Dallas Cowboys at Arizona Cardinals odds, picks and predictions

Analyzing Sunday’s Dallas Cowboys at Arizona Cardinals odds and lines, with expert NFL picks and predictions.

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The Dallas Cowboys (2-0) are on the road in Week 3 to take on the Arizona Cardinals (0-2). They play Sunday afternoon at State Farm Stadium with a 4:25 p.m. ET kickoff (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Cowboys vs. Cardinals odds, and make our expert NFL picks and predictions.

The Cowboys have started the season looking like the best team in the NFL, beating both the New York Jets and Giants by a combined 70-10 score. They have forced 7 turnovers and sacked opposing quarterbacks 10 times.

The Cardinals have played 2 close games, losing 20-16 in Week 1 to the Washington Commanders and then 31-28 to the Giants, getting outscored 31-8 in the second half. They have covered the spread in both games.

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Cowboys at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:30 p.m. ET.

  • Moneyline (ML): Cowboys -700 (bet $700 to win $100) | Cardinals +500 (bet $100 to win $500)
  • Against the spread (ATS): Cowboys -12.5 (-110) | Cardinals +12.5 (-110)
  • Over/Under (O/U): 43 (O: -110 | U: -110)

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Cowboys at Cardinals key injuries

Cowboys

  • OL Tyler Biadasz (hamstring) questionable
  • CB Trevon Diggs (knee) out
  • OL Zack Martin (ankle) questionble

Cardinals

  • DL Leki Fotu (shoulder) questionable
  • LD Carlos Watkins (biceps) out
  • LB Josh Woods (ankle) out

Cowboys at Cardinals picks and predictions

Prediction

Cowboys 34, Cardinals 13

Moneyline

The Cowboys have scored 70 points in 2 games. The Cardinals allowed 31 in the second half of last week’s loss.

The Cowboys have the league’s No. 1 defense. The Cardinals have scored only 11 second-half points this season.

There is no reason why the Cowboys should lose this game, but the -700 line is not worth the action.

PASS. 

Against the spread

The Cardinals are 2-0 ATS this season, but so are the Cowboys.

Arizona’s defense was great for 6 quarters but injuries sapped their depth, which led to 31 points allowed in the second half of last game.

Dallas’ defense should overwhelm the Cardinals’ offense with QB Joshua Dobbs leading the way, who has not thrown a touchdown pass yet.

BET COWBOYS -12.5 (-110). 

Over/Under

The question for this game is whether the Cardinals will be able to scored double-digit points. The Cowboys have reached 30 points in both games, but the total has not passed 40 points in either game yet.

They should reach the 30s. Can the Cardinals score more than 10? I think so.

BET OVER 43 (-110). 

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New York Giants at Arizona Cardinals odds, picks and predictions

Analyzing Sunday’s New York Giants at Arizona Cardinals odds and lines, with expert NFL picks and predictions.

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The New York Giants (0-1) are on the road in Week 2 to take on the Arizona Cardinals (0-1) in their 2023 home opener Sunday. Kickoff from State Farm Stadium is 4:05 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Giants vs. Cardinals odds, and make our expert NFL picks and predictions.

The Giants opened the season by getting shut out 40-0 at home by the Dallas Cowboys. They turned the ball over 3 times (2 interceptions, 1 lost fumble) and QB Daniel Jones was sacked 7 times and fumbled twice (although both were recovered).

The Cardinals lost 20-16 on the road to the Washington Commanders but covered as 7-point underdogs. Arizona had 6 sacks and 3 takeaways but QB Josh Dobbs lost 2 fumbles that resulted in 10 Washington points.

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Giants at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:05 p.m. ET.

  • Moneyline (ML): Giants -210 (bet $210 to win $100) | Cardinals +170 (bet $100 to win $170)
  • Against the spread (ATS): Giants -4 (-110) | Cardinals +4 (-110)
  • Over/Under (O/U): 39.5 (O: -110 | U: -110)

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Giants at Cardinals key injuries

Giants

  • LB Azeez Ojulari (hamstring) doubtful
  • WR Wan’Dale Robinson (knee) doubtful
  • OL Andrew Thomas (hamstring) questionable

Cardinals

  • Budda Baker (hamstring) questionable
  • DL L.J. Collier (biceps) out
  • DL Leki Fotu (shoulder) questionable
  • LB Josh Woods (ankle) out

Giants at Cardinals picks and predictions

Prediction

Cardinals 22, Giants 20

Moneyline

The Cardinals got almost nothing offensively in Week 1, netting only 210 total yards (and 60 of those came on 2 plays in their 1st possession), and the defense scored the only touchdown. However, the Giants’ defense isn’t as good as the Commanders’.

The problems of protection that New York had last week should again be a problem against Arizona. The Cards had 6 sacks last week and have sacked Jones 14 times in his 2 career starts vs. them.

BET CARDINALS (+170).

Against the spread

When the line opened at Giants -5.5, this was an easy pick.

The Cardinals proved to be tougher than expectations had them while the Giants — a playoff team last year — looked exceptionally bad in Week 1.

This is a home opener for Arizona with a new coaching staff, so there will be some extra energy in the stadium. There will be plenty of Giants fans as well, but the Cardinals should be able to do a little more offensively than they did in Week 1.

Expect a close game at a minimum and take the Cardinals to cover if you can’t quite take them to win outright.

BET CARDINALS +4 (-110).

Over/Under

Neither team’s game hit the Over in Week 1 but this game’s 39.5-point projected total is low.

The Cardinals and Commanders had 36 total points and Arizona didn’t score an offensive touchdown.

New York’s offense is probably better than Washington’s. New York’s defense isn’t as good as Washington’s, so Arizona should be able to do a little better.

I lean OVER 39.5 (-110).

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Arizona Cardinals at Washington Commanders odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Washington Commanders Week 1 odds and lines, with expert NFL picks and predictions.

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The Arizona Cardinals visit the Washington Commanders Sunday as both teams open their 2023 NFL seasons. Kickoff from FedExField is 1 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Commanders odds, and make our expert NFL picks and predictions.

Both teams finished in last place in their respective divisions and have the longest odds to win their division this year.

The Cardinals have a new head coach (Jonathan Gannon) and general manager (Monti Ossenfort) after finishing 4-13 in 2022. QB Kyler Murray begins the season on PUP as he recovers from a torn ACL suffered in December so newly-acquired QB Joshua Dobbs will start in Arizona’s season opener. The Cardinals went 2-1 in the preseason.

The Commanders added offensive coordinator/assistant head coach Eric Bienemy, formerly of the Kansas City Chiefs, to head coach Ron Rivera’s staff. Washington has new ownership and a new starting quarterback as 2nd-year QB Sam Howell gets the nod. Washington finished 8-8-1 last season.

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Cardinals at Commanders odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:57 a.m. ET.

  • Moneyline (ML): Cardinals +240 (bet $100 to win $240) | Commanders -300 (bet $300 to win $100)
  • Against the spread (ATS): Cardinals +7 (-110) | Commanders -7 (-110)
  • Over/Under (O/U): 38 (O: -110 | U: -110)

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Cardinals at Commanders key injuries

Cardinals

  • OL Kelvin Beachum (hand) out
  • WR Marquise Brown (hamstring) questionable
  • TE Zach Ertz (knee) questionable

Commanders

  • DE James Smith-Williams (oblique) questionable
  • DE Chase Young (neck) questionable

Cardinals at Commanders picks and predictions

Prediction

Commanders 16, Cardinals 10

Moneyline

The Cardinals won 30-15 when these teams last met on Sept. 20, 2020, although things looked a lot different then.

Dobbs is winless in 2 NFL starts, both last season as a member of the Tennessee Titans. Howell is 1-0 in his one start late last season against the Dallas Cowboys’ backups.

The Commanders are playing in front of a sold-out home crowd for the first time in years and the Cardinals have the lowest projected win total in the NFL.

The Cardinals did not score more than 18 points in any preseason game.

PASS.

Against the spread

The Commanders were 8-8-1 ATS last season; the Cardinals were 8-9 ATS.

Arizona’s starting defense did not allow a point in limited preseason action and the Commanders are projected to have the league’s worst scoring offense by ESPN.

Arizona’s offense will struggle against Washington’s tough defensive front but the Commanders will also struggle to score points.

I’m expecting a low-scoring close game.

BET CARDINALS +7 (-110).

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Over/Under

This game already has the lowest projected total of the week.

It will be a sludge match of punts if what the Cardinals’ starters do in the regular season is anything like they did on defense in the preseason.

The Cardinals with Dobbs at quarterbacks simply don’t have the playmaking and Howell has not shown enough to prove he can put up lots of points.

BET UNDER 38 (-110).

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Arizona Cardinals at Minnesota Vikings odds, picks and predictions

Analyzing Saturday’s Arizona Cardinals at Minnesota Vikings preseason odds and lines, with expert NFL picks and predictions.

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The Arizona Cardinals (1-1) wrap up their preseason slate on the road against the Minnesota Vikings (0-2). Kickoff is Saturday at 1 p.m. ET at U.S. Bank Stadium. Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Vikings odds, and make our expert NFL picks and predictions.

The Cardinals were the league’s biggest underdog in each of their 1st 2 preseason contests. They won their preseason opener 18-17 at home against the Denver Broncos as 6-point underdogs and then lost 38-10 at home last week to the Kansas City Chiefs, failing to cover the 7.5-point spread. The Over (4.5) hit in the game.

The Vikings lost their preseason opener 24-13 to the Seattle Seahawks on the road, giving up a pair of 2nd-half TDs. Last week, they lost at home 24-16 to the Tennessee Titans as 2.5-point underdogs. The Over (36.5) hit in the game.

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Cardinals at Vikings odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 1:12 a.m. ET,

  • Moneyline (ML): Cardinals +105 (bet $100 to win $105) | Vikings -125 (bet $125 to win $100)
  • Against the spread (ATS): Cardinals +1.5 (-110) | Vikings -1.5 (-110)
  • Over/Under (O/U): 38.5 (O: -110 | U: -110)

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Cardinals at Vikings picks and predictions

Prediction

Cardinals 20, Vikings 17

Moneyline

Neither team is likely to play any starters, especially after holding 2 days of joint competitive practices. It will be rookies and players battling for roster spots. Since neither team is going to have their starters in more than the other, it really is a tossup as to who comes out on top.

Preseason games are unreliable and volatile, so the best way is to take a batch of games and go with the plus odds of the underdogs on the moneyline for the best payout.

BET CARDINALS (+105).

Against the spread

A 1.5-point spread isn’t much, but there have been 2 ties and 3 single-point wins in 2 weeks of the preseason so far.

That said, because preseason games are volatile and unreliable, especially in preseason finales when starters don’t typically play at all, there is no reason to bet the spread when both have minus odds.

PASS.

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Over/Under

The Cardinals’ preseason opener had 35 total points and last week’s contest had 48. The Vikings had 37 in their opener and 40 last week. They allowed 24 points in both games.

The Cardinals, though, have only 28 combined points in the preseason. They did play starters for longer in both games. Minnesota has not scored more than 16.

BET UNDER 38.5 (-110).

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Kansas City Chiefs at Arizona Cardinals odds, picks and predictions

Analyzing Saturday’s Kansas City Chiefs at Arizona Cardinals odds and lines, with expert NFL picks and predictions.

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The Kansas City Chiefs (0-1) visit the Arizona Cardinals (1-0) Saturday. Kickoff from State Farm Stadium is at 8 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around the Chiefs vs. Cardinals odds, and make our expert NFL picks and predictions.

The Chiefs opened the preseason with a 26-24 road loss vs. the New Orleans Saints Sunday. Kansas City had a 24-17 lead in the 4th quarter but gave up a touchdown with 1:20 left to allow New Orleans to get back into things. QB Chris Oldadokun tossed an interception just a few plays later that led to the Saints hitting the game-winning field goal as time expired.

The Cardinals opened the preseason at home with an 18-17 comeback win over the Denver Broncos last Friday. Arizona trailed 17-10 with 1:30 left but went on a 10-play, 75-yard drive and scored on an 18-yard touchdown pass and successful 2-point conversion with 2 seconds remaining.

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Chiefs at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 9:34 a.m. ET,

  • Moneyline (ML): Chiefs -300 (bet $300 to win $100) | Cardinals +240 (bet $100 to win $240)
  • Against the spread (ATS): Chiefs -7.5(-110) | Cardinals +7.5 (-110)
  • Over/Under (O/U): 40.5 (O: -110 | U: -110)

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Chiefs at Cardinals picks and predictions

Prediction

Cardinals 23, Chiefs 20

Moneyline

The Chiefs are expected to play their starters for around the first half, although QB Patrick Mahomes could play less than that. The Cardinals have not said how long they will play their starters.

In any case, it will be backups and NFL hopefuls deciding the outcome of the game. Preseason games are extremely unreliable and volatile for betting purposes.

The best way to bet on these preseason exhibitions is to simply play the underdog on the moneyline for the value.

BET CARDINALS (+240).

Against the spread

The Cardinals are 1-0 ATS with their preseason-opening win. The Chiefs are 0-1 ATS in the preseason with their loss.

But again, preseason games are too volatile for trend-follow bets.

PASS.

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Over/Under

Seven of the 16 preseason games last week had more than 40 total points. The Cardinals scored 18 second-half points. The Chiefs’ game had 50 total points last week.

BET OVER 40.5 (-110).

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Denver Broncos at Arizona Cardinals odds, picks and predictions

Analyzing Friday’s Denver Broncos at Arizona Cardinals odds and lines, with expert NFL picks and predictions.

The Denver Broncos open their preseason slate on the road Friday against the Arizona Cardinals. Kickoff from State Farm Stadium is at 10 p.m. ET (NFL Network). Below, we analyze BetMGM Sportsbook’s lines around the Broncos vs. Cardinals odds, and make our expert NFL picks and predictions.

Both the Broncos and Cardinals debut new coaching staffs after a bad 2022 season.

The Broncos will again go with QB Russell Wilson under center after a disastrous first season with the club but now have Sean Payton taking over as head coach and new defensive coordinator Vance Joseph joining from the Cardinals after spending 4 years in Arizona. Denver could be missing starting OL Mike McGlinchey and S Justin Simmons, both of whom were injured this week.

The Cardinals also hired a new head coach in Jonathan Gannon, who joins from the Philadelphia Eagles. His coordinators, Drew Petzing and Nick Rallis, are first-time coordinators. QB Kyler Murray (knee) and TE Zach Ertz (knee) are on the PUP (physically unable to perform) list and haven’t resumed practicing after suffering knee injuries last season.

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Broncos at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:16 a.m. ET,

  • Moneyline (ML): Broncos -225 (bet $225 to win $100) | Cardinals +180 (bet $100 to win $180)
  • Against the spread (ATS): Broncos -5.5 (-110) | Cardinals +5.5 (-110)
  • Over/Under (O/U): 37 (O: -110 | U: -110)

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Broncos at Cardinals picks and predictions

Prediction

Cardinals 24, Broncos 20

Moneyline

There is really only one way to bet on the preseason, and it is betting the underdog on the moneyline.

Why?

Preseason games aren’t good for trends and you don’t know who will play. The games usually end up being decided by players who don’t usually make NFL final rosters.

Gannon did tell reporters this week that one of his goals for the game is to win.

BET CARDINALS (+180).

Against the spread

There isn’t a good way to handicap the spread here. Which team’s starters play longer? Which team’s back-of-the-roster players make more plays?

That is too unreliable for a spread bet.

PASS.

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Over/Under

Neither of the 2 preseason games on Thursday had totals higher than 37.

Last year in the first week of the preseason, 12 of 16 games finished with totals of at least 37.

BET OVER 37 (-110).

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Arizona Cardinals at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (4-12) wrap up their season on the road in Week 18 against the NFC West champion San Francisco 49ers (12-4). Sunday’s kickoff at Levis Stadium is at 4:25 p.m. ET (FOX). Below, we analyze Tipico Sportsbook’s lines around the Cardinals vs. 49ers odds, and make our expert NFL picks and predictions.

The Cardinals have lost 6 straight games and 8 of their last 9. They lost 20-19 last week to the Atlanta Falcons on the final play of the game, but did cover  the 7-point spread as road underdogs. After starting 4 different QBs in 4 games, David Blough will make his 2nd consecutive start.

The 49ers head to the postseason with a shot at the No. 1 seed in the NFC. They have won 9 consecutive games and the last 4 with 7th-round rookie QB Brock Purdy starting in place of the injured Jimmy Garoppolo. They picked up a 37-34 overtime win over the Las Vegas Raiders last week, but failed to cover the 10-point spread as road favorites.

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Cardinals at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:33 a.m. ET.

  • Moneyline (ML): Cardinals +800 (bet $100 to win $800) | 49ers -1200 (bet $1200 to win $100)
  • Against the spread (ATS): Cardinals +14 (-108) | 49ers -14 (-112)
  • Over/Under (O/U): 39.5 (O: -111 | U: -109)

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Cardinals at 49ers key injuries

Cardinals

  • DL Zach Allen (hand) out
  • LB Zaven Collins (calf) out
  • RB James Conner (shin) out
  • DL Leki Fotu (shoulder) questionable
  • CB Antonio Hamilton (hip) out
  • WR DeAndre Hopkins (knee) out
  • QB Colt McCoy (concussion) out
  • CB Marco Wilson (neck) out

49ers

  • DT Arik Armstead (foot, ankle, illness) questionable
  • OL Aaron Banks (ankle, knee) out
  • QB Jimmy Garoppolo (foot) out
  • DT Kenny Givens (knee) out
  • LB Dre Greenlaw (back) out
  • DT Javon Kinlaw (knee, illness) questionable
  • CB Ambry Thomas (ankle) out

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Cardinals at 49ers picks and predictions

Prediction

49ers 31, Cardinals 13

Moneyline

The Cardinals have a 4th-string QB starting without many of their starters. Their season is over.

The 49ers are trying to play for the No. 1 seed. They have won 9 straight.

The Cardinals have no incentive to win, but there is no reason to bet the 49ers on the moneyline.

PASS. 

Against the spread

The 49ers are 10-6 ATS and, before failing to cover the spread in their win over the Raiders last week, they had covered the spread in 6 straight.

They beat the Cardinals by 28 in Week 11 in Mexico City (38-10).

The Cardinals have covered the spread the last 2 weeks, but were going against a bad defense in Atlanta and a bad offense against Tampa Bay. The Cardinals will not be able to do much this week.

BET 49ERS -14 (-112).

Over/Under

The 49ers have the league’s No. 1 defense. Outside of allowing 34 points last week, in the previous 8 games they allowed 12.1 points per game.

The Cardinals have failed to score 20 points in 5 of their last 6 while the Niners have scored over 30 in 5 of their last 7 games.

BET OVER 39.5 (-111).

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Arizona Cardinals at Atlanta Falcons odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Atlanta Falcons Week 17 odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (4-11) are on the road in Week 17 to take on the Atlanta Falcons (5-10) Sunday on New Year’s Day. Kickoff is 1 p.m. ET at Mercedes-Benz Stadium in Atlanta. Below, we analyze Tipico Sportsbook’s lines around the Cardinals vs. Falcons odds, and make our expert NFL picks and predictions.

The Cardinals have lost 5 games in a row and 7 of their last 8 contests. They will have the 4th starting QB in 4 games as David Blough gets the start after Colt McCoy had concussion symptoms return. The Cardinals lost 19-16 last week in overtime to the Tampa Bay Buccaneers, covering the 7.5-point spread as underdogs.

The Falcons have dropped 4 straight games and 6 of their last 7. They are coming off a 17-9 loss to the Baltimore Ravens on the road as 6.5-point underdogs. Rookie QB Desmond Ridder makes his 3rd NFL start. He has not yet thrown a touchdown pass.

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Cardinals at Falcons odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:45 p.m. ET.

  • Moneyline (ML): Cardinals +210 (bet $100 to win $210) | Falcons -250 (bet $250 to win $100)
  • Against the spread (ATS): Cardinals +6 (-113) | Falcons -6 (-107)
  • Over/Under (O/U): 41.5 (O: -110 | U: -110)

Cardinals at Falcons key injuries

Cardinals

  • OL Kelvin Beachum (knee, ankle) questionable
  • RB James Conner (illness) questionable
  • CB Antonio Hamilton (hip) questionable
  • WR DeAndre Hopkins (knee) questionable
  • QB Colt McCoy (concussion) out
  • OL Billy Price (knee) questionable
  • CB Marco Wilson (neck) questionable

Falcons

  • OL Chuma Edoga (knee) questionable

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Cardinals at Falcons picks and predictions

Prediction

Falcons 21, Cardinals 13

Moneyline

The Cardinals have not won in Atlanta since the 1993 season, having lost 9-straight meetings there with the Falcons.

The Falcons are 4-3 at home this season, and the Cardinals are 3-3 on the road.

The Cardinals are 0-10 when allowing their opponent to rush for at least 100 yards. Atlanta has the No. 3 rushing attack in the league, averaging 160.8 rushing yards per game, and they have failed to reach 100 yards in a game only once this season.

But there is not enough value on the ML to bet the Falcons.

PASS. 

Against the spread

The Cardinals have only mustered 3 touchdowns since QB Kyler Murray got hurt and have not had a passing touchdown. Blough makes his first start with the Cardinals after signing with them last week.

The Falcons are 8-7 ATS this season but have failed to cover the spread in 3 of their last 4 games.

However, their rushing attack will be too much for the Cardinals, and Arizona’s offense just isn’t doing anything right now.

BET FALCONS -6 (-107).

Over/Under

The Falcons have averaged 14 points per game over their last 4 games.

The Cardinals are averaging 15.6 point over their last 5 weeks.

The Under is 4-0 in the Falcons’ last 4 games.

BET UNDER 41.5 (-110).

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Tampa Bay Buccaneers at Arizona Cardinals odds, picks and predictions

Analyzing Sunday’s Tampa Bay Buccaneers at Arizona Cardinals odds and lines, with expert NFL picks, predictions and best bets.

To close out the NFL’s 3-game Christmas schedule, the Tampa Bay Buccaneers (6-8) have a road game against the Arizona Cardinals (4-10) Sunday night. Kickoff is 8:20 p.m. ET at State Farm Stadium (NBC). Below, we analyze Tipico Sportsbook’s lines around the Buccaneers vs. Cardinals odds, and make our expert NFL picks and predictions.

The Buccaneers have lost 3 of their last 4 games yet still lead the NFC South. Last week, they lost 34-23 to the Cincinnati Bengals at home as 3.5-point underdogs.

The Cardinals are down to their third-string quarterback. Kyler Murray was lost for the season with a torn ACL. Backup Colt McCoy suffered a concussion last week and was ruled out this week, so Trace McSorley will make his first NFL start. The Cardinals have lost 4 games in a row and 6 of their last 7. They lost 24-15 on the road to the Denver Broncos last week as 7.5-point underdogs.

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Buccaneers at Cardinals odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 9:15 a.m. ET.

  • Moneyline (ML): Buccaneers -370 (bet $370 to win $100) | Cardinals +305 (bet $100 to win $305)
  • Against the spread (ATS): Buccaneers -7.5 (-110) | Cardinals +7.5 (-110)
  • Over/Under (O/U): 40 (O: -110 | U: -110)

Buccaneers at Cardinals key injuries

Buccaneers

  • Mike Edwards (hamstring) questionable
  • WR Julio Jones (knee) questionable
  • LB Carl Nassib (pectoral) out
  • Keanu Neal (toe) questionable
  • OL Donovan Smith (foot) out
  • NT Vita Vea (calf) out
  • Antoine Winfield Jr. (ankle) questionable
  • OL Tristan Wirfs (ankle) questionable

Cardinals

  • DL Zach Allen (hand) out
  • OL Kelvin Beachum (knee, ankle) questionable
  • WR Marquise Brown (groin) questionable
  • OL Max Garcia (shoulder) questionable
  • CB Antonio Hamilton (back) questionable
  • QB Colt McCoy (concussion) out
  • CB Byron Murphy (back) out

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Buccaneers at Cardinals picks and predictions

Prediction

Buccaneers 24, Cardinals 13

Moneyline

At first look, there is no question who should win. It is Tom Brady vs. Trace McSorley. While the Bucs have dropped 3 of their last 4, the losses have come against 2 teams headed to the postseason and 1 that is battling for a playoff berth.

The Cardinals have fallen apart. They have scored 15 or fewer points in 3 of their last 4 games and have allowed at least 20 unanswered points in their last 2 games.

But betting the moneyline has no money to be made unless you are expecting a Christmas miracle win for the Cardinals.

PASS.

Against the spread

The Bucs are 3-10-1 ATS, the worst mark in the league.

But the Cardinals have covered the spread only once in their last 10 games.

They will struggle against Tampa’s defense, and the Tampa offense might be slow early on, but even the Broncos’ lowest-scoring offense in the league put up 24 against the Cardinals last week.

BET BUCCANEERS -7.5 (-110).

Over/Under

Since Murray’s injury, the Cardinals have not had a game go higher than 40 total points.

Five of the Bucs’ last 6 games have not reached 41 total points.

BET UNDER 40 (-110).

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Arizona Cardinals at Denver Broncos odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Denver Broncos odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (4-9) face the Denver Broncos (3-10) on the road in a Week 15 battle of backups quarterbacks. Sunday’s kickoff at Empower Field at Mile High is 4:05 p.m. (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Cardinals vs. Broncos odds, and make our expert NFL picks and predictions.

The Cardinals have lost 3 games in a row and 5 of their last 6, and they lost starting QB Kyler Murray for the rest of the season with a torn ACL. Their last loss was Monday 27-13 to the New England Patriots as 2-point home underdogs.

The Broncos have lost their last 5 games and will be without QB Russell Wilson. They lost 34-28 to the Kansas City Chiefs last Sunday, but covered the 8.5-point spread as road underdogs.

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Cardinals at Broncos odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:01 a.m. ET.

  • Moneyline (ML): Cardinals +105 (bet $100 to win $105) | Broncos -125 (bet $125 to win $100)
  • Against the spread (ATS): Cardinals +2 (-112) | Broncos -2 (-108)
  • Over/Under (O/U): 36.5 (O: -114 | U: -106)

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Cardinals at Broncos key injuries

Cardinals

  • DL Zach Allen (hand) out
  • WR Marquise Brown (illness) questionable
  • OL Rashaad Coward (chest) questionable
  • CB Antonio Hamilton (back) questionable
  • CB Byron Murphy (back) out
  • CB Marco Wilson (neck) questionable

Broncos

  • WR Kendall Hinton (hamstring) out
  • DE Dre’Mont Jones (hip) questionable
  • DT D.J. Jones (shoulder, illness) questionable
  • OL Dalton Risner (shoulder) questionable
  • WR Courtland Sutton (hamstring) out
  • QB Russell Wilson (concussion) out

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Cardinals at Broncos picks and predictions

Prediction

Cardinals 19, Broncos 16

Moneyline

The Cardinals have played better on the road than they have at home with 3 of their 4 wins away from home. The Broncos are 2-4 at home this season.

The Cardinals have won 3 games that QB Colt McCoy has started in his 2 years in Arizona. The Broncos are 1-1 in games Brett Rypien has started in his 3 years in Denver.

The question will come down to whether Arizona’s offense can stay on schedule and move the ball against a strong Denver defense.

Denver’s offense is the lowest-scoring unit in the league at 14.9 points per game, while the Cardinals are last in the league, giving up 26.8 points per game.

Neither team is built to play from behind, but McCoy’s experience will be the difference in this game.

BET CARDINALS (+105).

Against the spread

The Cardinals are 6-7 ATS this season, having covered the spread twice in losses.

The Broncos are 5-8 ATS and have covered the spread in each of their last 2 games, both losses. Denver is 0-5 ATS this season when favored.

I like the Cardinals to cover, but with only a 2-point spread and positive odds on the moneyline for the outright win, you are better off betting the Cardinals on the moneyline. PASS.

Over/Under

The Over has hit only twice this season in Denver’s games while all but 1 of the Cardinals’ games this season have had at least 37 total points. However, with McCoy at QB, they have scored 23 points combined in 2 games.

The Broncos scored 28 last week against Chiefs, but have scored 16 or fewer in 7 of their last 10 games.

BET UNDER 36.5 (-106).

Want action on this NFL game or any other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

Follow Jess Root on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Access more NFL coverage:

BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWireTitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire

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