Jaguars Bills odds picks prediction spread over/under betting line

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The Jacksonville Jaguars (2-2) and Buffalo Bills (3-1) meet Sunday at Tottenham Hotspur Stadium in London. Kickoff is set for 9:30 a.m. ET (NFL Network). Below, we analyze FanDuel Sportsbook’s lines around the Jaguars vs. Bills odds, and make our expert NFL picks and predictions.

Jacksonville will be playing its second game in a row in London after defeating Atlanta 23-7 as a 3-point favorite last Sunday. Jacksonville was the home team in the contest which took place at Wembley Stadium. It will be the designated road team against the Bills in this game.

The Bills are coming off 3 wins of at least 28 points. Their most recent was a 48-20 win as 3-point favorites over the Miami Dolphins last Sunday. The win put them in 1st place in the AFC East, heading into London.

After 4 turnovers in Week 1, QB Josh Allen has improved each week. This culminated last Sunday with 21-of-25 passing for 320 yards and 4 TDs. Allen has gotten into MVP form, and this has allowed the Bills to make easy work of recent opponents.

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Jaguars vs. Bills odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:12 p.m. ET.

Moneyline (ML): Jaguars +198 (bet $100 to win $198) | Bills -240 (bet $240 to win $100)
Against the spread (ATS): Jaguars +5.5 (-110) | Bills -5.5 (-110)
Over/Under (O/U): 48.5 (O: -110 | U: -110)

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Jaguars vs. Bills key injuries

Jaguars

WR Jamal Agnew (quad) questionable
CB Christian Braswell (hamstring) out
WR Zay Jones (knee) questionable
LB Devin Lloyd (thumb) out

Bills

OLB Von Miller (ACL) questionable
DE Greg Russo (foot) out
CB Tre’Davious White (Achilles) out

Jaguars vs. Bills picks and predictions

Prediction

Bills 31, Jaguars 2

Moneyline

PASS.

Neither side is worth making a wager on. Buffalo is too high at -240 and Jacksonville does not offer enough value at +198.

Against the spread

BET BUFFALO -5.5 (-110).

Buffalo has won its past 3 games by an average of 30 points. In this time, it has only allowed 33 points to its opponents while the offense has failed to score under 37 points.

WR Stefon Diggs and Allen have put any off-season strife behind them, and the connection in the pass game is as strong as ever.

While the injury to White is concerning, Jacksonville is dealing with several injuries at the WR position. This will make it difficult for the Jags to take advantage of the missing All-Pro.

Despite Jacksonville already having played in London and being there for a week, Buffalo is the better team. 5.5 points is not enough, and if the number stays below 7, Buffalo is the side.

Over/Under

BET OVER 48.5 (-110).

While many of the games played in London have gone Under, these games are normally played at Wembley Stadium — a grass field made specifically for soccer. This game will be played at the new Tottenham Hotspur Stadium. A stadium built with input from the NFL to make it more conducive to NFL games. It has a field turf surface and in the 2 matchups it hosted in 2022, both games went Over.

With the offense of Buffalo averaging 41 points in the past 3 games, it could get this game to go Over by itself. But Jacksonville will score a bit as well. This total should be closer to 52. With it being so low, take OVER 48.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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Tag: Jaguars Bills odds picks prediction spread over/under betting line

Jacksonville Jaguars vs. Buffalo Bills odds, picks and predictions