Tag: San Francisco 49ers vs. Arizona Cardinals odds predictions pick betting line spread

San Francisco 49ers vs. Arizona Cardinals odds, picks and predictions

Analyzing Monday’s San Francisco 49ers vs. Arizona Cardinals odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (5-4) and Arizona Cardinals (4-6) face off in the NFL’s final international game of the season. They play Monday night at Estadio Azteca in Mexico City with kickoff at 8:15 p.m. ET  (ESPN). Below, we analyze Tipico Sportsbook‘s lines around the 49ers vs. Cardinals odds, and make our expert NFL picks and predictions.

The Cardinals beat the Rams 27-17 in Week 10 as 3.5-point underdogs. QB Colt McCoy, starting in place of an injured Kyler Murray, threw a TD pass and RB James Conner rushed for 2 TDs. The win snapped a 2-game losing streak.

The 49ers beat the Los Angeles Chargers 22-16 last week but failed to cover the 8.5-point spread as favorites. They have won 2 straight games and are undefeated in NFC West games.

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49ers vs. Cardinals odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:57 p.m. ET.

  • Moneyline (ML): 49ers -455 (bet $455 to win $100) | Cardinals +350 (bet $100 to win $350)
  • Against the spread (ATS): 49ers -10 (-110) | Cardinals +10 (-110)
  • Over/Under (O/U): 43 (O: -110 | U: -110)

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49ers vs. Cardinals key injuries

49ers

  • DT Arik Armstead (foot, ankle) out
  • DE Samson Ebukam (quadriceps, Achilles) questionable

Cardinals

  • TE Zach Ertz (knee) out
  • OL Max Garcia (shoulder) out
  • WR DeAndre Hopkins (hamstring) questionable
  • OL D.J. Humphries (back) out
  • CB Byron Murphy (back) out
  • QB Kyler Murray (hamstring) out

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49ers vs. Cardinals picks and predictions

Prediction

49ers 24, Cardinals 20

Moneyline

The Cardinals swept the Niners last season and have won 3 of the last 4 meetings.

McCoy led the Cardinals to a 31-17 win last season in Santa Clara, so the Cardinals are capable of pulling off a win without Murray.

However, with four starting offensive linemen down, the 49ers’ pass rush will be too much and the run game will be hard to stop with Elijah Mitchell and Christian McCaffrey. 

The 49ers allow the fewest yards in the NFL.

The 49ers should win, but PASS on the moneyline because there is better value elsewhere.

Against the spread

Up until last week’s win over the Chargers, the 49ers had covered the spread in every win this season.

The Cardinals are 5-5 ATS this season, covering the spread once in a loss.

The Cardinals historically play the 49ers tough and 10 points is a lot to lay in this game.

BET CARDINALS +10 (-110).

Over/Under

While the 49ers allow only an average of 18.1 points per game, the Cardinals are averaging 29.0 per game in their last 4 contests, which corresponds with the return of WR DeAndre Hopkins.

The Cardinals allow an average of 25.8 points per game.

BET OVER 43 (-110).

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Underdog corner: 3 best NFL ATS picks and predictions for Week 5

Assessing the NFL betting odds and lines for Week 5, with three predictions and picks for the best ATS underdog bets to make.

After a hot start, we cooled off here in Week 4, cashing in on only one of our three weekly selections. But, hey, 9-3 after four weeks? Certainly no hanging heads here. Below, we look at the top NFL underdog ATS picks and predictions of Week 5.

Also see: All Week 5 odds and lines

NFL underdog predictions: Week 5

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 4:15 p.m. ET.

Cincinnati Bengals +3.5 (-125) vs. Green Bay Packers

QB Aaron Rodgers and the Packers have bounced back nicely from their season-opening debacle against the New Orleans Saints, by reeling off three straight wins.

The Bengals are also 3-1 and have won with a promising mix of young offensive talent, led by second-year QB Joe Burrow and rookie WR Ja’Marr Chase, along with an improved and underrated defense.

That should be more than enough to at least keep it close — and possibly even win outright — at home against a banged-up Green Bay squad which likely will be without some key offensive linemen, its best pass rusher and top cornerback.

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San Francisco 49ers +5.5 (-112) at Arizona Cardinals

QB Kyler Murray and the Cards are the league’s final unbeaten team and are coming off a huge 37-20 win over the previously undefeated Los Angeles Rams as 3.5-point road underdogs.

That, however, makes this a prime letdown spot for Arizona as it hosts an angry 49ers squad hitting the road off two straight stinging home setbacks.

Even though it likely will be rookie Trey Lance starting at QB for the Niners, they have had recent success in this NFC West series, winning three of the last four meetings.

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Buffalo Bills +2.5 (-102) at Kansas City Chiefs

K.C. is favored by less than a field goal at home Sunday night for the first time ever in a game QB Patrick Mahomes is slated to start.

That’s a giveaway right there that the wrong team might be favored in this rematch of last season’s AFC Championship Game won 38-24 by the Chiefs.

Both squads once again have top-three scoring offenses with top-level QBs, but the huge difference is defense as the Bills have surrendered the fewest points (44) and total yards (867) in the league while the Chiefs rank 31st in both categories, giving up 125 points and 1,751 yards.

With the spread under 3 points, take the Bills on the money line at +120 to earn a measure of revenge.

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

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San Francisco 49ers at Arizona Cardinals odds, picks and prediction

Previewing the San Francisco 49ers at Arizona Cardinals Week 16 betting odds and lines, with NFL betting picks, tips and predictions.

The Arizona Cardinals (8-6) take on the San Francisco 49ers (5-9) in one of three Saturday games in Week 16. Kickoff is Saturday afternoon at 4:30 p.m. ET at State Farm Stadium in Glendale, AZ.

Below, we preview the 49ers-Cardinals betting odds and lines and make our NFL picks and predictions.

49ers at Cardinals: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 1:40 a.m. ET.

  • Money line: 49ers +200 (bet $100 to win $200) | Cardinals -250 (bet $250 to win $100)
  • Against the spread/ATS: 49ers +5 (-110) | Cardinals -5 (-110)
  • Over/Under: 48.5 (O: -110 | U: -110)

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49ers at Cardinals: Game notes

  • San Francisco has lost three games in a row, six out of seven and has been eliminated from postseason contention. The Cardinals have won two in a row and can potentially clinch a playoff berth this weekend.
  • Cardinals QB Kyler Murray is coming off a career-high 406 passing yards in Week 15 with three passing touchdowns and a rushing touchdown. He was named NFC Offensive Player of the Week for the third time this season.
  • Arizona has collected 14 sacks in the last two weeks.
  • 49ers QB C.J. Beathard is making his first start of 2020 in place of the injured Jimmy Garoppolo and Nick Mullens. Beathard is 1-9 in his career as a starter.
  • In the Cardinals’ 24-20 season-opening win over the 49ers, QR DeAndre Hopkins had a career-high 14 receptions for 151 yards.

49ers at Cardinals: Key injuries

49ers

  • QB Nick Mullens (elbow) out
  • RB Raheem Mostert (ankle) out
  • WR Deebo Samuel (hamstring) out
  • CB Richard Sherman (calf) out
  • S Jimmie Ward (concussion) questionable
  • CB Emmanuel Moseley (hamstring) questionable

Cardinals

  • LB Dennis Gardeck (knee) out
  • RB Chase Edmonds (knee, ankle) questionable
  • WR Larry Fitzgerald (groin) questionable
  • TE Dan Arnold (back) questionable
  • LB Haason Reddick (shoulder) questionable

49ers at Cardinals: Odds, betting lines, predictions and picks

Prediction

Cardinals 31, 49ers 17

Money line (?)

Arizona is playing good football again, winning two in a row after losing three straight. San Francisco has lost six of seven and is down to its third-string quarterback and does not have its top running back, receiver, pass rusher, cornerback and safety.

Beathard is making his fifth appearance against the Cardinals in his career. He has never beaten them and Arizona needs to win to stay in control of the No. 7 seed in the NFC. Take the CARDINALS (-250).

Against the spread (?)

In addition to losing six of seven games, the 49ers have failed to cover in any of those six losses. They are 5-9 ATS this season. Arizona is 7-7 ATS but has won and covered in their last two games after failing to cover the spread in five straight. They should be able to move the ball and score points on a depleted 49ers defense and maintain their playoff chances.

Take the CARDINALS -5 (-110).

Over/Under (?)

The Cardinals’ offense seems to be back on track. Their games have gone Over only five times this season but those five times have been in the last eight games. San Francisco’s games have gone Under in three of five. Arizona’s offense will be fine, but with Beathard at QB without the 49ers’ top offensive players, they will struggle.

Take UNDER 48.5 POINTS (-110).

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