Green Bay Packers vs. San Francisco 49ers odds predictions pick betting line spread

Green Bay Packers at San Francisco 49ers odds, picks and prediction

Analyzing Friday’s Green Bay Packers at San Francisco 49ers preseason odds and lines, with expert NFL picks, predictions and best bets.

The Green Bay Packers and San Francisco 49ers meet in their preseason opener Friday. Kickoff from Levi’s Stadium for 8:30 p.m. ET (NFL Network). Below, we analyze Tipico Sportsbook‘s lines around the Packers vs. 49ers odds, and make our best NFL picks, predictions and bets.

The Packers will have their starting offensive line in action Friday, although MVP QB Aaron Rodgers will not play. Backup QB Jordan Love is expected to draw the start and will likely play plenty.

The 49ers might potentially start QB Nate Sudfeld, with former Iowa State product QB Brock Purdy as the backup. If new starter QB Trey Lance does play, it likely will be a cameo, and the team is unlikely to use QB Jimmy Garoppolo and risk a potential injury that would crush his possible trade value. WR/RB Deebo Samuel is also unlikely to suit up.

Packers at 49ers odds

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 3:41 p.m. ET.

Money line (ML): Packers +115 (bet $100 to win $115) | 49ers -140 (bet $140 to win $100)
Against the spread (ATS): Packers +2.5 (+100) | 49ers -2.5 (-120)
Over/Under (O/U): 33.5 (O: -103 | U: -117)

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Packers at 49ers picks and predictions

Prediction

Packers 19, 49ers 13

Money line

The PACKERS (+115) are a value play on the road in their opener, as Love is a talented player who should be able to run the offense well in his time on the field. The 49ers are likely to have plenty of star players on the offensive side of the football resting, while the Pack will have most starters going.

Against the spread

The PACKERS +2.5 (+100) are an okay play at even-money, although my preference would be playing them straight up for the better payout. I don’t expect to see Lance play for the 49ers, and Jimmy G is unlikely to play, too. If it’s Sudfeld and Purdy handling the offense, it won’t end well for the home side.

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Over/Under

The UNDER 33.5 (-117) is the play. The Packers defense is nasty, and they’re likely to be facing a third- and fourth-string quarterback. The 49ers will struggle to put points on the board. The first preseason game is traditionally low-scoring, and these teams will give the Under bettors what they want.

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Green Bay Packers at San Francisco 49ers odds, picks and prediction

Analyzing the Green Bay Packers at San Francisco 49ers Week 3 odds and lines, with expert NFL picks, predictions and best bets.

Sunday Night Football in Week 3 features the Green Bay Packers (1-1) visiting the San Francisco 49ers (2-0). Kickoff is 8:20 p.m. ET at Levi’s Stadium. Below, we look at the Packers at 49ers odds and lines, and make our best NFL picks, predictions and bets.

Green Bay started the year by getting throttled 38-3 on the road against the New Orleans Saints. Packers QB Aaron Rodgers threw 2 interceptions and was held without a touchdown pass and just 133 passing yards. The Packers gained only 229 yards. They bounced back in Week 2 on Monday Night Football with a 35-17 win over the Detroit Lions. Rodgers had 4 touchdown passes in the win.

The 49ers are one of three undefeated teams in the NFC West. They opened the season with a 41-33 win in Week 1 over the Detroit Lions. They were up 41-17 with under 10 minutes left before the Lions scored a couple of garbage-time touchdowns. They then beat the Philadelphia Eagles 17-11 in Week 2.

Packers at 49ers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 9:09 a.m. ET.

Money line: Packers +135 (bet $100 to win $135) | 49ers -170 (bet $170 to win $100)
Against the spread (ATS): Packers +3.5 (-122) | 49ers -3.5 (-102)
Over/Under (O/U): 50.5 (O: -115 | U: -105)

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Packers at 49ers key injuries

Packers

LT Elgton Jenkins (ankle) out

49ers

DE Arik Armstead (adductor) questionable
DT Javon Kinlaw (knee) questionable
RB Elijah Mitchell (shoulder) doubtful
RB JaMycal Hasty (ankle) out
CB Emmanuel Moseley (knee) questionable

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Packers at 49ers odds, lines, predictions and picks

Prediction

Packers 23, 49ers 20

Money line

This will be the fourth year in a row the Packers and 49ers face each other in the regular season and the third straight regular-season game between them in San Francisco. They split the previous two regular-season meetings at Levi’s Stadium.

It is tough to know whether either team is good offensively based on the first couple of weeks of the season. The 49ers piled on 41 points in Week 1 but struggled to move the ball in Week 2. The Packers scored 35 last week but managed only a field goal in their opener against the Saints.

The game becomes the measuring stick for both teams.

49ers QB Jimmy Garoppolo is nothing like Rodgers when he gets going, and Rodgers got going last week. The Niners are down their top two running backs to start the year, as Raheem Mostert is on injured reserve and Elijah Mitchell is doubtful.

Take the PACKERS (+135).

Against the spread

If the Packers more closely resemble how they played in Week 2 rather than Week 1 they are one of the best teams in the entire NFC. If the Niners do the same they will not have much of a chance to slow the Packers.

San Francisco will struggle to cover Green Bay’s receivers. The 49ers are already missing CB Jason Verrett for the season and with Moseley uncertain for the game.

Expecting an outright Packers win, I like them even more against the spread. Take the PACKERS +3.5 (-122).

Over/Under

Both teams are 1-1 O/U this year. However, both their big-scoring games came against the same opponent.

The Niners’ second game did not even crack 30 points, while the Packers’ season opener barely cracked the 40s.

Can the two teams together get into the 50s? I don’t think they will.

Take UNDER 50.5 (-105).

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NFL Prop Bets Payday: 4 Green Bay Packers at San Francisco 49ers prop predictions

Highlighting four Green Bay Packers at San Francisco 49ers prop bet predictions ahead of their Week 9 Thursday Night Football matchup.

The Green Bay Packers (5-2) and San Francisco 49ers (4-4) meet at Levi’s Stadium on Thursday Night Football in Week 9, but both teams will look much different than most will expect. Injuries and COVID-19 have ravaged the starting rosters and plenty of less recognizable faces will be stepping up in primetime for the 8:20 p.m. ET kickoff. Below, we give you five prop bet predictions to consider for the Packers-49ers Thursday Night Football matchup from the BetMGM game menu.

Packers at 49ers prop bets to make for Thursday Night Football

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 3:25 p.m. ET.

49ers QB Nick Mullens OVER 20.5 completions (+125)

The 49ers are without their top three wide receivers in Deebo Samuel, Brandon Aiyuk and Kendrick Bourne after Bourne tested positive for COVID Wednesday. TEs George Kittle and Jordan Reed are also sidelined by injuries. Most teams would lean on the running game in this situation, but the 49ers are also without Raheem Mostert, Tevin Coleman and Jeff Wilson.

Mullens, who’s filling in for injured QB Jimmy Garoppolo, should throw close to 40 times with negative game script against Rodgers. If so, he’ll be likely to go OVER 20.5 (+125) completions, and that’s where the better value lies.

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49ers RB Jerick McKinnon OVER 59.5 rushing+receiving yards (-110)

McKinnon has twice topped 40 receiving yards this season with other totals of 20 and 39 yards. He’ll be leaned on as Mullens’ top healthy target and in a game script that’ll force the 49ers to throw. This is a very low line and a high-confidence bet.

Packers TE Robert Tonyan and 49ers RB Jerick McKinnon both to record 50+ receiving yards (+1000)

McKinnon should be the No. 1 target for Mullens Thursday night and Tonyan has developed into Rodgers’ No. 2 or 3 option in most matchups. With Green Bay’s backfield an underwhelming pair of replacements, look for Rodgers to help run the clock with throws to his big tight end in the middle of the field.

Mullens to score 49ers’ first touchdown (+1100)

Mullens has made 10 career starts with 13 total appearances. He has experience and will be able to keep San Francisco in this game for at least a short while.

We often see overmatched quarterbacks on injury-riddled teams look to do a little more on their own, especially near the goal line. There’s a good chance this will be the case for the third-year backup and the 11-1 payout offers plenty of incentive for a small bet on Mullens to score the Niners’ first – and likely only – touchdown of the game.

I’d hedge with a smaller bet on No San Francisco Touchdown at +1000.

Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

Also see:

Packers at 49ers odds, picks and prediction
Big opportunity awaits Dexter Williams on Thursday Night Football (Packers Wire)
49ers statistical leaders at halfway point (Niners Wire)

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Green Bay Packers at San Francisco 49ers odds, picks and prediction

Previewing the Green Bay Packers at San Francisco 49ers Week 9 betting odds and lines, with NFL betting picks, tips and predictions.

The Green Bay Packers (5-2) visit the injury-ravaged San Francisco 49ers (4-4) at Levi’s Stadium for Thursday Night Football in Week 9. Kickoff will be at 8:20 p.m. ET. Below, we preview the Packers-49ers betting odds and lines and make our NFL picks and predictions.

Packers at 49ers betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 5:15 a.m. ET.

Money line: Packers -250 (bet $250, win $100) | 49ers +200 (bet $100, win $200)
Against the spread/ATS: Packers -5.5 (-110) | 49ers +5.5 (-110)
Over/Under: 49.5 (O: -110 | U: -110)

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Packers at 49ers game notes

The Packers have lost two of their last three games after a strong 4-0 start. They dropped a 28-22 decision to the NFC North rival Minnesota Vikings at Lambeau Field last week.
The 49ers took a 37-27 loss at the NFC West rival Seattle Seahawks in Week 8. The loss snapped a two-game win streak for the Niners.
49ers QB Nick Mullens will make his third start of the season in Week 9. In all, he has completed 70.4% of 98 pass attempts for 852 yards and 4 touchdowns against 3 interceptions. QB Jimmy Garoppolo (ankle) was placed on the Reserve/Injured list.
The Packers backfield is a mess coming into this one. RB Aaron Jones (calf) is expected to miss a second straight game. RBs A.J. Dillon and Jamaal Williams were placed on the Reserve/COVID-19 list. Fifth-year pro Tyler Ervin should lead the group in Week 9; he has 76 yards from scrimmage on 10 touches this season.
Green Bay is 5-2 against the spread but covers by just 1.9 points per game. San Francisco is 4-4 ATS and covers by an average of 0.9 PPG.
The Packers are 4-3 against the Over/Under while the Niners are 4-4 against the projected point totals.

Packers at 49ers key injuries

Packers

RB Aaron Jones (calf) doubtful
LB Preston Smith (shoulder) questionable
WR Equanimeous St. Brown (knee) questionable
RB Jamaal Williams (COVID-19) out
RB A.J. Dillon (COVID-19) out

49ers

RB Tevin Coleman (knee) questionable
QB Jimmy Garoppolo (ankle) out/IR
TE George Kittle (foot) out/IR
WR Deebo Samuel (hamstring) out
S Jaquiski Tartt (groin) questionable

Packers at 49ers: Odds, prediction, betting lines and picks

Prediction

Packers 27, 49ers 13

Money line (?)

The PACKERS (-250) and an angry QB Aaron Rodgers have an excellent bounce-back opportunity against the banged-up Niners. The Packers’ replacement-level backfield for TNF isn’t much of a detriment with the Niners down to their third-string (Jerick McKinnon) and fourth-string (JaMycal Hasty) running backs as well.

Lean on Rodgers and WR Davante Adams to outduel Mullens and The Replacements in the Bay Area.

Against the spread (?)

There’s much better value to be had by backing the PACKERS -5.5 (-110) to win by at least 6 points. So long as Rodgers is able to get Green Bay out to the early lead, there’s just no way for San Francisco to keep pace.

No team in the NFL has the current injury troubles of the reigning NFC champions.

Over/Under (?)

The corresponding pick here is the UNDER 49.5 (-110). The Packers will get an early lead and then be able to sit back and stifle Mullens and the Niners’ passing attack.

Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

Also see:

Report: Big gap between Packers, Texans within failed trade for Will Fuller (Packers Wire)
Kittle out 8 weeks with broken bone in foot (Niners Wire)

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Gannett may earn revenue from audience referrals to betting services. Newsrooms are independent of this relationship and there is no influence on news coverage.

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