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The Denver Broncos (0-1) visit the San Francisco 49ers (0-1) Saturday. Kickoff from Levi’s Stadium is at 8:30 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around the Broncos vs. 49ers odds, and make our expert NFL picks and predictions.
The Broncos lost 18-17 at the Arizona Cardinals Aug. 11. Denver gave up an 18-yard TD pass and a successful 2-point conversion with 2 seconds left in the game, after taking a 17-10 lead with 1:30 remaining.
The 49ers got a TD pass from QB Trey Lance in their preseason opener but were outscored 24-0 the rest of the way in a 34-7 loss at the Las Vegas Raiders Sunday.
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Broncos at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:42 a.m. ET.
- Moneyline (ML): Broncos -185 (bet $185 to win $100) | 49ers +150 (bet $100 to win $150)
- Against the spread (ATS): Broncos -4 (-110) | 49ers +4 (-110)
- Over/Under (O/U): 39.5 (O: -110 | U: -110)
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Broncos at 49ers picks and predictions
Prediction
49ers 23, Broncos 21
Moneyline
Both teams lost last week—the Broncos on the road and the 49ers at home.
The Broncos expect to get their starters 20-24 snaps in this game.
The 49ers are expected to get their starters some work, but QB Sam Darnold is expected to get most of the action under center.
As with all preseason games, unless 1 team builds too big of a lead while the starters are in the game, the final outcome is decided by backups and NFL hopefuls—which is nothing to confidently rely upon.
The smartest play for an uncertain outcome in an exhibition is to bet the plus odds on the moneyline.
BET 49ERS (+150).
Against the spread
Both teams failed to cover the spread last week. The Broncos lost outright despite being favored. The 49ers also were favored in their straight-up loss.
But without any nice plus odds to bet and an uncertain outcome decided by players who will not play much in the regular season—or might not be in the league—avoid the spread.
PASS.
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Over/Under
The Broncos’ preseason opener had the Under cash in, but the Over hit in the 49ers’ loss.
Half of the 16 preseason games last week had at least 40 total points, including the Niners’ 34-7 loss.
BET OVER 39.5 (-110).
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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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