San Francisco 49ers betting odds line spread pick predictions best bets

San Francisco 49ers at Miami Dolphins odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Miami Dolphins odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (6-8) and Miami Dolphins (6-8) meet Sunday. Kickoff from Hard Rock Stadium is set for 4:25 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Dolphins odds, and make our expert NFL picks and predictions.

The 49ers have lost 4 of their last 5 games and are coming off a 12-6 home loss to the LA Rams Dec. 12 as 2.5-point favorites.

The Dolphins are coming off a 20-12 loss at the Houston Texans Dec. 15, failing to cover the spread as 2.5-point underdogs. It was their second loss in the last 3 games after winning 3 in a row Nov. 11-24.

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49ers at Dolphins odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 4:27 p.m. ET.

Moneyline (ML): 49ers -115 (bet $115 to win $100) | Dolphins -105 (bet $105 to win $100)
Against the spread (ATS): 49ers -1 (-110) | Dolphins +1 (-110)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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49ers at Dolphins key injuries

49ers

DE Robert Beal Jr. (ankle) questionable
DE Nick Bosa (hip, oblique) questionable
LB Dre Greenlaw (Achilles, knee) questionable
RB Isaac Guerendo (hamstring) out
LT Trent Williams (ankle) out

Dolphins

OT Terron Armstead (knee) questionable
LB Bradley Chubb (knee) questionable
WR Dee Eskridge (knee) doubtful
LS Blake Ferguson (non-football illness) out
LB Cameron Goode (knee) questionable
WR Tyreek Hill (wrist/personal) questionable
OT Kendall Lamm (back) questionable
WR Jaylen Waddle (knee) doubtful

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49ers at Dolphins picks and predictions

Prediction

Dolphins 24, 49ers 17

Moneyline

The Niners are down to their fourth-string RB in Patrick Taylor Jr., as Guerendo is out and Christian McCaffrey and Jordan Mason are on injured reserve. They also are without their starting left tackle.

They have scored 10 or fewer points in 3 of their last 4 games.

The Dolphins have averaged 25.8 points in their last 8 games since QB Tua Tagovailoa returned from injured reserve.

BET DOLPHINS (-105).

Against the spread

Taking the point and having to pay an extra 5 cents on the dollar isn’t worth the safety net of pushing on a 1-point straight-up loss.

PASS.

Over/Under

The Niners have allowed a combined 25 points in their last 2 games despite giving up 24 or more in 6 of the previous 8.

The Dolphins have held opponents to 20 or fewer points in 4 of their last 6 games.

BET UNDER 44.5 (-110).

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LA Rams at San Francisco 49ers odds, picks and predictions

Analyzing LA Rams at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The LA Rams (7-6) and San Francisco 49ers (6-7) will meet for the second time this season on Thursday night for a pivotal Week 15 game at Levi’s Stadium in Santa Clara. Kickoff is set for 8:15 p.m. ET (Prime Video). Let’s analyze BetMGM Sportsbook’s NFL odds around the Rams vs. 49ers odds, and make our expert NFL picks and predictions.

The Rams beat the 49ers 27-24 in Week 3 as a 6-point road underdog as the Over 44.5 cashed.

The Rams crept above .500 for the first time this season when they beat the Buffalo Bills 44-42 as 3.5-point underdogs on Sunday. It was the highest-scoring game of the season, featuring 12 total TDs, 902 yards and 0 turnovers. Los Angeles has won 2 straight games and is second in the NFC West.

The 49ers also came away with a win in Week 14, steamrolling the Chicago Bears at home 38-13. The 49ers had 452 total yards of offense compared to only 162 for the Bears, a dominant victory from start to finish. The 49ers are still 2 games back of the Seahawks for the division lead, but a win will keep them in the mix for another division title.

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Rams at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Wednesday at 2:37 p.m. ET.

Moneyline (ML): Rams +130 (bet $100 to win $130) | 49ers -155 (bet $155 to win $100)
Against the spread (ATS): Rams +3 (-120) | 49ers -3 (+100)
Over/Under (O/U): 49.5 (O: -110 | U: -110)

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Rams at 49ers key injuries

Rams

CB Cobie Durant (chest) questionable
C Beaux Limmer (knee) questionable
WR Demarcus Robinson (shoulder) questionable

49ers

DE Nick Bosa (hip/oblique) questionable
RB Isaac Guerendo (foot) questionable
OT Trent Williams (ankle) questionable
LB Dre Greenlaw (Achilles) questionable

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Rams at 49ers picks and predictions

Prediction

Rams 27, 49ers 24

Moneyline

The Rams already beat the 49ers once this year and now they’re going for the season sweep of their rivals. Their win over the Bills on Sunday was far more impressive than San Francisco’s victory against the Bears, even if it was only by 2 points.

The offense is just about fully healthy, which will be a problem for the 49ers’ banged-up defense. And with San Francisco down to either its third- or fourth-string running back, a rushing attack that’s given the Rams fits over the years will be shorthanded.

With QB Matthew Stafford playing lights out in recent weeks, the Rams will take down their rival on the road Thursday. BET RAMS (+130) to win outright.

Against the spread

With the spread sitting at the key number of +3, it’s not a bad idea to sprinkle a bit on the Rams to cover just in case they lose a close one to the 49ers. However, I’d rather just play the ML and bet Los Angeles to win its third straight game.

LEAN RAMS +3 (-120).

Over/Under

The Rams nearly went over the total by themselves last week against the Bills, putting up 44 points on their own. Their defense has struggled to stop anyone in recent weeks, giving up 560 rushing yards in their last three games, so the 49ers should be able to score on the LA defense.

The Rams, meanwhile, seemingly found something on offense against Buffalo. And with WR Puka Nacua playing perhaps better than he ever has, the Rams’ passing attack will give the 49ers’ secondary trouble.

BET OVER 49.5 (-110).

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Chicago Bears at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Chicago Bears at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The Chicago Bears (4-8) hit the West Coast to face the San Francisco 49ers (5-7) Sunday in the late-afternoon slate. Kickoff from Levi’s Stadium is set for 4:25 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bears vs. 49ers odds, and make our expert NFL picks and predictions.

The Bears nearly upset the 11-1 Detroit Lions Thanksgiving Day. They botched a play late in the game where they could have used a timeout and wasted precious time on the clock, which really shot them in the foot. It also cost coach Matt Eberflus his job as he was dismissed after the 23-20 defeat. QB Caleb Williams was impressive, going 20-for-39 for 256 yards, 3 TDs and 0 INTs. But it was Chicago’s sixth loss in a row.

The Niners dropped their third in a row as they couldn’t handle the blizzard-like conditions in Buffalo in a 35-10 loss to the Bills. They also lost RB Christian McCaffrey (knee) for the season, and RB Jordan Mason (shoulder) is also out for this one. They will turn to fourth-round pick Isaac Guerendo in the backfield.

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Bears at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 6:46 p.m. ET.

Moneyline (ML): Bears +145 (bet $100 to win $145) | 49ers -175 (bet $175 to win $100)
Against the spread (ATS): Bears +3.5 (-115) | 49ers -3.5 (-105)
Over/Under (O/U): 44 (O: -110 | U: -110)

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Bears at 49ers key injuries

Bears

C Ryan Bates (concussion) out
RB Roschon Johnson (concussion) out
WR D.J. Moore (quadriceps) questionable
RB D’Andre Swift (quadriceps) questionable

49ers

OG Aaron Banks (concussion) questionable
DE Nick Bosa (hip, oblique) doubtful
LB Dre Greenlaw (Achilles) out
RB Jordan Mason (shoulder) out
OT Trent Williams (knee) out

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Bears at 49ers picks and predictions

Prediction

Bears 24, 49ers 21

Moneyline

You don’t hear him talked about a lot because of the overnight sensation Washington Commanders QB Jayden Daniels became, but Williams is having a solid rookie season. He hasn’t thrown an interception in nearly 2 months.

Over the last 3 weeks, he has gone 75-for-117 (64.1%) for 827 yards (275.7 per game), 5 TDs and 0 INTs. He also rushed for 143 yards. These all came against playoff teams in the Green Bay Packers, Minnesota Vikings and Lions.

I’m picking the upset, but Williams is only part of the equation. How will the Bears stop the Niners? They’ll have to contain TE George Kittle, and the Bears are top-10 in defending the position over the last 5 weeks.

Take the BEARS +145.

Against the spread

I’m foregoing the spread since we’re picking the upset. I like CALEB WILLIAMS OVER 220.5 PASSING YARDS (-115). The Niners are severely banged up, and he has really thrown the ball well of late.

Over/Under

Both of these teams are Under teams. Chicago is 4-6 O/U in its last 10, and the Niners are 5-4-1. I have this sneaking Over, though, because the weather conditions will be a breath of fresh air for both teams. The Niners literally played in a blizzard in Buffalo last week, and while Chicago was in a dome for Thanksgiving, they had 3 straight games in the elements at Soldier Field beforehand.

Take the OVER 44 (-110).

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First look: Chicago Bears at San Francisco 49ers odds and lines

Looking at Sunday’s Chicago Bears at San Francisco 49ers Week 14 NFL odds, lines and trends. Here’s what you need to know.

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The Chicago Bears (5-6) take on the San Francisco 49ers (5-7) Sunday in Week 14. Kickoff from Levi’s Stadium is set for 4:25 p.m. ET (FOX). Below, we look at Bears vs. 49ers odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The Bears just missed upsetting the 11-1 Detroit Lions Thanksgiving Day. They succumbed by a 23-20 final score but covered as 10-point dogs. The Bears dismissed coach Matt Eberflus as they dropped their sixth game in a row on an important sequence where they could have used a timeout. QB Caleb Williams was impressive, going 20-for-39 for 256 yards, 3 TDs and 0 INTs.

The Niners lost their third straight in a 35-10 defeat in a blizzard at the Buffalo Bills Sunday night. They also lost RB Christian McCaffrey to a potentially season-ending knee injury. RB Jordan Mason stepped up and rushed 13 times for 78 yards. The Niners couldn’t get anything going in the snowy conditions otherwise.

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Bears at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 10:10 a.m. ET.

Moneyline (ML): Bears +185 (bet $100 to win $185) | 49ers -225 (bet $225 to win $100)
Against the spread (ATS): Bears +5.5 (-110) | 49ers -5.5 (-110)
Over/Under (O/U): 44.5 (O: -105 | U: -115)

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2024 betting stats

ML: Bears 4-8 | 49ers 5-7
ATS: Bears 6-4-2 | 49ers 4-8
O/U: Bears 4-8 | 49ers 6-5-1

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Bears vs. 49ers head-to-head

The Niners lead the all-time series 35-33-1. The teams have traded wins over the last 6 meetings. They haven’t faced off since Sept. 11, 2022, when the Bears prevailed 19-10 at Solider Field. QB Trey Lance was under center and ineffective. He threw for 164 yards for 0 TDs and 1 INT while rushing 13 times for 54 yards.

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San Francisco 49ers at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff from Highmark Stadium is set for 8:20 p.m. ET (NBC). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Bills odds, and make our expert NFL picks and predictions.

The Niners’ season is on life support in the basement of the NFC West. The good news is they’re just 1 win under the division-leading Seattle Seahawks. The bad news is they have to leapfrog 3 teams to take the West crown. The 49ers have lost 2 straight after a 38-10 defeat in the Frozen Tundra of Green Bay last week. QB Brandon Allen threw for 199 yards, 1 TD and 1 INT. QB Brock Purdy (shoulder) is expected back for this one.

The Bills exit their bye week after outclassing the Kansas City Chiefs 30-21. QB Josh Allen went 27-for-40 for 262 yards, 1 TD and 1 INT, but his 26-yard rushing touchdown was the eventual game-winner. RB James Cook amassed just 20 yards on 9 carries, but 2 of those ended in the end zone. Buffalo has won 6 straight.

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49ers at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 2:40 p.m. ET.

Moneyline (ML): 49ers +225 (bet $100 to win $225) | Bills -275 (bet $275 to win $100)
Against the spread (ATS): 49ers +6 (-110) | Bills -6 (-105)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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49ers at Bills key injuries

49ers

DE Nick Bosa (hip, oblique) out
CB Deommodore Lenoir (knee) out
QB Brock Purdy (shoulder) probable
OT Trent Williams (knee) out

Bills

WR Keon Coleman (wrist) questionable
TE Dalton Kincaid (knee) out
LB Matt Milano (biceps) questionable

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49ers at Bills picks and predictions

Prediction

49ers 20, Bills 17

Moneyline

This game is going to be ugly in the best kind of way. Heavy snowfall is expected with strong winds and a gametime temperature of 27 degrees. The Bills have run away with the AFC East, and this one means so much more to San Francisco than Allen and Co. The absence of Kincaid, who is great on underneath and short-yardage routes is also key.

Yes, the Niners are a warm-weather team. Purdy played 4 years at Iowa State, which is susceptible to cold temps. Purdy, RB Christian McCaffrey and TE George Kittle can’t be counted out here. In a battle of fortitude, the Niners need it more. I’m taking my shot on 49ERS +225.

Against the spread

If you aren’t completely on board with my bold prediction, I still think 49ERS +6 (-110) is a good bet. The conditions will keep the ball out of the air for the most part. San Francisco’s backs, particularly Jordan Mason, match up well with Buffalo’s.

Over/Under

This is an Under game. With the forecast, I’m really surprised the total hasn’t slipped below 40. Heavy snow, cold temps and wind make for an UNDER 44.5 (-110) cash.

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San Francisco 49ers at Green Bay Packers odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Green Bay Packers odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (5-5) and Green Bay Packers (7-3) meet Sunday in a rematch from last season’s playoffs. Kickoff from Lambeau Field is set for 4:25 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Packers odds, and make our expert NFL picks and predictions.

San Francisco lost 20-17 to the Seattle Seahawks in Week 11 while failing to cover as a 6-point favorite. The 49ers allowed a game-winning drive to the Seahawks to cap off a game where the Niners finished with over 33 minutes of possession. 49ers QB Brock Purdy will miss the game with a shoulder injury.

Green Bay narrowly escaped with a 20-19 win over the Chicago Bears Sunday while failing to cover as a 6-point favorite. The Packers blocked Chicago’s game-winning FG attempt just after QB Jordan Love rushed for a TD to put the Packers ahead.

The 49ers beat the Packers 24-21 in the NFC divisional round last season.

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49ers at Packers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 12:53 a.m. ET.

Moneyline (ML): 49ers +200 (bet $100 to win $200) | Packers -250 (bet $250 to win $100)
Against the spread (ATS): 49ers +5.5 (-110) | Packers -5.5 (-110)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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49ers at Packers key injuries

49ers

DL Nick Bosa (hip/oblique) out
QB Brock Purdy (shoulder) out
OL John Feliciano (knee) questionable
CB Charvarious Ward (personal) out
OT Trent Williams (ankle) questionable

Packers

CB Jaire Alexander (knee) out
LB Edgerrin Cooper (hamstring) out

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49ers at Packers picks and predictions

Prediction

Packers 21, 49ers 10

Moneyline

PASS.

The Packers will pick up the win here as -250 favorites and with Purdy out, but they are not worth the risk as such heavy favorites. Pass on this play and bet on the spread and/or total instead.

Against the spread

LEAN PACKERS -5.5 (-110).

Green Bay is the much healthier team and has played like the better team this season. With how San Francisco has underperformed to this point of the season, and with Purdy’s injury, the Packers should be able to cover here.

This is a lean because the Packers are 0-4 ATS in their last 4 games and because San Francisco is still a talented enough team to potentially make this a close game.

Over/Under

BET UNDER 44.5 (-110).

The Under has hit in back-to-back games for Green Bay and is 4-1-1 in the Packers’ last 6 overall. For San Francisco, the Under is also 2-0 in its last 2 overall and is 3-1 in its last 4 outings. The Under has also hit in each of the last 2 matchups between these squads.

With Purdy out, San Francisco’s offense will struggle, which will help this game stay Under 45 total points.

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Seattle Seahawks at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Seattle Seahawks at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The Seattle Seahawks (4-5) are on the road in Week 11 taking on the San Francisco 49ers (5-4). Kickoff from Levi’s Stadium is Sunday at 4:05 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Seahawks vs. 49ers odds, and make our expert NFL picks and predictions.

The Seahawks, coming off their bye, have lost 2 straight games and 5 of their last 6 after a 3-0 start to the season. Their last game was a 26-20 overtime home loss to the LA Rams as 1-point underdogs.

The 49ers have won 2 in a row. They beat the Tampa Bay Buccaneers 23-20 on the road last week on a last-second field goal by K Jake Moody. They failed to cover the 6.5-point spread as favorites.

The 49ers won the first meeting this year 36-24 in Seattle in Week 6.

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Seahawks at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 12:21 a.m. ET.

Moneyline (ML): Seahawks +240 (bet $100 to win $240) | 49ers -300 (bet $300 to win $100)
Against the spread (ATS): Seahawks +6.5 (-110) | 49ers -6.5 (-110)
Over/Under (O/U): 48 (O: -110 | U: -110)

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Seahawks at 49ers key injuries

Seahawks

TE Noah Fant (groin) out
TE Brady Russell (foot) out
C Connor Williams (personal – announced retirement) out

49ers

OL Aaron Banks (thigh) questionable
DE Nick Bosa (hip) questionable
DT Kevin Givens (groin) out
OL Jon Feliciano (knee) questionable
DE Yetur Gross-Matos (knee) questionable
CB Darrell Luter (pelvis) doubtful
TE George Kittle (hamstring) questionable
CB Charvarius Ward (personal) out
OL Trent Williams (ankle) questionable
P Mitch Wishnowsky (back) out

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Seahawks at 49ers picks and predictions

Prediction

49ers 27, Seahawks 23

Moneyline

Seattle has allowed 29.7 points per game in the 6 games after their 3-0 start while San Francisco has allowed between 20 and 28 points in each of their last 5 games.

The Niners have beaten the Seahawks in 6 straight games. San Fran can tie the idle Arizona Cardinals atop the NFC West with a win. They should pick up the win,, even though they are banged up, but -300 odds aren’t worth the action.

PASS.

Against the spread

The 49ers are 5-1 ATS in their last 6 games against Seattle, but their wins in the last 2 games have not been by more than 6 points.

Four of Seattle’s losses this season have been by more than 6 points, but with so many injuries for the Niners, this will stay close.

BET SEAHAWKS +6.5 (-110).

Over/Under

Their first meeting had 60 total points, but only 2 of the last 6 games for the Niners have surpassed 48. None of the last 3 games for the Seahawks have topped 48.

But with the Seahawks allowing nearly 30 points per game in the last 6 contests and San Francisco’s opponents averaging 24 over the last 5, expect some points.

BET OVER 48 (-110).

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Dallas Cowboys at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Dallas Cowboys at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The Dallas Cowboys (3-3) take on the San Francisco 49ers (3-4) on Sunday Night Football. Kickoff from Levi’s Stadium is set for 8:20 p.m. ET (NBC). Let’s analyze BetMGM Sportsbook’s NFL odds around the Cowboys vs. 49ers odds, and make our expert NFL picks and predictions.

The Cowboys were punked in a 47-9 home defeat to the Detroit Lions before their bye last week. Dallas is now 0-3 at home and 3-0 on the road. QB Dak Prescott was 17-for-33 for 178 yards, 0 TDs and 2 INTs. WR CeeDee Lamb did what he could with 7 catches for 89 yards on 14 targets.

The Niners were upended 28-18 at home by the Kansas City Chiefs last week as 2-point favorites. QB Brock Purdy threw 3 picks, but he was able to run in 2 touchdowns. They also lost star WR Brandon Aiyuk (knee) to a torn ACL and MCL for the season. WR Deebo Samuel (wrist, illness) and TE George Kittle (foot) are both questionable this week, and the 49ers’ options are wearing thin.

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Cowboys at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 1:56 a.m. ET.

Moneyline (ML): Cowboys +180 (bet $100 to win $180) | 49ers -225 (bet $225 to win $100)
Against the spread (ATS): Cowboys +4.5 (-110) | 49ers -4.5 (-110)
Over/Under (O/U): 47 (O: -110 | U: -110)

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Cowboys at 49ers key injuries

Cowboys

CB DaRon Bland (foot) out
LB Eric Kendricks (shoulder) questionable
DE Micah Parsons (ankle) out
DT Jordan Phillips (wrist) out
LB Nick Vigil (foot) questionable

49ers

WR Brandon Aiyuk (knee) out
WR Jauan Jennings (hip) out
TE George Kittle (foot) probable
CB Deommodore Lenoir (illness) questionable
RB Christian McCaffrey (Achilles) out
PK Jake Moody (ankle) out
WR Deebo Samuel (wrist, illness) probable

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Cowboys at 49ers picks and predictions

Prediction

49ers 24, Cowboys 17

Moneyline

The Cowboys are reeling on defense without DE Demarcus Lawrence (foot) and Parsons. Their pass rush has been awful. As a defensive team, they’re the worst in fantasy over the last 5 weeks and have just 7 sacks in that span. The Niners have won 3 matchups in a row, and the Cowboys haven’t defeated them since 2020.

The Niners should win this game, but they’re nowhere near worth dropping -225 on.

Instead, I’m rolling with BROCK PURDY OVER 18.5 RUSHING YARDS (-110). He has hit this number 3 games in a row.

Against the spread

I’m rolling with 49ERS -4.5 (-110) here. They’ve defeated the Cowboys by 5+ points in each of their 3 consecutive victories over them. The lack of a Dallas pass rush should give Purdy the time to pick them apart.

Over/Under

This number looks a little high at first glance.

The Under has cashed in 2 of the last 3 meetings. It has cashed in 2 of the last 3 Niners games and 2 of the last 3 Cowboys games.

Take the UNDER 47 (-110).

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Looking to check out the latest NFL odds and perhaps make a wager or two? Our guide to NFL betting apps breaks down the top features and offers from BetMGM, Caesars, Fanatics Sportsbook and more.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Ryan Dodson on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

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Kansas City Chiefs at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Kansas City Chiefs at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The Kansas City Chiefs (5-0) take on the San Francisco 49ers (3-3) Sunday afternoon. Kickoff from Levi’s Stadium is set for 4:25 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Chiefs vs. 49ers odds, and make our expert NFL picks and predictions.

The defending champs have dealt with a slew of injuries, and QB Patrick Mahomes really has not been himself thus far. Yet, they sit at 5-0. Before their Week 6 bye, they dispatched the New Orleans Saints 26-13. Mahomes threw for 331 yards, 0 TDs and 1 INT. RB Kareem Hunt rushed 27 times for 102 yards and a score.

Niners coach Kyle Shanahan is 0-4 against Chiefs coach Andy Reid. That includes 2 regular-season matchups and 2 Super Bowls. You had better believe that Shanahan is aware of that. RB Jordan Mason (shoulder) left last week’s game — and killed a parlay for me — with a sprained AC joint. He made it back to a full practice Friday and will be able to go. The Niners smoked the Seattle Seahawks 36-24 on Thursday Night Football last week.

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Chiefs at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 10:41 p.m. ET.

Moneyline (ML): Chiefs +100 (bet $100 to win $100) | 49ers -120 (bet $120 to win $100)
Against the spread (ATS): Chiefs +1.5 (-110) | 49ers -1.5 (-110)
Over/Under (O/U): 47 (O: -110 | U: -110)

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Chiefs at 49ers key injuries

Chiefs

DE Michael Danna (pectoral) out
RB Isiah Pacheco (leg) out
WR Rashee Rice (knee) out
WR JuJu Smith-Schuster (hamstring) questionable

49ers

WR Jauan Jennings (hip) out
RB Christian McCaffrey (Achilles) out
WR Ricky Pearsall (chest) questionable

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Chiefs at 49ers picks and predictions

Prediction

49ers 24, Chiefs 20

Moneyline

The Niners haven’t beaten the Chiefs since 2014, but that came at home, and I’m calling a similar finish to the 22-17 one then. Despite all of the injuries and lack of continuity, QB Brock Purdy has completed 65.4% of his passes for 1,629 yards, 9 TDs and 4 INTs. He was very good in last year’s Super Bowl OT loss, and he’ll get it done Sunday. You can go with the 49ers (-120), but it makes more sense to ride with the spread.

Against the spread

If you like San Fran’s side here, this is the way to go. Single-point victories are pretty unlikely, and there’s more value on 49ERS -1.5 (-110).

Over/Under

The Chiefs have a home run hitter in rookie WR Xavier Worthy, but other than that, they really rely on Hunt’s ground-and-pound game. The Niners have more downfield threats, but they, too, rely on Mason’s ball control. The Chiefs are 2-3 O/U thus far, and the Niners are 4-2. While there is no comparison of the circumstances, last year’s Super Bowl needed OT to go Over 46.5. I look for a similar struggle.

Take the UNDER 47 (-110).

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Looking to check out the latest NFL odds and perhaps make a wager or two? Our guide to NFL betting apps breaks down the top features and offers from BetMGM, Caesars, Fanatics Sportsbook and more.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Ryan Dodson on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

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San Francisco 49ers at Seattle Seahawks odds, picks and predictions

Analyzing Thursday’s San Francisco 49ers at Seattle Seahawks odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (2-3) take on the Seattle Seahawks (3-2) Thursday in a NFC West showdown. Kickoff from Lumen Field is set for 8:15 p.m. ET (Prime Video). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Seahawks odds, and make our expert NFL picks and predictions.

Niners fans began sounding the alarms after a 24-23 loss to the Arizona Cardinals as 7.5-point favorites at home Sunday. This team was expected to be the best team in the NFC, and now they’re in danger of going 2-4 in a divisional battle in a hostile environment. QB Brock Purdy was 19-for-35 for 244 yards, 1 TD and 2 INTs last week. WR Brandon Aiyuk took most of that attention with 8 grabs for 147 yards on 12 targets.

The Seahawks have dropped 2 straight after a 29-20 letdown against the New York Giants as 7-point faves Sunday. QB Geno Smith was 28-for-40 for 284 yards, 1 TD and 0 INTs. The Seahawks got nothing going on the ground. Outside of Smith rushing for 72 yards on 4 carries, RBs Kenneth Walker III and Zach Charbonnet combined for 7 carries for 30 yards.

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49ers at Seahawks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Wednesday at 1:59 p.m. ET.

Moneyline (ML): 49ers -185 (bet $185 to win $100) | Seahawks +150 (bet $100 to win $150)
Against the spread (ATS): 49ers -3.5 (-105) | Seahawks +3.5 (-115)
Over/Under (O/U): 49 (O: -110 | U: -110)

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49ers at Seahawks key injuries

49ers

S Talanoa Hufanga (wrist) questionable
TE George Kittle (ribs) questionable
RB Christian McCaffrey (Achilles) out
PK Jake Moody (ankle) out
CB Charvarius Ward (knee) questionable
LB Fred Warner (ankle) questionable

Seahawks

LB Derick Hall (foot) questionable
FS Julian Love (hamstring) questionable
DT Byron Murphy (hamstring) questionable
LB Uchenna Nwosu (thigh) out

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49ers at Seahawks picks and predictions

Prediction

49ers 24, Seahawks 21

Moneyline

I’m not touching this 49ers ML with a 10-foot pole. The Seahawks are 2-1 at home this year, and they’re in a situation where they need a win, too. The thing that moves the needle for me, though, is the Niners’ rushing attack. RB Jordan Mason has averaged 107.2 rushing yards per game and topped 82 yards in 4 of 5. The Seahawks have allowed the 8th-most rushing yards to RBs this season. Take JORDAN MASON OVER 81.5 RUSHING YARDS (-115).

Against the spread

I like Seattle here and actually give them a shot to win outright at home. The Niners have beaten them 5 straight times, but they’re not getting much from anyone outside of Mason, Aiyuk and sometimes Kittle. Take the SEAHAWKS +3.5 (-115).

Over/Under

These teams haven’t had a total this large in 6 matchups, dating back to 2021. The Over is 3-2-1 in that span. Seattle is 4-1 O/U thus far, and San Fran is 3-2. I think the total has overcorrected to that, and I don’t see it going north of 49.

Take the UNDER 49 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Ryan Dodson on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

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