Arizona Cardinals at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Arizona Cardinals open the 2024 regular season on the road against the Buffalo Bills. The game kicks off Sunday at 1 p.m. ET at Highmark Stadium (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Bills odds, and make our expert NFL picks and predictions.

The Cardinals open the season with a healthy QB Kyler Murray and an improved defensive starting lineup. RB James Conner and TE Trey McBride are coming off career seasons. They are coming off a 4-win season and hope to take the next step, being competitive enough to perhaps make the playoffs.

The Bills remade their receiver room and their secondary. They have won the AFC East 4 straight years and hope to be a Super Bowl contender as QB Josh Allen leads the way.

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Cardinals at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1 p.m. ET.

  • Moneyline (ML): Cardinals +240 (bet $100 to win $240) | Bills -300 (bet $300 to win $100)
  • Against the spread (ATS): Cardinals +6.5 (-110) | Bills -6.5 (-110)
  • Over/Under (O/U): 47.5 (O: -105 | U: -115)

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Cardinals at Bills key injuries

Cardinals

  • Joey Blount (back) questionable
  • TE Tip Reiman (ankle) questionable
  • WR Xavier Weaver (oblique) out

Bills

  • DE Javon Solomon (oblique) out
  • DE Dawuane Smoot (toe) questionable

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Cardinals at Bills picks and predictions

Prediction

Bills 30, Cardinals 24

Moneyline

The Cardinals have not won in Buffalo since 1971. They have major question marks on defense with the pass rush, and they were bad against the run last season.

However, the Cardinals were a top-five offense over the final four games of the season and could be better with the addition of rookie WR Marvin Harrison Jr. 

It won’t be enough to get the upset, so the Bills should win, and you shouldn’t bet them at -300 because it isn’t worth the action.

PASS. 

Against the spread

Arizona’s offense should be able to test the Bills’ new secondary. Allen has thrown 5 INTs in his last 2 season openers, which will keep the game close.

The Cardinals went 9-8 ATS in a season they were 4-13 straight up.

Arizona is likely to have a lot of high-scoring close games. This should be one of them.

BET CARDINALS +6.5 (-110). 

Over/Under

Their last matchup in 2020 in Arizona had 62 total points.

Three of the Bills’ final 4 games, including the postseason, has totals of 48 or higher.

Both teams should score points.

BET OVER 47.5 (-105).

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Carolina Panthers at Buffalo Bills odds, picks and predictions

Analyzing Saturday’s Carolina Panthers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (1-1) welcome the Carolina Panthers (0-2) to Highmark Stadium Saturday for the final week of preseason. Kickoff is set for 1 p.m. ET. Below, we analyze FanDuel Sportsbook’s lines around the Panthers vs. Bills odds, and make our expert NFL picks and predictions.

The Bills lost to the Chicago Bears 33-6 in Week 1 of the preseason, failing to cover as 3-point home favorites. They did bounce back and beat the Pittsburgh Steelers 9-3 on the road Saturday, closing as 2.5-point underdogs. Buffalo is 1-1 against the spread (ATS) and 1-1 O/U. QB Josh Allen has only played 1 drive, completing 2 of 3 passes for 22 yards.

The Panthers have lost both preseason games, dropping the first battle 17-3 to the New England Patriots on the road and the second one 15-12 to the visiting New York Jets. Carolina failed to cover in both, closing as a 6.5-point underdog in the opener and a 1.5-point favorite Aug. 17. QB Bryce Young has yet to attempt a pass in the preseason, so he might see a drive Saturday.

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Panthers at Bills odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:59 a.m. ET.

  • Moneyline (ML): Panthers -230 (bet $230 to win $100) | Bills +190 (bet $100 to win $190)
  • Against the spread: Panthers -4.5 (-115) | Bills +4.5 (-105)
  • Over/Under (O/U): 31.5 (O: -105 | U: -115)

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Panthers at Bills picks and predictions

Prediction

Panthers 17, Bills 13

Moneyline

PASS.

There’s not much value here. The Panthers (-230) haven’t shown enough to be heavy favorites, and paying more than twice your potential return in a preseason game is far too risky.

Against the spread

BET BILLS +4.5 (-105).

The home underdog is the best play here. The Bills are coming off a win in which their defense allowed just 3 points to the Steelers. While they did allow 33 the first week, 20 of those were in the 4th quarter, so their defense held strong for most of the game.

The Panthers haven’t got much of anything going in the preseason, scoring a combined 15 points while allowing 32. They have lost both and failed to cover both. With that in mind, take the underdog here, and back BILLS +4.5 (-105).

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Over/Under

BET UNDER 31.5 (-115).

The Panthers are 0-2 O/U, having scored 12 or fewer points in both games. They likely won’t play Young much, and outside of him, their skill players lack the ability to create that offensive magic. They totaled 156 total yards against the Jets.

The Bills have yet to score double digits as well and only went Over when they allowed 33 points to Chicago in Week 1. Considering those trends for both sides and in the preseason in general, back UNDER 31.5 (-115).

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Buffalo Bills at Pittsburgh Steelers odds, picks and predictions

Analyzing Saturday’s Buffalo Bills at Pittsburgh Steelers odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (0-1) visit the Pittsburgh Steelers (0-1) Saturday night in Week 2 of the preseason. Kickoff from Acrisure Stadium is scheduled for 7 p.m. ET (NFL Network). Below, we analyze BetMGM Sportsbook’s lines around the Bills vs. Steelers odds, and make our expert NFL picks and predictions.

Buffalo opened its preseason with a 33-6 loss against the Chicago Bears while failing to cover as a 3.5-point home favorite. QB Josh Allen started the game and went 2 of 3 for 22 yards, while QB Mitch Trubisky saw a majority of the snaps and went 10 of 18 for 82 yards.

The Steelers dropped their first game with a 20-12 loss against the Houston Texans while failing to cover as 3.5-point home favorites. QB Justin Fields saw minimal action going 5 of 6 for 67 yards, and QB Kyle Allen played the rest of the way and went 17 of 23 for 193 yards with a touchdown and interception.

Bills at Steelers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:20 a.m. ET.

  • Moneyline (ML): Bills +115 (bet $100 to win $115) | Steelers -135 (bet $135 to win $100)
  • Against the spread (ATS): Bills +1.5 (-110) | Steelers -1.5 (-110)
  • Over/Under (O/U): 38.5 (O: -115 | U: -105)

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Bills at Steelers picks and predictions

Prediction

Steelers 27, Bills 16

Moneyline

PASS.

The Steelers (-135) have a more commanding offense, but anything is possible in the preseason, so it may be worth a sprinkle on the Bills (+115).

Against the spread

BET PITTSBURGH -1.5 (-110).

With QB Russell Wilson set to see playing time for Pittsburgh Saturday, followed by Fields and Allen, expect a quick start against the Bills. The Buffalo defense allowed 33 points in Week 1 and has not made the changes to adjust quickly enough against two 1st-team caliber quarterbacks who are capable of captaining high-octane offenses.

Over/Under

BET OVER 38.5 (-110).

In their respective openers, both teams allowed a combined 53 points on defense. While both defenses should settle in a bit in Week 2, the offensive production for both should, as well. Expect Pittsburgh to carry more of the load, but both offenses should produce more points Saturday.

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Chicago Bears at Buffalo Bills odds, picks and predictions

Analyzing Saturday’s Chicago Bears at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Chicago Bears and Buffalo Bills meet at Highmark Stadium Friday. Kickoff is scheduled for 1 p.m. ET (NFL Network/NFL+). Below, we analyze BetMGM Sportsbook’s lines around the Bears vs. Bills odds, and make our expert NFL picks and predictions.

The Bears opened their preseason slate last week in the Hall of Fame Game in Canton, Ohio. They beat the Texans 21-17 in a weather-shortened game as 2.5-point underdogs. However, most books voided full-time bets since 55 minutes were not played, as per the industry standard.

The Buffalo Bills begin their preseason play with a lot of questions after a ton of roster changeover this offseason, but one thing is certain, QB Josh Allen will be the starter. They finished last season 11-6, losing in the divisional round to the Kansas City Chiefs.

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Bears at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:55 a.m. ET.

  • Moneyline (ML): Bears +125 (bet $100 to win $125) | Bills -150 (bet $150 to win $100)
  • Against the spread (ATS): Bears +2.5 (-110) | Bills -2.5 (-110)
  • Over/Under (O/U): 38.5 (O: -110 | U: -110)

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Bears at Bills picks and predictions

Prediction

Bears 24, Bills 20

Moneyline

We’ve seen the Bears play in the Hall of Fame Game and look competent on offense without their star No. 1 overall pick QB Caleb Williams suiting up. He will see his 1st action in this game in Orchard Park.

Allen and his offense will get around a quarter of action against a Bears defense which allowed Texans QB Davis Mills to put up 17 points in the 1st half. I like the Bills to get up early, but with the combination of Bears QBs Brett Rypien and Tyson Bagent to come back and win it in the 2nd half.

BET BEARS (+125).

Against the spread

I’m not touching a point spread in a preseason game; it’s just too volatile to get reasonable trends. You will continue to see vanilla offenses and defenses.

PASS.

Over/Under

Nine of the 16 games in preseason Week 1 last year had totals of Over 37. The Bears and Texans hit 38 points in a weather-shortened game.

As I mentioned above, Allen should get enough work to put up some points early. I love the fact that Rypien and Bagent are battling for the No. 2 spot on the depth chart, which means they’ll be out there looking to score every drive.

BET OVER 38.5 (-110).

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Tampa Bay Buccaneers at Buffalo Bills odds, picks and predictions

Analyzing Thursday’s Tampa Bay Buccaneers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Tampa Bay Buccaneers (3-3) and Buffalo Bills (4-3) meet for Thursday Night Football in Week 8 at Highmark Stadium. Kickoff is scheduled for 8:15 p.m. ET (Prime Video). Below, we analyze FanDuel Sportsbook’s lines around the Buccaneers vs. Bills odds, and make our expert NFL picks and predictions.

The Buccaneers are coming off a disappointing 16-13 setback at Raymond James Stadium in Tampa against the division rival Atlanta Falcons. The offense has had a power outage in the past 2 games, totaling just 19 points across the past 2 losses, spoiling a tremendous defensive effort.

Tampa has allowed just 18.0 PPG in the past 2 games, and the Bucs are allowing just 17.4 PPG overall, cashing the Under in 5 of 6 outings to date.

The Bills will also be happy to get back in action with a quick turnaround. Buffalo was stunned 29-25 on the road against a bad New England Patriots team. The Bills have dropped 2 of the past 3 games overall, while failing to cash against the spread (ATS) in 3 in a row. The offense has dropped off significantly, averaging just 19.7 PPG in the past 3 games after going for 41.0 PPG in the previous 3 contests.

Tampa hasn’t faced an AFC opponent so far this season. Buffalo is 2-0 straight up (SU) and ATS against the NFC in 2023.

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Buccaneers at Bills odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 5:33 p.m. ET.

  • Moneyline (ML): Buccaneers +320 (bet $100 to win $320) | Bills -405 (bet $405 to win $100)
  • Against the spread (ATS): Buccaneers +8.5 (-110) | Bills -8.5 (-110)
  • Over/Under (O/U): 42.5 (O: -115 | U: -105)

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Buccaneers at Bills key injuries

Buccaneers

  • OG Matt Feiler (knee) out
  • WR Chris Godwin (neck) questionable
  • QB Baker Mayfield (knee) questionable
  • S Kaevon Merriweather (ankle) out
  • DT Vita Vea (groin) questionable

Bills

  • TE Dawson Knox (wrist) out
  • LB Von Miller (knee) available
  • TE Quintin Morris (ankle) out
  • DT Ed Oliver (toe) questionable
  • DT Jordan Phillips (back) available
  • LB Baylon Spector (hamstring) out

Buccaneers at Bills picks and predictions

Prediction

Bills 23, Buccaneers 18

Moneyline

The Bills (-405) will cost you more than 4 times your potential return, and that’s risky business. Yes, Buffalo will be angry after a stunning loss against 1 of the worst teams in the NFL last weekend. However, the Bills offense, which has been struggling lately, faces a stiff test against one of the better defenses in the NFC.

PASS, and focus on the spread instead.

Against the spread

The BUCCANEERS +8.5 (-110) were my initial lean, but Mayfield was limited in practice. If he is ruled out, and backup QB Blaine Gabbert is entrusted with the start, then it’s all-in on the Bills -8.5 (-110). The line is likely to shift dramatically, too. Mayfield could very well be a game-time decision, as he tests his knee in pregame warmups, so be careful.

Over/Under

UNDER 42.5 (-105) is worth playing lightly, but again, be careful.

The Bills defense was dinged for 29 points by a shaky Patriots defense, so even the Bucs could get loose for some points here. That’s not expected, however. And the Bills offense has really had its issues lately, and that isn’t likely to be ironed out on a short week against a very good defensive unit.

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Buffalo Bills at New England Patriots odds, picks and predictions

Analyzing Sunday’s Buffalo Bills at New England Patriots odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (4-2) visit the New England Patriots (1-5) on Sunday. Kick from Gillette Stadium is set for 1 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Bills vs. Patriots odds, and make our expert NFL picks and predictions.

The Bills skidded past the Giants 14-9 last week on Sunday Night Football while failing to cover as 15-point home favorites. QB Josh Allen went 19 of 30 for 169 yards with 2 touchdowns and an interception. His top receiver was WR Stefon Diggs who hauled in 10 receptions for 100 yards while being targeted 16 times. No other Bills receiver had more than 2 receptions and only 2 other receivers had more than a single target.

Last week, the Patriots fell 21-17 to the Raiders while failing to cover as 3-point road underdogs. QB Mac Jones went 24 of 33 for 200 yards and an interception in the loss. Both New England TDs came on the ground with RB Rhamondre Stevenson and RB Ezekiel Elliot each finding the endzone.

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Bills at Patriots odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:58 a.m. ET.

  • Moneyline (ML): Bills -375 (bet $375 to win $100) | Patriots +300 (bet $100 to win $300)
  • Against the spread (ATS): Bills -7.5 (-110) | Patriots +7.5 (-110)
  • Over/Under (O/U): 40 (O: -110 | U: -110)

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Bills at Patriots key injuries

Bills

  • CB Kaiir Elam (ankle) questionable
  • RB Damien Harris (concussion) out
  • DT Ed Oliver (toe) out

Patriots

  • David Andrews (ankle) available
  • Trent Brown (chest) available
  • Kyle Dugger (foot) questionable
  • DT Davon Godchaux (ankle) questionable
  • TE Hunter Henry (ankle) questionable
  • CB Jonathan Jones (knee) questionable
  • Mike Onwenu (ankle) questionable
  • Riley Reiff (knee) out
  • WR JuJu Smith-Schuster (concussion) questionable
  • Cole Strange (knee) questionable
  • LB Josh Uche (knee, foot) out

Bills at Patriots picks and predictions

Prediction

Bills 27, Patriots 10

Moneyline

PASS.

The Bills are so much better than the Patriots that the outcome of the game shouldn’t be a consideration. However, at -375, the Bills aren’t worth a play. Don’t put them in your moneyline parlays either.

Against the spread

BET BILLS -7.5 (-110).

The Bills have been favored in all 6 games so far this season, and they are 0-2 against the spread (ATS) when a double-digit favorite. But, when they are a favorite of 3-9.5, they are 3-1 ATS. The Bills offense scored 38, 37, and 48 in back-to-back weeks before going for 20 in Week 5 and 14 in Week 6. This offense should bounce back.

The opposite can be said of the Pats, who have scored 20 points over the last 3 weeks. There’s no reason to have confidence they can get going here. They are 1-5 ATS and 0-4 ATS as an underdog.

Back BILLS -7.5 (-110).

Over/Under

LEAN UNDER 40 (-110).

The Pats have gone Under in 5 straight games and have scored more than 17 just once this season. They have gone Under in 2 games in which they allowed 34 or more points, so even if the Bills offense bounces back, the total may not top 40.

The Bills are 2-4 O/U and have gone Under in 3 of their last 4 games. They have had a total of Under 45 or lower in 3 games, all of which went Under. Take UNDER 40 (-110).

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New York Giants at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s New York Giants at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The New York Giants (1-4) and Buffalo Bills (3-2) meet Sunday night at Highmark Stadium. Kickoff is scheduled for 8:20 p.m. ET (NBC). Below, we analyze BetMGM Sportsbook’s lines around the Giants vs. Bills odds, and make our expert NFL picks and predictions.

The Giants failed to cover for the 5th straight game last week as they fell 31-16 to the Miami Dolphins. The Under squeaked by, partly due to the Giants’ continued futility on offense. The Giants are last in the NFL with 255.2 yards/game and 2nd-to-last with 12.4 points per game. QB Daniel Jones has already been ruled out, and Tyrod Taylor will be under center. Things could become brighter if RB Saquon Barkley is able to return from his high-ankle sprain.

The Bills, who were -5.5 favorites, were upended by the Jacksonville Jaguars 25-20 last week. The Under cashed as there were just 18 points scored in the first half in London. The Bills are 3-2 ATS on the season but 2-0 at home. WR Stefon Diggs is tied for the NFL lead with 5 touchdowns.

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Giants at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1:29 p.m. ET.

  • Moneyline (ML): Giants +675 (bet $100 to win $675) | Bills -1110 (bet $1,110 to win $100)
  • Against the spread (ATS): Giants +14.5 (-105) | Bills -14.5 (-115)
  • Over/Under (O/U): 44 (O: -110 | U: -110)

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Giants at Bills key injuries

Giants

  • RB Saquon Barkley (ankle) questionable
  • RB Gary Brightwell (ankle) questionable
  • DT D.J. Davidson (knee) questionable
  • QB Daniel Jones (neck) out
  • OG Shane Lemieux (groin)
  • LB Micah McFadden (ankle) questionable
  • OT Evan Neal (ankle) questionable
  • LB Azeez Ojulari (ankle) out
  • OT Matt Peart (shoulder) out
  • C John Michael Schmitz (shoulder) out
  • OT Andrew Thomas (hamstring) out
  • TE Darren Waller (groin) questionable

Bills

  • CB Dane Jackson (foot) questionable
  • TE Dalton Kincaid (concussion) questionable
  • TE Dawson Knox (wrist) questionable

Giants at Bills picks and predictions

Prediction

Bills 27, Giants 10

Moneyline

The Bills come into this one 3rd in the league at 31.8 points per game, and the Giants are decimated by injuries. So this really shouldn’t be a contest. You’d have to have a few too many adult beverages to consider betting -1100 on the Bills, however.

Barkley is questionable, and if he suits up, it’s not unthinkable for the Giants to take a pseudo-home game. PASS on the ML, but I like STEFON DIGGS LONGEST RECEPTION OVER 26.5 (-110). He has catches of 30+ yards in 3 straight games.

Against the spread

The Giants have failed to cover any game this season and have lost the last 3 games by an average of 18 points. Covering this 14.5-point spread is tempting against an inconsistent Bills team, but I just can’t do it until Barkley is ruled out.

PASS.

Over/Under

The Bills are 2-3 O/U this season, and 44 is a staggering number considering the Giants have averaged just 10.33 points per game the last 3 weeks. Buffalo would have to top 30 to hit an Over, and they have done that in their 3 wins and not in their 2 losses. I’ll stay conservative and LEAN UNDER 44 (-110).

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Jacksonville Jaguars vs. Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Jacksonville Jaguars vs. Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Jacksonville Jaguars (2-2) and Buffalo Bills (3-1) meet Sunday at Tottenham Hotspur Stadium in London. Kickoff is set for 9:30 a.m. ET (NFL Network). Below, we analyze FanDuel Sportsbook’s lines around the Jaguars vs. Bills odds, and make our expert NFL picks and predictions.

Jacksonville will be playing its second game in a row in London after defeating Atlanta 23-7 as a 3-point favorite last Sunday. Jacksonville was the home team in the contest which took place at Wembley Stadium. It will be the designated road team against the Bills in this game.

The Bills are coming off 3 wins of at least 28 points. Their most recent was a 48-20 win as 3-point favorites over the Miami Dolphins last Sunday. The win put them in 1st place in the AFC East, heading into London.

After 4 turnovers in Week 1, QB Josh Allen has improved each week. This culminated last Sunday with 21-of-25 passing for 320 yards and 4 TDs. Allen has gotten into MVP form, and this has allowed the Bills to make easy work of recent opponents.

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Jaguars vs. Bills odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:12 p.m. ET.

  • Moneyline (ML): Jaguars +198 (bet $100 to win $198) | Bills -240 (bet $240 to win $100)
  • Against the spread (ATS): Jaguars +5.5 (-110) | Bills -5.5 (-110)
  • Over/Under (O/U): 48.5 (O: -110 | U: -110)

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Jaguars vs. Bills key injuries

Jaguars

  • WR Jamal Agnew (quad) questionable
  • CB Christian Braswell (hamstring) out
  • WR Zay Jones (knee) questionable
  • LB Devin Lloyd (thumb) out

Bills

  • OLB Von Miller (ACL) questionable
  • DE Greg Russo (foot) out
  • CB Tre’Davious White (Achilles) out

Jaguars vs. Bills picks and predictions

Prediction

Bills 31, Jaguars 2

Moneyline

PASS.

Neither side is worth making a wager on. Buffalo is too high at -240 and Jacksonville does not offer enough value at +198.

Against the spread

BET BUFFALO -5.5 (-110).

Buffalo has won its past 3 games by an average of 30 points. In this time, it has only allowed 33 points to its opponents while the offense has failed to score under 37 points.

WR Stefon Diggs and Allen have put any off-season strife behind them, and the connection in the pass game is as strong as ever.

While the injury to White is concerning, Jacksonville is dealing with several injuries at the WR position. This will make it difficult for the Jags to take advantage of the missing All-Pro.

Despite Jacksonville already having played in London and being there for a week, Buffalo is the better team. 5.5 points is not enough, and if the number stays below 7, Buffalo is the side.

Over/Under

BET OVER 48.5 (-110).

While many of the games played in London have gone Under, these games are normally played at Wembley Stadium — a grass field made specifically for soccer. This game will be played at the new Tottenham Hotspur Stadium. A stadium built with input from the NFL to make it more conducive to NFL games. It has a field turf surface and in the 2 matchups it hosted in 2022, both games went Over.

With the offense of Buffalo averaging 41 points in the past 3 games, it could get this game to go Over by itself. But Jacksonville will score a bit as well. This total should be closer to 52. With it being so low, take OVER 48.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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Miami Dolphins at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Miami Dolphins at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Miami Dolphins (3-0) visit the Buffalo Bills (2-1) Sunday at 1 p.m. ET (CBS). Below, we analyze FanDuel Sportsbook’s lines around the Dolphins vs. Bills odds, and make our expert NFL picks and predictions.

The Dolphins are coming off a 70-20 home rout as 6-point favorites vs. the Denver Broncos. After a game in which RBs De’Von Achane and Raheem Mostert each finished with 4 TDs, Miami will find it more difficult going up against a stouter Buffalo defense.

Buffalo is on a 2-game win streak after losing its opener to the New York Jets on Monday night. The Bills are coming off a 37-3 “rocking chair” victory at the Washington Commanders as 5-point favorites.

This is the Bills’ 2nd home game — they beat the Las Vegas Raiders 38-10 as 7.5-point favorites in Week 2.

The Dolphins will be facing their 3rd road game of the young season. A season-opening 36-34 win as 3-point underdogs at the Los Angeles Chargers was followed by a 24-17 divisional win as 1-point favorites at New England.

Miami has proven it can win on the road thus far but hasn’t faced elite teams. The combined record of Miami’s first 3 opponents is just 2-7.

This is an important game for both teams and the NFL landscape. The Bills will be looking to show they’re still the dominant team in the AFC East, while the Dolphins hope to show it belongs among the best teams in the league.

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Dolphins at Bills odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 6:23 p.m. ET.

  • Moneyline (ML): Dolphins +126 (bet $100 to win $126) | Bills -148 (bet $148 to win $100)
  • Against the spread (ATS): Dolphins  +3 (-115) | Bills -3 (-105)
  • Over/Under (O/U): 53.5 (O: -105 | U: -115)

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Dolphins at Bills key injuries

Dolphins

  • OL Terron Armstead (back, ankle, knee) questionable
  • SS DeShon Elliott (ankle, groin) questionable
  • LB Jaelan Phillips (oblique) out
  • C Connor Williams (groin) questionable

Bills

  • S Jordan Poyer (knee) out

Dolphins at Bills picks and predictions

Prediction

Bills 27, Dolphins 21

Moneyline

BUFFALO (-148) is the safer wager to make here.

The Dolphins will finally play a good team in the Bills. We have yet to figure out how good Miami really is. This will be a good barometer to judge.

Playing at home, the Bills will look to assert their dominance over their AFC East Division rivals after the Dolphins just put up 70 on the hapless Broncos.

Backing the Bills -3 (-105) is a better wager, but if you want the safety of not worrying about having to win by at least 3 points, the ML of -148 is not outrageous for Buffalo and would make a good addition to a small parlay.

Against the spread

BUFFALO -3 (-105)  is my play.

Sure, Miami is coming off the impressive 70-point outing, but it came against a lackluster Denver — which yielded 35 points in a 2-point loss to the Commanders in Week 2.

The Dolphins offensive line has been playing better than expected. However, with C Connor Williams and LT Terron Armstead listed on the injury report, the Bills pass rush could be able to harass Miami QB Tua Tagovailoa throughout the day.

While Miami has the offense to compete, the Dolphins defense — with CB Jalen Ramsey (knee) out and CB Xavien Howard aging — will find it challenging to slow down a Bills offense led by QB Josh Allen and WR Stefon Diggs.

Buffalo laying -3 (105) is a surprising number after seeing what Miami did to Denver last week, but it doesn’t scare me away from making this wager. BACK BUFFALO -3 (-105.)

Over/Under

UNDER 53.5 (-115) is the way to go.

The last time a team scored 70 or more points was the 1966 Washington team. In the following game, it won at the Dallas Cowboys 34-31. It also came following a bye week, something the Dolphins don’t have the benefit of.

Buffalo has only allowed 13 points in the past 2 games — 10 to the Las Vegas Raiders and 3 to the Commanders. While Miami’s offense provides a much bigger threat, the Bills defense will slow the Dolphins enough to keep this UNDER 53.5 (-115).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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First look: Miami Dolphins at Buffalo Bills odds and lines

Looking at Sunday’s Miami Dolphins at Buffalo Bills NFL odds, lines and trends. Here’s what you need to know.

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The Miami Dolphins (3-0) and Buffalo Bills (2-1) meet Sunday in a 1 p.m. ET (CBS) kickoff at Highmark Stadium. Below, we look at Dolphins vs. Bills odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

On Sunday, Miami became the 1st team to score 70 points in a single game since 1966. The Dolphins covered a -6 line and cruised to a 70-20 win over the Denver Broncos. Miami is now 3-0 to start a season for the 2nd year in a row.

The Bills covered a -3 line in a 37-3 triumph at the Washington Commanders Sunday. Buffalo now returns home, where it has gone 10-1 across its last 11 regular-season games. An efficient Bills offense — one ranked 4th in the NFL at 5.0 yards per rush and 3rd in pass accuracy with a 72.7% mark — has managed 75 points over the last 2 weeks.

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Dolphins at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 1:40 p.m. ET.

  • Moneyline: Dolphins +125 (bet $100 to win $125) | Bills -150 (bet $150 to win $100)
  • Against the spread (ATS): Dolphins +2.5 (-105) | Bills -2.5 (-115)
  • Over/Under (O/U): 53.5 (O: -115 | U: -105)

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2023 betting stats

  • ML: Dolphins 3-0 | Bills 2-1
  • ATS: Dolphins 3-0 | Bills 2-1
  • O/U: Dolphins 2-1 | Bills 1-2

Dolphins vs. Bills head-to-head

In 114 regular-season games, the Dolphins lead 61–52–1. But the Bills have won 9 of the last 10 meetings and 7 in a row played in Buffalo.

The public has had this meeting ironed out in recent years. Since 2018, the Dolphins are 5-4-1 ATS. The Under is 3-1 across the last 4 meetings.

Play our free daily Pick’em Challenge and win! Play now!

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWireTitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire

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