New York Giants at Buffalo Bills odds, picks and predictions

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The New York Giants (1-4) and Buffalo Bills (3-2) meet Sunday night at Highmark Stadium. Kickoff is scheduled for 8:20 p.m. ET (NBC). Below, we analyze BetMGM Sportsbook’s lines around the Giants vs. Bills odds, and make our expert NFL picks and predictions.

The Giants failed to cover for the 5th straight game last week as they fell 31-16 to the Miami Dolphins. The Under squeaked by, partly due to the Giants’ continued futility on offense. The Giants are last in the NFL with 255.2 yards/game and 2nd-to-last with 12.4 points per game. QB Daniel Jones has already been ruled out, and Tyrod Taylor will be under center. Things could become brighter if RB Saquon Barkley is able to return from his high-ankle sprain.

The Bills, who were -5.5 favorites, were upended by the Jacksonville Jaguars 25-20 last week. The Under cashed as there were just 18 points scored in the first half in London. The Bills are 3-2 ATS on the season but 2-0 at home. WR Stefon Diggs is tied for the NFL lead with 5 touchdowns.

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Giants at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1:29 p.m. ET.

Moneyline (ML): Giants +675 (bet $100 to win $675) | Bills -1110 (bet $1,110 to win $100)
Against the spread (ATS): Giants +14.5 (-105) | Bills -14.5 (-115)
Over/Under (O/U): 44 (O: -110 | U: -110)

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Giants at Bills key injuries

Giants

RB Saquon Barkley (ankle) questionable
RB Gary Brightwell (ankle) questionable
DT D.J. Davidson (knee) questionable
QB Daniel Jones (neck) out
OG Shane Lemieux (groin)
LB Micah McFadden (ankle) questionable
OT Evan Neal (ankle) questionable
LB Azeez Ojulari (ankle) out
OT Matt Peart (shoulder) out
C John Michael Schmitz (shoulder) out
OT Andrew Thomas (hamstring) out
TE Darren Waller (groin) questionable

Bills

CB Dane Jackson (foot) questionable
TE Dalton Kincaid (concussion) questionable
TE Dawson Knox (wrist) questionable

Giants at Bills picks and predictions

Prediction

Bills 27, Giants 10

Moneyline

The Bills come into this one 3rd in the league at 31.8 points per game, and the Giants are decimated by injuries. So this really shouldn’t be a contest. You’d have to have a few too many adult beverages to consider betting -1100 on the Bills, however.

Barkley is questionable, and if he suits up, it’s not unthinkable for the Giants to take a pseudo-home game. PASS on the ML, but I like STEFON DIGGS LONGEST RECEPTION OVER 26.5 (-110). He has catches of 30+ yards in 3 straight games.

Against the spread

The Giants have failed to cover any game this season and have lost the last 3 games by an average of 18 points. Covering this 14.5-point spread is tempting against an inconsistent Bills team, but I just can’t do it until Barkley is ruled out.

PASS.

Over/Under

The Bills are 2-3 O/U this season, and 44 is a staggering number considering the Giants have averaged just 10.33 points per game the last 3 weeks. Buffalo would have to top 30 to hit an Over, and they have done that in their 3 wins and not in their 2 losses. I’ll stay conservative and LEAN UNDER 44 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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