10 Best College Football Predictions Against The Spread: Week 12. Big Week, Big Games, Big Picks

There’s no messing around with the 10 best college football predictions against the spread. These are the biggest games in the biggest week so far.

5. Michigan State at Ohio State

LINE Ohio State -19
ATS PICK Michigan State

I get it, no one will be shocked if Ohio State goes off and hangs 60 on the board, but for a game of this magnitude the line is too damn high.

It’s been a wee bit lost in the 2021 narrative, but the Spartan defense is awful.

If got lit up by Michigan – according to the committee, the 552 yards allowed by the MSU D mattered – Purdue lit up the secondary like a Christmas tree, and Bailey Zappe and the WKU high-octane passing attack rolled for close to 500 yards through the air.

Now CJ Stroud and his NFL receivers are about to have a whole lot of fun. However …

Just how much do you believe in the Ohio State defense?

It hasn’t played anyone who can run since Oregon rolled for 269 yards on the ground in Week 2 after Mohamed Ibrahim and Minnesota rumbled for over 200 in the opener. Michigan State is going to run Kenneth Walker over and over and over again.

That should be enough to keep this from getting too out of hand.

Speaking of the Gophers …

NEXT: College Football Pick Against The Spread No. 4: Minnesota at Indiana