10 Best College Football Predictions Against The Spread Week 4

10 best predictions and picks against the spread and point totals for the Week 4 college football games.

10 best predictions for the big Saturday of college football. What games appear to be the best bets and best picks for the Week 4 games?


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Week 4: College Week 3: NFL
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Results So Far: 28-12-1

1) We’re FINALLY done with most of the FCS vs FBS games. The silly season is over and conference plays kicks in full force, which means …

2) Now we settle in.

Everyone overreacts after Week 1, and then everything is skewed a bit after Week 2. After Week 3 we can pretty much figure out how things are going, and that’s why the theme of the week is this …

Go with what you know until proven otherwise.

For example, I misfired last week by not going with Oklahoma -10.5 over Nebraska. We know Nebraska is bad, and until proven otherwise, the idea is to go against it when the spread is reasonable, like it was against the Sooners. Of course OU won in a walk.

You’ll see what I mean, starting with …

Click on each game for the preview

10. UMass at Temple

POINT TOTAL 43.5
ATS PICK UNDER

Fair warning: there’s a spiteful aspect to this pick.

Rutgers -17 over Temple was my No. 1 call of last week, and it wasn’t even close. Now the Owls owe me.

What do we know, and what did we learn from that disaster? The Temple defense is pretty good.

The offense didn’t do much of anything, but the defense held Rutgers to just over 200 yards, and that was after stuffing Lafayette.

Is there any concern that the Owl O could go off on a UMass defense that gave up 42 to Tulane and 55 to Toledo? Not really, and if it does, it’s not likely to get up to 40 and the defense might be able to take care of the rest.

UMass will score, but it should hang around 10-to-14. This will get dicey late, but this should come in around the high 30s.

Okay, now deep breath as I ditch the theme for this next pick, and we shall never speak of it again …

9. Iowa at Rutgers

POINT TOTAL 33.5
ATS PICK Over

I hate this pick.

I hate picking this game, I hate that I feel compelled to add this to the list, and I hate that I’m feeding this to a trusting public that might actually watch this abomination if it invests in it one way or another.

I know, I know, I’ve hammered Iowa unders HARD so far this year, and it’s been a breeze.

How obnoxious have Iowa games been? The total points scored in the three games is 54. You know how hard that is to do?

As my standard line has been this season, you could set the total for an Iowa game at 1.5 and I’d still go under. Ha, ha – we all had a good laugh, killed some time, and …

If the final score in this is 3-2, fine.

A point total of 33.5 is just too obscene. If you take the over and it doesn’t work, it’s not your fault.

Now that I’ve gone off the rails …

8. Virginia at Syracuse

POINT TOTAL 55
ATS PICK Under

I don’t like this pick either, but for an entirely different reason …

Friday night games are weird.

Everyone’s rhythm is off, there’s a strange vibe, crazy things happen, and they generally fail to follow any logic or reason.

And I know, I don’t have to add this game to the list – just like I didn’t have to put Iowa vs Rutgers on here – but if things go to form and we go with what we know, including it is a moral imperative.

Virginia just doesn’t score.

The Illinois loss got to a total of 27, and the win over Old Dominion last week ended up at 30.

Could the Cavaliers find their mojo and start winging it around like they did in 2021? Yeah, but they haven’t done it yet.

Syracuse hung 48 on the board against UConn, but that’s UConn – Virginia’s D is okay. The Purdue game was a relative shootout that went back-and-forth late, and that only got to 61 and went over on the late TD pass.

This has a far better chance of hanging around the 20s for each team than the 30s.

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7. Tulsa at Ole Miss

POINT TOTAL 65.5
ATS PICK Over

I keep waiting for Tulsa’s offensive fever to break, but it’s not happening.

It’s been one of he biggest stunners of the year so far – Tulsa leads the nation in passing after three games.

It’s averaging 413 yards per outing after bombing away on Wyoming, Northern Illinois, and Jacksonville State to get there – no one else is averaging more than 389. The O has needed to crank it up in shootout after shootout, and to be warned, there’s one big concern here.

The Old Miss defense has been outstanding.

It allowed just 13 points in three games, but it hasn’t faced a strong passing game since the 28-10 win over Troy to kick things off.

This has a few things to like. It starts with the Rebel offense finding its groove – it should handle most of the 65.5 on its own. That means Tulsa will keep firing to keep up, there should be a few late points, and something very doable like 40+ish to 20ish should combine to get to 66.

There are more point total picks to come, but until then, going with what we know …

6. Florida Atlantic at Purdue

LINE Purdue -17
ATS PICK Purdue

It’s scary when things seem this simple.

Florida Atlantic’s defense has been awful against the two decent teams it faced, and it hasn’t dealt with anyone like Purdue yet.

The Owls have a slew of decent things going their way, but they’ve been abysmal against anyone who can throw a forward pass – they were ripped to shreds in the 41-38 loss to Ohio, and were hit for 339 passing yards by UCF in the 40-14 loss.

By the way, Purdue likes to throw.

Everyone is on FAU, and I’m not entirely sure why other than Aidan O’Connell is iffy. Even so, Purdue will throw for 400 yards and score in the 40s.

If you think the Owls have 24ish points in them on the road against a 1-2 Big Ten team that desperately needs a good performance thanks to last second losses to Penn State and Syracuse, okay.

NEXT: College Football Pick Against the Spread No. 5: Utah at Arizona State

SEC Predictions, Schedule, Game Previews, Lines, TV: Week 4

SEC schedule and previews for all of the Week 4 games of the 2022 season, highlighted by Arkansas vs Texas A&M, Florida at Tennessee, and Missouri at Auburn

SEC schedule and previews for all of the Week 4 games of the 2022 season, highlighted by Arkansas vs Texas A&M, Florida at Tennessee, and Missouri at Auburn


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Click on each game for the preview and prediction

Results So Far
Straight Up 33-8, ATS 23-16, o/u 22-17

Bowling Green at Mississippi State

12:00, SEC Network
Line: Mississippi State -30, o/u: 52.5

Kent State at Georgia

12:00, SEC Network/ESPN+
Line: Georgia -46, o/u: 59

Missouri at Auburn

12:00, ESPN
Line: Auburn -7, o/u: 51

Florida at Tennessee

3:30, CBS
Line: Tennessee -11, o/u: 62.5

Tulsa at Ole Miss

4:00, SEC Network
Line: Ole Miss -21.5, o/u: 65.5

Northern Illinois at Kentucky

7:00, ESPN2
Line: Kentucky -25, o/u: 53.5

Arkansas at Texas A&M

7:00, ESPN
Line: Texas A&M -2.5, o/u: 48.5

Charlotte at South Carolina

7:30, ESPNU
Line: South Carolina -22, o/u: 69.5

New Mexico at LSU

7:30, SEC Network/ESPN+
Line: LSU -30.5, o/u: 45.5

Vanderbilt at Alabama

7:30, SEC Network
Line: Alabama -40.5, o/u: 58.5

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CFN 1-131 Rankings | Bowl Projections
CFN Week 4 Expert Picks | Week 4 Schedule
NFL Expert Predictions | NFL Schedule, Picks

Ole Miss vs Tulsa Prediction, Game Preview

Ole Miss vs Tulsa game preview, prediction, and breakdown for the Week 4 game on Saturday, September 24

Ole Miss vs Tulsa prediction, game preview, how to watch. Week 4, Saturday, September 24


Ole Miss vs Tulsa How To Watch

Date: Saturday, September 24
Game Time: 4:00 ET
Venue: Vaught-Hemingway Stadium, Oxford, MS
How To Watch: SEC Network
Record: Ole Miss (3-0), Tulsa (2-1)
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CFN 1-131 Rankings | Bowl Projections
CFN Week 4 Expert Picks | Week 4 Schedule
NFL Expert Predictions | NFL Schedule, Picks
What 12-Team Playoff Would Look Like
Top 10 Coach Hot Seat List: After Week 3
Contact/Follow @ColFootballNews & @PeteFiutak

Ole Miss vs Tulsa Game Preview

Why Tulsa Will Win

The Golden Hurricane have been a blast so far.

Don’t just blow off that 54-17 win over Jacksonville State. Rich Rodriguez’s team is dangerous, and there wasn’t any problem as Davis Brin and the nation’s No. 1 passing attack went off, and now it all gets to roll against an Ole Miss defense that hasn’t exactly been pushed yet.

Troy has a little bit of an air show, Georgia Tech doesn’t and Central Arkansas is Central Arkansas. Now the Rebel defense has to hold up, the offense has to keep the balance it showed over the first three games, and it’s going to have to do it all while almost never having the ball.

Tulsa – even with its style of offense – can control the clock. Ole Miss doesn’t get about time of possession.

However …

CFN Expert Picks, Week 4

Why Ole Miss Will Win

The Rebel running game has been fantastic.

This is the Lane Kiffin offense that made Matt Corral a big deal and would love to wing it around the yard, but it’s the ground attack that’s ripping everything up.

The Rebels are fifth in the nation in rushing averaging 272 yards per game with 12 touchdowns so far, and now they’re going to rip through a Tulsa defensive front that hasn’t been awful, but is about to give up enough yards to matter.

The Ole Miss O line has been great, the defense has been better so far than it’s been in the Kiffin era, and …

Week 4 Schedule, Predictions, Game Preview

What’s Going To Happen

Get ready to have some fun.

Yeah, Ole Miss has allowed 13 points so far. Yeah, the D line has been great at generating plays behind the line. Yeah, Tulsa has managed to handle the problems on one side with lots of production on the other.

This is going to be a back-and-forth firefight, and Ole Miss has the ability to outlast the other side.

NFL Expert Picks, Week 3

Ole Miss vs Tulsa Prediction, Line

Ole Miss 48, Tulsa 27
Line: Ole Miss -21.5, o/u: 65.5
ATS Confidence out of 5: 2
Ole Miss vs Tulsa Must See Rating (out of 5): 3.5

College coaches all over America this week are raising awareness and research dollars for Duchenne Muscular Dystrophy, a progressive genetic disorder that takes the lives of young men. Fans can donate to Coach To Cure MD online or by texting the word CURE to 501501 to give $25.

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