San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Saturday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks and predictions.

The San Francisco Giants (41-41) and the San Diego Padres (49-36) play the third contest of a 4-game set at Petco Park in San Diego. First pitch is scheduled for 7:15 p.m. ET (FOX). Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

Season series: Padres lead series 6-2

The Giants are looking to at least gain a split in this 4-game set after losing the first 2 games. San Francisco has been outscored 8-4 in the first 2 games.

The Padres have won 2 in a row, bouncing back after a 1-8 skid in the previous 9 outings. San Diego enters play 20-8 in the past 28 against a left-handed starting pitcher.

Giants vs. Padres projected starters

LHP Carlos Rodon vs. RHP Yu Darvish

Rodon (7-5, 2.87 ERA) makes his 17th start of the season. He has a 1.11 WHIP, 3.0 BB/9 and 11.1 K/9 through 91 IP.

  • Is 3-4 with a 3.46 ERA with a .215 opponent batting average in 52 IP across 9 road starts.
  • Allowed 2 ER, 5 H and 4 BB with 6 K across 6 IP in a loss against the Padres May 21 in San Francisco.

Darvish (7-4, 3.53 ERA) makes his 16th start of the season. He has a 1.01 WHIP, 1.7 BB/9 and 8.1 K/9 through 94 1/3 IP.

  • Is 4-1 with a sparkling 1.75 ERA across 46 1/3 IP in 7 home starts with 45 K and a .163 opponent batting average.
  • Was tagged for a season-high 9 ER and 8 H in a season-low 1 2/3 IP in a loss at San Francisco April 12.

Giants vs. Padres odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8 a.m. ET.

  • Money line (ML): Giants -110 (bet $110 to win $100) | Padres -110 (bet $110 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+165) | Padres +1.5 (-205)
  • Over/Under (O/U): 6.5 (O: -122 | U: -102)

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Giants vs. Padres picks and predictions

Prediction

Giants 5, Padres 3

Money line

The GIANTS (-110) are the play based on how they handled Darvish in the first outing. The veteran right-hander just didn’t stick around very long, and he barely broke a sweat before getting knocked out of the game. San Francisco is still a risky play, as it is just 1-8 in the past 9 games overall, and 0-4 in the past 4 vs. teams with a winning overall record.

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Run line/Against the spread

The Padres +1.5 (-205) will cost you more than 2 times your potential return if you’re looking for a little insurance. It’s just not worth it.

PASS.

Over/Under

The OVER 6.5 (-122) is the play, as that’s an awfully low total.

The Over is 5-2 in the 7 games for the Giants, while going 5-1 in the past 6 following a loss.

For the Padres, while the Under is 4-1 in the past 5 against winning teams, the Over is 4-1 in the past 5 at Petco, and 4-0-1 in the past 5 at home vs. LHP.

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