Tampa Bay Buccaneers at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Tampa Bay Buccaneers at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Tampa Bay Buccaneers (6-6) are on the road in Week 14 to take on the San Francisco 49ers (8-4). Kickoff Sunday at Levi Stadium is at 4:25 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Buccaneers vs. 49ers odds, and make our expert NFL picks and predictions.

The Buccaneers engineered a 2-score, 4th-quarter comeback last week on Monday night for a 17-16 home win over the New Orleans Saints as 3.5-points favorites. The have won 3 of their last 4 games overall.

The 49ers, despite losing QB Jimmy Garoppolo for what could be the rest of the season with a broken foot, won their 5th straight game last Sunday with a 33-17 victory over the Miami Dolphins.

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Buccaneers at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:11 a.m. ET.

  • Moneyline (ML): Buccaneers +160 (bet $100 to win $160) | 49ers -190 (bet $190 to win $100)
  • Against the spread (ATS): Buccaneers +3.5 (-115) | 49ers -3.5 (-105)
  • Over/Under (O/U): 37 (O: -109 | U: -111)

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Buccaneers at 49ers key injuries

Buccaneers

  • Mike Edwards (hamstring) doubtful
  • RB Leonard Fournette (foot) questionable
  • DL Akiem Hicks (foot) questionable
  • CB Sean Murphy-Bunting (quad) questionable
  • OL Tristan Wirfs (ankle, knee) doubtful
  • Antoine Winfield (ankle) doubtful

49ers

  • DL Nick Bosa (hamstring) questionable
  • QB Jimmy Garoppolo (foot) out
  • DB Tarvarious Moore (knee) out
  • DL Hassan Ridgeway (pectoral) out

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Buccaneers at 49ers picks and predictions

Prediction

Buccaneers 20, 49ers 13

Moneyline

The 49ers have the league’s No. 1 defense in yards and points allowed. Opponents score only 15.8 points per game and 283.9 yards per game.  However, Tampa’s defense is no slouch, allowing only 18.3 points and 313.8 yards per game.

The Bucs rank 27th in scoring at only 18.1 points per game, while the 49ers are 13th at 23.5 PPG.

Tampa has had time to prepare for 49ers QB Brock Purdy. The Bucs will focus on slowing the run game and make Purdy make plays. The 49ers are 9-29 when anyone other than Garoppolo starts at QB.

It is hard to believe that Purdy could outduel QB Tom Brady, yet the 49ers are favored. This is a great underdog bet to make.

BET BUCCANEERS (+160).

Against the spread

The Bucs are only 3-8-1 ATS this season. The Bucs have only covered the spread once in their last 10 games. However, this is the 1st time all season they have not been favored.

The 49ers are 7-5 ATS. In their 5-game winning streak, they have covered the spread 4 times.

The 49ers will come down to earth with Purdy at QB, but the ATS bet for the Bucs isn’t has good as the moneyline.

PASS.

Over/Under

The Over has hit in only 2 games for the Bucs this season. The Bucs have held opponents to 16 or fewer points in 3 of their last 4 games. And you can expect the San Francisco offense to struggle against Tampa’s defense.

BET UNDER 37 (-111).

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