Arizona Cardinals at Denver Broncos odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Denver Broncos odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (4-9) face the Denver Broncos (3-10) on the road in a Week 15 battle of backups quarterbacks. Sunday’s kickoff at Empower Field at Mile High is 4:05 p.m. (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Cardinals vs. Broncos odds, and make our expert NFL picks and predictions.

The Cardinals have lost 3 games in a row and 5 of their last 6, and they lost starting QB Kyler Murray for the rest of the season with a torn ACL. Their last loss was Monday 27-13 to the New England Patriots as 2-point home underdogs.

The Broncos have lost their last 5 games and will be without QB Russell Wilson. They lost 34-28 to the Kansas City Chiefs last Sunday, but covered the 8.5-point spread as road underdogs.

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Cardinals at Broncos odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:01 a.m. ET.

  • Moneyline (ML): Cardinals +105 (bet $100 to win $105) | Broncos -125 (bet $125 to win $100)
  • Against the spread (ATS): Cardinals +2 (-112) | Broncos -2 (-108)
  • Over/Under (O/U): 36.5 (O: -114 | U: -106)

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Cardinals at Broncos key injuries

Cardinals

  • DL Zach Allen (hand) out
  • WR Marquise Brown (illness) questionable
  • OL Rashaad Coward (chest) questionable
  • CB Antonio Hamilton (back) questionable
  • CB Byron Murphy (back) out
  • CB Marco Wilson (neck) questionable

Broncos

  • WR Kendall Hinton (hamstring) out
  • DE Dre’Mont Jones (hip) questionable
  • DT D.J. Jones (shoulder, illness) questionable
  • OL Dalton Risner (shoulder) questionable
  • WR Courtland Sutton (hamstring) out
  • QB Russell Wilson (concussion) out

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Cardinals at Broncos picks and predictions

Prediction

Cardinals 19, Broncos 16

Moneyline

The Cardinals have played better on the road than they have at home with 3 of their 4 wins away from home. The Broncos are 2-4 at home this season.

The Cardinals have won 3 games that QB Colt McCoy has started in his 2 years in Arizona. The Broncos are 1-1 in games Brett Rypien has started in his 3 years in Denver.

The question will come down to whether Arizona’s offense can stay on schedule and move the ball against a strong Denver defense.

Denver’s offense is the lowest-scoring unit in the league at 14.9 points per game, while the Cardinals are last in the league, giving up 26.8 points per game.

Neither team is built to play from behind, but McCoy’s experience will be the difference in this game.

BET CARDINALS (+105).

Against the spread

The Cardinals are 6-7 ATS this season, having covered the spread twice in losses.

The Broncos are 5-8 ATS and have covered the spread in each of their last 2 games, both losses. Denver is 0-5 ATS this season when favored.

I like the Cardinals to cover, but with only a 2-point spread and positive odds on the moneyline for the outright win, you are better off betting the Cardinals on the moneyline. PASS.

Over/Under

The Over has hit only twice this season in Denver’s games while all but 1 of the Cardinals’ games this season have had at least 37 total points. However, with McCoy at QB, they have scored 23 points combined in 2 games.

The Broncos scored 28 last week against Chiefs, but have scored 16 or fewer in 7 of their last 10 games.

BET UNDER 36.5 (-106).

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