49ers Seahawks odds picks prediction spread over/under betting line

San Francisco 49ers at Seattle Seahawks odds, picks and predictions

Analyzing Thursday’s San Francisco 49ers at Seattle Seahawks odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (9-4) meet the Seattle Seahawks (7-6) for a Thursday Night Football matchup in Week 15. Kickoff at Lumen Field in Seattle is scheduled for 8:15 p.m. ET (Prime Video). Below, we analyze Tipico Sportsbook’s lines around the 49ers vs. Seahawks odds, and make our expert NFL picks and predictions.

The 49ers (-3.5) throttled the visiting Tampa Bay Buccaneers by a 35-7 score, but the victory came with a huge price. WR Deebo Samuel suffered ankle and knee injuries in the 1st half, and is unlikely to play with the short turnaround.

QB Brock Purdy outdueled future Hall of Famer QB Tom Brady, and it wasn’t even close actually. Purdy tossed 2 TDs while running for another, and RB Christian McCaffrey totaled 153 total scrimmage yards with 2 scores.

The Seahawks are coming off a disappointing home loss to the Carolina Panthers 30-24 as 4-point favorites. As such, Seattle has failed to cover in its last 4 games, while winning just once during the span.

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49ers at Seahawks odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 9:56 p.m. ET.

Moneyline (ML): 49ers -180 (bet $180 to win $100) | Seahawks +155 (bet $100 to win $155)
Against the spread: 49ers -3.5 (-104) | Seahawks +3.5 (-116)
Over/Under (O/U): 43 (O: -107 | U: -113)

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49ers at Seahawks key injuries

49ers

DT Arik Armstead (foot, ankle) questionable
QB Jimmy Garoppolo (foot) out
RB Christian McCaffrey (knee) questionable
QB Brock Purdy (oblique, rib) questionable
WR Deebo Samuel (ankle, knee) doubtful

Seahawks

RB DeeJay Dallas (ankle) questionable
S Quandre Diggs (shoulder) questionable
S Ryan Neal (knee) questionable
RB Kenneth Walker III (ankle) questionable

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49ers at Seahawks picks and predictions

Prediction

49ers 25, Seahawks 16

Moneyline

The 49ERS (-180) are a little on the expensive side here, especially on the road. However, the Seahawks (+155) were abysmal last time out against the Panthers, while San Francisco steamrolled Tampa Bay. Momentum is definitely on the side of the visitors, and the 49ers and their coaching staff appear to have confidence in Purdy.

There is risk, as the offense should look a little different with Deebo on the shelf, but with weapons like McCaffrey and George Kittle, Frisco still has plenty of talented skill-position players to get it done.

Against the spread

Play the 49ERS -3.5 (-104), even though 3 and a hook is never an attractive line when playing a favorite.

Still, the 49ers had no problem dusting the Buccaneers and covering by a mile, while the Seahawks suffered the damaging home loss as a favorite last week.

Seattle has issues on offense, missing key skill position players, particularly at tailback, and the ones who will be up are a little nicked at the moment.

Over/Under

UNDER 43 (-113) is a rather high number given the fact San Francisco rolls in with the league’s No. 1 defense in terms of total yards allowed (286.8), rushing yards allowed (75.1) and points allowed (15.2).

Yes, Seattle’s defense has struggled, but the Niners are going to gain yardage in short chunks with Deebo on the shelf.

The Under is 9-3 in San Francisco’s last 12 games against winning teams, while cashing at a 4-0 clip in the last 4 road outings against teams with a winning home record.

While the Over has been the dominant trend for the Seahawks, including the damaging Week 14 loss, the Under is 6-2 in its last 8 TNF apperances, and 10-4 in the previous 14 against teams with a winning overall record.

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San Francisco 49ers at Seattle Seahawks odds, picks and prediction

Analyzing Sunday’s San Francisco 49ers at Seattle Seahawks odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (6-5) are on the road against the Seattle Seahawks (3-8) in Week 13 for a classic NFC West rivalry game. Kickoff is 4:25 p.m. ET at Lumen Field. Below, we look at the 49ers vs. Seahawks odds and lines, and make our best NFL picks, predictions and bets.

The 49ers have won three games in a row and four of their last five. They have scored 30 or more points while averaging 170 rushing yards across the four victories. Their one hiccup in the last five was a 31-17 loss to the Cardinals where they only mustered 39 rushing yards.

The Seahawks are a mess. They have lost three in a row and six of their last seven games. Since QB Russell Wilson returned from injured reserve they have scored a total of 28 points combined in three games. Wilson still has not won a home game this season.

49ers at Seahawks odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 8:30 p.m. ET.

Money line: 49ers -175 (bet $175 to win $100) | Seahawks +140 (bet $100 to win $140)
Against the spread (ATS): 49ers -3.5 (+100) | Seahawks +3.5 (-120)
Over/Under (O/U): 45.5 (O: -108 | U: -112)

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49ers at Seahawks key injuries

49ers

LB Dre Greenlaw (groin) out
WR Deebo Samuel (groin) out
RB Trey Sermon (ankle) out
LB Fred Warner (hamstring) doubtful
LB Marcell Harris (concussion) questionable

Seahawks

G Damien Lewis (elbow) doubtful
RB Rashaad Penny (hamstring) questionable
RB Alex Collins (abdomen) questionable
RB Travis Homer (calf) questionable

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49ers at Seahawks odds, lines, predictions and picks

Prediction

Seahawks 24, 49ers 23

Money line

Wilson’s finger injury was supposed to take four to eight weeks to recover and we enter the seventh week since he suffered the injury. It’s been clear that he’s not been 100% in the three games since he’s returned.

However, even with the struggles at home this season, the Seahawks beat the 49ers once this season and have done so 14 of the last 16 times they have played each other.

Rivalry games are always weird. With Samuel out and their linebackers banged up, this is the perfect week for an upset.

Take the SEAHAWKS (+140).

Against the spread

The Seahawks are 5-6 ATS this season but have failed to cover the spread in the three games since Wilson’s return.

The 49ers started the year 1-5 ATS but are 4-1 ATS in their last five games.

However, expecting the outright Seattle win, take the SEAHAWKS +3.5 (-120).

Over/Under

The Seahawks have only had one game this season hit the Over, an overtime game in Week 2.

The 49ers have had four of their last six games go Over the projected total.

This is the game the Seahawks come alive a little.

Take OVER 45.5 (-108).

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Underdog Corner: 3 best NFL picks and predictions for Week 13

Assessing the NFL betting odds and lines for Week 13, with three predictions and picks for the best underdog bets to make.

We were 1-2 here last week in Underdog Corner, hitting on the Miami Dolphins and coming up short with the Indianapolis Colts and Minnesota Vikings.
It was only our third losing week of the season, though, as our against-the-spread record stands at 25-11 (.694). A full 21 of those 25 underdog ATS winners have won outright as well.
That established, it’s on to our three selections for lucky Week 13.

NFL underdog predictions: Week 13

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 4:30 p.m. ET.

New Orleans Saints +4.5 (-110) vs. Dallas Cowboys

The Cowboys still have a two-game lead atop the NFC East but have dropped three of their last four contests and continue to battle COVID issues with head coach Mike McCarthy out for this Thursday night road game.

The struggle also is real for the Saints, who have lost four straight since a Halloween upset of the defending-champion Tampa Bay Buccaneers. But New Orleans’ health fortunes finally appear to be on the upswing with Taysom Hill set to take the reins at quarterback, and stud RB Alvin Kamara likely to play for the first time since Week 9.

Additionally, New Orleans has been one of the league’s best with 12-4 ATS/11-5 SU records as an underdog since 2018, so we’re banking on the SAINTS (+4.5) to keep it close in the Week 13 opener.

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Los Angeles Chargers +3.5 (-120) at Cincinnati Bengals

The Bengals have put together back-to-back double-digit wins to move to 7-4. But their other two-game win streaks this season have been followed by losses, and we could easily see that happening again with the whole city still celebrating the Bengals’ first season sweep of the hated Pittsburgh Steelers since 2009.

The up-and-down Chargers, meanwhile, were stymied in a 28-13 road loss to the Denver Broncos on Sunday to fall to 6-5.

The Bolts, though, have performed better as underdog (6-4 ATS) than favorite (7-9) over the last two seasons, so we’ll take CHARGERS (+3.5) catching the field goal-and-the-hook Sunday.

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Seattle Seahawks +3.5 (-120) vs. San Francisco 49ers

These are two NFC West rivals trending in completely different directions with the Niners having won and covered in four of their last five while the 3-8 Seahawks have dropped six of seven since beating the host 49ers 28-21 in Week 4.

But we’re banking on one last stand from Russell Wilson and Co., who have won 13 of the last 15 meetings (10-5 ATS) against San Francisco, who will be without injured do-it-all WR Deebo Samuel in this one.

Take the SEAHAWKS (+3.5) and the points at home.

Also see: All Week 13 odds and lines

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San Francisco 49ers at Seattle Seahawks odds, picks and prediction

Previewing the San Francisco 49ers at Seattle Seahawks Week 8 betting odds and lines, with NFL betting picks, tips and predictions.

The San Francisco 49ers (4-3) visit the NFC West rival Seattle Seahawks (5-1) Sunday of Week 8 for a 4:25 p.m. ET kickoff at CenturyLink Field. Below, we preview the 49ers-Seahawks betting odds and lines and make our NFL picks and predictions.

49ers at Seahawks betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 7:50 a.m. ET.

Money line: 49ers +130 (bet $100 to win $130) | Seahawks -152 (bet $152 to win $100)
Against the spread/ATS: 49ers +3 (-115) | Seahawks -3 (-106)
Over/Under: 53.5 (O: -115, U: -106)

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49ers at Seahawks game notes

The 49ers enter on a two-game win streak following a 33-6 rout of the New England Patriots on the road. The 49ers, who were a 3-point dog, outgained the Pats 467 total yards to 241, while the defense finished with four interceptions. San Francisco QB Jimmy Garopollo was an impressive 20 of 25 for 277 passing yards, but he was picked off twice.
Seattle lost its first game of the season, falling to the Arizona Cardinals 37-34 in overtime last Sunday night. QB Russell Wilson threw for 388 yards (33 of 50), but was picked off three times, including an interception in overtime. WR Tyler Lockett caught all three of Wilson’s TD passes and finished with 15 receptions for 200 yards. The Seahawks were 3.5-point favorites.
The 49ers are 4-3 ATS, while the Seahawks are 4-2 ATS.
San Francisco owns a 3-4 O/U record, averaging 25.5 points per game. On the defensive end, the 49ers allow just 19.5 PPG to rank fifth in the league.
Seattle is 4-2 O/U and leads the league in scoring (33.8) and total yards (425.2) per game. The defense yields 28.7 PPG.
The rivals split their two games last season with Seattle winning at San Francisco 27-24 in overtime on Nov. 11 in what could be considered the game of the year. The 49ers responded by winning in Seattle 26-21 seven weeks later.

49ers at Seahawks key injuries

49ers

LB Kwon Alexander (ankle) probable
WR Deebo Samuel (hamstring) questionable
S Jaquiski Tartt (groin) questionable
S Jimmie Ward (quadriceps) questionable
RB Jeff Wilson Jr. (ankle) out/IR

Seahawks

S Jamal Adams (groin/illness) questionable
T Duane Brown (knee) questionable
RB Chris Carson (foot) questionable
CB Shaquill Griffin (concussion/hamstring) questionable
RB Carlos Hyde (hamstring) questionable
G Mike Iupati (back) questionable
DE Benson Mayowa (ankle) questionable

49ers at Seahawks: Odds, prediction, betting lines and picks

Prediction

Seahawks 28, 49ers 23

Money line (?)

While I have the Seahawks (-152) winning, I’m going to PASS and focus on the spread.

Against the spread (?)

The SEAHAWKS -3 (-106) are the way to go. Don’t play if the line climbs to -3.5 or higher. If it drops to -2.5, which I doubt it will, it becomes my STRONGEST PLAY – 1.5 times your usual wager.

Seattle will have had a full week to think about how it blew the 10-point, fourth-quarter lead at Arizona. Wilson & Co. will be focused and will not lose back-to-back.

Over/Under (?)

This is a tough call. As mentioned, the Seahawks feature the best offense in the league and the 49ers defense ranks fifth. I’m calling for a small play on the UNDER 53.5 (-106) – half your usual wager. Don’t play if the line drops to 52.5 or lower.

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Johnny’s 2020 NFL record / Strongest plays	2-5-1 / 1-2-1
2019 NFL record / Strongest plays	17-10-1 / 7-4
2020 overall record (all sports)	125-97-3
Strongest plays (all sports)	63-37-1

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Also see:

49ers jump 4 spots in NFL Wire power rankings (Niners Wire)
How Dunlap trade can save Seattle’s season (Seahawks Wire)

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