San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Tuesday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks and predictions.

The San Francisco Giants (54-55) continue their 3-game series with the San Diego Padres (61-51) Tuesday at Petco Park. First pitch in Game 2 is scheduled for 9:40 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

San Francisco shut out San Diego 1-0 in Monday’s series opener as the Giants’ pitching staff was dominant. The Padres had just 1 runner in scoring position and only left 4 runners on base.

Season series: San Diego leads 6-5, but San Francisco has scored 10 more runs (46-36)

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Giants at Padres projected starters

RHP Alex Cobb vs. RHP Joe Musgrove

Cobb is 3-6 with a 4.08 ERA, 1.27 WHIP, 2.6 BB/9 and 9.5 K/9 in 88 1/3 IP across 17 starts.

  • Last start: Lost 3-0 Wednesday at home vs. the Los Angeles Dodgers with 6 1/3 IP, 3 ER, 4 H, 3 BB and 8 K
  • 2022 vs. the Padres: 1 start, a 13-2 home win April 12 with 5 IP, 2 ER, 4 H, 2 BB and 10 K

Musgrove is 8-5 with a 3.00 ERA, 1.03 WHIP, 2.1 BB/9 and 9.0 K/9 in 120 IP over 19 starts.

  • Last start: Lost 7-3 at home Thuraday vs. the Colorado Rockies with 4 2/3 IP, 6 ER, 8 H, 1 HR, 1 BB and 6 K
  • 2022 vs. the Giants: 1-0 with a 0.00 ERA (14 IP), 5 H, 7 BB and 10 K in 2 starts

Giants at Padres odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:21 p.m. ET.

  • Money line (ML): Giants +145 (bet $100 to win $145) | Padres -180 (bet $180 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-155) | Padres -1.5 (+125)
  • Over/Under (O/U): 7.5 (O: +100 | U: -125)

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Giants at Padres picks and predictions

Prediction

Giants 4, Padres 3

Money line

PASS.

Musgrove has shut down San Francisco’s lineup this season and the Giants are 32-37 vs. right-handed starters.

But the Padres (-180) are out of my price range because San Diego actually has a minus-7.3% return on investment (ROI) as home favorites in 2022.

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Run line/Against the spread

BET HALF-UNIT on the GIANTS +1.5 (-155) because the Padres -1.5 (+125) have the 4th-worst RL ROI as home favorites in MLB at minus-31.6%. In fact, a $100 bettor would be down $1,587 if they bet San Diego’s RL as home favorites this year.

Also, there’s a “Pros vs. Joe’s” scenario in the betting market. A slight majority of the cash is on the Giants but more than 80% of the bets are on the Padres, per Pregame.com. It’s wise to follow the money when it’s counter to the public since sharps wager a lot more dough than public bettors.

Over/Under

BET HALF-UNIT on the UNDER 7.5 (-125) since Musgrove deals vs. San Francisco, the Giants are 10-13-1 O/U as road underdogs and Petco Park is the most pitcher-friendly venue in baseball according to park factor.

It’s only a LEAN to the UNDER 7.5 (-125) since I’m going to take a shot on San Francisco’s RL and this is a sharp total without much value on either side.

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Monday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks and predictions.

The San Francisco Giants (53-55) head down the coast to start a 3-game series with the San Diego Padres (61-50). First pitch from Petco Park is scheduled for 9:40 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

San Francisco is 5-5 straight up (SU) in its last 10 games and swept a 2-game interleague series with the Bay Area neighbor Oakland Athletics Saturday-Sunday after losing 4 straight at home to the Los Angeles Dodgers.

San Diego is also 5-5 SU over its last 10 but has lost 4 consecutive outings, which includes being swept in a 3-game series at the Dodgers this past weekend.

Season series: The Padres lead 6-4 but the Giants have a plus-9 run differential in those meetings (45-36).

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Giants at Padres projected starters

LHP Alex Wood vs. LHP Blake Snell

Wood is 7-9 with a 4.42 ERA, 1.25 WHIP, 2.2 BB/9 and 8.9 K/9 in 106 IP over 21 starts.

  • Last start: Loss, 9-5, at home vs. the Dodgers Tuesday with 5 1/3 IP, 6 ER, 9 H, 1 HR, 1 BB and 6 K.
  • 2022 vs. the Padres: 1-1 with a 4.40 ERA (14 1/3 IP, 7 ER), 16 H, 1 HR, 4 BB and 18 K in 3 starts.

Snell is 4-5 with a 4.16 ERA, 1.33 WHIP, 4.6 BB/9 and 11.7 K/9 in 67 IP across 13 starts.

  • Last start: Win, 9-1, at home vs. the Colorado Rockies Wednesday with 6 IP, 1 ER, 4 H, 0 BB and 9 K.
  • 2022 vs. the Giants: 1 start — a 6-3 home win July 8 — with 6 IP, 1 ER, 3 H, 1 HR, 2 BB and 11 K.

Giants at Padres odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:41 p.m. ET.

  • Money line (ML): Giants +155 (bet $100 to win $155) | Padres -190 (bet $190 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-135) | Padres -1.5 (+110)
  • Over/Under (O/U): 7.5 (O: -107 | U: -115)

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Giants at Padres picks and predictions

Prediction

Padres 5, Giants 1

Money line

LEAN towards “flat-betting” or parlaying the PADRES (-190) with another similarly priced favorite for a better payout.

San Diego’s ML price is a little expensive and we are getting the worst of the number. The Padres opened as -161 ML favorites per Pregame.com but have been steamed up by sharp action to the current number.

However, Snell’s stuff is much nastier than Wood’s and Snell has been finding his groove lately. He has won 3 straight starts, allowing just 2 earned runs over 17 innings during that span with a 21/3 K/BB rate. Also, Snell dominated the Giants when they last met in July.

San Diego’s RL is my favorite look in this game but the PADRES (-190) is the right side.

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Run line/Against the spread

BET PADRES -1.5 (+110) because Snell has been shutting down opposing lineups and the Giants are 3-5 RL as road underdogs vs. left-handed starters and 13-28 RL vs. NL West foes.

Over/Under

LEAN UNDER 7.5 (-115).

There’s a “Pros vs. Joe’s” scenario in the betting market because more money is on the Under whereas more bets have been placed on the Over, according to Pregame.com.

It’s wiser to follow the money in these situations since professional bettors wager a lot more dough than your average Joe. Also, the UNDER 7.5 (-115) being pricier insinuates it’s the sharper side.

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Sunday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks and predictions.

The San Diego Padres (49-37) host the San Francisco Giants (42-41) Sunday for their 4-game series finale at Petco Park. First pitch is scheduled for 4:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

San Diego has won 2 of the first 3 meetings. However, the Giants beat the Padres, 3-1, Saturday thanks to a complete-game, 12-strikeout gem thrown by San Francisco SP Carlos Rodon.

Season series: San Diego leads 6-3, and the Padres have a plus-3 run differential in those meetings.

Giants at Padres projected starters

LHP Alex Wood vs. LHP MacKenzie Gore

Wood is 5-7 with a 4.83 ERA, 1.33 WHIP, 2.3 BB/9 and 8.6 K/9 in 78 1/3 IP over 16 starts.

  • Last start: No-decision in San Francisco’s 6-2 loss at the Arizona Diamondbacks Tuesday with 5 IP, 1 ER, 4 H, 0 BB and 4 K.
  • 2022 vs. the Padres: 0-1 with an 8.59 ERA (7 1/3 IP, 7 ER), 13 H, 1 HR, 3 BB and 10 K in 2 starts.

Gore is 4-3 with a 3.18 ERA, 1.35 WHIP, 4.4 BB/9 and 9.4 K/9 in 65 IP across 12 starts and 1 bullpen outing.

  • Last start: No-decision in San Diego’s 4-2 win Sunday at the Los Angeles Dodgers with 5 2/3 IP, 1 ER, 5 H, 4 BB and 3 K.
  • 2022 vs. the Giants: One start — a 10-1 win May 22 in San Francisco — with 6 IP, 1 ER, 3 H, 2 BB and 6 K.

Giants at Padres odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:30 a.m. ET.

  • Money line (ML): Giants +102 (bet $100 to win $102) | Padres -125 (bet $125 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+165) | Padres +1.5 (-205)
  • Over/Under (O/U): 7.5 (O: -130 | U: +105)

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Giants at Padres picks and predictions

Prediction

Padres 4, Giants 3

Money line

BET PADRES (-125) because they are better vs. left-handed pitching, and San Diego’s bullpen is stronger than San Francisco’s.

The Padres are 20-10 vs. lefty starters while the Giants are 15-10 against lefties. San Diego’s lineup ranks ahead of San Francisco’s vs. left-handed pitching in wRC+ (104-103), wOBA (.313-.312), K/BB rate (0.45-0.38) and hard-hit rate (28.9-27.2%), per FanGraphs, and runs per 9 (4.82-4.76).

Also, San Diego’s bullpen is 7th in xFIP (3.66), 4th in K/BB rate (3.22) and 5th in WHIP (1.13), per FanGraphs. Whereas San Francisco’s bullpen has a 4.14 xFIP (ranked 22nd), a 2.41 K/BB rate (21st) and a 1.36 WHIP (26th).

That said, I’d only BET a half-unit on the PADRES (-125) since there’s sketchy reverse line movement in the betting market. Most of the action is on San Diego, but the line is moving towards San Francisco, according to Pregame.com. I’m nervous that the oddsmakers are laying a trap.

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Run line/Against the spread

PASS.

I’m not confident enough to “sprinkle” on the RL regardless of how chunky it is because San Diego has flipped to RL underdogs with the Giants moving to RL favorites.

Over/Under

LEAN UNDER 7.5 (+105).

There’s a “line freeze” in the betting market for the total since a vast majority of the action is on the Over 7.5 (-130), per Pregame.com, but the total hasn’t budged off the opener. It’s suspicious whenever the oddsmakers don’t adjust the line according to the market movement.

Also, the Giants are 7-9-1 O/U as road underdogs. The Padres are 15-19-1 O/U as home favorites and 12-20 O/U vs. NL West foes.

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Saturday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks and predictions.

The San Francisco Giants (41-41) and the San Diego Padres (49-36) play the third contest of a 4-game set at Petco Park in San Diego. First pitch is scheduled for 7:15 p.m. ET (FOX). Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

Season series: Padres lead series 6-2

The Giants are looking to at least gain a split in this 4-game set after losing the first 2 games. San Francisco has been outscored 8-4 in the first 2 games.

The Padres have won 2 in a row, bouncing back after a 1-8 skid in the previous 9 outings. San Diego enters play 20-8 in the past 28 against a left-handed starting pitcher.

Giants vs. Padres projected starters

LHP Carlos Rodon vs. RHP Yu Darvish

Rodon (7-5, 2.87 ERA) makes his 17th start of the season. He has a 1.11 WHIP, 3.0 BB/9 and 11.1 K/9 through 91 IP.

  • Is 3-4 with a 3.46 ERA with a .215 opponent batting average in 52 IP across 9 road starts.
  • Allowed 2 ER, 5 H and 4 BB with 6 K across 6 IP in a loss against the Padres May 21 in San Francisco.

Darvish (7-4, 3.53 ERA) makes his 16th start of the season. He has a 1.01 WHIP, 1.7 BB/9 and 8.1 K/9 through 94 1/3 IP.

  • Is 4-1 with a sparkling 1.75 ERA across 46 1/3 IP in 7 home starts with 45 K and a .163 opponent batting average.
  • Was tagged for a season-high 9 ER and 8 H in a season-low 1 2/3 IP in a loss at San Francisco April 12.

Giants vs. Padres odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8 a.m. ET.

  • Money line (ML): Giants -110 (bet $110 to win $100) | Padres -110 (bet $110 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+165) | Padres +1.5 (-205)
  • Over/Under (O/U): 6.5 (O: -122 | U: -102)

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Giants vs. Padres picks and predictions

Prediction

Giants 5, Padres 3

Money line

The GIANTS (-110) are the play based on how they handled Darvish in the first outing. The veteran right-hander just didn’t stick around very long, and he barely broke a sweat before getting knocked out of the game. San Francisco is still a risky play, as it is just 1-8 in the past 9 games overall, and 0-4 in the past 4 vs. teams with a winning overall record.

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Run line/Against the spread

The Padres +1.5 (-205) will cost you more than 2 times your potential return if you’re looking for a little insurance. It’s just not worth it.

PASS.

Over/Under

The OVER 6.5 (-122) is the play, as that’s an awfully low total.

The Over is 5-2 in the 7 games for the Giants, while going 5-1 in the past 6 following a loss.

For the Padres, while the Under is 4-1 in the past 5 against winning teams, the Over is 4-1 in the past 5 at Petco, and 4-0-1 in the past 5 at home vs. LHP.

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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San Francisco Giants at San Diego Padres odds, picks and prediction

Analyzing Sunday’s San Francisco Giants at San Diego Padres odds and lines, with MLB picks and predictions.

The San Francisco Giants (16-11) and San Diego Padres (16-12) play the finale of a three-game set Sunday at Petco Park with a 4:10 p.m. ET first pitch. Let’s analyze BetMGM Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

RHP Kevin Gausman is the projected starting pitcher for the Giants. He is 1-0 with a 2.14 ERA, 0.86 WHIP, 9.1 K/9 and 2.7 BB/9 over 33 2/3 IP through five starts.

Gausman allowed just 1 earned run on 2 hits and 1 walk with 11 strikeouts over a season-high 8 innings last Saturday in a no-decision against the Miami Marlins. He also allowed just 1 run on 5 hits and 1 walk through 7 innings in a no-decision April 7 in San Diego.

RHP Joe Musgrove is the projected starting pitcher for the Padres. He is 2-2 with a 1.24 ERA, 0.66 WHIP, 12.7 K/9 and 1.6 BB/9 over 29 IP spanning 5 starts.

Musgrove allowed 2 runs (1 earned) on 3 hits with 2 walks over 3 innings of a no-decision last time out at Dodger Stadium last Sunday.

MLB betting offers/promotions

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Giants at Padres odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 3:20 p.m. ET.

  • Money line: Off the board (OTB)
  • Against the spread/ATS: OTB
  • Over/Under: OTB

Prediction

Padres 6, Giants 3

Money line (ML)

While the odds were off the board at the time of publishing, the Padres are looking to complete the sweep, and they’re a good bet to do so.

San Diego has rattled off three consecutive wins, with an average of 7.0 runs per game while allowing just 2.33 runs per outing. The Giants offense dried up in the first two contests of this series.

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Run line/Against the spread (ATS)

The Padres are worth a small-unit play to win by 2-plus runs with Musgrove on the bump.

The Giants lost three of their last four games, and three of their last four losses were by 2 or more runs.

Over/Under (O/U)

The Over will be the lean, as it is 4-1 in San Francisco’s past five outings and 2-2-1 in Gausman’s five starts to date.

The Over is 6-2 across the past eight games for San Diego, too. While the Under is 4-1 in Musgrove’s five starts overall, the Over hit in his most recent showing.

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San Francisco Giants at San Diego Padres odds, picks and prediction

Analyzing Saturday’s San Francisco Giants at San Diego Padres odds and lines, with MLB picks and predictions.

The San Francisco Giants (16-10) clash with the San Diego Padres (15-12) Saturday in Game 2 of their three-game series at Petco Park. First pitch is scheduled for 8:40 p.m. ET. Let’s analyze BetMGM Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

The Padres overcame the Giants in a 3-2 win Friday, as RHP Yu Darvish pitched a 6 1/3-inning, 12-strikeout and 1-ER gem.

Season series: Tied 2-2.

RHP Anthony DeSclafani makes his sixth start for the Giants Saturday. He is 2-0 with a 1.50 ERA (30 IP, 5 ER), 0.97 WHIP, 2.1 BB/9 and 9.0 K/9.

  • Last outing: Complete-game shutout win with 3 H, 1 BB, and 9 K in the Giants’ 12-0 victory over the Colorado Rockies Monday.
  • Career vs. the Padres: 1-0 with a 2.17 ERA (29 IP, 7 ER), 1.00 WHIP and 7.4 K/9 in 5 starts.
  • DeSclafani pitched to a no-decision at San Diego April 5, throwing 5 IP with 1 ER, 4 H, 3 BB and 4 K in San Francisco’s 3-2 win.
    • Career at Petco Park: 0-0 with a 1.59 ERA (17 IP, 3 ER), 0.94 WHIP and 8.5 K/9 in 3 starts.

LHP Blake Snell takes the mound for the Padres. He is 0-0 with a 3.92 ERA (20 2/3 IP, 9 ER), 1.45 WHIP, 5.2 BB/9 and 13.5 K/9 over 5 starts.

  • Last outing: No-decision in 5 1/3 IP with 2 ER, 7 H, 2 BB and 7 K in San Diego’s 5-4 loss to the Los Angeles Dodgers last Saturday.
  • Career vs. Giants: 0-0 with a 3.60 ERA (5 IP, 2 ER), 1.20 WHIP and 14.4 K/9 in 1 start (April 7, 2021).

MLB betting offers/promotions

BetMGM Sportsbook offers available in CO, IA, IN, MI, NJ, PA, TN, VA and WV. New customer offers, terms and conditions apply.

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Giants at Padres odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 9:30 a.m. ET.

  • Money line: Giants +150 (bet $100 to win $150) | Padres -185 (bet $185 to win $100)
  • Against the spread/ATS: Giants +1.5 (-135) | Padres -1.5 (+110)
  • Over/Under: 7.5 (O: +100 | U: -120)

Prediction

Padres 5, Giants 1

Money line (ML)

PASS with a slight “lean” to the Padres (-185) because I’m confident enough in Snell to entertain putting San Diego’s money line in a parlay with a similarly priced favorite for a plus-money payout.

For a straight-up Padres victory, however, the money line bet is a no-go.

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Run line/Against the spread (ATS)

May has been DeSclafani’s least effective month throughout his career. He has a 5.47 ERA and 1.52 WHIP—both the highest of any month—and his 7.0 K/9 is his lowest of any month.

Additionally, DeSclafani is getting the start on four days of rest and his numbers on a four-day rest stack up similarly to his May production. His ERA and WHIP are higher than when he gets five or six-plus days off and his winning percentage is the lowest of the rest splits.

Furthermore, Snell had a so-so outing in his first career start against the Giants in early April, but San Francisco’s lineup will be easier for Snell to navigate this time around. The Giants are without their second and third hitters in RF Mike Yastrzemski and 2B Donovan Solano.

BET PADRES -1.5 (+110) for 1 unit.

Over/Under (O/U)

Even though I’m anticipating/betting on DeSclafani’s regression back to his usual form as the season moves along, he did have a strong outing against the Padres earlier this season and has always pitched well in Petco Park.

Also, the Under is 5-0-1 in the last six Giants-Padres meetings and 13-3 in San Diego’s last 16 home games.

Slight “LEAN” to the UNDER 7.5 (-120) for a quarter unit if at all because I prefer the Padres’ side more than the total.

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San Francisco Giants at San Diego Padres odds, picks and prediction

Analyzing Wednesday’s San Francisco Giants at San Diego Padres odds and lines, with MLB picks and predictions.

The San Francisco Giants (2-3) and San Diego Padres (4-2) close out a three-game series with a Wednesday matinee at Petco Park. First pitch will be at 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

RHP Kevin Gausman is the projected starting pitcher for the Giants. Last year, the veteran hurler went 3-3 with a 3.62 ERA, 1.11 WHIP, 11.9 K/9 and 2.4 BB/9 in 59 2/3 IP over 12 appearances. Gausman allowed just four base runners in 6 2/3 IP in his 2021 debut vs. Seattle.

LHP Blake Snell takes the pill for the Padres. In 2020 with Tampa Bay, Snell went 4-2 with a 3.24 ERA, 1.2 WHIP, 11.3 K/9 and 3.2 BB/9 in 50 IP over 11 starts. The 28-year-old went 4 2/3 scoreless frames in his Padres debut (April 2 vs. Arizona). Snell walked two and punched out eight.

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Giants at Padres odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 7:50 a.m. ET.

  • Money line: Giants +135 (bet $100 to win $135) | Padres -160 (bet $160 to win $100)
  • Against the spread/ATS: Giants +1.5 (-150) | Padres -1.5 (+125)
  • Over/Under: 7.5 (O: -115 | U: -105)

Prediction

Padres 5, Giants 3

Money line (ML)

Peg Kevin Gausman as a bounce-back candidate after his fine season debut against the Mariners. Gausman has a history as a slow starter (.770 OPS allowed in March/April appearances).

The Padres are without SS Fernando Tatis, Jr. (shoulder), and that may be impacting San Diego fade bettors a bit too much. A year ago, the Friars went 8-2 against the Giants, and overall San Diego was a robust 21-11 on its home turf.

TAKE SAN DIEGO -160.

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Run line/Against the spread (ATS)

The Padres went 8-2 against the Giants last season and outscored San Francisco 59-35. San Diego won more than one-third of its games by 5-plus runs in 2020.

CONSIDER PADRES -1.5 (+125) AS A SMALLER-UNIT PLAY IN WEDNESDAY’S MATINEE GET-AWAY GAME.

Over/Under (O/U)

The NL West foes have split two low-scoring games so far in the series.  The best arms in the bullpens are a bit less available for this one. Peg the rubber match as a line watch: consider the evenly priced OVER 7.5 (-115).

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San Francisco Giants at San Diego Padres odds, picks and prediction

Analyzing Tuesday’s San Francisco Giants at San Diego Padres odds and lines, with MLB picks and predictions.

The San Francisco Giants (2-2) and San Diego Padres (3-2) play the second game of a three-game set Tuesday at 10:10 p.m. ET at Petco Park. Let’s analyze BetMGM Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

RHP Aaron Sanchez is the projected starting pitcher for the Giants. He was 5-14 with a 5.89 ERA, 1.62 WHIP, 7.9 K/9 and 4.7 BB/9 in 131 1/3 IP in his 27 starts in 2019 with the Toronto Blue Jays and Houston Astros. He hasn’t pitched in a Major League game since Aug. 20, 2019, after having reconstructive shoulder surgery.

RHP Yu Darvish is the projected starting pitcher for the Padres. He is 0-0 with a 7.71 ERA, 1.93 WHIP, 11.6 K/9 and 1.9 BB/9 over 4 2/3 IP through his first start of the 2021 season. He hasn’t faced the Giants since Aug. 21, 2019, when he allowed 7 runs – 6 earned – and 7 hits in 5 1/3 innings with no walks and 8 strikeouts in a no-decision as a member of the Chicago Cubs.

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Giants at Padres odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 1:20 p.m. ET.

  • Money line: Giants +170 (bet $100 to win $170) | Padres -200 (bet $200 to win $100)
  • Against the spread/ATS: Giants +1.5 (-115) | Padres -1.5 (-105)
  • Over/Under: 7.5 (O: -115 | U: -105)

Prediction

Padres 6, Giants 2

Money line (ML)

The Padres (-200) are a risky play at two times your potential return, although I do expect them to bounce back after losing the series opener.

San Diego’s offense should get back on track against Sanchez, although the Padres did lose SS Fernando Tatis Jr. to a left shoulder subluxation Monday. He will be forced to miss some time.

PASS.

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Run line/Against the spread (ATS)

The PADRES -1.5 (-105) are a better play at near even money despite the lack of Tatis.

They’re facing a guy who hasn’t pitched in an MLB game since Aug. 2019. Sanchez could come in rather tentative, or he could be amped up which could lead to a lot of mistakes. Either way, it’s hard to imagine Sanchez keeping the Giants in this one.

Over/Under (O/U)

OVER 7.5 (-115) is the lean in Game 2 of this series.

Again, it has been a while since Sanchez has pitched, so the Padres should be able to jump all over him early.

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San Francisco Giants at San Diego Padres odds, picks and prediction

Analyzing Monday’s San Francisco Giants at San Diego Padres odds and lines, with MLB picks and predictions.

The San Francisco Giants (1-2) and San Diego Padres (3-1) tangle in a Monday night NL West series opener at Petco Park. First pitch will be at 10:10 p.m. ET. Let’s analyze BetMGM Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

RHP Anthony DeSclafani is the projected starting pitcher for the Giants. Last year for the Cincinnati Reds, the veteran hurler went 1-2 with a 7.22 ERA, 1.69 WHIP, 6.7 K/9, and 4.3 BB/9 in 33 2/3 IP over nine games (seven starts). DeSclafani has allowed a mere .608 OPS in nine career March/April games.

LHP Adrian Morejon is the projected starting pitcher for the Padres. In 2020, Morejon went 2-2 with a 4.66 ERA, 1.24 WHIP, 11.6 K/9, and 1.9 BB/9 in 19 1/3 IP over nine appearances (four starts). The third-year Major Leaguer has big stuff; his ERA in 2020 was inflated by 39% of fly balls allowed leaving the yard. Morejon throws 96, and he induced a 13.0% swinging-strike rate last summer.

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Giants at Padres odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 5:20 p.m. ET.

  • Money line: Giants +125 (bet $100 to win $125) | Padres -150 (bet $150 to win $100)
  • Against the spread/ATS: Giants +1.5 (-150) | Padres -1.5 (+125)
  • Over/Under: 8.5 (O: -105 | U: -115)

Prediction

Padres 4, Giants 3

Money line (ML)

DeSclafani had a solid spring and the Giants are the lean if any price bounce avails itself. The tag here plummeted in the morning.

Take the Giants if you can wait out a +130.

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Run line/Against the spread (ATS)

BACK THE GIANTS +1.5 (-150).

San Francisco figures to be at its best against lefty pitching.

Over/Under (O/U)

The Under 8.5 (-115) is the lean, but on a humid night with an outward breeze and plenty of pitching uncertainly, a PASS is suggested.

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