San Francisco 49ers betting odds line spread pick predictions best bets

Cincinnati Bengals at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Cincinnati Bengals at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (5-2) welcome the Cincinnati Bengals (3-3) to Levi’s Stadium Sunday. Kickoff is set for 4:25 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Bengals vs. 49ers odds, and make our expert NFL picks and predictions.

The 49ers lost to the Minnesota Vikings 22-17 in Week 7, failing to cover as 6.5-point road favorites. San Fran has lost 2 straight games yet is 3-0 straight up and against the spread (ATS) at home. The 49ers will be without star WR Deebo Samuel. They are led by RB Christian McCaffrey, who has 11 total touchdowns on the season.

The Bengals are riding a 2-game winning streak and are coming off their bye. In Week 6, Cincinnati beat the Seattle Seahawks 17-13 at home, covering as a 3-point home favorite. It has covered in 2 straight games and is 2-3-1 ATS this season. WR Ja’Marr Chase has been the most lethal weapon for Cincinnati, totaling 556 receiving yards through 6 games.

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Bengals at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 3:19 p.m. ET.

Moneyline (ML): Bengals +185 (bet $100 to win $185) | 49ers -225 (bet $225 to win $100)
Against the spread (ATS): Bengals +5.5 (-115) | 49ers -5.5 (-105)
Over/Under (O/U): 43.5 (O: -110 | U: -110)

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Bengals at 49ers key injuries

Bengals

LB Akeem Davis-Gaither (knee) out

49ers

WR Deebo Samuel (shoulder) out
OT Trent Williams (ankle) questionable

Bengals at 49ers picks and predictions

Prediction

49ers 23, Bengals 20

Moneyline

PASS.

The 49ers have been too good at home to suggest they won’t be able to come out on top. However, they are the more banged-up side and could struggle given those injuries.

Against the spread

BET BENGALS +5.5 (-115).

The 49ers just haven’t looked like the dominant San Fran team most have been used to. The absence of Samuel is a reason why, as is the injury to Williams. Even if Williams plays, he may not be 100%, and that could loom large. The 49ers have failed to cover as 8.5-point favorites and 6.5-point favorites over the last 2 weeks, both straight-up losses as well.

The Bengals are healthy and coming off a bye. QB Joe Burrow suffered from a calf strain in the preseason which lingered and impacted his ability. He had the 2nd-most touchdowns last season and has just 7 through 6 games. Expect his health to propel the Bengals here.

Take BENGALS +5.5 (-115).

Over/Under

LEAN UNDER 43.5 (-110).

The 49ers are 3-3-1 O/U this season and 0-1-1 O/U in their last 2 games. They have scored 17 in each of the last 2 weeks after scoring 30 or more in their first 5 games of the season.

The offense has stalled, and without Samuel and with an injured Williams, that may continue. The Bengals defensive line is their strength, and it should be able to get after QB Brock Purdy.

The Bengals are 2-4 O/U and 1-3 O/U in their last 4 games. They have scored more than 20 points in just 1 of their last 4 games. Against an elite defense, they could again have issues getting in the end zone.

Take UNDER 43.5 (-110).

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San Francisco 49ers at Minnesota Vikings odds, picks and predictions

Analyzing Monday’s San Francisco 49ers at Minnesota Vikings odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (5-1) face the Minnesota Vikings (2-4) at 8:15 p.m. ET Monday at U.S. Bank Stadium (ABC/ESPN). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Vikings odds, and make our expert NFL picks and predictions.

After scoring 30 or more points in each of their first 5 games, the 49ers were shut down by the Browns 19-17 on Oct. 15 in the worst game of QB Brock Purdy‘s career. He completed just 12 of 27 passes for 125 yards with 1 touchdown and 1 interception. The 49ers are 4-2 against the spread (ATS).

The Vikings kept hope alive for their season with a 19-13 win over the Chicago Bears. The Vikings defense knocked Bears QB Justin Fields out of the game and needed a defensive touchdown from LB Jordan Hicks to lock down the win and improve Minnesota to 2-3-1 ATS.

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49ers at Vikings odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 10:13 p.m. ET.

Moneyline (ML): 49ers -300 (bet $300 to win $100) | Vikings +240 (bet $100 to win $240)
Against the spread (ATS): 49ers -7 (-105) | Vikings +7 (-115)
Over/Under (O/U): 43 (O: -110 | U: -110)

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49ers at Vikings key injuries

49ers

LB Dre Greenlaw (hamstring) questionable
RB Christian McCaffrey (oblique) questionable
WR Deebo Samuel (shoulder) out
OT Trent Williams (ankle) doubtful

Vikings

G Ezra Cleveland (foot) out

49ers at Vikings picks and predictions

Prediction

49ers 31, Vikings 17

Moneyline

PASS.

The 49ers should win this one with relative ease — even if their injured stars don’t play or are limited. But a 1:3 ratio for return on investment is too steep a price to pay.

Against the spread

TAKE 49ERS -7 (-105).

The 49ers are the best team in the NFC and can dominate on both sides of the ball. The Vikings and QB Kirk Cousins have struggled badly in prime-time games, and without Justin Jefferson, the team is without its most dynamic player.

The 49ers are capable of blowing the doors off the Vikings, even if McCaffrey is out or limited. The Vikings are among the worst teams in the league in terms of turnovers (13), and the 49ers lead the league in giveaway/takeaway ratio (plus-8). That’s a bad combination for the Vikings.

Over/Under

TAKE OVER 43 (-110).

The 49ers have scored 30 or more points in 5 of 6 games and have a good chance of doing that against Minnesota’s risk-taking, blitz-happy defense. Big plays will be available to the 49ers offense if the line can pick up Minnesota’s blitzes.

San Francisco has outscored its opponents 41-6 in the 1st quarter this season and 106-54 in the 1st half. If the Vikings get behind, they will become 1-dimensional and could end up passing 40 or more times. That should help give them enough points to do their part to get this score Over.

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San Francisco 49ers at Cleveland Browns odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Cleveland Browns Week 6 odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (5-0) and Cleveland Browns (2-2) meet for a Week 6 matchup Sunday at Cleveland Browns Stadium. Kickoff is scheduled for 1 p.m. ET (FOX). Below, we analyze FanDuel Sportsbook’s lines around the 49ers vs. Browns odds, and make our expert NFL picks and predictions.

The 49ers took the Dallas Cowboys behind the shed on Sunday Night Football in Week 5, winning 42-10 as 3.5-point home favorites as the Over (45) cashed. The Niners have covered 4 of 5 games overall, while cashing the Over in 3 of the past 4 outings.

San Francisco’s only game against an AFC team resulted in a 30-7 road win against the Pittsburgh Steelers in Week 1, winning as a 1-point favorite while cashing the Under (41).

The Browns are coming off a bye, and presumably that would mean a lot of the bumps and bruises have healed. However, QB Deshaun Watson is dealing with a bone bruise near the rotator cuff of his throwing shoulder, and he will miss a 2nd consecutive game. QB P.J. Walker will make the start, after rookie QB Dorian Thompson-Robinson got the nod in Week 4 prior to the bye.

Weather will be a factor in Cleveland, with the forecast showing temperatures in the mid-50’s with a 50% chance of precipitation and winds anywhere from 17-20 mph, gusting to 25-30 mph from the north-northwest right off of Lake Erie.

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49ers at Browns odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 8:27 p.m. ET.

Moneyline (ML): 49ers -560 (bet $560 to win $100) | Browns +420 (bet $100 to win $420)
Against the spread (ATS): 49ers -9.5 (-114) | Browns +9.5 (-106)
Over/Under (O/U): 35.5 (O: -115 | U: -105)

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49ers at Browns key injuries

49ers

LB Dre Greenlaw (hamstring) questionable
RB Elijah Mitchell (knee) questionable

Browns

OG Joel Bitonio (knee) out
TE David Njoku (face, hand) questionable
C Ethan Pocic (chest, foot, knee) questionable
WR Cedric Tillman (hip) out
QB Deshaun Watson (shoulder) out

49ers at Browns picks and predictions

Prediction

49ers 29, Browns 12

Moneyline

The 49ers (-560) will cost you more than 5½ times your potential return. While the unbeaten Niners figure to take care of the home side with a backup QB, it’s a lot of risk traveling cross-country, while playing in ugly weather conditions.

However, you’d have to be taking part in “420” to bet the Browns (+420) at this price. Cleveland is going to face a heavy dose of RB Christian McCaffrey, and Walker and the Browns are unlikely to have many answers for the suffocating defense of Frisco.

PASS.

Against the spread

The 49ERS -9.5 (-114) opened as 3.5-point favorites earlier in the week, but the money poured in at that price, then jumped dramatically upon news of the Watson situation. I don’t think Watson would impact the game greatly against this defense, especially with wet and windy conditions.

Cleveland’s run game has really struggled since RB Nick Chubb went down early in Week 2, and it hasn’t recovered. You’ll need longer cleats, and a strong run game on a slippery track, with the weather forcing the offense to the ground. San Francisco has it, Cleveland doesn’t.

Over/Under

OVER 35.5 (-115) is way too low.

Yes, both of these teams have great defenses. Yes, Watson is out, and Walker is in, but I expect the 49ers to do a lot of the heavy lifting, with CMC going wild on the ground.

The 49ers could very well take care of this number all on their own.

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Dallas Cowboys at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Dallas Cowboys at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The Dallas Cowboys (3-1) take a trip to California to visit the San Francisco 49ers (4-0) Sunday. Kickoff from Levi’s Stadium is set for 8:20 p.m. ET (NBC). Below, we analyze BetMGM Sportsbook’s lines around the Cowboys vs. 49ers odds, and make our expert NFL picks and predictions.

Dallas handed coach Bill Belichick the worst loss of his career in a 38-3 victory Sunday, covering as a 6-point favorite. QB Dak Prescott was solid in the win as he completed 28 of his 34 passes for 261 yards and 1 TD, but the defense was the star of that show. The Boys’ defense scored on both a fumble return TD and an interception return TD in the 2nd quarter while also racking up 3 turnovers, 2 sacks and 4 tackles for loss.

San Francisco covered as a 14.5-point favorite in a 35-16 win over the Arizona Cardinals Sunday. Both QB Brock Purdy and RB Christian McCaffrey were stellar in the win. Purdy set a new 49ers franchise record in completion percentage (95%) as he completed 20 of his 21 passes for 283 yards, 1 TD and 1 rushing TD. McCaffrey set a new career high in TDs in a game (4) as he ran for 3 on the ground and caught a 6-yard TD pass.

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Cowboys at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:25 p.m. ET.

Moneyline (ML): Cowboys +145 (bet $100 to win $145) | 49ers -175 (bet $175 to win $100)
Against the spread (ATS): Cowboys +3.5 (-120) | 49ers -3.5 (+100)
Over/Under (O/U): 45 (O: -110 | U: -110)

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Cowboys at 49ers key injuries

Cowboys

LB Damone Clark (shoulder) questionable
TE Peyton Hendershot (ankle) questionable
S Malik Hooker (shoulder) questionable
LB Micah Parsons (knee) questionable

49ers

OG Jon Feliciano (concussion) questionable
LB Dre Greenlaw (ankle) questionable
WR Jauan Jennings (shin) questionable
RB Elijah Mitchell (knee) out
WR Deebo Samuel (knee/ribs) questionable
CB Charvarious Ward (heel) questionable

Cowboys at 49ers picks and predictions

Prediction

49ers 24, Cowboys 20

Moneyline

PASS.

I like the 49ers to pick up their 3rd-consecutive win vs. Dallas, but a -185 favorite is not worth the risk. Bet on the spread and/or total instead.

Against the spread

LEAN 49ERS -3.5 (+100).

This 49ers team is on a roll right now as McCaffrey has scored a TD in 13 straight games, and Purdy is still undefeated in the regular season as a starter (9-0). The Cowboys’ defense is real, and I expect them to make things tough on this Niners offense. However, Prescott has proven to be turnover prone in big moments, especially when trailing, and I expect that trend to continue here and help the Niners cover.

Over/Under

BET UNDER 45 (-110).

San Francisco ranks 2nd in total offense, averaging 398 yards per game, but both of these teams are known for their defenses. Dallas’ defense ranks 2nd in total yards allowed per game (259.8) while San Francisco’s defensive unit ranks 5th (284.3). I expect both teams’ edge rushers to make life hard on these QBs and look for each to throw at least 1 interception. This will be a close game filled with defense and not much explosive offense.

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Arizona Cardinals at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The Arizona Cardinals (1-2) are on the road in Week 4 for their 1st divisional game of the season, taking on the San Francisco 49ers (3-0). Kickoff is Sunday afternoon at 4:25 p.m. ET at Levi’s Stadium (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. 49ers odds, and make our expert NFL picks and predictions.

The Cardinals picked up their 1st win of the season last week, defeating the Dallas Cowboys 28-16 as 12.5-point home underdogs. They lost their first 2 games of the season but have covered the spread in all 3 games.

The 49ers defeated the New York Giants 30-12 last Thursday night as 10.5-point home favorites.

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Cardinals at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:55 a.m. ET.

Moneyline (ML): Cardinals +625 (bet $100 to win $625) | 49ers -1000 (bet $1,000 to win $100)
Against the spread (ATS): Cardinals +14 (-110) | 49ers -14 (-110)
Over/Under (O/U): 43.5 (O: -110 | U: -110)

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Cardinals at 49ers key injuries

Cardinals

LB Krys Barnes (finger) questionable
WR Marquise Brown (thumb) questionable
RB Keaontay Ingram (neck) questionable
OL Paris Johnson (ankle) questionable
DL Jonathan Ledbetter (finger) out
LB Josh Woods (ankle) out

49ers

LB Dre Greenlaw (ankle) questionable
WR Jauan Jennings (shin) doubtful
RB Elijah Mitchell (knee) questionable
WR Deebo Samuel (rib, knee) questionable

Cardinals at 49ers picks and predictions

Prediction

49ers 30, Cardinals 20

Moneyline

The Cardinals have led at halftime in every game this season and scored on all 5 first-half possessions last week. They have not turned the ball over in their last 2 weeks and rushed for 222 yards against Dallas.

However, the 49ers are a better-coached team than Dallas and their defense has allowed only 53 rushing yards per game.

The 49ers defense and rushing attack will ultimately wear down Arizona’s defense and offense, but there is no money to be made on the moneyline.

PASS.

Against the spread

The Cardinals are 3-0 ATS this season with a better-than-expected defense that has 12 sacks and 23 passes defended. They are not turning the ball over, and they play with effort and intensity.

But RB Christian McCaffrey leads the NFL in rushing yards and has scored a touchdown in 12 straight games.

While the 49ers have not been great in the red zone, the Cardinals can’t expect them to go 1-for-5 in the red zone with an interception and turnover on downs like the Cowboys last week.

Arizona can, though, get pressure on 49ers QB Brock Purdy and has picked off a pass every game.

Arizona will not win but should threaten throughout.

BET CARDINALS +14 (-110).

Over/Under

The Over is 2-1 in the Cardinals’ last 2 games, and they have scored 28 points in those games.

The 49ers have scored 30 points in every game this season.

BET OVER 43.5 (-110).

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New York Giants at San Francisco 49ers odds, picks and predictions

Analyzing Thurday’s New York Giants at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The New York Giants (1-1) battle the San Francisco 49ers (2-0) on Thursday Night Football. Kickoff from Levi’s Stadium is set for 8:15 p.m. ET (Prime Video). Below, we analyze BetMGM Sportsbook’s lines around the Giants vs. 49ers odds, and make our expert NFL picks and predictions.

After a 40-0 loss in the opener, the Giants extended their scoreless streak to 6 quarters and trailed the Arizona Cardinals 20-0 at the half on Sunday. New York scored 31 points in the 2nd half to win 31-28, but failed to cover as 5-point favorites. QB Daniel Jones finished 26 of 37 for 321 yards with 2 TDs and an interception. S Jason Pinnock showed out on defense with 13 total tackles, including 10 solos and 3 tackles for loss.

San Francisco took down the Los Angeles Rams last week with a 30-23 road victory to push as 7-point favorites. RB Christian McCaffrey led the way on offense with 20 carriers for 116 yards and a TD while tacking on 3 receptions for 19 yards.

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Giants at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 9:41 p.m. ET.

Moneyline (ML): Giants +400 (bet $100 to win $400) | 49ers -550 (bet $550 to win $100)
Against the spread (ATS): Giants +10 (-110) | 49ers -10 (-110)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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Giants at 49ers key injuries

Giants

RB Saquon Barkley (ankle) out
G Ben Bredeson (concussion) out
LB Micah McFadden (neck) questionable
DE Azeez Ojulari (hamstring) out
WR Wan’Dale Robinson (knee) questionable
T Andrew Thomas (hamstring) out

49ers

WR Brandon Aiyuk (shoulder) questionable
CB Ambry Thomas (knee) questionable

Giants at 49ers picks and predictions

Prediction

49ers 31, Giants 17

Moneyline

PASS.

At -550 odds, there is no profit to be made betting on the 49ers to win at home. They have looked dominant on both sides of the ball so far this year outscoring opponents 60-30. Expect more of the same Thursday night.

Against the spread

LEAN 49ERS -10 (-110).

As seen above, the Giants enter Thursday beaten up. Missing multiple starters on their defense, while facing a potential MVP in McCaffrey, it will be difficult for New York to get crucial stops. Even with Aiyuk possibly sidelined, QB Brock Purdy has multiple weapons that he will be able to locate and extend San Fran’s lead allowing them to cover.

New York will have to come out with a bang. If they find themselves in a hole similar to that of last week, there will be no opportunity for them to climb out.

Over/Under

BET OVER 44.5 (-110).

Primarily, many of the points will come from San Francisco and its offense. They find many different ways to spread the ball and keep the defense on their toes. Through 2 weeks of play, the Niners have 4 TDs on the ground and 2 TDs through the air. What may allow the Giants to score is gaining critical field position with the Niners tendency to turn the ball over. In their 2 games, they have fumbled the ball 6 times.

The Giants demonstrated in the 2nd half last week their potential to put points on the board. For that reason, the Over is the best choice in this game.

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San Francisco 49ers at Los Angeles Rams odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Los Angeles Rams odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (1-0) and Los Angeles Rams (1-0) renew their rivalry Sunday in the first of two meetings this season. Kickoff from SoFi Stadium is set for 4:05 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Rams odds, and make our expert NFL picks and predictions.

The 49ers looked like one of the teams to beat this year in Week 1 as they crushed the Pittsburgh Steelers 30-7 as 1-point favorites. San Francisco was carried on offense by RB Christian McCaffrey who put up 152 rushing yards and 1 TD on 22 carries while the defense swarmed Steelers QB Kenny Pickett, holding Pittsburgh to just 15 first downs — 3 of which came from penalties.

The Rams stunned a lot of people with a lopsided win of their own in Week 1, beating the Seattle Seahawks 30-13 as 4-point underdogs. Los Angeles held Seattle to just 12 total yards in the 2nd half while outscoring them 23-0 over the final 30 minutes. QB Matthew Stafford led the way with 334 yards passing, although he didn’t throw a touchdown pass in the victory.

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49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 9:46 a.m. ET.

Moneyline (ML): 49ers -350 (bet $350 to win $100) | Rams +280 (bet $100 to win $280)
Against the spread (ATS): 49ers -7.5 (-110) | Rams +7.5 (-110)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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49ers at Rams key injuries

49ers

LB Dre Greenlaw (groin) questionable
CB Samuel Womack (knee) questionable

Rams

WR Puka Nacua (oblique) questionable

49ers at Rams picks and predictions

Prediction

49ers 27, Rams 21

Moneyline

This game got a lot more interesting after the Rams blew out the Seahawks in the opener. They came into the season looking like they would struggle mightily without the stars they dumped this offseason, but played much better than expected.

That being said, the 49ers (-350) should still win this game, as they have their last 8 regular-season matchups with the Rams. They have L.A.’s number and I expect that to continue, I’m just not betting the moneyline at -350 in a rivalry game.

PASS.

Against the spread

Everything points to the 49ers covering the spread in this one. They’re the better team, they’re healthier and they’re 8-2 ATS in their last 10 games against the Rams. Yet, I find myself thinking the Rams will cover.

The offensive line is improved, the defense played better than expected and Nacua looks like the real deal as a 5th-round rookie (although his status for Sunday is unknown).

BET RAMS +7.5 (-110) to cover, but pass if this number gets down to 7.

Over/Under

The total went Under in the first game for both the Rams and 49ers this season and has cashed in 2 of the last 4 meetings between these teams.

However, the Rams’ defense isn’t as good as it seemed last week and the offense is still very capable of putting up points with Stafford, Nacua and a much-improved offensive line.

BET OVER 44.5 (-110).

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San Francisco 49ers at Pittsburgh Steelers odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Pittsburgh Steelers odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers and Pittsburgh Steelers meet in Week 1 NFL action Sunday. Kickoff from Acrisure stadium is set for 1 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Steelers, and make our expert NFL picks and predictions.

The 49ers’ 2022 season ended with a 31-7 loss in the NFC Championship at the hands of the Philadelphia Eagles. Rookie QB Brock Purdy was a star for the 49ers after coming in as the 3rd-string QB in week 13 of last year’s regular season, but suffered a UCL injury in the NFC Championship loss. Reigning Defensive Player of the Year DE Nick Bosa ended his contract holdout Wednesday, agreeing to a 5-year $170 million contract.

Coach Mike Tomlin extended his streak of years without a losing season to 16 as the Steelers won their final 4 games in 2022. The Steelers were 7-2 in their final 9 games after their week 9 bye, yet missed the playoffs while finishing with a 9-8 record. All indications are that 2nd-year QB Kenny Pickett has made a significant jump and Steelers fans are hopeful to make the playoffs in a very crowded AFC.

Against the AFC last year the 49ers went 3-2 straight up and 1-4 against the spread (ATS), while the Over was 3-2 in such games.

Against the NFC last year the Steelers were 4-1 overall and 4-1 ATS, with the Under being 3-2.

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49ers at Steelers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 6:20 p.m. ET.

Moneyline (ML): 49ers -130 (bet $130 to win $100) | Steelers +110 (bet $100 to win $110)
Against the spread (ATS): 49ers -2 (-110) | Steelers -2 (-110)
Over/Under (O/U): 41.5 (O: -110 | U: -110)

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49ers at Steelers key injuries

49ers

S Talanoa Hufanga (knee) questionable
TE George Kittle (groin) questionable
WR Ray-Ray McCloud III (wrist) questionable
K Jake Moody (quad) questionable
CB Charvarius Ward (heel) questionable

Steelers

DT Cameron Heyward (stomach) questionable
DT Larry Ogunjobi (foot) questionable

49ers at Steelers picks and predictions

Prediction

49ers 21, Steelers 20

Moneyline

BET 49ERS (-130).

I like backing the 49ers to win here and I see them as a true title contender, and with Bosa being back in action they should be firing on all cylinders. I am worried about the injury to Kittle as there is a real possibility that he doesn’t suit up, but this star-studded 49ers offense should be fine either way. Many have the Steelers as a team that will surprise fans this season, and I agree, but I don’t think they have enough to top the 49ers in their opener.

Against the spread

LEAN STEELERS +2 (-110).

This is a very slight lean that you should play lightly as the 49ers are the more talented team, but I think the Steelers will keep this game very close.

I have questions about what Purdy will look like coming off his injury and while he was great for the 49ers last year, I am not sure that we will see quite that level of production this time around. If Pickett can perform the way he did in the preseason I expect the Steelers to be a much better team offensively than last year.

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Over/Under

LEAN UNDER 41.5 (-110).

These are 2 teams with very good defenses, and that will show in this game. The Steelers still have a very questionable offensive line and I expect Bosa and the 49ers’ phenomenal defensive line to expose that early and pressure Pickett on nearly every drop back. Similarly, I expect Tomlin and this Steelers defense full of crafty veterans to continue to be a very solid run stopping defense, putting more pressure on Purdy to make plays.

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Los Angeles Chargers at San Francisco 49ers odds, picks and predictions

Analyzing Friday’s Los Angeles Chargers at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (1-1) welcome the Los Angeles Chargers (1-1) to Levi’s Stadium Friday. Kickoff is set for 10 p.m. ET (NFL Network). Below, we analyze BetMGM Sportsbook’s lines around the Chargers vs. 49ers odds, and make our expert NFL picks and predictions.

The Chargers beat the Los Angeles Rams 34-17 in Week 1 of the preseason with QB Easton Stick passing for 109 yards and a TD. In the Chargers 22-17 loss to the New Orleans Saints in Week 2, Stick had 233 yards and 2 INTs. Expect star QB Justin Herbert to make his preseason debut against the 49ers. Los Angeles’ top two wide receivers, Mike Williams and Keenan Allen have also yet to play this preseason.

The 49ers lost the Las Vegas Raiders 34-7 in Week 1 as QB Trey Lance went 10-for-15 for 112 passing yards and a TD. In Week 2, the 49ers beat the Denver Broncos 21-20 and Lance went 12-for-18 for 173 yards, a TD and INT. QB Sam Darnold also played and was 11-for-14 for 109 yards, a TD and and INT. Expected starter QB Brock Purdy went 4-of-5 for 65 yards. All 3 QBs should see time on Friday.

Chargers at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday 10:52 a.m. ET,

Moneyline (ML): Chargers +260 (bet $100 to win $260) | 49ers -350 (bet $350 to win $100)
Against the spread (ATS): Chargers +7.5 (-110) | 49ers -7.5 (-110)
Over/Under (O/U): 37.5 (O: -110 | U: -110)

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Chargers at 49ers picks and predictions

Prediction

49ers 24, Chargers 17

Moneyline

PASS.

The 49ers have more starter-quality QBs and should be able to win this game; nonetheless, the home side is not worth backing at (-350). The value isn’t there.

Similarly, Stick has performed well for the Chargers and should be able to keep this game competitive. With Herbert potentially making his debut, the Chargers may get a boost from their star as well. Still, they aren’t worth taking at (+260).

Against the spread

LEAN CHARGERS +7.5 (-110).

The Chargers took down the Rams 34-17 then lost 22-17. They are averaging 25.5 points per game, and while Stick hasn’t performed the best as a passer, he did have 2 TDs on the ground in their Week 2 loss. The Chargers 1st-round pick, WR Quentin Johnston, has also been involved and should see another healthy dose of snaps.

The 49ers were destroyed by the Raiders and then beat the Broncos at home by a point. They haven’t been overly impressive despite playing several former starters. I wouldn’t expect them to blow out Los Angeles.

Take CHARGERS +7.5 (-110).

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Over/Under

BET OVER 37.5 (-110).

Both teams have topped this total in every preseason game. The Chargers average 25.5 points per game and have allowed 19.5 per game. San Fran is averaging 14 per game but allowing 27 per game.

Stick has been able to produce consistent offense and will likely get the majority of snaps. He has big-play possibilities but is also turnover prone which could get the 49ers score more often.

With Purdy looking good and likely to play several series along with the competent Darnold behind him, expect San Fran to do its part to help the Over. Back OVER 37.5 (-110).

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Denver Broncos at San Francisco 49ers odds, picks and predictions

Analyzing Saturday’s Denver Broncos at San Francisco 49ers preseason odds and lines, with expert NFL picks and predictions.

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The Denver Broncos (0-1) visit the San Francisco 49ers (0-1) Saturday. Kickoff from Levi’s Stadium is at 8:30 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around the Broncos vs. 49ers odds, and make our expert NFL picks and predictions.

The Broncos lost 18-17 at the Arizona Cardinals Aug. 11. Denver gave up an 18-yard TD pass and a successful 2-point conversion with 2 seconds left in the game, after taking a 17-10 lead with 1:30 remaining.

The 49ers got a TD pass from QB Trey Lance in their preseason opener but were outscored 24-0 the rest of the way in a 34-7 loss at the Las Vegas Raiders Sunday.

Broncos at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:42 a.m. ET.

Moneyline (ML): Broncos -185 (bet $185 to win $100) | 49ers +150 (bet $100 to win $150)
Against the spread (ATS): Broncos -4 (-110) | 49ers +4 (-110)
Over/Under (O/U): 39.5 (O: -110 | U: -110)

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Broncos at 49ers picks and predictions

Prediction

49ers 23, Broncos 21

Moneyline

Both teams lost last week—the Broncos on the road and the 49ers at home.

The Broncos expect to get their starters 20-24 snaps in this game.

The 49ers are expected to get their starters some work, but QB Sam Darnold is expected to get most of the action under center.

As with all preseason games, unless 1 team builds too big of a lead while the starters are in the game, the final outcome is decided by backups and NFL hopefuls—which is nothing to confidently rely upon.

The smartest play for an uncertain outcome in an exhibition is to bet the plus odds on the moneyline.

BET 49ERS (+150).

Against the spread

Both teams failed to cover the spread last week. The Broncos lost outright despite being favored. The 49ers also were favored in their straight-up loss.

But without any nice plus odds to bet and an uncertain outcome decided by players who will not play much in the regular season—or might not be in the league—avoid the spread.

PASS.

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Over/Under

The Broncos’ preseason opener had the Under cash in, but the Over hit in the 49ers’ loss.

Half of the 16 preseason games last week had at least 40 total points, including the Niners’ 34-7 loss.

BET OVER 39.5 (-110).

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