San Francisco Giants at San Diego Padres odds, picks and prediction

Analyzing Wednesday’s San Francisco Giants at San Diego Padres odds and lines, with MLB picks and predictions.

The San Francisco Giants (2-3) and San Diego Padres (4-2) close out a three-game series with a Wednesday matinee at Petco Park. First pitch will be at 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

RHP Kevin Gausman is the projected starting pitcher for the Giants. Last year, the veteran hurler went 3-3 with a 3.62 ERA, 1.11 WHIP, 11.9 K/9 and 2.4 BB/9 in 59 2/3 IP over 12 appearances. Gausman allowed just four base runners in 6 2/3 IP in his 2021 debut vs. Seattle.

LHP Blake Snell takes the pill for the Padres. In 2020 with Tampa Bay, Snell went 4-2 with a 3.24 ERA, 1.2 WHIP, 11.3 K/9 and 3.2 BB/9 in 50 IP over 11 starts. The 28-year-old went 4 2/3 scoreless frames in his Padres debut (April 2 vs. Arizona). Snell walked two and punched out eight.

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Giants at Padres odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 7:50 a.m. ET.

  • Money line: Giants +135 (bet $100 to win $135) | Padres -160 (bet $160 to win $100)
  • Against the spread/ATS: Giants +1.5 (-150) | Padres -1.5 (+125)
  • Over/Under: 7.5 (O: -115 | U: -105)

Prediction

Padres 5, Giants 3

Money line (ML)

Peg Kevin Gausman as a bounce-back candidate after his fine season debut against the Mariners. Gausman has a history as a slow starter (.770 OPS allowed in March/April appearances).

The Padres are without SS Fernando Tatis, Jr. (shoulder), and that may be impacting San Diego fade bettors a bit too much. A year ago, the Friars went 8-2 against the Giants, and overall San Diego was a robust 21-11 on its home turf.

TAKE SAN DIEGO -160.

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Run line/Against the spread (ATS)

The Padres went 8-2 against the Giants last season and outscored San Francisco 59-35. San Diego won more than one-third of its games by 5-plus runs in 2020.

CONSIDER PADRES -1.5 (+125) AS A SMALLER-UNIT PLAY IN WEDNESDAY’S MATINEE GET-AWAY GAME.

Over/Under (O/U)

The NL West foes have split two low-scoring games so far in the series.  The best arms in the bullpens are a bit less available for this one. Peg the rubber match as a line watch: consider the evenly priced OVER 7.5 (-115).

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