Tag: San Francisco 49ers betting odds line spread pick predictions best bets

Seattle Seahawks at San Francisco 49ers odds, picks and prediction

Previewing the Seattle Seahawks at San Francisco 49ers Week 17 betting odds and lines, with NFL betting picks, tips and predictions.

The Seattle Seahawks (11-4) have already locked up the NFC West and will simply be playing for playoff positioning in Week 17 when they visit the San Francisco 49ers (6-9). Sunday’s kickoff is set for 4:25 p.m. ET at the 49ers’ temporary home of State Farm Stadium in Glendale, Ariz. Below, we preview the Seahawks-49ers betting odds and lines and make our NFL picks and predictions.

Seahawks at 49ers: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at noon ET.

  • Money line: Seahawks -295 (bet $295 to win $100) | 49ers +240 (bet $100 to win $240)
  • Against the spread/ATS: Seahawks -6.5 (-110) | 49ers +6.5 (-110)
  • Over/Under: 45.5 (O: -115 | U: -105)

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Seahawks at 49ers: Game notes

  • The 49ers are 1-3 in their last four games, and just 2-6 in their last eight.
  • The Seahawks won their first meeting with the 49ers 37-27 in Week 8. They covered a 1-point spread.
  • The Seahawks are 0-5 ATS in their last five road games.
  • Seattle is 8-2 in its last 10 games against San Francisco, going 6-4 ATS in those games.
  • The total has gone Under in each of the Seahawks’ last seven games

Seahawks at 49ers: Key injuries

Seahawks

  • RB DeeJay Dallas (ankle) out
  • CB Jayson Stanley (hamstring) out
  • G Mike Iupati (neck) questionable
  • TE Greg Olsen (foot) questionable
  • RB Carlos Hyde (illness) questionable
  • S Damarious Randall (foot) questionable
  • OT Brandon Shell (ankle) questionable

49ers

  • DL Kevin Givens (non-injury) out
  • DT Javon Kinlaw (knee) out
  • DB Tarvarious Moore (ankle) questionable
  • CB Emmanuel Moseley (hamstring) questionable
  • LB Mark Nzeocha (illness) questionable
  • WR Deebo Samuel (hamstring) out
  • CB Richard Sherman (calf) out
  • CB K’Waun Williams (shin) out
  • WR Brandon Aiyuk (ankle) out
  • LB Dre Greenlaw (calf) out

Seahawks at 49ers: Odds, betting lines, predictions and picks

Prediction

Seahawks 27, 49ers 20

Money line (?)

The 49ers have nothing to play for and could opt to take a guarded approach with some of their banged-up players. They’ve also shown very few signs of life in the last two months, only the Los Angeles Rams and Arizona Cardinals since November began.

The Seahawks have stepped up on defense and should be able to slow down San Francisco’s offense, rolling to a win by at least one score. Take the SEAHAWKS (-295).

Against the spread (?)

I like the Seahawks against the spread even more than the money line. They’ve had trouble covering lately, but the 49ers are a beatable team and Seattle’s defense has improved significantly since the last meeting between these teams.

Take the SEAHAWKS -6.5 (-110) to cover and head into the postseason riding some momentum.

Over/Under (?)

This one’s tricky. I don’t expect the 49ers to move the ball that consistently against the Seahawks, but Seattle is also going up against a strong 49ers defense. The Seahawks will find the end zone a few times and the 49ers will break a long play or two to spark the offense.

Take the OVER 45.5 (-115) in this game, even though the total has gone Under in each of the Seahawks’ last seven.

Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

Also see:

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Gannett may earn revenue from audience referrals to betting services.  Newsrooms are independent of this relationship and there is no influence on news coverage.

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San Francisco 49ers at Arizona Cardinals odds, picks and prediction

Previewing the San Francisco 49ers at Arizona Cardinals Week 16 betting odds and lines, with NFL betting picks, tips and predictions.

The Arizona Cardinals (8-6) take on the San Francisco 49ers (5-9) in one of three Saturday games in Week 16. Kickoff is Saturday afternoon at 4:30 p.m. ET at State Farm Stadium in Glendale, AZ.

Below, we preview the 49ers-Cardinals betting odds and lines and make our NFL picks and predictions.

49ers at Cardinals: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 1:40 a.m. ET.

  • Money line: 49ers +200 (bet $100 to win $200) | Cardinals -250 (bet $250 to win $100)
  • Against the spread/ATS: 49ers +5 (-110) | Cardinals -5 (-110)
  • Over/Under: 48.5 (O: -110 | U: -110)

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49ers at Cardinals: Game notes

  • San Francisco has lost three games in a row, six out of seven and has been eliminated from postseason contention. The Cardinals have won two in a row and can potentially clinch a playoff berth this weekend.
  • Cardinals QB Kyler Murray is coming off a career-high 406 passing yards in Week 15 with three passing touchdowns and a rushing touchdown. He was named NFC Offensive Player of the Week for the third time this season.
  • Arizona has collected 14 sacks in the last two weeks.
  • 49ers QB C.J. Beathard is making his first start of 2020 in place of the injured Jimmy Garoppolo and Nick Mullens. Beathard is 1-9 in his career as a starter.
  • In the Cardinals’ 24-20 season-opening win over the 49ers, QR DeAndre Hopkins had a career-high 14 receptions for 151 yards.

49ers at Cardinals: Key injuries

49ers

  • QB Nick Mullens (elbow) out
  • RB Raheem Mostert (ankle) out
  • WR Deebo Samuel (hamstring) out
  • CB Richard Sherman (calf) out
  • S Jimmie Ward (concussion) questionable
  • CB Emmanuel Moseley (hamstring) questionable

Cardinals

  • LB Dennis Gardeck (knee) out
  • RB Chase Edmonds (knee, ankle) questionable
  • WR Larry Fitzgerald (groin) questionable
  • TE Dan Arnold (back) questionable
  • LB Haason Reddick (shoulder) questionable

49ers at Cardinals: Odds, betting lines, predictions and picks

Prediction

Cardinals 31, 49ers 17

Money line (?)

Arizona is playing good football again, winning two in a row after losing three straight. San Francisco has lost six of seven and is down to its third-string quarterback and does not have its top running back, receiver, pass rusher, cornerback and safety.

Beathard is making his fifth appearance against the Cardinals in his career. He has never beaten them and Arizona needs to win to stay in control of the No. 7 seed in the NFC. Take the CARDINALS (-250).

Against the spread (?)

In addition to losing six of seven games, the 49ers have failed to cover in any of those six losses. They are 5-9 ATS this season. Arizona is 7-7 ATS but has won and covered in their last two games after failing to cover the spread in five straight. They should be able to move the ball and score points on a depleted 49ers defense and maintain their playoff chances.

Take the CARDINALS -5 (-110).

Over/Under (?)

The Cardinals’ offense seems to be back on track. Their games have gone Over only five times this season but those five times have been in the last eight games. San Francisco’s games have gone Under in three of five. Arizona’s offense will be fine, but with Beathard at QB without the 49ers’ top offensive players, they will struggle.

Take UNDER 48.5 POINTS (-110).

Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

Also see:

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Gannett may earn revenue from audience referrals to betting services.  Newsrooms are independent of this relationship and there is no influence on news coverage.

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San Francisco 49ers at Dallas Cowboys odds, picks and prediction

Previewing the San Francisco 49ers at Dallas Cowboys Week 15 betting odds and lines, with NFL betting picks, tips and predictions.

The San Francisco 49ers (5-8) visit “Jerry’s World” Sunday for a Week 15 game against the Dallas Cowboys (4-9) at the AT&T Stadium. Kickoff is scheduled for 1 p.m. ET. Below, we preview the 49ers-Cowboys betting odds and lines and make our NFL picks and predictions.

49ers at Cowboys: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 10:48 p.m. ET.

  • Money line: 49ers -175 (bet $175 to win $100) | Cowboys +145 (bet $100 to win $145)
  • Against the spread/ATS: 49ers -3 (-110) | Cowboys +3 (-110)
  • Over/Under: 44.5 (O: -115 | U: -105)

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49ers at Cowboys: Game notes

  • Playing at its temporary home in Glendale, Ariz., San Francisco was dominated by the Washington Football Team’s defense in a 23-15 loss in Week 14. The 49ers’ defense kept Washington’s offense out of the end zone, but WFT scored two defensive touchdowns, including DE Chase Young’s 47-yard fumble return and S Kamren Curl’s 76-yard interception return.
  • 49ers’ gambling records: 5-8 ATS and 6-7 O/U.
  • Dallas eased past the host Cincinnati Bengals 30-7 in QB Andy Dalton’s revenge game last week. However, the result was based more on the Bengals losing than the Cowboys winning. Dallas had fewer first downs and total yards than Cincinnati, and only possessed the ball for 25:19. The Cowboys defense forced 3 turnovers, including DE Aldon Smith’s 78-yard fumble return for a score.
  • Cowboys’ gambling records: 3-10 ATS and 7-6 O/U.
  • While these storied franchises have been NFC rivals for decades, they haven’t played a meaningful head-to-head game in years. The last meeting ended in a Cowboys’ 40-10 road win in 2017.

49ers at Cowboys: Key injuries

49ers

  • WR Deebo Samuel (hamstring) out
  • C Hroniss Grasu (knee) out
  • LB Fred Warner (stinger) questionable
  • CB K’Waun Williams (ankle) questionable
  • CB Emmanuel Moseley (hamstring) questionable

Cowboys

  • RB Ezekiel Elliott (calf) questionable
  • FS Xavier Jones (groin) questionable
  • CB Deante Burton (shoulder) out
  • CB Rashard Robinson (knee) questionable

49ers at Cowboys: Odds, betting lines, predictions and picks

Prediction

Cowboys 24, 49ers 20

Money line (?)

A lot has happened since the 49ers lost in Super Bowl 54, and based on their 2020 returns, they shouldn’t be a road favorite over a team that has one less loss. When you audit the 49ers’ wins there isn’t a lot to be impressed with.

San Francisco beat NFC West rival Los Angeles Rams twice, which head coach Kyle Shanahan seemingly has cast a spell on, an extremely one-dimensional New England Patriots squad, a winless New York Jets team and a 5-8 New York Giants team.

This is more of a bet against an overrated 49ers team, but I’ll TAKE COWBOYS (+145) for a half-unit.

Against the spread (?)

The market apparently doesn’t agree with the old football adage that you are what your record says you are. According to Pregame.com, 60% of the money bet is on the 49ers, which has pushed them from a 2.5-point favorite when the line opened to the current -3.

The public betting a road favorite is a nice spot if you believe in the fade the market handicapping angle. There is too much talent on this Cowboys team for it to be 3-10 ATS this season. That record is going to even out a little. Playing a 49ers team which has lost five of its last six ATS is a good matchup for Dallas.

GIMME COWBOYS +3 (-110) for 1 unit.

Over/Under (?)

PASS ON THE TOTAL with a slight lean on the Over 44.5 (-115). Even 49ers backup QB Nick Mullens can put up points against a Cowboys defense which ranks dead last in points allowed per game. Plus, all the injuries to San Francisco’s defense make that unit a shell of its 2020 self.

Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

Also see:

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Gannett may earn revenue from audience referrals to betting services.  Newsrooms are independent of this relationship and there is no influence on news coverage.

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Washington Football Team vs. San Francisco 49ers odds, picks and prediction

Previewing the Washington Football Team vs. San Francisco 49ers Week 14 betting odds and lines, with NFL betting picks, tips and predictions.

The Washington Football Team (5-7) and the San Francisco 49ers (5-7) meet Sunday of Week 14 for a 4:25 p.m. ET kickoff at State Farm Stadium (home of the Arizona Cardinals) in Glendale, Ariz.

The 49ers will be the home team as the game was moved from their regular home of Levi’s Stadium due to Santa Clara County, Calif., COVID-19 protocols. Below, we preview the Washington-49ers betting odds and lines and make our NFL picks and predictions.

Washington vs. 49ers: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 1:45 a.m. ET.

  • Money line: Washington +130 (bet $100 to win $130) | 49ers -155 (bet $155 to win $100)
  • Against the spread/ATS: Washington +3 (-115) | 49ers -3 (-105)
  • Over/Under: 43.5 (O: -110 | U: -110)

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Washington vs. 49ers: Game notes

  • Last Monday, Washington pulled off one of the biggest shockers of the season by handing the Pittsburgh Steelers (11-1) their first loss in a 23-17 upset. Washington, which was a 6-point road underdog, has won three in a row.
  • On a sour note for Washington, rookie RB Antonio Gibson injured his toe in the win and has been ruled out for Week 14. Gibson leads Washington with 659 rushing yards and 11 rushing TDs.
  • In their first game played in Arizona since the move due to COVID-19 issues, the 49ers lost as 1.5-point favorites to the Buffalo Bills 34-24 in the Monday Night Football game last week. It was the 49ers’ fourth loss in their last five games.
  • Washington and the New York Giants sit atop the woeful NFC East with identical 5-7 records, but the G-Men hold the tiebreaker thanks to a season sweep of Washington.
  • The 49ers are last in the NFC West but just one game back of the NFC’s last playoff spot, which is held by the 6-6 Minnesota Vikings.
  • The 49ers are 6-1 in their last seven vs. Washington, taking the most recent matchup 9-0 in Week 7 last season. The game was played in windy conditions in a steady rain as the visiting 49ers came up a point short of covering as 10-point favorites.

Betting stats:

  • ATS: Washington 7-5 | 49ers 5-7
  • O/U: Washington 5-7 | 49ers 6-6

Washington vs. 49ers: Key injuries

Washington

  • RB Antonio Gibson (toe) out
  • OT Morgan Moses (groin) questionable
  • OT Brandon Scherff (calf) questionable
  • OT David Sharp (knee) questionable

49ers

  • OT Tom Compton (concussion) out
  • DT Kevin Givens (non-injury related) out
  • CB Emmanuel Moseley (hamstring) doubtful
  • CB K’Waun Williams (ankle) questionable

Washington vs. 49ers: Odds, betting lines, predictions and picks

Prediction

49ers 24, Washington 17

Money line (?)

PASS. The 49ers (-155) catch a break with Washington (+130) having to play a second consecutive road game on a short week. However, the -155 juice isn’t worth betting.

Against the spread (?)

SAN FRANCISCO -3 (-105) is the STRONGEST PLAY – 1½ times your usual wager. Washington has been on a roll, but it will come up short with Gibson out. Look for 49ers QB Nick Mullens (1,958 passing yards, 9 TDs, 9 INTs) to get the best of Washington QB Alex Smith (1,363 passing yards, 4 TDs, 5 INTs), who played his first 7 seasons with San Francisco.

Over/Under (?)

The UNDER 43.5 (-110) is the way to go. Washington’s offense will struggle without its leading rusher, but the key here is that both defenses are better than average.

Washington allows 21.7 points per game (ranking eighth) and 310.9 yards per game (fourth). San Francisco allows 24.0 PPG (13th) and 326.3 YPG (sixth).

Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

Also see:

Johnny’s 2020 NFL record / Strongest plays 19-16-1 / 7-7-1
2019 NFL record / Strongest plays 17-10-1 / 7-4
2020 overall record (all sports) 160-120-3
Strongest plays (all sports) 78-47-1

Follow @JohnnyParlay11 on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Gannett may earn revenue from audience referrals to betting services.  Newsrooms are independent of this relationship and there is no influence on news coverage.

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Buffalo Bills vs. San Francisco 49ers odds, picks and prediction

Previewing the Buffalo Bills vs. San Francisco 49ers Week 13 betting odds and lines, with NFL betting picks, tips and predictions.

The primetime Week 13 Monday Night Football matchup features the Buffalo Bills (8-3) and San Francisco 49ers (5-6). Below, we preview the Bills-49ers betting odds and lines and make our NFL picks and predictions.

For the Bills, it is a road game, but it is not in Santa Clara, Calif., where the 49ers normally play. Because Santa Clara health protocols will not allow sports to be played there, the 49ers are in Arizona. Kickoff will be at 8:15 p.m. at State Farm Stadium in Glendale.

Bills vs. 49ers: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated 8:20 a.m. ET.

  • Money line: Bills -105 (bet $105 to win $100) | 49ers -112 (bet $112 to win $100)
  • Against the spread/ATS: Bills +1 (-115) | 49ers -1 (-105)
  • Over/Under: 47.5 (O: -105 | U: -115)

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Bills vs. 49ers: Game notes

  • Buffalo already lost this season at State Farm Stadium to the Arizona Cardinals on a last-second Hail Mary.
  • The Bills have won four of their last five games, the only loss being in Arizona.
  • San Francisco is 1-4 as the home team.
  • 49ers QB Nick Mullens is 2-3 as a starter this year. He has 1,642 passing yards, 6 touchdowns and 7 interceptions in seven total games.
  • Bills QB Josh Allen has completed 68.8% of his passes this season for 3,028 yards, 22 touchdowns and 8 interceptions.

Bills vs. 49ers: Key injuries

49ers

  • CB Emmanuel Moseley (hamstring) questionable
  • CB K’Waun Williams (ankle) out

Bills vs. 49ers: Odds, betting lines, predictions and picks

Prediction

Bills 27, 49ers 23

Money line (?)

This is a true tossup with the line, so there is value on both sides. The 49ers are coming off a big win last week over the Los Angeles Rams and are threatening to get back into the playoff race; however, the Bills have been on a roll, losing only once in their last five games.

The Niners have had to move all their operations to Arizona so they are not completely settled in. That will show in the game. Take the BILLS (-105).

Against the spread (?)

With a one-point spread, the only way to go is with the winner you take on the money line. Otherwise, you’re predicting a tie (virtually impossible) or negating the money line bet.

The San Francisco defense is solid, allowing only 315.2 yards per game and 23.1 points per game, but Buffalo’s offense is explosive. The Bills have five games of scoring at least 30 points and seven of at least 27. In Mullens’ five starts for the Niners, they have scored 20 points only twice. Take the BILLS +1 (-115).

Over/Under (?)

The Bills are 7-3-1 O/U, while the Niners are 5-6 O/U. Three of the Bills’ last four games hit the Over. Both teams should score roughly their season average (27.2 for the Bills, 23.7 for the 49ers) and should go Over the projected total. Take OVER 47.5 (-105).

Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

Also see:

Follow @senorjessroot on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Gannett may earn revenue from audience referrals to betting services.  Newsrooms are independent of this relationship and there is no influence on news coverage.

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San Francisco 49ers at New Orleans Saints odds, picks and prediction

Previewing the San Francisco 49ers at New Orleans Saints Week 10 betting odds and lines, with NFL betting picks, tips and predictions.

The San Francisco 49ers (4-5) visit the New Orleans Saints (6-2) Sunday of Week 10 for a 4:25 p.m. ET kickoff. Below, we preview the 49ers-Saints betting odds and lines and make our NFL picks and predictions.

49ers at Saints: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 9:05 a.m. ET.

  • Money line: 49ers +385 (bet $100 to win $385) | Saints -500 (bet $500 to win $100)
  • Against the spread/ATS: 49ers +10 (-110) | Saints -10 (-110)
  • Over/Under: 48.5 (O: -115 | U: -106)

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49ers at Saints: Game notes

  • Hampered by injuries and WR Kendrick Bourne‘s positive COVID-19 test, the 49ers (+6) were shorthanded and no match for the Green Bay Packers in a 34-17 home loss in the Week 9 Thursday Night Football game. San Francisco has lost two in a row and is in last place in the NFC West.
  • QB Jimmy Garoppolo, All-Pro TE George Kittle, RB Raheem Mostert and DE Nick Bosa were among the key 49ers who didn’t play Thursday and are not available for Week 10. WR Deebo Samuel and CB Richard Sherman hope to return.
  • With Garoppolo out, Nick Mullens started at QB and threw for 291 yards with a TD and a pick. For the season, he has completed 68.4% of his passes for 1,143 yards with 5 TDs vs. 4 INTs.
  • The Saints own a 5-game win streak after crushing the Tampa Bay Buccaneers 38-3 on the road as 3.5-point underdogs in the Week 9 Sunday Night Football game. New Orleans took over first place in the NFC South as QB Drew Brees threw for 222 yards and 4 TDs. The defense dominated the Bucs, keeping them off the scoreboard until 5:52 to go.
  • Brees, who has completed 74% of his passes for 2,120 yards with 17 TDs against 3 picks this season has WR Michael Thomas back. The 3-time Pro Bowler returned last week (5 catches, 51 yards) after missing 5 games due to injuries and was benched for a game following an altercation at practice.
  • The 49ers are 4-5 ATS, while the Saints are 3-5 ATS.
  • San Francisco owns a 5-4 O/U record, averages 25.0 points per game and allows 23.0 PPG (ranking 10th in the NFL).
  • Last week, New Orleans played its first Under game of the season after starting 7-0 vs. the O/U. The offense averages 30.5 PPG (4th), while the defense allows 25.0 PPG.
  • The 49ers won at the Saints 48-46 last year (Dec. 8). PK Robbie Gould kicked a 30-yard field goal as time expired.

49ers at Saints: Key injuries

49ers

  • RB Tevin Coleman (knee) questionable
  • LB Demetrius Flannigan-Fowles (hamstring) out
  • WR Deebo Samuel (hamstring) questionable
  • DB Richard Sherman (calf) questionable

Saints

  • OT Ryan Ramczyk (back) questionable
  • WR Michael Thomas (ankle, hamstring) questionable

49ers at Saints: Odds, betting lines, predictions and picks

Prediction

Saints 33, 49ers 9

Money line (?)

AVOID. The Saints (-500) are going to win, but risking five times your return is not wise and not worth the payoff.

Against the spread (?)

NEW ORLEANS -10 (-110) is the STRONGEST PLAY – 1.5 times your usual wager. San Francisco is missing too many key pieces to make this competitive. It could get ugly real fast.

Over/Under (?)

The UNDER 48.5 (-106) is worth backing. Facing the undermanned 49ers, there’s a good chance the Saints defense doesn’t allow a touchdown in back-to-back games.

Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

Also see:

Johnny’s 2020 NFL record / Strongest plays 9-8-1 / 2-3-1
2019 NFL record / Strongest plays 17-10-1 / 7-4
2020 overall record (all sports) 138-104-3
Strongest plays (all sports) 68-39-1

Follow @JohnnyParlay11 on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Gannett may earn revenue from audience referrals to betting services.  Newsrooms are independent of this relationship and there is no influence on news coverage.

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NFL Prop Bets Payday: 4 Green Bay Packers at San Francisco 49ers prop predictions

Highlighting four Green Bay Packers at San Francisco 49ers prop bet predictions ahead of their Week 9 Thursday Night Football matchup.

The Green Bay Packers (5-2) and San Francisco 49ers (4-4) meet at Levi’s Stadium on Thursday Night Football in Week 9, but both teams will look much different than most will expect. Injuries and COVID-19 have ravaged the starting rosters and plenty of less recognizable faces will be stepping up in primetime for the 8:20 p.m. ET kickoff. Below, we give you five prop bet predictions to consider for the Packers-49ers Thursday Night Football matchup from the BetMGM game menu.

Packers at 49ers prop bets to make for Thursday Night Football

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 3:25 p.m. ET.

49ers QB Nick Mullens OVER 20.5 completions (+125)

The 49ers are without their top three wide receivers in Deebo Samuel, Brandon Aiyuk and Kendrick Bourne after Bourne tested positive for COVID Wednesday. TEs George Kittle and Jordan Reed are also sidelined by injuries. Most teams would lean on the running game in this situation, but the 49ers are also without Raheem Mostert, Tevin Coleman and Jeff Wilson.

Mullens, who’s filling in for injured QB Jimmy Garoppolo, should throw close to 40 times with negative game script against Rodgers. If so, he’ll be likely to go OVER 20.5 (+125) completions, and that’s where the better value lies.

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49ers RB Jerick McKinnon OVER 59.5 rushing+receiving yards (-110)

McKinnon has twice topped 40 receiving yards this season with other totals of 20 and 39 yards. He’ll be leaned on as Mullens’ top healthy target and in a game script that’ll force the 49ers to throw. This is a very low line and a high-confidence bet.

Packers TE Robert Tonyan and 49ers RB Jerick McKinnon both to record 50+ receiving yards (+1000)

McKinnon should be the No. 1 target for Mullens Thursday night and Tonyan has developed into Rodgers’ No. 2 or 3 option in most matchups. With Green Bay’s backfield an underwhelming pair of replacements, look for Rodgers to help run the clock with throws to his big tight end in the middle of the field.

Mullens to score 49ers’ first touchdown (+1100)

Mullens has made 10 career starts with 13 total appearances. He has experience and will be able to keep San Francisco in this game for at least a short while.

We often see overmatched quarterbacks on injury-riddled teams look to do a little more on their own, especially near the goal line. There’s a good chance this will be the case for the third-year backup and the 11-1 payout offers plenty of incentive for a small bet on Mullens to score the Niners’ first – and likely only – touchdown of the game.

I’d hedge with a smaller bet on No San Francisco Touchdown at +1000.

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Green Bay Packers at San Francisco 49ers odds, picks and prediction

Previewing the Green Bay Packers at San Francisco 49ers Week 9 betting odds and lines, with NFL betting picks, tips and predictions.

The Green Bay Packers (5-2) visit the injury-ravaged San Francisco 49ers (4-4) at Levi’s Stadium for Thursday Night Football in Week 9. Kickoff will be at 8:20 p.m. ET. Below, we preview the Packers-49ers betting odds and lines and make our NFL picks and predictions.

Packers at 49ers betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 5:15 a.m. ET.

  • Money line: Packers -250 (bet $250, win $100) | 49ers +200 (bet $100, win $200)
  • Against the spread/ATS: Packers -5.5 (-110) | 49ers +5.5 (-110)
  • Over/Under: 49.5 (O: -110 | U: -110)

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Packers at 49ers game notes

  • The Packers have lost two of their last three games after a strong 4-0 start. They dropped a 28-22 decision to the NFC North rival Minnesota Vikings at Lambeau Field last week.
  • The 49ers took a 37-27 loss at the NFC West rival Seattle Seahawks in Week 8. The loss snapped a two-game win streak for the Niners.
  • 49ers QB Nick Mullens will make his third start of the season in Week 9. In all, he has completed 70.4% of 98 pass attempts for 852 yards and 4 touchdowns against 3 interceptions. QB Jimmy Garoppolo (ankle) was placed on the Reserve/Injured list.
  • The Packers backfield is a mess coming into this one. RB Aaron Jones (calf) is expected to miss a second straight game. RBs A.J. Dillon and Jamaal Williams were placed on the Reserve/COVID-19 list. Fifth-year pro Tyler Ervin should lead the group in Week 9; he has 76 yards from scrimmage on 10 touches this season.
  • Green Bay is 5-2 against the spread but covers by just 1.9 points per game. San Francisco is 4-4 ATS and covers by an average of 0.9 PPG.
  • The Packers are 4-3 against the Over/Under while the Niners are 4-4 against the projected point totals.

Packers at 49ers key injuries

Packers

  • RB Aaron Jones (calf) doubtful
  • LB Preston Smith (shoulder) questionable
  • WR Equanimeous St. Brown (knee) questionable
  • RB Jamaal Williams (COVID-19) out
  • RB A.J. Dillon (COVID-19) out

49ers

  • RB Tevin Coleman (knee) questionable
  • QB Jimmy Garoppolo (ankle) out/IR
  • TE George Kittle (foot) out/IR
  • WR Deebo Samuel (hamstring) out
  • S Jaquiski Tartt (groin) questionable

Packers at 49ers: Odds, prediction, betting lines and picks

Prediction

Packers 27, 49ers 13

Money line (?)

The PACKERS (-250) and an angry QB Aaron Rodgers have an excellent bounce-back opportunity against the banged-up Niners. The Packers’ replacement-level backfield for TNF isn’t much of a detriment with the Niners down to their third-string (Jerick McKinnon) and fourth-string (JaMycal Hasty) running backs as well.

Lean on Rodgers and WR Davante Adams to outduel Mullens and The Replacements in the Bay Area.

Against the spread (?)

There’s much better value to be had by backing the PACKERS -5.5 (-110) to win by at least 6 points. So long as Rodgers is able to get Green Bay out to the early lead, there’s just no way for San Francisco to keep pace.

No team in the NFL has the current injury troubles of the reigning NFC champions.

Over/Under (?)

The corresponding pick here is the UNDER 49.5 (-110). The Packers will get an early lead and then be able to sit back and stifle Mullens and the Niners’ passing attack.

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Seattle Seahawks home favorites against San Francisco 49ers in Week 8

The San Francisco 49ers open as road underdogs in their Week 8 matchup against the NFC West rival Seattle Seahawks.

The San Francisco 49ers (4-3) head to CenturyLink Field in Week 8 to face the NFC West rival Seattle Seahawks (5-1) Sunday. Below, we look at the early betting odds and lines at BetMGM Sportsbook.

Seattle lost their first game of the year on Sunday Night Football in Week 7 to NFC West rival Arizona Cardinals. The 37-34 overtime Seahawks defeat was the worst game of the season for QB Russell Wilson, who did throw three touchdowns but also three interceptions, including a pick in the red zone and an interception in overtime that led to Arizona’s game-winning field goal.

The 49ers went into Foxborough, Mass., and pummeled the New England Patriots 33-6 in Week 7. The 49ers gained 467 total yards to New England’s 241 (7.4 yards per play compared to 4.9 YPP) and picked off Pats QB Cam Newton three times. San Francisco, again, sustained crucial injuries as RB Jeff Wilson Jr. and WR Deebo Samuel were injured Sunday. Before Wilson exited the game in the third quarter with a high-ankle sprain, he carried the ball 17 times with 112 rushing yards and three touchdowns.

49ers at Seahawks betting odds, spread and line

Odds via BetMGM; last updated Monday at 2:30 p.m. ET.

  • Money line: 49ers +145 (bet $100 to win $145) / Seahawks -176 (bet $176 to win $100) | Bet now
  • Against the spread: 49ers +3.5, -115 (bet $115 to win $100) / Seahawks -3.5, -106 (bet $106 to win $100) | Bet now
  • Total: 53.5, Over -115 (bet $115 to win $100) / Under -106 (bet $106 to win $100) | Bet now

New to NFL betting?

Seattle is a -176 favorite with a win probability of 63.77% or fractional odds of 25/44 (1.57 decimal odds) in Week 8. The Seahawks need to win by 4 or more points for a Seahawks -3.5 (-106) bet to win.

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The 49ers are road underdogs with an implied win probability of 40.82%. Those odds are expressed fractionally as 29/20 or 2.45 decimal odds. If San Francisco wins outright or loses by fewer than 4 points, a 49ers +3.5 (-115) ticket cashes.

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