San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Saturday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (83-65) face the San Francisco Giants (72-76) in the 2nd game of their 3-game series Saturday. First pitch from Oracle Park is at 9:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 6-5.

The Padres won the opener Friday night 5-0 and retook the Wild Card lead over the Arizona Diamondbacks by a half game. They are 6-4 in  their last 10 games.

The Giants were shut out for the 2nd straight game Friday and have lost 3 of their last 4 games. They are 4-8 in their last 12 games.

Padres at Giants projected starters

RHP Joe Musgrove vs. RHP Mason Black

Musgrove (5-5, 4.54 ERA) makes his 17th start. He has a 1.28 WHIP, 2.4 BB/9 and 8.6 K/9 through 81 1/3 innings.

  • Last start: Loss, 4 1/3 IP, 6 ER, 8 H, 1 BB, 7 K in 7-6 home loss to the Giants Sunday
  • Had allowed only 4 ER in previous 5 starts combined
  • 4-5 with 4.46 ERA in 15 career starts vs. Giants

Black (0-3, 7.50 ERA) makes his 6th start and 7th appearance. He has a 1.63 WHIP, 3.0 BB/9 and 8.3 K/9 through 24 innings.

  • Last start: Loss, 4 2/3 IP, 4 ER, 6 H, 1 BB, 6 K in 5-1 road loss to the Padres last Friday, his only career game against the them
  • Has allowed 4+ ER in 3 of 5 starts

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of MLB odds. Lines last updated at 12:40 p.m. ET.

  • Moneyline (ML): Padres -160 (bet $160 to win $100) | Giants +135 (bet $100 to win $135)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+105) | Giants +1.5 (-125)
  • Over/Under (O/U): 7.5 (O: -115 | U: -105)

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 2

Moneyline

The Giants have scored 2 or fewer runs in their last 4 losses. They beat Musgrove last week, but Black has not been great thus far,

Musgrove got lit up for 6 runs in his last start, but his ERA was 1.16 in his previous 4.

He will bounce back, but the run line is the better bet for the Padres.

PASS. 

Run line/Against the spread

Seven of the Padres’ last 9 wins have been by more than 1 run. All 5 of their wins over the Giants this season have been by 2+ runs.

Seven of the Giants’ last 10 losses have been my multiple runs.

BET PADRES -1.5 (+105). 

Over/Under

Six of the 11 games they have played against each other this season have had 8 or more runs.

The Giants’ last 4 losses have not reached 8 total runs.

Six of the Padres’ last 10 games have not reached 8 total runs.

BET UNDER 7.5 (-105). 

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Friday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (82-65) and San Francisco Giants (72-75) open a 3-game series Friday. First pitch from Oracle Park is at 10:15 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 6-4

The Padres were off Thursday after Wednesday’s 5-2 loss at the Seattle Mariners for a 2-game series split. They have lost 3 of their last 4 games and trail the Arizona Diamondbacks by a half-game for the top NL Wild Card spot.

The Giants are coming off a 2-1 series loss to the visiting Milwaukee Brewers, dropping the Thursday finale 3-0. They are 4-7 in their last 11 games.

Padres at Giants projected starters

RHP Dylan Cease vs. RHP Logan Webb

Cease (12-11, 3.71 ERA) makes his 31st start. He has a 1.09 WHIP, 3.2 BB/9 and 10.9 K/9 through 170 innings.

  • Last start: Loss, 6 IP, 4 ER, 6 H, 2 BB, 4 K in 6-3 home defeat to Giants Saturday; Webb was San Francisco’s starter
  • 2024 vs. Giants: 0-2, 4.32 ERA (16 2/3 IP, 8 ER), 1.08 WHIP, 9.2 K/9 in 3 starts
  • Career vs. Giants: 2-2, 3.38 ERA (26 2/3 IP, 10 ER), 1.16 WHIP, 9.8 K/9 in 5 starts

Webb (12.9, 3.46 ERA) makes his 31st start. He has a 1.23 WHIP, 2.2 BB/9 and 7.4 K/9 through 189 2/3 innings.

  • Last start: Win, 6 IP, 3 ER, 10 H, 2 BB, 3 K Saturday
  • 2024 vs. Padres: 1-0, 3.32 ERA (19 IP, 7 ER), 1.53 WHIP, 5.2 K/9 in 3 starts
  • Career vs. Padres: 4-2, 2.70 ERA (76 2/3 IP, 23 ER), 1.19 WHIP, 7.2 K/9 in 13 appearances (12 starts)

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of MLB odds. Lines last updated at 11 a.m. ET.

  • Moneyline (ML): Padres -115 (bet $115 to win $100) | Giants -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+155) | Giants +1.5 (-190)
  • Over/Under (O/U): 7 (O: -105 | U: -115)

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Padres at Giants picks and predictions

Prediction

Giants 5, Padres 3

Moneyline

The GIANTS (-105) are 6-2 in Webb’s last 8 starts. They took 2 out of 3 games last weekend in San Diego over the Padres. They have held opponents to 3 or fewer runs in 5 of their last 7 games.

The Padres are 2-7 in their last 9 games when they allow 4 or more runs.

The Giants have scored 4 or more in 6 of their last 10 games.

BET GIANTS (-105).

Run line/Against the spread

The Giants are 4-1 ATS in their last 5 games. The Padres are 4-9 ATS in their last 13 games.

The Padres are 14-17 ATS as road favorites.

But If you like the Giants +1.5, the -190 odds aren’t it. With -105 odds for them to win outright, go with the ML.

PASS.

Over/Under

Six of 10 games between the 2 teams have had more than 7 total runs.

Seven of the Giants’ last 11 games have had at least 7 total runs. Webb’s last 4 starts have all had more than 7 total runs.

Nine of the last 11 for the Padres have had totals of 7 or more.

BET OVER 7 (-105).

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (78-80) and San Francisco Giants (78-80) meet for the final time this season on Wednesday. First pitch from Oracle Park is 9:45 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 7-5

The Padres lost the opener 2-1, but bounced back Tuesday night with a 4-0  win. They have won 10 of their last 12 games, but are 1 game from being eliminated from Wild Card contention.

The Giants are 3-9 in their last 12 games. They also are 1 game from being eliminated.

Padres at Giants projected starters

RHP Matt Waldron vs. LHP Sean Manaea

Waldron (1-3, 4.58 ERA) makes his 6th start and 8th appearance. He has a 1.25 WHIP, 2.5 BB/9 and 7.4 K/9 in 35 1/3 innings.

  • Last start: No-decision, 5 2/3 IP, 1 ER, 3 H, 2 BB, 9 K in 4-2 home win over St. Louis Cardinals on Friday
  • Allowed 1 ER in 5 IP in a no-decision vs. Giants Aug. 31

Manaea (7-6, 4.51 ERA) makes his 10th start and 37th appearance. He has a 1.25 WHIP, 3.4 BB/9 and 9.7 K/9 in 111 2/3 innings.

  • Last start: Win, 7 IP, 0 R, 3 H, 0 BB, 2 K in 5-1 victory at the Los Angeles Dodgers on Friday
  • Is 2-1 with 2.00 ERA in 3 starts since rejoining the rotation

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Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:21 p.m. ET.

  • Moneyline (ML): Padres -110 (bet $110 to win $100) | Giants -110 (bet $110 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+150) | Giants +1.5 (-185)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 2

Moneyline

The Padres have won 10 of their last 12 games and, while they are only 34-43 on the road this season, they have won 5 of their last 6 road games. Also, Waldron has only allowed 3 runs in his last 2 starts (11 IP).

You can take Padres straight up and it isn’t a bad play but you have win more on the spread, based on their recent play.

PASS.

Run line/Against the spread

Thirty of the Padres’ last 31 wins have been by 2 or more runs. They have covered the spread in 9 of their last 12 games. Meanwhile, 7 of the Giants’ last 8 losses have been by 2 or more runs.

BET PADRES -1.5 (+150).

Over/Under

Half of the 12 games between the  teams have not reached 9 runs. The last 4 meetings have had fewer than 9. And 6 of the Padres’ last 7 games have not reached 9 runs.

BET UNDER 8.5 (-115).

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Tuesday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (77-80) and San Francisco Giants (78-79) play the 2nd game of a 3-game set Tuesday at Oracle Park. First pitch is scheduled for 9:45 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 6-5

The Padres lost 2-1 as -114 favorites as the Under (7) hit in the series opener Monday. San Diego has lost 2 of 3 and has fallen to 5½ games back of the Arizona Diamondbacks and the Chicago Cubs, who are tied for the final 2 NL Wild Cards.

Giants LF Michael Conforto batted in both runs for San Francisco with a 2-run single in the 8th inning. The Giants have won just 3 of their last 11 outings and are 4½ games out of the final NL Wild Card spot.

Padres at Giants projected starters

RHP Seth Lugo vs. LHP Kyle Harrison

Lugo (7-7, 3.79 ERA) makes his 26th start. He has a 1.24 WHIP, 2.2 BB/9 and 8.7 K/9 in 137 2/3 innings.

  • Last start: No-decision, 6 IP, 2 ER, 7 H, 2 BB, 7 K in 3-2 home victory vs. Colorado Rockies Wednesday
  • 2023 road stats: 3-3, 3.91 ERA (73 2/3 IP, 32 ER) in 13 starts
  • 2023 vs. Giants: 1-0, 0.82 ERA (11 IP, 1 ER) in 2 starts — Most recent: Win, 6 IP, 0 ER, 3 H, 1 BB, 4 K in 4-0 home victory Sept. 3
  • Career vs. Giants: 3-2, 2.52 ERA (35 2/3 IP, 10 ER) across 4 starts and 11 relief appearances

Harrison (1-1, 4.85 ERA) makes his 7th start. The rookie has a 1.28 WHIP, 2.7 BB/9 and 9.4 K/9 in 29 2/3 innings.

  • Last start: No-decision, 5 1/3 IP, 2 ER, 3 H, 1 BB, 2 K in 7-2 loss at Los Angeles Dodgers Thursday
  • 2023 home stats: 1-0, 3.52 ERA (15 1/3 IP, 6 ER) in 3 starts
  • Career vs. Padres: Loss, 5 2/3 IP, 6 ER, 6 H, 2 BB, 5 K in 1 start, a 6-1 road loss Sept. 2

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Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:21 a.m. ET.

  • Moneyline (ML): Padres -125 (bet $125 to win $100) | Giants +105 (bet $100 to win $105)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+135) | Giants +1.5 (-160)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 4

Moneyline

The PADRES (-125) will get eliminated with 1 more loss this season. They would also get eliminated by 1 more win for the Diamondbacks and Cubs, but that is out of their control. San Diego scored 6 runs on Harrison the 1st time they saw him, and I expect it to have a similar performance Tuesday in a must-win scenario.

BET PADRES (-125).

Run line/Against the spread

The Giants are 19-7 on the run line this season as home underdogs. San Francisco +1.5 (-160) will probably hit, but there’s no need to pay the higher price on the run line when San Diego ML is the better play.

PASS. Bet the moneyline and/or the total instead.

Over/Under

The Over is 22-19-4 (53.7%) this season when the Padres are road favorites. San Diego scored just 1 run Monday, and I expect it to bounce back vs. the rookie Harrison.

The Under has hit in 4 straight games for San Francisco, but its last Over cashed in Harrison’s most recent start.

BET OVER 8.5 (-105).

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Monday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (77-79) and San Francisco Giants (77-79) open a 3-game set Monday at Oracle Park. First pitch is scheduled for 9:45 p.m. ET (FS1). Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 6-4

The Padres won 12-2 as -189 home favorites vs. the St. Louis Cardinals as the Over (8) hit Sunday. San Diego has won 9 of its last 10 games and is tied with San Francisco in the NL Wild Card standings, 5 games back of the Chicago Cubs for the final spot.

The Giants lost 3-2 as +149 underdogs at the Los Angeles Dodgers as the Under (9) cashed Sunday. San Francisco is 2-8 in its last 10 games.

Padres at Giants projected starters

LHP Blake Snell vs. RHP Logan Webb

Snell (14-9, 2.33 ERA) makes his 32nd start. He has a 1.20 WHIP, 5.0 BB/9 and 11.7 K/9 in 174 innings.

  • Last start: No-decision, 7 IP, 0 ER, 0 H, 4 BB, 10 K in 2-0 home victory vs. Colorado Rockies Tuesday
  • 2023 road stats: 5-4, 2.13 ERA (84 2/3 IP, 20 ER) in 15 starts
  • 2023 vs. Giants: 2-0, 0.00 ERA (12 IP) across 2 starts
  • Career vs. Giants: 5-1, 1.83 ERA (44 1/3 IP, 9 ER) over 8 starts

Webb (10-13, 3.35 ERA) makes his 33rd start. He has a 1.08 WHIP, 1.3 BB/9 and 8.1 K/9 in 207 innings.

  • Last start: Loss, 6 IP, 3 ER, 9 H, 2 BB, 4 K in 7-1 loss at Arizona Diamondbacks Wednesday
  • 2023 home stats: 6-6, 2.37 ERA (102 2/3 IP, 27 ER) in 15 starts
  • Career vs. Padres: 2-2, 2.77 ERA (48 2/3 IP, 15 ER) in 8 starts and 1 relief appearance — last faced San Diego in 2022

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Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:46 a.m. ET.

  • Moneyline (ML): Padres -115 (bet $115 to win $100) | Giants -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+155) | Giants +1.5 (-190)
  • Over/Under (O/U): 7 (O: +100 | U: -120)

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Padres at Giants picks and predictions

Prediction

Padres 3, Giants 2

Moneyline

The PADRES (-115) are one of the hottest teams in MLB right now as they continue on their very unlikely postseason push. Snell has been dominant in 2 starts this season vs. the Giants, who have been struggling to win games lately. It may be too little, too late for San Diego’s playoff aspirations, but I’ll still take the hotter team with the better pitcher.

BET PADRES (-115).

Run line/Against the spread

The Giants are 18-7 on the run line this season as home underdogs, according to TeamRankings.com. San Francisco +1.5 (-190) will likely hit, but there’s no need to pay the higher price on the run line when San Diego ML is the better play.

PASS. Bet the moneyline and/or the total instead.

Over/Under

The Under is 43-30-2 (58.9%) in Giants home games this season and has hit in 4 of the Padres’ last 5 overall. With Snell and Webb on the mound in a must-win game for both teams, I like UNDER 7 (-120) to cash Monday at Oracle Park.

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Thursday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks and predictions.

The San Diego Padres (35-39) and San Francisco Giants (42-32) meet Thursday in the finale of a 4-game NL West series. First pitch from Oracle Stadium is slated for 3:45 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 3-2

San Diego is looking to avoid being swept. The Friars have only been swept in 1 other series this season, May 12-14 at the Los Angeles Dodgers.

The Giants are orange-hot. They head into Thursday afternoon looking for their 11th consecutive victory. Over its 10 straight wins, San Francisco has averaged 8 runs per game on a high-contact .859 OPS. Prior to this series, the Giants had gone just 2-6 over 8 home games from May 30-June 11.

San Francisco is 2nd in the NL West, 2 1/2 games behind the Arizona Diamondbacks and 7 games ahead of the 4th-place Padres.

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Padres at Giants projected starters

LHP Blake Snell vs. LHP Alex Wood

Snell (3-6, 3.48 ERA) makes his 15th start. He has a 1.29 WHIP, 4.8 BB/9 and 11.2 K/9 in 75 innings.

  • Owns an 18.9% swinging-strike rate over his last 3 starts and is facing a Giants offense that has filed a 25.7 whiff percentage against southpaws
  • Owns a 3.15 ERA on the road over the last 2 years

Wood (2-1, 4.11 ERA) is making his 9th start. He has a 1.46 WHIP, 4.1 BB/9 and 8.7 K/9 in 35 innings across 9 games (8 starts).

  • Owns a 3.70 ERA, 1.23 WHIP over 249 career games
  • Has an 8.10 ERA over his last 3 home starts
  • Has gone past 5 innings just once this season

Padres at Giants odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:20 a.m. ET.

  • Moneyline: Padres -130 (bet $130 to win $100) | Giants +110 (bet $100 to win $110)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+126) | Giants +1.5 (-152)
  • Over/Under (O/U): 8 (O: -120 | U: -102)

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 4

Moneyline

The Padres lost Wednesday’s game 4-2; they are 6-0 across their last 6 games after scoring 2-or-less runs the prior game.

San Diego is 0-6 in extra innings and 5-13 in 1-run games. The Friars are deserving of a better record than where they stand. Also, figure their schedule as being tougher than that of the Giants so far.

The lefty-lefty match-up favors the Padres; the better side of their platoon splits have them owning a top-10 OPS (.768) against lefties.

Swimming upstream against a San Francisco win streak is not ideal. Some bettors may want to avoid this play or dial down the unit percentage, but PADRES (-130) has value.

Run line/Against the spread

The Over has a lean, but the return here on San Diego is not great. PASS.

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Over/Under

The Over is 9-4 in the last 13 series meetings.

The Friars average just 3.70 RPG at home, but on the road that figure jumps to 4.65.

An outward breeze is in the forecast, and there is some lean against both starters and the Padre bullpen. Both bullpens have some availability concerns at the back end.

BACK THE OVER 8 (-120). Consider a partial-unit play unless the price drops to -115 or better.

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks and predictions.

The San Diego Padres (35-38) and San Francisco Giants (41-32) meet Wednesday for the 3rd game of a 4-game NL West set. First pitch from Oracle Stadium is slated for 9:45 p.m. ET (MLB Network). Let’s analyze FanDuel Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 2-2

San Diego has dropped the 1st 2 games of this series, and the Padres are just 2-4 over their last 6 games. They sit 4th in  the NL West, 8 1/2 game out of 1st place.

The Giants head into Wednesday night looking for their 10th consecutive victory. San Francisco’s offense has banged out an .877 OPS over that span. The Giants have outscored opponents 76-29 over the 9 straight wins and have surged into 2nd place in the NL West, 2 1/2 games behind the Arizona Diamondbacks.

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Padres at Giants projected starters

RHP Yu Darvish vs. RHP Ryan Walker

Darvish (5-5, 4.74 ERA) makes his 14th start of the season. He owns a 1.20 WHIP, 2.8 BB/9 and 9.6 K/9 in 74 innings.

  • Has yielded 10 R over his last 10 1/3 IP and owns a 6.75 ERA in his last 7 starts
  • Has a 9.75 ERA over his last 5 starts against San Francisco

Walker (2-0, 1.65 ERA) is tabbed for his 2nd start. He has a 1.16 WHIP, 1.7 BB/9 and 8.3 K/9 in 16 1/3 IP across 12 games (1 start).

  • The 27-year-old rookie has pitched 20 1/3 IP in Triple-A this season (0.89 ERA, 0.85 WHIP)
  • Likely to serve as an opener with LHP Sean Manaea (2-3, 5.84 ERA, 1.38 WHIP) logging bulk innings behind him

Padres at Giants odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:45 a.m. ET.

  • Moneyline: Padres -124 (bet $124 to win $100) | Giants +106 (bet $100 to win $106)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+128) | Giants +1.5 (-154)
  • Over/Under (O/U): 8 (O: -115 | U: -105)

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 4

Moneyline

The Padres are 9-3 in the last 12 series meetings and are 6-2 in the last 8 games in San Francisco.

San Diego is 0-6 in extra innings and 5-12 in 1-run games. The Friars are deserving of a better record than where they stand. Also, peg their schedule as being tougher than the Giants’ so far.

San Diego batters own a .968 OPS against Manaea, and their platoon numbers favor at-bats against southpaws.

TAKE THE PADRES (-124).

Run line/Against the spread

The Over has a lean, and that makes the Run line favorite worth looking into. But we should want more return here. PASS.

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Over/Under

The Friars average just 3.70 RPG at home, but on the road that figure jumps to 4.72.

A stiff breeze blowing outward is in the forecast for Wednesday’s game. With the way the Giants are hitting and the way the Padres have pounded Manaea in the past, the lean is toward the Over.

BACK THE OVER 8 (-115).

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Tuesday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks and predictions.

The San Diego Padres (35-37) and San Francisco Giants (40-32) meet Tuesday to tangle in the 2nd game of a 4-game set. First pitch from Oracle Stadium is slated for 9:45 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 2-1

San Diego lost Monday’s series opener 7-4 in 10 innings. The 7 runs allowed marked just the 2nd time since June 5 the Friars allowed more than 6 in a single game. San Diego ranks 4th in MLB with a 3.75 ERA on the season.

The Giants have scored 6 runs or more in 6 straight games and have won 8 straight overall. San Francisco’s offense has authored a robust .889 OPS over that span.

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Padres at Giants projected starters

RHP Seth Lugo vs. RHP Anthony DeSclafani

Lugo (3-3, 4.10 ERA) is lined up for his 9th start. He’s posted a 1.37 WHIP, 2.4 BB/9 and 8.2 K/9 through 41 2/3 IP.

  • Comes off the IL (calf) without a rehab assignment to the minors after having last pitched on May 16
  • Owns a 3.52 and 1.18 WHIP ERA over 283 career games (46 starts)

DeSclafani (4-6, 4.31 ERA) makes his 15th start. He has a 1.19 WHIP, 1.9 BB/9 and 6.8 K/9 through 79 1/3 IP.

  • Got off to a hot start but has struggled over his last 8 outings (6.31 ERA); has allowed 5 ER in 2 of his last 3 starts
  • Current Padres own an aggregate .858 OPS against him

Padres at Giants odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:50 a.m. ET.

  • Moneyline: Padres -106 (bet $106 to win $100) | Giants -110 (bet $100 to win $110)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+158) | Giants +1.5 (-192)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

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Padres at Giants picks and predictions

Prediction

Padres 6, Giants 4

Moneyline

The Padres are 9-2 in the last 11 series meetings and are 6-1 in the last 7 games in San Francisco.

Lugo will see a lot of lefty bats in the San Francisco lineup. He’s been hurt from that side so far this season (.830 OPS) but alongside a .383 batting average on balls in play. For his career, he’s held lefty bats to a .670 OPS.

San Diego is 0-6 in extra innings and 5-12 in 1-run games. They are deserving of a better record than where they stand. Peg their schedule as being tougher than the Giants’ so far.

TAKE THE PADRES (-106).

Run line/Against the spread

If the price stays at Padres -1.5 (+158) or better, this play can be mixed with the above (say, a half unit on the moneyline and a half on the run line) for some extra leverage.

BACK THE PADRES -1.5 (+158).

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Over/Under

The Over is 4-1 in the last 5 series meetings in San Francisco.

The Friars average just 3.70 RPG at home, but on the road that figure jumps to 4.77.

A hefty wind blowing out is in the forecast for Tuesday’s game. With the way the Giants are hitting and the way the Padres have pounded DeSclafani in the past, this one could be near the number by the 7th-inning stretch.

BACK THE OVER 8.5 (-115).

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Monday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

The San Diego Padres (35-36) and San Francisco Giants (39-32) meet Monday to kick off a 4-game series. First pitch from Oracle Park is set for 9:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 2-0

The Padres won 5-4 as -151 home favorites Sunday vs. the Tampa Bay Rays. San Diego scored 3 runs in the 3rd inning and 1 run in both the 4th and 5th innings to take a 5-2 that it never gave up despite giving up 2 runs in the 8th frame. San Diego has won back-to-back games on Saturday and Sunday after suffering back-to-back losses on Thursday and Friday.

San Francisco won 7-3 as a +104 road underdog Sunday vs. the Los Angeles Dodgers. The Giants held a 3-2 lead heading into the top of the 6th before they exploded for 4 runs to seal the game and complete the 3-0 sweep of the Dodgers. San Francisco has won 7 straight games heading into this series to move into 2nd place in the NL West, 3 1/2 games back of the division-leading Arizona Diamondbacks.

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Padres at Giants projected starters

RHP Michael Wacha vs. RHP Ryan Walker

Wacha (7-2, 2.89 ERA) makes his 14th start. He has a 1.06 WHIP, 2.5 BB/9 and 8.3 K/9 through 74 2/3 IP.

  • Last outing: Win, 6 2/3 IP, 0 ER, 4 H, 1 BB, 5 K in a 5-0 home victory Wednesday vs. Cleveland Guardians
  • Career vs. San Francisco: 2-0 with a 1.42 ERA (38 IP, 6 ER), 31 H, 32 K, 1.11 WHIP across 7 starts

Walker (2-0, 1.23 ERA) makes his 1st start and 12th appearance. He has a 1.02 WHIP, 1.2 BB/9 and 9.2 K/9 through 14 2/3 IP.

  • Last outing: No-decision, 1 1/3 IP, 0 ER, 2 H, 0 BB, 0 K as a reliever in a 7-5 road win Friday vs. Los Angeles Dodgers
  • First career start vs. San Diego

Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7 a.m. ET.

  • Moneyline (ML): Padres -110 (bet $110 to win $100) | Giants -110 (bet $110 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+145) | Giants +1.5 (-175)
  • Over/Under (O/U): 8.5 (O: -120 | U: +100)

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 4

Moneyline

LEAN PADRES (-110).

The Giants are the hotter team but have not yet proven they can beat the Padres this year, losing both previous meetings. San Francisco is 18-17 at home this season whereas the Padres are 16-16 on the road, meaning neither team has a whopping advantage here. However, San Diego is 9-1 in the last 10 meetings with San Francisco, earning it the lean here.

Run line/Against the spread

PASS.

I could really see this bet going either way and while I am confident in the Padres winning, I’m not confident in them winning by 2 or more runs. However, the Giants at +1.5 (-175) is not worth the juice as they are far too heavy of a favorite in the run line for this game.

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Over/Under

BET OVER 8.5 (-120).

The Over is 5-0 in San Francisco’s last 5 games and 6-1 in its last 7 games overall. The Over is also 5-1 in the last 6 matchups between these clubs and 8-2 in their last 10 meetings.

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks and predictions.

The San Diego Padres (72-59) and San Francisco Giants (61-67) meet Wednesday at 3:45 p.m. ET to close out a 3-game series at Oracle Park. Let’s analyze Tipico Sportsbook‘s lines around the Padres vs. Giants odds with MLB picks and predictions.

Season series: San Diego leads 10-5

San Diego has struggled on the road since midsummer but has taken the first 2 games in this series and is 4-1 on its current road trip. A Friar’s offense that produced just 1.50 runs per game from Aug. 18-24 has rebounded to crank out 6.80 RPG in 5 games since.

The Giants have lost 6 straight games. San Francisco owns a bloated 4.56 ERA and1.52 WHIP over that losing streak. The Giants are just 10-16 in August.

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Padres at Giants projected starters

RHP Joe Musgrove vs. LHP Alex Wood

Musgrove (8-6, 2.96 ERA) owns a 1.05 WHIP, 1.8 BB/9 and 8.7 K/9 through 142 2/3 IP across 23 starts.

  • Was touched up for 5 R (2 ER) on 8 hits in 3 2/3 IP in his last start Friday at the Kansas City Royals
  • Has allowed 2 ER in his last 26 IP against San Francisco

Wood (8-11, 5.00 ERA) is lined up for his 26th start. He has a 1.24 WHIP, 2.1 BB/9 and 9.0 K/9 through 126 IP.

  • Is coming off back-to-back clunkers, having allowed 7 runs Aug. 19 at the Colorado Rockies and 8 runs Friday at the Minnesota Twins
  • Has been quite good against San Diego this season with a 3.05 ERA and 1.11 WHIP across 4 starts

Padres at Giants odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:40 a.m. ET.

  • Money line: Padres -145 (bet $145 to win $100) | Giants +120 (bet $100 to win $120)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+115) | Giants +1.5 (-140)
  • Over/Under (O/U): 7.5 (O: -108 | U: -112)

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Padres at Giants picks and predictions

Prediction

Padres 4, Giants 3

Money line

The Giants are a lean in a vacuum with this pricing. However, they are 2-10 with a .589 OPS in their last dozen games. San Francisco is also tougher against left-handers (.745 OPS) than right-handers (.687).

PASS.

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Run line/Against the spread

Worth a LINE WATCH due to some San Diego bullpen fatigue. Take the Giants +1.5 if you can get them at -140 or better.

Over/Under

We’ve seen some baked-in Under to this match-up but have been cautious to dive in due to pricing. That changes for this Wednesday matinee.

Both starters have good numbers against the batters they’ll see tonight. Wood, in particular, has significantly better expected-ERA figures. On a cool day in pitcher-friendly Oracle Park, consider a partial-unit play on the UNDER 7.5 (-112). Go in with full ammunition at -105 or better.

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