease (7-9, 4.58 ERA) made 33 starts last season for the White Sox. He finished with a 1.42 WHIP, 4.0 BB/9 and 10.9 K/9 through 177 IP.

  • 2023 home splits: 3-7, 4.20 ERA (94 1/3 IP, 44 ER — 8 HR), 48 BB, 104 K in 17 starts
  • White Sox were 16-17 in the 33 games Cease started last season
  • 2023 vs. San Francisco: Win, 5 IP, 1 ER (1 HR), 5 BB, 1 H in a 7-3 home victory

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Giants at Padres odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11 a.m. ET.

  • Moneyline (ML): Giants +110 (bet $100 to win $110) | Padres -130 (bet $130 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-194) | Padres -1.5 (+160)
  • Over/Under (O/U): 7.5 (O: -112 | U: -108)

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Giants at Padres picks and predictions

Prediction

Padres 5, Giants 3

Moneyline

BET PADRES (-130).

The Giants will likely play most of their game from the bullpen with Hicks transitioning to the rotation. San Fran didn’t have a terrific set or relievers last season, finishing 14th in the MLB in reliever ERA.

San Diego was solid at home last season, ending 44-37. It was also 43-37 following a loss last season. The Padres should have the pitching edge and have tallied at least 6 runs in 2 of their last 3 games.

Take the home side here and back PADRES (-130).

Run line/Against the spread

PASS.

There’s no real value here. The Giants are too expensive to play as a run-line underdog while the Padres are too risky to take as a run-line favorite. Ultimately, the moneyline has the best team-specific value.

Over/Under

LEAN OVER 7.5 (-112).

If there’s one thing both teams have done well this season, it is hit the Over. The Padres are averaging 8 runs per game over their last 3 games and are 3-1 O/U on the season.

The Giants are 2-0 O/U and have scored at least 4 per game while allowing 4.5 per game in their 2 performances this season. Neither team has an ace taking the mound.

With that in mind, expect the offenses to stay hot and take OVER 7.5 (-112).

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Friday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (0-1) and San Diego Padres (2-1) play the 2nd game of a 4-game set Friday at Petco Park. First pitch is scheduled for 9:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 1-0

San Francisco dropped Thursday’s series opener 6-4. With the setback, the Giants are now 2-5 across their last 7 season openers. Dating back to last September, San Francisco is 1-6 in their last 7 games against San Diego.

San Diego plated 4 runs in the bottom of the 7th inning, pulling off a comeback from a 3-2 deficit in Thursday’s contest. The Padres went 4 of 12 with runners in scoring position.

Giants at Padres projected starters

LHP Kyle Harrison vs. RHP Joe Musgrove

Harrison (1-1, 4.15 ERA in 2023) makes his 1st start this season and 8th of his career. He had a 1.15 WHIP, 2.9 BB/9 and 9.1 K/9 in 34 2/3 innings last season.

  • 2023 with Sacramento (AAA): 1-3, 4.66 ERA (65 2/3 IP, 34 ER), 48 BB in 20 starts
  • 2023 road stats: 0-1, 6.28 ERA (14 1/3 IP, 10 ER) in 3 starts
  • Career vs. Padres: Loss, 5 2/3 IP, 6 ER, 6 H, 2 BB, 5 K in 1 start, a 6-1 road loss Sept. 2, 2023

Musgrove (0-0, 16.88 ERA) makes his 2nd start. He allowed 5 ER on 7 H and 2 BB with 2 K in 2 2/3 IP in his debut vs. the Los Angeles Dodgers in Seoul, South Korea March 21.

  • Missed last 3 months of 2023 with a shoulder injury
  • Per ESPN, has held current Giants batters to a collective .627 OPS
  • 2023 stats: 10-3, 3.05 ERA (97 1/3 IP, 33 ER) in 17 starts
  • 2023 home stats: 6-1, 3.04 ERA (56 1/3 IP, 19 ER) in 10 starts
  • 2023 vs. Giants: No-decision, 3 1/3 IP, 7 ER, 6 H, 1 BB, 3 K in 1 start, a 16-11 home win April 29
  • Career vs. Giants: 4-3, 3.86 ERA (74 2/3 IP, 32 ER) in 13 starts

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Giants at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:50 a.m. ET.

  • Moneyline: Giants +125 (bet $100 to win $125) | Padres -150 (bet $150 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-165) | Padres -1.5 (+140)
  • Over/Under (O/U): 8 (O: +100 | U: -120)

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Giants at Padres picks and predictions

Prediction

Padres 5, Giants 4

Moneyline

The San Diego weather report calls for an outward breeze, and Harrison figures as a fly-ball pitcher. There are questions on both sides of this mound match-up, but Musgrove figures as the more projectable and dependable hurler.

The Friars (-150) do have a left-leaning lineup and one that struggled against port-siders in 2023 (.683 OPS), but in his rookie-season small sample, Harrison did not exactly mow down lefty batters (1.068 OPS allowed).

Dating back to last August, San Diego is 11-4 across its last 15 games at Petco Park.

BET PADRES (-150).

Run line/Against the spread

PASS: Peg the ML as having the best leverage in this matchup.

Over/Under

The last 9 games of this series have seen the winning club score at least 5 runs. Peg the Padre bats as having some confidence after Thursday’s comeback. San Francisco had a robust .817 OPS in spring training, and batters on both sides get the likely benefit of a breeze blowing out.

FanDuel Sportsbook has the best value price here: BACK THE OVER 7.5 (-112).

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Thursday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (0-0) open the season against the San Diego Padres (1-1) on Thursday. The NL West rivals meet at Petco Park with 1st pitch scheduled for a 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Padres won last year’s series 8-5

By many accounts, San Diego underplayed its talent level in going 82-80 a year ago. The Padres, now several pieces lighter after shedding salary, placed 3rd in the NL West, 3 games ahead of San Francisco.

The Giants went 79-83 last season. They were quite good May-June, going 35-20 with a run differential to match. But San Francisco faded down the stretch, especially late. They went just 9-19 after Sept. 1.

Thursday’s game marks the Giants’ season opener. The Friars split 2 feature games against the Los Angeles Dodgers on March 20-21 in Seoul, South Korea.

Giants at Padres projected starters

Logan Webb vs Yu Darvish

Webb went 11-13 with a 3.25 ERA last season. He logged a 1.07 WHIP, 1.3 BB/9 and 8.1 K/9 in 216 IP last season.

  • Owns a tidy 3.07 ERA across the last 3 seasons (92 games)
  • Faced San Diego just once last season, allowing 1 run in 9 IP
  • Struggled in spring training, allowing 37 hits and 26 ER in 21 1/13 IP

Darvish went 8-10 with a 4.56 ERA last season. He notched a 1.3 WHIP, 2.8 BB/9 and 9.3 K/9 across 136 1/3 IP.

  • Started March 20 game vs. Dodgers in South Korea: went 3 2/3 IP, allowing 1 unearned run on 2 H with 3 BB and 3 K
  • Pitched 12 IP against the Giants in 2023: allowed 8 R on 12 H

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Giants at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 10:45 9.m. ET.

  • Moneyline: Giants -105 (bet $105 to win $100) | Padres -115 (bet $100 to win $115)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+210) | Padres +1.5 (-170)
  • Over/Under (O/U): 7.5 (O: -110 | U: -110)

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Giants at Padres picks and predictions

Prediction

Giants 4, Padres 3

Moneyline

The Giants are a decent futures play in 2024, and Webb on the mound puts a good foot forward for the visitors. Plus the Giants banged the ball around pretty good in Cactus League play. Their .817 OPS ranked 3rd in MLB batting.

San Diego has to deal with the baseball rarity of multi-day travel and extra off days.

BET SAN FRANCISCO (-105).

Run line/Against the spread

PASS: Peg the ML as having the best leverage in this matchup.

Over/Under

The Under has cashed in 5 straight San Francisco-San Diego meetings and is the slight lean here.

The pitching starts at (mostly) square one for both sides. Rotations are at the top and bullpens are fresh. Mix in a weather report that calls for a double-digit win blowing in from left, and the low side is the way to go.

BACK THE UNDER 7.5 (-110).

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Sunday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (70-66) and the San Diego Padres (64-73) wrap up a 4-game series Sunday at Petco Park. First pitch is scheduled for 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 5-4

The Giants are looking for the split of the 4-game set after dropping the past 2 games at Petco Park. The Padres have outscored the Giants 13-4 in the 2 victories after San Francisco won 7-2 in the series opener Thursday.

San Francisco is still 5-3 across the past 8 games overall, with the Under cashing in 4 of the past 6 games. However, the Over is 4-2 in the previous 6 road games for the Giants.

San Diego halted a 3-game losing streak with the victories in the previous 2 outings. Still, the Padres are a dismal 3-6 in the past 9 games overall. The Over is 6-2-1 during the 9-game span, with the Padres pitching staff yielding 5 or more runs in 6 of the contests.

Giants at Padres projected starters

RHP Alex Cobb vs. RHP Seth Lugo

Cobb (7-5, 3.57 ERA) makes his 26th start. He has a 1.30 WHIP, 2.2 BB/9 and 8.0 K/9 in 141 1/3 innings.

  • Last start: Win, 9 IP, 1 ER, 1 H, 1 BB and 8 K in 6-1 home win vs. Cincinnati Reds Tuesday
  • 2023 road splits: 2-3, 4.98 ERA (72 1/3 IP, 40 ER), 11 HR, 1.53 WHIP, .302 opponent batting average (OBA) in 14 starts

Lugo (5-6, 3.67 ERA) makes his 22nd start. He has a 1.22 WHIP, 2.0 BB/9 and 8.8 K/9 in 115 1/3 innings.

  • Last start: No-decision, 6 IP, 3 R (2 ER), 6 H, 1 BB, 6 K in a 6-5 road loss vs. St. Louis Cardinals Tuesday
  • 2023 home splits: 3-4, 3.15 ERA (52 IP, 24 ER), 6 HR, 1.27 WHIP, .262 OBA in 10 starts

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Giants at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:33 a.m. ET.

  • Moneyline (ML): Giants +115 (bet $100 to win $115) | Padres -140 (bet $140 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-175) | Padres -1.5 (+145)
  • Over/Under (O/U): 8 (O: -115 | U: -105)

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Giants at Padres picks and predictions

Prediction

Padres 4, Giants 3

Moneyline

The PADRES (-140) are a decent play in the series finale. While Cobb has been solid for the Giants, and he is coming off a complete-game victory last time out, his splits on the road have been less than stellar. The veteran has a 2.09 ERA in 69 IP in 11 home starts while posting a dismal 4.98 ERA across 72 1/3 IP in 14 road assignments.

Run line/Against the spread

The GIANTS +1.5 (-175) are a little on the pricey side, but if you want some insurance, they’re not priced out of line.

The Giants are 6-5 in the past 11 games as underdogs on the run line, winning 4 of the games outright.

Over/Under

UNDER 8 (-105) is the lean.

The Under is 4-2 in the past 6 games overall for the Giants, while cashing at a 7-3-1 clip in the previous 11 starts by Cobb.

However, for the Padres, it’s been about the Over lately, going 6-2-1 in the past 9 games overall, which is the reason for this being just a lean. The Under is 4-2-1 in the past 7 starts for Lugo.

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Friday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks and predictions.

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The San Francisco Giants (70-64) and San Diego Padres (62-73) meet Friday at  9:40 p.m. ET for the 2nd game of a 4-game series at Petco Park. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 4-3

San Francisco won Thursday’s series opener 7-2, and the Giants are 4-1 over their last 5 games. They are also 4-1 across the last 5 games of their season series with the Padres.

San Diego has lost 3 straight games and 6 of its last 7. The Friars own a shaky 4.54 ERA over their last 12 games.

Giants at Padres projected starters

RHP Tristan Beck vs. RHP Michael Wacha

Beck (3-2, 3.52 ERA) makes his 2nd start and 30th appearance. He has a 1.14 WHIP, 2.4 BB/9 and 7.8 K/9 through 71 2/3 IP.

  • Last start: No-decision, 4 1/3 IP, 3 H, 3 ER, 1 BB, 5 K in 8-5 home win vs. Atlanta Braves Sunday
  • 2023 road stats: 0-1, 2.25 ERA in 32 IP across 15 relief appearances
  • Has never faced the Padres as a starter

Wacha (10-2, 2.84 ERA) makes his 19th start. He has a 1.11 WHIP, 2.9 BB/9 and 8 K/9 through 101 1/3 IP.

  • Last start: No-decision, 5 1/3 IP, 4 H, 4 ER, 5 BB, 5 K in a 10-6 loss at Milwaukee Brewers Sunday
  • 2023 home stats: 7-2, 2.21 ERA in 57 IP across 10 starts
  • Last 5 starts vs. Giants: 1-0, 2.52 ERA in 25 IP (2016-23)
  • Has made just 3 starts in the 2nd half — all since Aug. 15 — after missing time in July-August with a shoulder injury
  • Faced the Giants on June 19: No-decision, 6 IP, 2 ER, 4 H, 2 BB, 0 K in 7-4 road loss
  • Has benefited from a .252 batting average on balls in play this season

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Giants at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:06 p.m. ET.

  • Moneyline: Giants +115 (bet $100 to win $115) | Padres -135 (bet $134 to win $100)
  • Run line (RL)/Against the spread (ATS): Off the board
  • Over/Under (O/U): 8 (O: -120 | U: -+100)

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Giants at Padres picks and predictions

Prediction

Padres 6, Giants 4

Moneyline

Wacha is a definite fade. He is fortunate to have an ERA under 4.00 let alone under 3.00 considering the quality of contact he allows and his rates for walks, whiffs and ground balls.

San Diego is the overall team lean without any pitching attached. Add in Wacha going against a bullpen combo for San Francisco. It equals a PASS.

Run line/Against the spread

This play is OTB but I have no interest in a side either way, even when this line is released. PASS.

Over/Under

Beck has been a long reliever this season, but his pitch count jumped a couple of levels when he threw 70 pitches in his last start. How does he bounce back in this one?

Both starters — especially Wacha — are fly-ball hurlers. The weather report for this one calls for a 10-mile-an-hour breeze blowing out.

The Friars’ offense has been a disappointing one, with San Diego averaging just 4.47 runs per game. The Padres have been awful in high-leverage situations, and in those clutch plate appearances, they’ve logged a very low .247 BABIP.

FanDuel Sportsbook has an OVER 8 (-114) on the board, and that’s a solid play in this one.

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San Francisco Giants vs. San Diego Padres odds, picks and predictions

Analyzing Sunday’s San Francisco vs, San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

The San Francisco Giants (11-15) take on the San Diego Padres (14-14) Sunday in the final game of a 2-game series in Mexico City. First pitch at Estadio Alfredo Harp Helu is at 4:05 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 1-0

The Padres pounded their way to a 16-11 win on Saturday. They scored in 7 of the 8 innings in which they batted, homering 6 times. They are 6-3 in their last 9 games.

The Giants homered 5 times in the game and had an 8-5 lead in the tp of the 4th, but were outscored 11-3 the rest of the way. After a 5-game winning streak, they have lost 2 in a row.

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Giants vs. Padres projected starters

RHP Alex Cobb vs. RHP Yu Darvish

Cobb (1-1, 1.91 ERA) makes his 6th start. He has a 1.27 WHIP, 1.3 BB/9 and 8.3 K/9 in 28 1/3 IP.

  • Last start April 24 vs. St. Louis: 9 IP, 6 H, 0 ER, 1 BB, 4 K
  • Has not allowed more than 2 R in any start this season

Darvish (1-2, 3.00 ERA) makes his 5th start. He has a 1.13 WHIP, 4.5 BB/9 and 9.4 K/9 in 24 IP.

  • Walked season-high 5, but got 1st win, allowing 1 ER and 2 H in 5 2/3 IP in April 23 start vs. Padres
  • Padres are 1-3 in his 4 starts

Giants vs. Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:43 a.m. ET.

  • Moneyline (ML): Giants +120 (bet $100 to win $120) | Padres -145 (bet $145 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-130) | Padres -1.5 (+105)
  • Over/Under (O/U): 20.5 (O: -105 | U: -115)

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Giants vs. Padres picks and predictions

Prediction

Giants 8, Padres 7

Moneyline

The Giants are 5-2 in their last 7 games. They have won Cobb’s last 2 starts and he hasn’t allowed more than 2 runs in any start.

The Padres are 6-3 in their last 9 games. Darvish has allowed only 1 run in 3 of his 4 starts and 5 in 6 1/3 IP in his other start.

BET GIANTS (+120).

Run line/Against the spread

The Giants are 10-6 ATS as underdogs while the Padres are 7-10 ATS as the favorites. Expecting a Giants outright win, betting the moneyline makes more sense than the run line.

PASS.

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Over/Under

The 1st game of the series had 27 total runs. The elevation in Mexico City is more than 2,200 feet higher than in Denver, where games are known to have lots of runs.

However, 20.5 total runs is crazy high.

The Giants have been involved in only 2 games with more than 20 runs all season. The Padres have only played 1 — on Saturday.

BET UNDER 20.5 (-115).

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San Francisco Giants vs. San Diego Padres odds, picks and predictions

Analyzing Saturday’s San Francisco Giants vs. San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

The San Francisco Giants (11-14) open a 2-game series against the San Diego Padres (13-14) Saturday at Estadio Alfredo Harp Helú in Mexico City, Mexico. First pitch is scheduled for 6:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting. The Padres recorded a 13-6 record against the Giants in 2022.

The Giants lost 6-0 to the St. Louis Cardinals Thursday. San Francisco had won 5 consecutive games before the loss.

The Padres fell 5-2 to the Chicago Cubs on Thursday. San Diego has tallied a 5-5 record in its last 10 games.

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Giants vs. Padres projected starters

LHP Sean Manaea vs. RHP Joe Musgrove

Manaea (0-1, 6.61 ERA) makes his 4th start and 6th appearance. He has a 1.29 WHIP, 3.9 BB/9 and 9.9 K/9 through 16 1/3 IP.

  • Has notched 6 IP or more in only 1 of his 5 appearances (3 starts) this season
  • Allowed at least 1 home run in 4 of his 5 outings

Musgrove (1-0, 5.40 ERA) makes his 2nd start. He has a 1.40 WHIP, 0.0 BB/9 and 10.8 K/9 through 5 IP.

  • Allowed 3 ER on 7 H with 0 BB and 6 K across 5 IP in season debut victory over the Arizona Diamondbacks last Saturday
  • Boasts a 4-3 record with a 3.15 ERA, 1.05 WHIP, and 9.1 K/9 in 12 career starts against the Giants

Giants vs. Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:30 a.m. ET.

  • Moneyline (ML): Giants +150 (bet $100 to win $150) | Padres -185 (bet $185 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-110) | Padres -1.5 (-110)
  • Over/Under (O/U): 15.5 (O: -110 | U: -110)

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Giants vs. Padres picks and predictions

Prediction

Padres 7, Giants 5

Moneyline

PASS.

Even with the Padres (-185) expected to secure the win on Saturday, taking them straight up isn’t advised at the current odds.

Run line/Against the spread

PADRES -1.5 (-110) is the pick in this NL West matchup in Mexico City. The Padres have the pitching advantage with Musgrove on the mound and Manaea on a short leash from the Giants to begin the season.

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Over/Under

UNDER 15.5 (-110) is how I’d wager on the total with it being such a high number. The elevation in Mexico City could lead to more runs in this showdown, but neither team has been hitting well enough to feel confident in 16-plus runs being scored.

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Tuesday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks and predictions.

The San Francisco Giants (80-80) and San Diego Padres (88-72) play the second game of a 3-game set Tuesday at Petco Park. First pitch is scheduled for 9:40 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

Season series: Padres lead 12-5

The Giants lost for just the 3rd time in their last 14 games after dropping a 7-4 decision in the series opener Monday.

San Francisco RHP Shelby Miller recorded the loss in a relief appearance, allowing 5 ER on 2 H with 1 K through 1 1/3 IP. San Diego starter RHP Joe Musgrove threw 6 scoreless innings and LF Wil Myers hit a 3-run HR to cap off a 7-run 8th inning.

The Padres remain 1 game ahead of the Philadelphia Phillies for the 2nd spot in the NL wild-card standings. Philadelphia holds the season-series tiebreaker, in case the Phillies and Padres finish with the same record.

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Giants at Padres projected starters

LHP Carlos Rodón vs. LHP Sean Manaea

Rodón (14-8, 2.88 ERA) makes his 32nd start. He has a 1.03 WHIP, 2.6 BB/9 and 12.0 K/9 through 178 IP.

  • Last start: Win Thursday vs. the Colorado Rockies with 6 IP, 0 ER, 2 H, 0 BB and 10 K
  • Highest K/9 in MLB
  • 2022 vs. the Padres: 1-2 with a 3.79 ERA (19 IP, 8 ER) in 3 starts

Manaea (7-9, 5.15 ERA) makes his 28th start and 30th appearance. He has a 1.34 WHIP, 2.9 BB/9 and 8.9 K/9 through 152 IP.

  • Last appearance: No-decision Thursday vs. the Los Angeles Dodgers with 4 IP, 1 ER, 2 H, 0 BB and 3 K
  • Last start: No-decision Sept. 23 at the Rockies with 3 2/3 IP, 3 ER, 6 H, 3 BB and 2 K
  • Has lost 4 of his last 5 decisions
  • 2022 vs. the Giants: 0-1 with a 4.76 ERA (17 IP, 9 ER) in 3 starts

Giants at Padres odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at  11:52 a.m. ET.

  • Moneyline (ML): Giants +125 (bet $100 to win $125) | Padres -155 (bet $155 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-175) | Padres -1.5 (+135)
  • Over/Under (O/U): 7.5 (O: +105 | U: -130)

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Giants at Padres picks and predictions

Prediction

Padres 4, Giants 2

Moneyline

BET PADRES (-155).

San Diego is still playing for seeding in the NL wild-card standings. The Padres’ offense got back on track Monday putting up 7 runs in 1 inning and should lead San Diego to another win Tuesday. Manaea has also been solid for San Diego in his last 3 appearances, allowing a combined 6 ER through 12 2/3 IP.

Run line/Against the spread

BET PADRES -1.5 (+135).

Four of the Padres’ last 5 wins have been by multiple runs. Despite how good Rodón has been this season, San Diego hasn’t seemed to struggle vs. the lefty and should be able to win convincingly Tuesday.

Over/Under

PASS.

The Padres’ offense looked dangerous in the 8th inning Monday, but Rodón is still one of the best strikeout pitchers in MLB. There is too much conflicting data in this matchup to confidently bet the total either way.

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Monday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks and predictions.

The San Francisco Giants (53-55) head down the coast to start a 3-game series with the San Diego Padres (61-50). First pitch from Petco Park is scheduled for 9:40 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

San Francisco is 5-5 straight up (SU) in its last 10 games and swept a 2-game interleague series with the Bay Area neighbor Oakland Athletics Saturday-Sunday after losing 4 straight at home to the Los Angeles Dodgers.

San Diego is also 5-5 SU over its last 10 but has lost 4 consecutive outings, which includes being swept in a 3-game series at the Dodgers this past weekend.

Season series: The Padres lead 6-4 but the Giants have a plus-9 run differential in those meetings (45-36).

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Giants at Padres projected starters

LHP Alex Wood vs. LHP Blake Snell

Wood is 7-9 with a 4.42 ERA, 1.25 WHIP, 2.2 BB/9 and 8.9 K/9 in 106 IP over 21 starts.

  • Last start: Loss, 9-5, at home vs. the Dodgers Tuesday with 5 1/3 IP, 6 ER, 9 H, 1 HR, 1 BB and 6 K.
  • 2022 vs. the Padres: 1-1 with a 4.40 ERA (14 1/3 IP, 7 ER), 16 H, 1 HR, 4 BB and 18 K in 3 starts.

Snell is 4-5 with a 4.16 ERA, 1.33 WHIP, 4.6 BB/9 and 11.7 K/9 in 67 IP across 13 starts.

  • Last start: Win, 9-1, at home vs. the Colorado Rockies Wednesday with 6 IP, 1 ER, 4 H, 0 BB and 9 K.
  • 2022 vs. the Giants: 1 start — a 6-3 home win July 8 — with 6 IP, 1 ER, 3 H, 1 HR, 2 BB and 11 K.

Giants at Padres odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:41 p.m. ET.

  • Money line (ML): Giants +155 (bet $100 to win $155) | Padres -190 (bet $190 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-135) | Padres -1.5 (+110)
  • Over/Under (O/U): 7.5 (O: -107 | U: -115)

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Giants at Padres picks and predictions

Prediction

Padres 5, Giants 1

Money line

LEAN towards “flat-betting” or parlaying the PADRES (-190) with another similarly priced favorite for a better payout.

San Diego’s ML price is a little expensive and we are getting the worst of the number. The Padres opened as -161 ML favorites per Pregame.com but have been steamed up by sharp action to the current number.

However, Snell’s stuff is much nastier than Wood’s and Snell has been finding his groove lately. He has won 3 straight starts, allowing just 2 earned runs over 17 innings during that span with a 21/3 K/BB rate. Also, Snell dominated the Giants when they last met in July.

San Diego’s RL is my favorite look in this game but the PADRES (-190) is the right side.

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Run line/Against the spread

BET PADRES -1.5 (+110) because Snell has been shutting down opposing lineups and the Giants are 3-5 RL as road underdogs vs. left-handed starters and 13-28 RL vs. NL West foes.

Over/Under

LEAN UNDER 7.5 (-115).

There’s a “Pros vs. Joe’s” scenario in the betting market because more money is on the Under whereas more bets have been placed on the Over, according to Pregame.com.

It’s wiser to follow the money in these situations since professional bettors wager a lot more dough than your average Joe. Also, the UNDER 7.5 (-115) being pricier insinuates it’s the sharper side.

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