10 Best College Football Predictions Against The Spread: Week 12. Big Week, Big Games, Big Picks

There’s no messing around with the 10 best college football predictions against the spread. These are the biggest games in the biggest week so far.

What college football games appear to be the best bets and the best picks going into Week 12? The 10 best predictions against the spread are the biggest games in the biggest week so far. 


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Week 12 Fearless Predictions, Game Previews 
CFN Week 12 Experts Picks: College
CFN Week 11 Experts Picks: NFL 
Week 12 Schedule, Game Times, Game Previews
Game Previews ACC | Big Ten | Big 12 | Pac-12 | SEC
College Football Playoff Rankings Reaction

Contact/Follow @ColFootballNews & @PeteFiutak

Results So Far ATS: 69-53-1

No goofing around

No gimmicks – the Kansas train finally came to a crashing halt, and in spectacular fashion. However, that was an overall plus to save my bacon after an offseason lobbying effort to get everyone to go over on the KU season win total of 1 or 1.5.

No obscure Group of Five on Group of Five action – because, to be honest, I couldn’t find anything.

No, it’s time to gear up and get in shape for what’s coming with the monster Thanksgiving Week around the corner – I’ll do this Wednesday before the Thursday and Friday games and then another version Friday night – leading into the conference championships leading into the bowl games.

But first, a bonus pick because I can’t resist, and because I’m not messing with a streak after falling into last week’s calls of Utah State outright over San Jose State (48-17 Aggies) and Nevada covering the 3 against San Diego State (SDSU 23-21).

It’s arguably the biggest game of the weekend, and I’m not going with it because I’m compromised.

For nine months I picked Utah to beat Oregon outright, and now 1) I hate Utah giving away points, 2) the pick fits my narrative, and that’s not a good thing – forgive the nauseating pretentiousness; I just chugged a latte at 2 am – and 3) I was yelled at by Oregon people that it’s not going to be as obvious as Oregon loses to Utah, Oregon beats Oregon State, Oregon beats Utah for Pac-12 Championship and goes on to beat random-good Big Ten team in the Rose Bowl.

Whatever. Of course that’s what’s going to happen. Utah -3. (BTW, biggest badass game preview photo ever for that.)

10 biggest college football games, 10 biggest college football picks. Here we go, starting with …

Click on each game for the preview

10. Virginia at Pitt

LINE Pitt -14.5
ATS PICK Virginia

Forgive me for doing this for a second week in a row.

Last week I loved the over in Virginia-Notre Dame, but that was based on Cavalier QB Brennan Armstrong playing. As it turned out, he couldn’t go with his injured rib and the team was a disaster in the 28-3 Irish win that didn’t come within ten miles of the total.

I might change this on the fly if news comes out about Armstrong one way or another, but at the moment the line is based on him not playing.

If he plays – and I’m guessing he tries everything to get out there with the Coastal Division still up for grabs – the line might plummet fast and the 14.5 should be a gift. However, that doesn’t quite jibe with the point total of 66.5.

If he’s not playing, UNDER if you can still get the 66.5. If he is playing, stay away from the total.

CFN Week 12 Experts Picks: College

9. SMU at Cincinnati

LINE Cincinnati -11
ATS PICK Cincinnati

I know this goes completely against my unwavering belief that Cincinnati not obliterating everyone with this schedule of meh is a disqualifier for the College Football Playoff, but I don’t believe in SMU at all.

No, Cincinnati hasn’t been as good as it should’ve been against awful teams, but yeah, Navy is quirky, and yeah, Tulsa is tough – and loses after bringing a decent fight – and the team did pull away from Tulane and USF.

SMU has been good enough over the last few years to get to the big stage, and then lose. Last year it was the 42-13 loss to Cincinnati. In 2019 it was the 54-48 loss to Memphis, and in 2018 – granted, that team was just okay – it was a 48-20 loss to UCF.

Cincinnati QB Desmond Ridder is playing better lately than he’s getting credit for, the lack of a consistent running game shouldn’t matter in this, and …

If this 2021 Bearcat ride ends, I think it happens either at East Carolina next week or against Houston in the AAC Championship.

CFN Week 11 Experts Picks: NFL

8. Oklahoma State at Texas Tech

LINE Oklahoma State -10.5
ATS PICK Oklahoma State

Interim head man Sonny Cumbie is coaching up this Texas Tech team through a tough situation. It fought well in a loss to Kansas State, got picked apart by Oklahoma, and then pulled off a Big 12 game-changer with a win over Iowa State. However …

Oklahoma State is fabulous.

This defense is incredible – it has yet to allow more than 24 points and gave up just 23 total in the last three games – the offense is finding its stride, and for all of his Mike Gundyness, Mike Gundy is really, really good at this and has his team peaking at the right time.

Texas Tech freshman QB Donovan Smith looks like a superstar to build around after ripping up Iowa State. However, Iowa State doesn’t get into the backfield like Oklahoma State does.

Donovan, meet the No. 1 pass rush and No. 3 defense in college football.

NEXT: College Football Pick Against The Spread No. 7: Nebraska at Wisconsin

SEC Predictions, Schedule, Game Previews, Lines, How To Watch: Week 12

SEC Schedule, Game Previews, Predictions for Week 12, highlighted by Arkansas at Alabama, Florida at Missouri, and Auburn at South Carolina

SEC college football predictions, schedule, game previews, lines, and how to watch for Week 12 of the season.


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Click on each game for game preview & prediction 

SEC Results So Far
SU: 70-24, ATS: 54-39-1, Point Total: 49-42-1

College Football Expert Picks, CFN Week 12

Saturday, November 20

Charleston Southern at Georgia

12:00, ESPN+/SEC Network
Line: COMING, o/u: COMING
 

Prairie View A&M at Texas A&M

12:00, ESPN+/SEC Network
Line: COMING, o/u: COMING
 

New Mexico State at Kentucky

12:00, SEC Network
Line: Kentucky -36, o/u: 60
 

Tennessee State at Mississippi State

12:00, ESPN+/SEC Network
Line: COMING, o/u: COMING
 

Arkansas at Alabama

3:30, CBS
Line: Alabama -21, o/u: 57.5
 

Florida at Missouri

4:00, SEC Network
Line: Florida -8.5, o/u: 69.5

Auburn at South Carolina

7:00, ESPN
Line: Auburn -7.5, o/u: 44.5

South Alabama at Tennessee

7:30, ESPNU
Line: Tennessee -28, o/u: 62

Vanderbilt at Ole Miss

7:30, SEC Network
Line: Ole Miss -36, o/u: 64.5

ULM at LSU

9:00, ESPN2
Line: LSU -29, o/u: 58.5

College Football Schedule, Predictions, Week 12

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Fearless Predictions of Every Game
Bowl Projections | Rankings

College Football Expert Picks, Predictions: Week 12

College football expert picks and predictions for Week 12’s biggest games including Michigan State at Ohio State, Wake Forest at Clemson, Oregon at Utah, UCLA at USC, and Arkansas at Alabama

College football expert picks, predictions for Week 12, highlighted by Michigan State at Ohio State, Wake Forest at Clemson, Oregon at Utah, UCLA at USC, and Arkansas at Alabama


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* next to the pick means the team will win, but not cover.
Click on each game for the game preview and CFN Prediction

CFN Fearless Predictions & Game Previews

Week 12 College Football Expert Picks
WMU at EMU | NIU at Buffalo
CMU at Ball St | Louisville at Duke
Arizona at Wash St | SDSU at UNLV
Michigan St at Ohio St | Iowa St at OU
Wake Forest at Clemson | Illinois at Iowa
Ga Tech at Notre Dame | Arkansas at Bama
SMU at Cincinnati | Michigan at Maryland
Nebraska at Wisconsin | Florida at Missouri
UCLA at USC | Baylor at Kansas State
Auburn at South Carolina | Oregon at Utah
Virginia at Miami | Oklahoma St at Tex Tech
Arizona St at Oregon St | Col St at Hawaii
Results So Far | Week 12 Schedule  

Western Michigan at Eastern Michigan

7:30, ESPN2
Line: Western Michigan -5.5, o/u: 68

Patrick Conn, LSUTigersWire.com WMU
Adam Dubbin, GatorsWire.com WMU
Jeff Feyerer, CFN: WMU
Pete Fiutak, CFN: EMU
Dan Harralson, VolsWire.com: WMU*
Phil Harrison, BuckeyesWire.com: WMU
Jeremy Mauss, MWwire.com: EMU
Johnny Rosenstein, SportsBookWire.com: WMU*
Nick Shepkowski, FightingIrishWire.com: WMU
Joe Vitale, UGAWire.com: WMU
Clucko the Chicken, CFN: WMU
CONSENSUS PICK: WMU

NEXT: Northern Illinois at Buffalo Expert Picks, Predictions

SEC Predictions, Game Previews, Lines, TV: Week 12

Check out all the fearless predictions, game previews, lines and TV listings for Week 12 of the SEC season.

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Check out all the fearless predictions, game previews, lines and TV listings for Week 12 of the SEC season.


How are the SEC predictions so far?
SU 58-16, ATS 32-30-3, o/u: 30-35


Results So Far: SU 54-13, ATS 28-27-3, o/u: 28-30

Click on each game for game preview & prediction 

Alabama at Mississippi State

12:00 ESPN | Get Tickets
BetMGM Line: Alabama -20.5, o/u: 62.5
Bet on this game with BetMGM  

Florida at Missouri

12:00 CBS | Get Tickets
BetMGM Line: Florida -6.5, o/u: 48.5
Bet on this game with BetMGM
Live Stream: fuboTV (click to watch for free)

Georgia at Auburn

3:30 CBS | Get Tickets
BetMGM Line: Georgia -2.5, o/u: 43.5
Bet on this game with BetMGM
Live Stream: fuboTV (click to watch for free)

Kentucky at Vanderbilt

3:30 SEC Network | Get Tickets
BetMGM Line: Kentucky -9.5, o/u: 43.5
Bet on this game with BetMGM
Live Stream: fuboTV (click to watch for free)

LSU at Ole Miss

7:00 ESPN | Get Tickets
BetMGM Line: LSU -20.5, o/u: 63.5
Bet on this game with BetMGM

South Carolina at Texas A&M

7:30 SEC Network | Get Tickets
BetMGM Line: Texas A&M -10.5, o/u: 50.5
Bet on this game with BetMGM
Live Stream: fuboTV (click to watch for free)

– CFN Fearless Predictions & Game Previews

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College Football Expert Picks, Predictions: Week 12

The picks and predictions from the college football experts fro Week 12 of the season.

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 If there’s an *next to the pick, that means the team will win, but not cover.

INSTRUCTIONS: Make your pick against the spread. For example …
– If you think Florida will win -7 over Miami: Florida
– If you think Miami will win outright: Miami
– If you think Florida will win, but NOT cover: Florida*

Week 12 Fearless Predictions, Game Previews 
ACC | Big Ten | Big 12 | Pac-12 | SEC
AAC | C-USA | Ind | MAC | MW | Sun Belt
CFN Fearless Predictions & Game Previews
Week 12 Expert Picks & Predictions
10 Best Predictions Against The Spread
Week 12 Final Thoughts, Betting Advice
10 Best Point Total Predictions

Results So Far …

Gill Alexander: SU: 163-64, ATS: 121-100-5
@beatingthebook, VSIN
Jeff Feyerer: SU: 166-60, ATS: 116-105-5
@JeffFeyererCFN
Pete Fiutak: SU: 163-64, ATS: 110-111-5
@PeteFiutakCFN
Dan Harralson: SU: 164-63, ATS: 115-106-5
@danharralson, VolsWire.com
Phil Harrison: SU: 163-64, ATS: 109-112-5
@PhilHarrisonBW, BuckeyesWire.com
Isaiah Hole: SU: 164-62, ATS: 120-101-5
@IsaiahHole, WolverinesWire.com
Wil Hunter: SU: 159-67, ATS: 97-125-4
@wil__hunter, SpartansWire.com
Jeremy Mauss: SU: 170-56, ATS: 115-106-5
@MWCWire, MWwire.com
Kegan Reneau: SU: 156-70, ATS: 110-111-5
@KeganReneau, SoonersWire.com
Johnny Rosenstein: SU: 163-63, ATS: 104-117-5
@JohnnyParlay11, SportsBookWire.com
Nick Shepkowski: SU: 161-65, ATS: 110-111-5
@Shep670, CFN Podcast
Scott Steehn: SU: 153-73, ATS: 116-105-5
@Steehnroller, WinnersandWhiners.com
Keith Stewart: SU: 145-61, ATS: 115-106-5
WinnersandWhiners.com
Joe Vitale: SU: 165-61, ATS: 121-100-5
@JoeVitale, UGAwire.com
Chris Wassel: SU: 159-67, ATS: 101-120-5
@ChrisWasselDFS, SportsBookWire.com
Joe Williams: SU: 157-69, ATS: 101-121-4
@JoeWilliamsVI, SportsBookWire.com
Big Game Ben Niewoehner: SU: 41-19, ATS: 36-39-3
Clucko The Chicken (a coin flip): SU: 104-122, ATS: 113-108-5
CONSENSUS PICK: SU: 168-58, ATS: 112-109-5


Week 12 Expert Picks
EMU at Akron | WMU at Ohio
BGSU at Miami Univ. | NIU at Toledo
Buffalo at Kent St | UNC at Pitt
La Tech at Marshall | Fresno St at SDSU
Wisc. at Nebraska | Indiana at Penn St
MSU at Michigan | Florida at Missouri
Ohio St at Rutgers | Georgia at Auburn
Wake Forest at Clemson | Navy at ND
Minnesota at Iowa | LSU at Ole Miss
UCLA at Utah | Arizona at Oregon


Tuesday, November 12

Eastern Michigan at Akron

CFN Game Preview & Prediction
6:00 ESPNU | Get Tickets
Live Stream: fuboTV (click to watch for free)
BetMGM Line: Eastern Michigan -17, o/u: 47
Bet on this with BetMGM or for latest line

Gill Alexander
@beatingthebook, VSIN: EMU
Jeff Feyerer
@JeffFeyererCFN: EMU*
Pete Fiutak
@PeteFiutakCFN: EMU
Dan Harralson
@danharralson, VolsWire.com: EMU*
Phil Harrison
@PhilHarrisonBW, BuckeyesWire.com: EMU*
Isaiah Hole
@IsaiahHole, WolverinesWire.com: EMU
Will Hunter
@wil__hunter, SpartansWire.com: EMU
Jeremy Mauss
@MWCWire,MWwire.com: EMU
Kegan Reaneau
@KeganReneau, SoonersWire.com: COMING
Johnny Rosenstein
@JohnnyParlay11, SportsBookWire.com: EMU*
Nick Shepkowski
@Shep670, CFN Podcast: EMU
Scott Steehn
@Steehnroller, WinnersandWhiners.com: EMU
Keith Stewart
WinnersandWhiners.com: EMU
Joe Vitale
@JoeVitale, UGAwire.com: EMU
Chris Wassel
@ChrisWasselDFS, SportsBookWire.com: EMU
Joe Williams
@JoeWilliamsVI, SportsBookWire.com: EMU
Big Game Ben Niewoehner CFN EMU*
Clucko The Chicken (a coin flip): Akron
CONSENSUS PICK: Eastern Michigan


Western Michigan at Ohio

CFN Game Preview & Prediction
6:30 ESPN2 | Get Tickets
Live Stream: fuboTV (click to watch for free)
BetMGM Line: Ohio -1.5, o/u: 61
Bet on this with BetMGM or for latest line

Gill Alexander
@beatingthebook, VSIN: Ohio
Jeff Feyerer
@JeffFeyererCFN: Ohio
Pete Fiutak
@PeteFiutakCFN: Ohio
Dan Harralson
@danharralson, VolsWire.com: Ohio
Phil Harrison
@PhilHarrisonBW, BuckeyesWire.com: Ohio
Isaiah Hole
@IsaiahHole, WolverinesWire.com: WMU
Will Hunter
@wil__hunter, SpartansWire.com: WMU
Jeremy Mauss
@MWCWire,MWwire.com: Ohio
Kegan Reaneau
@KeganReneau, SoonersWire.com: COMING
Johnny Rosenstein
@JohnnyParlay11, SportsBookWire.com: Ohio
Nick Shepkowski
@Shep670, CFN Podcast: Ohio
Scott Steehn
@Steehnroller, WinnersandWhiners.com: WMU
Keith Stewart
WinnersandWhiners.com: Ohio
Joe Vitale
@JoeVitale, UGAwire.com: Ohio
Chris Wassel
@ChrisWasselDFS, SportsBookWire.com: WMU
Joe Williams
@JoeWilliamsVI, SportsBookWire.com: WMU
Big Game Ben Niewoehner CFN WMU
Clucko The Chicken (a coin flip): WMU
CONSENSUS PICK: Ohio

NEXT: Bowling Green at Miami University, Northern Illinois at Toledo