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The Arizona Cardinals (1-2) are on the road in Week 4 for their 1st divisional game of the season, taking on the San Francisco 49ers (3-0). Kickoff is Sunday afternoon at 4:25 p.m. ET at Levi’s Stadium (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. 49ers odds, and make our expert NFL picks and predictions.
The Cardinals picked up their 1st win of the season last week, defeating the Dallas Cowboys 28-16 as 12.5-point home underdogs. They lost their first 2 games of the season but have covered the spread in all 3 games.
The 49ers defeated the New York Giants 30-12 last Thursday night as 10.5-point home favorites.
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Cardinals at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:55 a.m. ET.
- Moneyline (ML): Cardinals +625 (bet $100 to win $625) | 49ers -1000 (bet $1,000 to win $100)
- Against the spread (ATS): Cardinals +14 (-110) | 49ers -14 (-110)
- Over/Under (O/U): 43.5 (O: -110 | U: -110)
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Cardinals at 49ers key injuries
Cardinals
- LB Krys Barnes (finger) questionable
- WR Marquise Brown (thumb) questionable
- RB Keaontay Ingram (neck) questionable
- OL Paris Johnson (ankle) questionable
- DL Jonathan Ledbetter (finger) out
- LB Josh Woods (ankle) out
49ers
- LB Dre Greenlaw (ankle) questionable
- WR Jauan Jennings (shin) doubtful
- RB Elijah Mitchell (knee) questionable
- WR Deebo Samuel (rib, knee) questionable
Cardinals at 49ers picks and predictions
Prediction
49ers 30, Cardinals 20
Moneyline
The Cardinals have led at halftime in every game this season and scored on all 5 first-half possessions last week. They have not turned the ball over in their last 2 weeks and rushed for 222 yards against Dallas.
However, the 49ers are a better-coached team than Dallas and their defense has allowed only 53 rushing yards per game.
The 49ers defense and rushing attack will ultimately wear down Arizona’s defense and offense, but there is no money to be made on the moneyline.
PASS.
Against the spread
The Cardinals are 3-0 ATS this season with a better-than-expected defense that has 12 sacks and 23 passes defended. They are not turning the ball over, and they play with effort and intensity.
But RB Christian McCaffrey leads the NFL in rushing yards and has scored a touchdown in 12 straight games.
While the 49ers have not been great in the red zone, the Cardinals can’t expect them to go 1-for-5 in the red zone with an interception and turnover on downs like the Cowboys last week.
Arizona can, though, get pressure on 49ers QB Brock Purdy and has picked off a pass every game.
Arizona will not win but should threaten throughout.
BET CARDINALS +14 (-110).
Over/Under
The Over is 2-1 in the Cardinals’ last 2 games, and they have scored 28 points in those games.
The 49ers have scored 30 points in every game this season.
BET OVER 43.5 (-110).
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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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