10 Best College Football Predictions Against The Spread Week 4

10 best predictions and picks against the spread and point totals for the Week 4 college football games.

10 best predictions for the big Saturday of college football. What games appear to be the best bets and best picks for the Week 4 games?

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Results So Far: 28-12-1

1) We’re FINALLY done with most of the FCS vs FBS games. The silly season is over and conference plays kicks in full force, which means …

2) Now we settle in.

Everyone overreacts after Week 1, and then everything is skewed a bit after Week 2. After Week 3 we can pretty much figure out how things are going, and that’s why the theme of the week is this …

Go with what you know until proven otherwise.

For example, I misfired last week by not going with Oklahoma -10.5 over Nebraska. We know Nebraska is bad, and until proven otherwise, the idea is to go against it when the spread is reasonable, like it was against the Sooners. Of course OU won in a walk.

You’ll see what I mean, starting with …

Click on each game for the preview

10. UMass at Temple


Fair warning: there’s a spiteful aspect to this pick.

Rutgers -17 over Temple was my No. 1 call of last week, and it wasn’t even close. Now the Owls owe me.

What do we know, and what did we learn from that disaster? The Temple defense is pretty good.

The offense didn’t do much of anything, but the defense held Rutgers to just over 200 yards, and that was after stuffing Lafayette.

Is there any concern that the Owl O could go off on a UMass defense that gave up 42 to Tulane and 55 to Toledo? Not really, and if it does, it’s not likely to get up to 40 and the defense might be able to take care of the rest.

UMass will score, but it should hang around 10-to-14. This will get dicey late, but this should come in around the high 30s.

Okay, now deep breath as I ditch the theme for this next pick, and we shall never speak of it again …

9. Iowa at Rutgers


I hate this pick.

I hate picking this game, I hate that I feel compelled to add this to the list, and I hate that I’m feeding this to a trusting public that might actually watch this abomination if it invests in it one way or another.

I know, I know, I’ve hammered Iowa unders HARD so far this year, and it’s been a breeze.

How obnoxious have Iowa games been? The total points scored in the three games is 54. You know how hard that is to do?

As my standard line has been this season, you could set the total for an Iowa game at 1.5 and I’d still go under. Ha, ha – we all had a good laugh, killed some time, and …

If the final score in this is 3-2, fine.

A point total of 33.5 is just too obscene. If you take the over and it doesn’t work, it’s not your fault.

Now that I’ve gone off the rails …

8. Virginia at Syracuse


I don’t like this pick either, but for an entirely different reason …

Friday night games are weird.

Everyone’s rhythm is off, there’s a strange vibe, crazy things happen, and they generally fail to follow any logic or reason.

And I know, I don’t have to add this game to the list – just like I didn’t have to put Iowa vs Rutgers on here – but if things go to form and we go with what we know, including it is a moral imperative.

Virginia just doesn’t score.

The Illinois loss got to a total of 27, and the win over Old Dominion last week ended up at 30.

Could the Cavaliers find their mojo and start winging it around like they did in 2021? Yeah, but they haven’t done it yet.

Syracuse hung 48 on the board against UConn, but that’s UConn – Virginia’s D is okay. The Purdue game was a relative shootout that went back-and-forth late, and that only got to 61 and went over on the late TD pass.

This has a far better chance of hanging around the 20s for each team than the 30s.

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7. Tulsa at Ole Miss


I keep waiting for Tulsa’s offensive fever to break, but it’s not happening.

It’s been one of he biggest stunners of the year so far – Tulsa leads the nation in passing after three games.

It’s averaging 413 yards per outing after bombing away on Wyoming, Northern Illinois, and Jacksonville State to get there – no one else is averaging more than 389. The O has needed to crank it up in shootout after shootout, and to be warned, there’s one big concern here.

The Old Miss defense has been outstanding.

It allowed just 13 points in three games, but it hasn’t faced a strong passing game since the 28-10 win over Troy to kick things off.

This has a few things to like. It starts with the Rebel offense finding its groove – it should handle most of the 65.5 on its own. That means Tulsa will keep firing to keep up, there should be a few late points, and something very doable like 40+ish to 20ish should combine to get to 66.

There are more point total picks to come, but until then, going with what we know …

6. Florida Atlantic at Purdue

LINE Purdue -17

It’s scary when things seem this simple.

Florida Atlantic’s defense has been awful against the two decent teams it faced, and it hasn’t dealt with anyone like Purdue yet.

The Owls have a slew of decent things going their way, but they’ve been abysmal against anyone who can throw a forward pass – they were ripped to shreds in the 41-38 loss to Ohio, and were hit for 339 passing yards by UCF in the 40-14 loss.

By the way, Purdue likes to throw.

Everyone is on FAU, and I’m not entirely sure why other than Aidan O’Connell is iffy. Even so, Purdue will throw for 400 yards and score in the 40s.

If you think the Owls have 24ish points in them on the road against a 1-2 Big Ten team that desperately needs a good performance thanks to last second losses to Penn State and Syracuse, okay.

NEXT: College Football Pick Against the Spread No. 5: Utah at Arizona State

College Football Expert Picks, Predictions: Week 4

Week 4 college football expert picks and predictions highlighted by Florida at Tennessee, Wisconsin at Ohio State, and Arkansas at Texas A&M

College football expert picks, predictions for Week 4, including Florida at Tennessee, Wisconsin at Ohio State, and Arkansas at Texas A&M

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* next to the pick means the team will win, but not cover.
Click on each game for the game preview and CFN Prediction

West Virginia at Virginia Tech

Line: West Virginia -2.5, o/u: 50.5

Eric Bolin, RazorbacksWire.com: Virginia Tech
Evan Bredeson, CornhuskersWire.com: Virginia Tech
Tony Cosolo, ColoradoBuffaloesWire.com: West Virginia
Jeff Feyerer, CFN: West Virginia
Pete Fiutak, CFN: West Virginia
Cami Griffin, LonghornsWire.com: West Virginia
Dan Harralson, VolsWire.com: West Virginia
Phil Harrison, BuckeyesWire.com: West Virginia
Jeremy Mauss, MWwire.com Virginia Tech
Kevin McGuire, NittanyLionsWire.com: West Virginia
Big Game Ben Niewoehner, CFN West Virginia
E, CFN West Virginia
Tyler Nettuno, LSUTigerswire.com Virginia Tech
Zack Pearson, TarHeelswire.com West Virginia
Johnny Rosenstein, SportsBookWire.com: Virginia Tech
Nick Shepkowski, FightingIrishWire.com: Virginia Tech
Scott Steehn, WinnersandWhiners.com: Virginia Tech
Joe Vitale, UGAWire.com: West Virginia
Clucko the Chicken (a coin flip), CFN: West Virginia

Week 4 College Football Expert Picks
WVU at Va Tech | Coastal Carolina at Georgia St

Virginia at Syracuse | Nevada at Air Force
Boise State at UTEP | Kent State at Georgia
Maryland at Michigan | Clemson at Wake Forest
Florida at Tennessee | Minnesota vs Michigan St
Texas at Texas Tech | Notre Dame at North Carolina
Oregon at Wash St | Arkansas vs Texas A&M
Vanderbilt at Alabama | Wisconsin at Ohio St

Kansas State at Oklahoma | USC at Oregon St

Wyoming at BYU | Western Michigan at SJSU
Stanford at Washington | Utah at Arizona State

Results So Far | NFL Week 3 Expert Picks

NEXT: Coastal Carolina at Georgia State Expert Picks, Predictions

ACC Predictions, Schedule, Game Previews, Lines, TV: Week 4

ACC schedule and previews for all of the Week 4 games of the 2022 season

ACC schedule and previews for all of the Week 4 games of the 2022 season, highlighted by Virginia at Syracuse, Notre Dame at North Carolina, and Boston College at Florida State

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Click on each game for the preview and prediction

Results So Far
Straight Up 29-7, ATS 17-18-1, o/u 27-8-1 

Thursday, September 22

West Virginia at Virginia Tech

7:30, ESPN
Line: West Virginia -1.5, o/u: 51.5

Friday, September 23

Virginia at Syracuse

7;00, ESPN
Line: Syracuse -9, o/u: 51.5

Saturday, September 24

Clemson at Wake Forest

12:00, ABC
Line: Clemson -7, o/u: 55.5

Rhode Island at Pitt

12:00, ACC Network
Line: TBA, o/u: TBA

Duke at Kansas

12:00, FS1
Line: Kansas -7.5, o/u: 66.5

USF at Louisville

12:00, ESPN3
Line: Louisville -14.5, o/u: 64.5

Middle Tennessee at Miami

3:30, ACC Network
Line: Miami -25.5, o/u: 53.5

Notre Dame at North Carolina

3:30, ABC
Line: North Carolina -1.5, o/u: 53.5

Georgia Tech at UCF

4:00, ESPNU
Line: UCF -20, o/u: 56.5

UConn at NC State

7:30, ESPN3
Line: NC State -39, o/u: 49.5

Boston College at Florida State

8:00, ACC Network
Line: Florida State -17.5, o/u: 48.5

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CFN 1-131 Rankings | Bowl Projections
CFN Week 2 Expert Picks | Week 2 Schedule
NFL Expert Predictions | NFL Predictions
What 12-Team Playoff Would Look Like

Virginia vs Syracuse Prediction, Game Preview

Virginia vs Syracuse game preview, prediction, and breakdown for the Week 4 game on Friday, September 23

Virginia vs Syracuse prediction, game preview, how to watch. Week 4, Friday, September 23

Virginia vs Syracuse How To Watch

Date: Friday, September 23
Game Time: 7:00 ET
Venue: JMA Wireless Dome, Syracuse, NY
How To Watch: ESPN
Record: Virginia (2-1), Syracuse (3-0)
Sign up and live stream college football on ESPN+

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CFN 1-131 Rankings | Bowl Projections
CFN Week 4 Expert Picks | Week 4 Schedule
NFL Expert Predictions | NFL Schedule, Picks
What 12-Team Playoff Would Look Like
Top 10 Coach Hot Seat List: After Week 3
Contact/Follow @ColFootballNews & @PeteFiutak

Virginia vs Syracuse Game Preview

Why Virginia Will Win

The offense hasn’t cranked it up yet.

The parts are there. Brennan Armstrong is a good veteran quarterback who has been just okay, but the explosion isn’t there – there’s more this group can do.

It’s going to show up at some point, but it might not need to if the grinding running game can hit the 240-yard mark like it did in two of the first three games.

On the other side, Syracuse might be 3-0, and it might have a passing game now, but the ground attack that was so devastating last season has been just okay.

The Orange D has been awful on third downs, the 30 penalties in three games are too many, and …

CFN Expert Picks, Week 4

Why Syracuse Will Win

Virginia has a big, BIG problem with turnovers.

The eight giveaways spread out over the first three games have been part of the reason why the offense with all the high-powered talent has stalled.

The O line hasn’t been great, third down conversions have been like pulling teeth, and this isn’t the team to be playing against right now if everything isn’t working.

Syracuse is playing with some serious swag. It came out and rocked Louisville, didn’t panic late against Purdue, and it’s getting a hugely efficient passing year out of Garrett Shrader to do along with the running Sean Tucker, who hasn’t gotten going yet.

It also helps that …

Week 4 Schedule, Predictions, Game Preview

What’s Going To Happen

Zero. That’s how many turnovers the Orange have given up so far.

That’s going to change relatively soon – expect two giveaways in this – but the team isn’t giving teams easy chances, and at the moment, Virginia needs them.

At some point the Cavalier offense will start to roll. Syracuse’s offense, though, will set too high a bar in this.

NFL Expert Picks, Week 3

Virginia vs Syracuse Prediction, Line

Syracuse 27, Virginia 17
Line: Syracuse -9, o/u: 54
ATS Confidence out of 5: 2
Virginia vs Syracuse Must See Rating (out of 5): 3

College coaches all over America this week are raising awareness and research dollars for Duchenne Muscular Dystrophy, a progressive genetic disorder that takes the lives of young men. Fans can donate to Coach To Cure MD online or by texting the word CURE to 501501 to give $25.

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