San Francisco 49ers betting odds line spread pick predictions best bets – Page 2

San Francisco 49ers at Las Vegas Raiders odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Las Vegas Raiders odds and lines, with expert NFL picks and predictions.

The San Francisco 49ers and the Las Vegas Raiders open their preseasons against each other Sunday afternoon at Allegiant Stadium. Kickoff is scheduled for 4 p.m. ET (NFL Network). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Raiders odds, and make our expert NFL picks and predictions.

These teams used to meet all the time when both were located in the Bay Area. This is the 1st preseason meeting since Aug. 29, 2021, when the 49ers thumped the Raiders 34-10 at Levi’s Stadium in Santa Clara as a 5.5-point favorite while the Over (36) cashed.

The 49ers and Raiders have been participating in joint practices in Nevada this week. QB Trey Lance will start for the 49ers as QB Brock Purdy is still recovering from the elbow injury he suffered in last season’s playoffs. QB Sam Darnold will also get some snaps

Former 49ers signal caller Jimmy Garoppolo is now the starter in Las Vegas, but he’ll only make a cameo, at best. Veteran backup QB Brian Hoyer also is likely to play little, if at all. Look for backup QBs Chase Garbers and Aidan O’Connell to get the longest looks, as they battle for the 3rd job.

The 49ers ended up winning and covering 2 of 3 preseason games in 2022, while the Under cashed in 2 of those 3 outings, too.

The Raiders played 4 preseason games a season ago with the Hall of Fame game, and Las Vegas was 4-0 against the spread (ATS). The Raiders also scored 23 or more points in 3 of the 4 outings. This organization has taken preseason games seriously in recent years, winning 11 of the past 13 outright.

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49ers at Raiders odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:42 a.m. ET

Moneyline (ML): 49ers -185 (bet $185 to win $100) | Raiders +150 (bet $100 to win $150)
Against the spread (ATS): 49ers -3.5 (-115) | Raiders +3.5 (-105)
Over/Under (O/U): 36 (O: -110 | U: -110)

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49ers at Raiders picks and predictions

Prediction

49ers 23, Raiders 12

Moneyline

Backing the 49ers (-185) straight up is foolish, as you can’t risk nearly 2 times your potential return on any game, let alone a preseason contest.

While San Francisco has more veterans and/or talented players on the field, particularly under center, AVOID, and look to the spread instead.

Against the spread

49ERS -3.5 (-115) are favored, and they’ll cost you a little extra. It should be worth it, however.

I don’t like the fact that the San Francisco offense will likely be without RB Christian McCaffrey and WR Deebo Samuel, but Lance will be starting out with the offense, while Darnold will also get a long look. The advantage under center is clearly in favor of the 49ers, as the Raiders will have the likes of Garbers and O’Connell playing a majority of the snaps.

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Over/Under

UNDER 36 (-110) is the lean in this preseason opener, as I just don’t trust the young signal callers for the Raiders, TE Darren Waller is now elsewhere, WR Davante Adams likely won’t play and RB Josh Jacobs is away from the team holding out. The Raiders offense should be rather disjointed, resulting in very few points.

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NFC Championship Game: San Francisco 49ers at Philadelphia Eagles odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Philadelphia Eagles odds and lines, with expert NFL picks, predictions and best bets.

[mm-video type=video id=01gqss5fpqb1w1q2hhjc playlist_id=none player_id=01evcg1x9ny8tb834m image=https://images2.minutemediacdn.com/image/upload/video/thumbnail/mmplus/01gqss5fpqb1w1q2hhjc/01gqss5fpqb1w1q2hhjc-d3a793d413793468f3adb10aae264917.jpg]

The San Francisco 49ers (15-4) battle the Philadelphia Eagles (15-3) Sunday in the NFC Championship Game. Kickoff from Lincoln Financial Field is scheduled for 3 p.m. ET (FOX). Below, we analyze Tipico Sportsbook’s lines around the 49ers vs. Eagles odds, and make our expert NFL picks and predictions.

San Francisco edged past the Dallas Cowboys 19-12 in the Divisional Round, covering as 3.5-point home favorites. The 49ers have won 12 consecutive games, have covered the spread in 3 straight games and are 9-1 against the spread (ATS) in the last 10. They’ve been a moneymaker this season, going 13-6 ATS combined in the regular season and playoffs.

QB Brock Purdy, aka Mr. Irrelevant in last year’s draft, is 7-0 since taking over the starting role after Jimmy Garoppolo suffered a broken foot in Week 13. The 49ers offense has been great, averaging 365.6 yards per game during the regular season to rank 5th in the league — it averaged 408.5 YPG in 2 playoff games — but the defense has performed even better. The 49ers defense ranks 1st in total yards allowed (300.6 YPG), 2nd against the rush (77.7) and 1st in opponent’s points scored (16.3 PPG).

The Eagles demolished the division rival New York Giants 38-7 last week in their 1st playoff game coming off a 1st-round bye. They easily covered as 8-point home favorites. Philadelphia is only 1-4 ATS in its last 5 games and 9-9 ATS overall, but it is 7-3 ATS in its last 10 home games.

MVP candidate QB Jalen Hurts has led the Eagles to a top-ranked offense this season. They rank top-10 in the league in total yards per game (3rd; 389.1), pass yards per game (9th; 241.5), rush yards per game (5th; 147.6) and points scored per game (3rd; 28.1).

This will be the first time San Francisco and Philadelphia have faced each other since 2021, a game in which the 49ers beat the Eagles 17-11 to cover as 3-point road favorites.

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49ers at Eagles odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10 p.m. ET.

Moneyline (ML): 49ers +130 (bet $100 to win $130) | Eagles -150 (bet $150 to win $100)
Against the spread: 49ers +2.5 (-101) | Eagles -2.5 (-119)
Over/Under (O/U): 45.5 (O: -112 | U: -108)

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49ers at Eagles key injuries

49ers

QB Jimmy Garoppolo (foot) out
RB Elijah Mitchell (groin) questionable

Eagles

None

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49ers at Eagles picks and predictions

Prediction

Eagles 24, 49ers 20

Moneyline

PASS.

With the Eagles’ odds set at -150, the better play is laying the points with the -119 juice.

Against the spread

LEAN EAGLES -2.5 (-119).

Philadelphia has played great in front of their home crowd this season where they boast an 8-2 record.

The Eagles defense ranks 2nd in the league in total yards allowed per game (301.5), 1st in passing yards per game (179.8) and 3rd in takeaways (27). The defense will prove to be too much for Purdy, who will be flying across the country and playing in Northeastern weather conditions for the first time in his young career.

Although San Francisco has plenty of offensive weaponry in their backfield, expect Coach of the Year candidate Nick Sirianni and defensive coordinator Jonathan Gannon to draw up some defensive schemes to confuse the young Niners QB.

In the last 10 meetings between these teams, the favorite is 7-3 ATS.

Over/Under

BET UNDER 45.5 (-108).

With 2 top-ranked defenses, points will be hard to come by. San Francisco ranks No. 1 in the NFL in total yards allowed per game (300.6) and the Eagles rank No. 2 (301.5). San Francisco ranks No. 2 in takeaways (28) and the Eagles rank No. 3 (27). With a chance to go to the Super Bowl on the line, both defenses will surely be on their A-game.

The Under is 7-0 in the 49ers’ last 7 playoff games and 4-1 in the Eagles’ last 5 games overall. The Under is also 4-0 in the last 4 meetings between these 2 teams.

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AFC: Bengals at Chiefs picks and predictions
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NFC Divisional Round: Dallas Cowboys at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Dallas Cowboys at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Dallas Cowboys (13-5) and San Francisco 49ers (14-4) meet Sunday in the Divisional Round of the NFL playoffs. Kickoff from Levi’s Stadium is set for 6:30 p.m. ET (FOX). Below, we analyze Tipico Sportsbook’s lines around the Cowboys vs. 49ers odds, and make our expert NFL picks and predictions.

The most recent meeting between these 2 teams was last postseason during Wild Card Weekend Jan. 16, 2022. The 49ers won 23-17 as 3.5-point road underdogs. WR Deebo Samuel rushed for a 26-yard TD in the 3rd quarter that gave San Francisco a comfortable 2-possession lead. He finished with 72 rushing yards (and 38 receiving), while RB Elijah Mitchell ran for 96 yards with a score.

The Cowboys, the NFC’s 5th seed, advanced here after covering the spread as 2.5-point favorites with a 31-14 win at the Tampa Bay Buccaneers Wild Card Weekend. QB Dak Prescott threw 4 TDs and ran for a 5th score as Dallas defeated QB Tom Brady for the 1st time in franchise history.

The 49ers, the NFC’s No. 2 seed, covered as 10-point home favorites on last week in a 41-23 win vs. the Seattle Seahawks. QB Brock Purdy finished with 3 passing TDs and ran for another, becoming the 1st rookie QB to account for 4 TDs in a postseason game.

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Cowboys at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:30 p.m. ET.

Moneyline (ML): Cowboys +180 (bet $100 to win $180) | 49ers -210 (bet $210 to win $100)
Against the spread (ATS): Cowboys +4 (-110) | 49ers -4 (-110)
Over/Under (O/U): 46.5 (O: -111 | U: -109)

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Cowboys at 49ers key injuries

Cowboys

S Jayron Kearse (knee) questionable
OL Jason Peters (hip) out

49ers

QB Jimmy Garoppolo (foot) out

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Cowboys at 49ers picks and predictions

Prediction

49ers 23, Cowboys 20

Moneyline

PASS.

The 49ers (-210) should be able to pull out the win, but betting 2.1 times the potential profit is a little expensive considering Purdy may be due for a letdown after such an impressive rookie campaign. Prescott should be the more reliable QB in this spot, but the Cowboys may struggle to put up a lot of points vs San Francisco’s No. 2 ranked total defense.

Against the spread

BET COWBOYS +4 (-110).

The Cowboys, as a franchise, may have turned a corner after defeating Brady for the 1st time in history. Dallas won a postseason road game for the 1st time in 30 years and should be able to carry that momentum into Sunday’s matchup. Purdy has been impressive for the 49ers, but Dallas’ defense is 1st in takeaways and should make it difficult for the rookie to win his 2nd postseason game. TAKE THE POINTS.

Over/Under

BET UNDER 46.5 (-109).

Dallas’ defense should continue to look dominant Sunday as the Under is 5-1 in the Cowboys’ last 6 January games. The Over is 4-0 in San Francisco’s last 4 games, but Purdy should regress toward the mean after a historic showing in his postseason debut. Dallas and San Francisco are 1st and 2nd, respectively, in takeaways per game and should make this game uncomfortable for both quarterbacks.

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NFC Wild Card: Seattle Seahawks at San Francisco 49ers odds, picks and predictions

Analyzing Saturday’s Seattle Seahawks at San Francisco 49ers Wild Card odds and lines, with expert NFL picks, predictions and best bets.

[mm-video type=video id=01gpk7ehqxd0kevjtk5m playlist_id=none player_id=01evcg1x9ny8tb834m image=https://images2.minutemediacdn.com/image/upload/video/thumbnail/mmplus/01gpk7ehqxd0kevjtk5m/01gpk7ehqxd0kevjtk5m-d9b8309707c8862defa1c7c9f0053c72.jpg]

The Seattle Seahawks (9-8) visit the NFC West rival San Francisco 49ers (13-4) to kick off Wild Card Weekend Saturday. Kickoff from Levi’s Stadium is set for 4:30 p.m. ET (FOX). Below, we analyze Tipico Sportsbook’s lines around the Seahawks vs. 49ers odds, and make our expert NFL picks and predictions.

The Seahawks made it to the postseason as the No. 7 seed in the NFC as they won their final 2 games of the season and got the help they needed from the Detroit Lions defeating the Green Bay Packers in Week 18. Seattle knocked off the New York Jets 23-6 as a 1-point underdog in Week 17 and the Los Angeles Rams 19-16 in overtime as a 5.5-point favorite to close out the regular season.

The 49ers are the hottest team in the NFL, having won their last 10 games. The last 5 wins were with rookie QB Brock Purdy, a 7th-round pick who is starting because of injuries to QBs Trey Lance and Jimmy Garoppolo. The Niners closed out the regular season with a 38-13 home win over the Arizona Cardinals as 14-point favorites.

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Seahawks at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:45 a.m. ET.

Moneyline (ML): Seahawks +410 (bet $100 to win $410) | 49ers -525 (bet $525 to win $100)
Against the spread (ATS): Seahawks +9.5 (-105) | 49ers -9.5 (-115)
Over/Under (O/U): 41.5 (O: -110 | U: -110)

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Seahawks at 49ers key injuries

Seahawks

RB DeeJay Dallas (ankle, quad) questionable
TE Noah Fant (knee) questionable
DL Shelby Harris (knee) questionable
OL Phil Haynes (ankle) questionable

49ers

QB Jimmy Garoppolo (foot) out
CB Ambry Thomas (ankle) out

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Seahawks at 49ers picks and predictions

Prediction

49ers 27, Seahawks 10

Moneyline

The 49ers are just playing great football right now. They won both meetings with the Seahawks after losing 6 straight against them dating back to 2019.

San Francisco scored more than 30 points in 5 of its final 6 games and held opponents to 17 or fewer points in 8 of its last 10 games.

The Seahawks went 4-3 on the road but the 49ers were 8-1 at home.

The 49ers (-525) should win but there isn’t any value in wagering more than 5 times your potential return.

PASS.

Against the spread

The Niners went 2-0 ATS against the Seahawks this season. They closed the season covering the spread in 7 of their final 8 games.

The Seahawks only covered the spread once in their final 8 games.

The Seahawks are 0-5 ATS in their last 5 games against the NFC.

BET 49ERS -9.5 (-115).

Over/Under

The 49ers scored 30 points or more in 5 of their final 6 games. The Over went 5-1 in those 6 games, missing only in the game that they fell short of 30 points.

Both matchups between the 2 two teams stayed Under the projected totals, and the Under was 4-0 in the Seahawks’ final 4 games.

BET UNDER 41.5 (-110).

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Arizona Cardinals at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (4-12) wrap up their season on the road in Week 18 against the NFC West champion San Francisco 49ers (12-4). Sunday’s kickoff at Levis Stadium is at 4:25 p.m. ET (FOX). Below, we analyze Tipico Sportsbook’s lines around the Cardinals vs. 49ers odds, and make our expert NFL picks and predictions.

The Cardinals have lost 6 straight games and 8 of their last 9. They lost 20-19 last week to the Atlanta Falcons on the final play of the game, but did cover the 7-point spread as road underdogs. After starting 4 different QBs in 4 games, David Blough will make his 2nd consecutive start.

The 49ers head to the postseason with a shot at the No. 1 seed in the NFC. They have won 9 consecutive games and the last 4 with 7th-round rookie QB Brock Purdy starting in place of the injured Jimmy Garoppolo. They picked up a 37-34 overtime win over the Las Vegas Raiders last week, but failed to cover the 10-point spread as road favorites.

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Cardinals at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:33 a.m. ET.

Moneyline (ML): Cardinals +800 (bet $100 to win $800) | 49ers -1200 (bet $1200 to win $100)
Against the spread (ATS): Cardinals +14 (-108) | 49ers -14 (-112)
Over/Under (O/U): 39.5 (O: -111 | U: -109)

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Cardinals at 49ers key injuries

Cardinals

DL Zach Allen (hand) out
LB Zaven Collins (calf) out
RB James Conner (shin) out
DL Leki Fotu (shoulder) questionable
CB Antonio Hamilton (hip) out
WR DeAndre Hopkins (knee) out
QB Colt McCoy (concussion) out
CB Marco Wilson (neck) out

49ers

DT Arik Armstead (foot, ankle, illness) questionable
OL Aaron Banks (ankle, knee) out
QB Jimmy Garoppolo (foot) out
DT Kenny Givens (knee) out
LB Dre Greenlaw (back) out
DT Javon Kinlaw (knee, illness) questionable
CB Ambry Thomas (ankle) out

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Cardinals at 49ers picks and predictions

Prediction

49ers 31, Cardinals 13

Moneyline

The Cardinals have a 4th-string QB starting without many of their starters. Their season is over.

The 49ers are trying to play for the No. 1 seed. They have won 9 straight.

The Cardinals have no incentive to win, but there is no reason to bet the 49ers on the moneyline.

PASS.

Against the spread

The 49ers are 10-6 ATS and, before failing to cover the spread in their win over the Raiders last week, they had covered the spread in 6 straight.

They beat the Cardinals by 28 in Week 11 in Mexico City (38-10).

The Cardinals have covered the spread the last 2 weeks, but were going against a bad defense in Atlanta and a bad offense against Tampa Bay. The Cardinals will not be able to do much this week.

BET 49ERS -14 (-112).

Over/Under

The 49ers have the league’s No. 1 defense. Outside of allowing 34 points last week, in the previous 8 games they allowed 12.1 points per game.

The Cardinals have failed to score 20 points in 5 of their last 6 while the Niners have scored over 30 in 5 of their last 7 games.

BET OVER 39.5 (-111).

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San Francisco 49ers at Las Vegas Raiders odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Las Vegas Raiders odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (11-4) will go up against the Las Vegas Raiders (6-9) on Sunday in Week 17 at Allegiant Stadium. Kickoff is scheduled for 4:05 p.m. ET (FOX). Below, we analyze Tipico Sportsbook’s lines around the 49ers vs. Raiders odds, and make our expert NFL picks and predictions.

The 49ers cruised to a 37-20 win over the Washington Commanders in Week 16 to cover as 6.5-point favorites at home. San Francisco has reeled off 8 straight wins and is currently the No. 3 seed in the NFC.

The Raiders lost 13-10 to the Pittsburgh Steelers in Week 16 as they failed to cover as 2.5-point underdogs on the road. Las Vegas was eliminated from playoff contention in Week 16 and have elected to bench QB Derek Carr in favor of QB Jarrett Stidham in the final 2 weeks.

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49ers at Raiders odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 7:38 p.m. ET.

Moneyline (ML): 49ers -450 (bet $450 to win $100) | Raiders +360 (bet $100 to win $360)
Against the spread (ATS): 49ers -9.5 (-109) | Raiders +9.5 (-111)
Over/Under (O/U): 42.5 (O: -110 | U: -110)

49ers at Raiders key injuries

49ers

DE Nick Bosa (illness) questionable
WR Deebo Samuel (ankle/knee) questionable
DT Arik Armstead (foot/ankle) questionable
RB Christian McCaffrey (knee) questionable

Raiders

QB Derek Carr (coach’s decision) out

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49ers at Raiders picks and predictions

Prediction

49ers 34, Raiders 13

Moneyline

Go ahead and AVOID the moneyline in this game despite San Francisco being close to double-digit favorites. While the 49ers should easily win, taking them straight up isn’t advised at the current odds.

Against the spread

49ers -9.5 (-109) is an easy choice in this game despite 9.5-point spreads being tough to cover in the NFL. Stidham will be making his 1st career start on Sunday against San Francisco’s No. 1 ranked defense.

The 49ers are 5-0 ATS in their last 5 games following an ATS win and 6-0 ATS in their last 6 games following a win.

Over/Under

Even though the Raiders could have a tough time scoring points, OVER 42 (-110) is an intriguing wager. The 49ers have been rolling with QB Brock Purdy under center and the defense should give him more possessions on Sunday, resulting in plenty of points for San Francisco.

The 49ers have hit the Over in 3 of their last 4 games overall. Meanwhile, the Raiders are 4-1 to the Over in 4 of their last 5 games against a team with a winning record.

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Washington Commanders at San Francisco 49ers odds, picks and predictions

Analyzing Saturday’s Washington Commanders at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Washington Commanders (7-6-1) are on the road in Week 16 to take on the NFC West champion San Francisco 49ers (10-4). They play Saturday afternoon at 4:05 p.m. ET at Levis Stadium in Santa Clara (CBS). Below, we analyze Tipico Sportsbook’s lines around the Commanders vs. 49ers odds, and make our expert NFL picks and predictions.

The Commanders lost to the New York Giants 20-12 last Sunday night at home as 4.5-point favorites. Their last 2 games were against the Giants. They won 3 in a row before that and currently are the No. 7 seed in the NFC.

The 49ers clinched the NFC West title with a 21-13 win over the Seattle Seahawks in Week 15 as 3-point favorites. They have won 7 games in a row.

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Commanders at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:57 a.m. ET.

Moneyline (ML): Commanders +250 (bet $100 to win $250) | 49ers -300 (bet $300 to win $100)
Against the spread (ATS): Commanders +6.5 (-109) | 49ers -6.5 (-111)
Over/Under (O/U): 37 (O: -115 | U: -105)

Commanders at 49ers key injuries

Commanders

OL Saahdiq Charles (concussion) out
S Kamren Curl (ankle) questionable
CB Benjamin St-Juste (ankle) questionable

49ers

QB Jimmy Garoppolo (foot) out
DL Kevin Givens (knee) out
WR Deebo Samuel (ankle, knee) out
CB Charvarius Ward (concussion) questionable

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Commanders at 49ers picks and predictions

Prediction

49ers 24, Commanders 10

Moneyline

The Commanders (+250) have played well on the road this season going 4-2-1, but face a 49ers team that is 6-1 at home. Washington has scored no more than 20 points in their last 3 games and face the league’s No. 1 defense in yards and points allowed.

The 49ers (-300) are riding a seven-game winning streak and have averaged 29.7 points a game over the last 3 weeks.

They should take care of business at home but the line doesn’t make it worth a wager on the moneyline.

PASS.

Against the spread

The Commanders are 7-6-1 ATS this season, matching their win-loss record.

The 49ers are 9-5 ATS, but have won each of their last 5 games by no fewer than 8 points.

BET 49ERS -6.5 (-111).

Over/Under

The projected total is low but both teams’ last game stayed under that total.

The 49ers have allowed an average of 11.0 points per game in their 7-game winning streak. The Commanders have not allowed more than 21 points in their last 10 games.

BET UNDER 37 (-105).

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San Francisco 49ers at Seattle Seahawks odds, picks and predictions

Analyzing Thursday’s San Francisco 49ers at Seattle Seahawks odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (9-4) meet the Seattle Seahawks (7-6) for a Thursday Night Football matchup in Week 15. Kickoff at Lumen Field in Seattle is scheduled for 8:15 p.m. ET (Prime Video). Below, we analyze Tipico Sportsbook’s lines around the 49ers vs. Seahawks odds, and make our expert NFL picks and predictions.

The 49ers (-3.5) throttled the visiting Tampa Bay Buccaneers by a 35-7 score, but the victory came with a huge price. WR Deebo Samuel suffered ankle and knee injuries in the 1st half, and is unlikely to play with the short turnaround.

QB Brock Purdy outdueled future Hall of Famer QB Tom Brady, and it wasn’t even close actually. Purdy tossed 2 TDs while running for another, and RB Christian McCaffrey totaled 153 total scrimmage yards with 2 scores.

The Seahawks are coming off a disappointing home loss to the Carolina Panthers 30-24 as 4-point favorites. As such, Seattle has failed to cover in its last 4 games, while winning just once during the span.

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49ers at Seahawks odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 9:56 p.m. ET.

Moneyline (ML): 49ers -180 (bet $180 to win $100) | Seahawks +155 (bet $100 to win $155)
Against the spread: 49ers -3.5 (-104) | Seahawks +3.5 (-116)
Over/Under (O/U): 43 (O: -107 | U: -113)

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49ers at Seahawks key injuries

49ers

DT Arik Armstead (foot, ankle) questionable
QB Jimmy Garoppolo (foot) out
RB Christian McCaffrey (knee) questionable
QB Brock Purdy (oblique, rib) questionable
WR Deebo Samuel (ankle, knee) doubtful

Seahawks

RB DeeJay Dallas (ankle) questionable
S Quandre Diggs (shoulder) questionable
S Ryan Neal (knee) questionable
RB Kenneth Walker III (ankle) questionable

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49ers at Seahawks picks and predictions

Prediction

49ers 25, Seahawks 16

Moneyline

The 49ERS (-180) are a little on the expensive side here, especially on the road. However, the Seahawks (+155) were abysmal last time out against the Panthers, while San Francisco steamrolled Tampa Bay. Momentum is definitely on the side of the visitors, and the 49ers and their coaching staff appear to have confidence in Purdy.

There is risk, as the offense should look a little different with Deebo on the shelf, but with weapons like McCaffrey and George Kittle, Frisco still has plenty of talented skill-position players to get it done.

Against the spread

Play the 49ERS -3.5 (-104), even though 3 and a hook is never an attractive line when playing a favorite.

Still, the 49ers had no problem dusting the Buccaneers and covering by a mile, while the Seahawks suffered the damaging home loss as a favorite last week.

Seattle has issues on offense, missing key skill position players, particularly at tailback, and the ones who will be up are a little nicked at the moment.

Over/Under

UNDER 43 (-113) is a rather high number given the fact San Francisco rolls in with the league’s No. 1 defense in terms of total yards allowed (286.8), rushing yards allowed (75.1) and points allowed (15.2).

Yes, Seattle’s defense has struggled, but the Niners are going to gain yardage in short chunks with Deebo on the shelf.

The Under is 9-3 in San Francisco’s last 12 games against winning teams, while cashing at a 4-0 clip in the last 4 road outings against teams with a winning home record.

While the Over has been the dominant trend for the Seahawks, including the damaging Week 14 loss, the Under is 6-2 in its last 8 TNF apperances, and 10-4 in the previous 14 against teams with a winning overall record.

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Tampa Bay Buccaneers at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Tampa Bay Buccaneers at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Tampa Bay Buccaneers (6-6) are on the road in Week 14 to take on the San Francisco 49ers (8-4). Kickoff Sunday at Levi Stadium is at 4:25 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Buccaneers vs. 49ers odds, and make our expert NFL picks and predictions.

The Buccaneers engineered a 2-score, 4th-quarter comeback last week on Monday night for a 17-16 home win over the New Orleans Saints as 3.5-points favorites. The have won 3 of their last 4 games overall.

The 49ers, despite losing QB Jimmy Garoppolo for what could be the rest of the season with a broken foot, won their 5th straight game last Sunday with a 33-17 victory over the Miami Dolphins.

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Buccaneers at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:11 a.m. ET.

Moneyline (ML): Buccaneers +160 (bet $100 to win $160) | 49ers -190 (bet $190 to win $100)
Against the spread (ATS): Buccaneers +3.5 (-115) | 49ers -3.5 (-105)
Over/Under (O/U): 37 (O: -109 | U: -111)

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Buccaneers at 49ers key injuries

Buccaneers

S Mike Edwards (hamstring) doubtful
RB Leonard Fournette (foot) questionable
DL Akiem Hicks (foot) questionable
CB Sean Murphy-Bunting (quad) questionable
OL Tristan Wirfs (ankle, knee) doubtful
S Antoine Winfield (ankle) doubtful

49ers

DL Nick Bosa (hamstring) questionable
QB Jimmy Garoppolo (foot) out
DB Tarvarious Moore (knee) out
DL Hassan Ridgeway (pectoral) out

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Buccaneers at 49ers picks and predictions

Prediction

Buccaneers 20, 49ers 13

Moneyline

The 49ers have the league’s No. 1 defense in yards and points allowed. Opponents score only 15.8 points per game and 283.9 yards per game. However, Tampa’s defense is no slouch, allowing only 18.3 points and 313.8 yards per game.

The Bucs rank 27th in scoring at only 18.1 points per game, while the 49ers are 13th at 23.5 PPG.

Tampa has had time to prepare for 49ers QB Brock Purdy. The Bucs will focus on slowing the run game and make Purdy make plays. The 49ers are 9-29 when anyone other than Garoppolo starts at QB.

It is hard to believe that Purdy could outduel QB Tom Brady, yet the 49ers are favored. This is a great underdog bet to make.

BET BUCCANEERS (+160).

Against the spread

The Bucs are only 3-8-1 ATS this season. The Bucs have only covered the spread once in their last 10 games. However, this is the 1st time all season they have not been favored.

The 49ers are 7-5 ATS. In their 5-game winning streak, they have covered the spread 4 times.

The 49ers will come down to earth with Purdy at QB, but the ATS bet for the Bucs isn’t has good as the moneyline.

PASS.

Over/Under

The Over has hit in only 2 games for the Bucs this season. The Bucs have held opponents to 16 or fewer points in 3 of their last 4 games. And you can expect the San Francisco offense to struggle against Tampa’s defense.

BET UNDER 37 (-111).

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Miami Dolphins at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Miami Dolphins at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

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The Miami Dolphins (8-3) visit the San Francisco 49ers (7-4) in a battle of division leaders Sunday. Kickoff from Levi’s Stadium is set for 4:05 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Dolphins vs. 49ers odds, and make our expert NFL picks and predictions.

The Dolphins have a 5-game winning streak after covering a 14-point spread in beating the Houston Texans 30-15 in Week 12. Miami had a brilliant 1st-half performance and led 30-0 at halftime and didn’t play their starters in the 2nd half. They are tied with Buffalo atop the AFC East.

The 49ers are on a 4-game winning streak since their blowout loss to the Kansas City Chiefs on Oct. 23. The NFC West leader won in Week 12 with a 13-0 shutout against the New Orleans Saints as 8-point favorites.

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Dolphins at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:24 a.m. ET.

Moneyline (ML): Dolphins +180 (bet $100 to win $170) | 49ers -210 (bet $210 to win $100)
Against the spread (ATS): Dolphins +4.5 (-109) | 49ers -4.5 (-111)
Over/Under (O/U): 45.5 (O: -112 | U: -108)

Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!

Dolphins at 49ers key injuries

Dolphins

OT Terron Armstead (pectoral) doubtful
QB Teddy Bridgewater (knee) questionable
RB Myles Gaskin (shoulder) questionable
CB Byron Jones (achilles) out

49ers

OT Spencer Burford (ankle) questionable
RB Elijah Mitchell (knee) out
WR Deebo Samuel (quad) questionable
OT Trent Williams (back) questionable

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Dolphins at 49ers picks and predictions

Prediction

49ers 38, Dolphins 35

Moneyline

PASS.

The 49ers will win this game because their defense will have the ability to not only put more pressure on the QB, but they will also be able to string together more stops. The defensive effort paired with the elite offensive playmaking ability will make this game a hard one for the Dolphins to win. But that doesn’t mean you should a bet -210 line.

Against the spread

BET DOLPHINS +4.5 (-110).

Both of these teams are very good and expected to make deep playoff runs, which is why this will be a close game. Whoever wins will do so by a field goal or less and whether it’s the 49ers or the Dolphins that win, this is your best bet.

Over/Under

LEAN OVER 45.5 (-112).

Both of these offenses are so high powered that it is hard for me to see this game being under 46 points. The Dolphins have scored 30+ point games in 4 straight games and the 49ers have some of the most talented players in the league at every position offensively. The 49ers defense is elite, but with 2 great offenses, expect the points to flow.

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