10 Best College Football Predictions Against The Spread Week 4

10 best predictions and picks against the spread and point totals for the Week 4 college football games.

10 best predictions for the big Saturday of college football. What games appear to be the best bets and best picks for the Week 4 games?


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Results So Far: 28-12-1

1) We’re FINALLY done with most of the FCS vs FBS games. The silly season is over and conference plays kicks in full force, which means …

2) Now we settle in.

Everyone overreacts after Week 1, and then everything is skewed a bit after Week 2. After Week 3 we can pretty much figure out how things are going, and that’s why the theme of the week is this …

Go with what you know until proven otherwise.

For example, I misfired last week by not going with Oklahoma -10.5 over Nebraska. We know Nebraska is bad, and until proven otherwise, the idea is to go against it when the spread is reasonable, like it was against the Sooners. Of course OU won in a walk.

You’ll see what I mean, starting with …

Click on each game for the preview

10. UMass at Temple

POINT TOTAL 43.5
ATS PICK UNDER

Fair warning: there’s a spiteful aspect to this pick.

Rutgers -17 over Temple was my No. 1 call of last week, and it wasn’t even close. Now the Owls owe me.

What do we know, and what did we learn from that disaster? The Temple defense is pretty good.

The offense didn’t do much of anything, but the defense held Rutgers to just over 200 yards, and that was after stuffing Lafayette.

Is there any concern that the Owl O could go off on a UMass defense that gave up 42 to Tulane and 55 to Toledo? Not really, and if it does, it’s not likely to get up to 40 and the defense might be able to take care of the rest.

UMass will score, but it should hang around 10-to-14. This will get dicey late, but this should come in around the high 30s.

Okay, now deep breath as I ditch the theme for this next pick, and we shall never speak of it again …

9. Iowa at Rutgers

POINT TOTAL 33.5
ATS PICK Over

I hate this pick.

I hate picking this game, I hate that I feel compelled to add this to the list, and I hate that I’m feeding this to a trusting public that might actually watch this abomination if it invests in it one way or another.

I know, I know, I’ve hammered Iowa unders HARD so far this year, and it’s been a breeze.

How obnoxious have Iowa games been? The total points scored in the three games is 54. You know how hard that is to do?

As my standard line has been this season, you could set the total for an Iowa game at 1.5 and I’d still go under. Ha, ha – we all had a good laugh, killed some time, and …

If the final score in this is 3-2, fine.

A point total of 33.5 is just too obscene. If you take the over and it doesn’t work, it’s not your fault.

Now that I’ve gone off the rails …

8. Virginia at Syracuse

POINT TOTAL 55
ATS PICK Under

I don’t like this pick either, but for an entirely different reason …

Friday night games are weird.

Everyone’s rhythm is off, there’s a strange vibe, crazy things happen, and they generally fail to follow any logic or reason.

And I know, I don’t have to add this game to the list – just like I didn’t have to put Iowa vs Rutgers on here – but if things go to form and we go with what we know, including it is a moral imperative.

Virginia just doesn’t score.

The Illinois loss got to a total of 27, and the win over Old Dominion last week ended up at 30.

Could the Cavaliers find their mojo and start winging it around like they did in 2021? Yeah, but they haven’t done it yet.

Syracuse hung 48 on the board against UConn, but that’s UConn – Virginia’s D is okay. The Purdue game was a relative shootout that went back-and-forth late, and that only got to 61 and went over on the late TD pass.

This has a far better chance of hanging around the 20s for each team than the 30s.

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7. Tulsa at Ole Miss

POINT TOTAL 65.5
ATS PICK Over

I keep waiting for Tulsa’s offensive fever to break, but it’s not happening.

It’s been one of he biggest stunners of the year so far – Tulsa leads the nation in passing after three games.

It’s averaging 413 yards per outing after bombing away on Wyoming, Northern Illinois, and Jacksonville State to get there – no one else is averaging more than 389. The O has needed to crank it up in shootout after shootout, and to be warned, there’s one big concern here.

The Old Miss defense has been outstanding.

It allowed just 13 points in three games, but it hasn’t faced a strong passing game since the 28-10 win over Troy to kick things off.

This has a few things to like. It starts with the Rebel offense finding its groove – it should handle most of the 65.5 on its own. That means Tulsa will keep firing to keep up, there should be a few late points, and something very doable like 40+ish to 20ish should combine to get to 66.

There are more point total picks to come, but until then, going with what we know …

6. Florida Atlantic at Purdue

LINE Purdue -17
ATS PICK Purdue

It’s scary when things seem this simple.

Florida Atlantic’s defense has been awful against the two decent teams it faced, and it hasn’t dealt with anyone like Purdue yet.

The Owls have a slew of decent things going their way, but they’ve been abysmal against anyone who can throw a forward pass – they were ripped to shreds in the 41-38 loss to Ohio, and were hit for 339 passing yards by UCF in the 40-14 loss.

By the way, Purdue likes to throw.

Everyone is on FAU, and I’m not entirely sure why other than Aidan O’Connell is iffy. Even so, Purdue will throw for 400 yards and score in the 40s.

If you think the Owls have 24ish points in them on the road against a 1-2 Big Ten team that desperately needs a good performance thanks to last second losses to Penn State and Syracuse, okay.

NEXT: College Football Pick Against the Spread No. 5: Utah at Arizona State

Big Ten Predictions, Schedule, Game Previews, Lines, TV: Week 4

Big Ten college football predictions, schedule, game previews, lines and TV listings for Week 4 of the season.

Big Ten college football predictions, schedule, game previews, lines and TV listings for Week 4 of the season.


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Click on each game for the preview and prediction

Results So Far
Straight Up 31-9, ATS 25-14-1, o/u 28-12

Chattanooga at Illinois

8:30, BTN
Line: Illinois -18.5, o/u: 40

Saturday, September 24

Maryland at Michigan

12:00, FOX
Line: Michigan -16.5, o/u: 65.5

Central Michigan at Penn State

12:00, BTN
Line: Penn State -27.5, o/u: 62.5

Indiana at Cincinnati

3:30, ESPN2
Line: Cincinnati -16.5, o/u: 57

Minnesota at Michigan State

3:30, BTN
Line: Minnesota -2.5, o/u: 51

Iowa at Rutgers

7:00, FS1
Line: Iowa -7.5, o/u: 34.5

Wisconsin at Ohio State

7:30, ABC
Line: Ohio State -19, o/u: 57

Miami University at Northwestern

7:30, BTN
Line: Northwestern -7, o/u: 49.5

Florida Atlantic at Purdue

7:30, BTN
Line: Purdue -19, o/u: 61

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Purdue vs Florida Atlantic Prediction, Game Preview

Purdue vs Florida Atlantic game preview, prediction, and breakdown for the Week 4 game on Saturday, September 24

Purdue vs Florida Atlantic prediction, game preview, how to watch. Week 4, Saturday, September 24


Purdue vs Florida Atlantic How To Watch

Date: Saturday, September 24
Game Time: 7:30 ET
Venue: Ross-Ade Stadium, West Lafayette, IN
How To Watch: BTN
Record: Purdue (1-2), Florida Atlantic (2-2)
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CFN Week 4 Expert Picks | Week 4 Schedule
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Purdue vs Florida Atlantic Game Preview

Why Florida Atlantic Will Win

Can the Owls catch Purdue moping?

The Boilermakers were two late pass plays away from being 3-0 – losing to Penn State on a late drive and collapsing against Syracuse last Saturday – and the focus will surely be on the Big Ten date at Minnesota  next week.

Florida Atlantic is going to come in and sling it around. The passing attack went nowhere in the 40-14 loss to UCF, but N’Kosi Perry has had a strong season so far, the offense is moving, and the offensive line is playing just well enough to keep the Boilermakers out of the backfield.

There’s one problem …

CFN Expert Picks, Week 4

Why Purdue Will Win

The Florida Atlantic pass defense has been awful.

It’s giving up 276 yards per game, it’s not picking up passes to make up for it, and that”s just the start of the problems.

No one has been hit with more penalty yards – granted, FAU played four games so far to get to the 295, but the 74 yards per game are still among the most in college football.

FAU has a pass rush, and it doesn’t matter. Aidan O’Connell will take target practice, he’ll spread the ball around with ease, and the best passing attack in the Big Ten will do whatever it wants.

Week 4 Schedule, Predictions, Game Preview

What’s Going To Happen

Can the Owl offense do anything to keep up? Not really.

Purdue might not be razor sharp, but it won’t matter as the offense takes over after a few drives, puts up 350 passing yards without breathing hard, and it gets out with a surprisingly high-scoring win.

There won’t be much drama, but expect plenty of points from both sides.

NFL Expert Picks, Week 3

Purdue vs Florida Atlantic Prediction, Line

Purdue 45, Florida Atlantic 20
Line: Purdue -19, o/u: 61
ATS Confidence out of 5: 4
Purdue vs Florida Atlantic Must See Rating (out of 5): 2

College coaches all over America this week are raising awareness and research dollars for Duchenne Muscular Dystrophy, a progressive genetic disorder that takes the lives of young men. Fans can donate to Coach To Cure MD online or by texting the word CURE to 501501 to give $25.

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