San Francisco 49ers vs. Los Angeles Rams odds lines money line against the spread Over Under

First look: San Francisco 49ers at Los Angeles Rams odds and lines

Looking at Xday’s VFullname at HFullname Week X NFL odds, lines and trends. Here’s what you need to know.

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After blowing out each of their opponents in Week 1, the Los Angeles Rams (1-0) and the San Francisco 49ers (1-0) will square off on Sunday afternoon at SoFi Stadium in Inglewood, Calif. Kickoff is set for 4:05 p.m. ET (FOX). Below, we look at 49ers vs. Rams odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The 49ers crushed the Pittsburgh Steelers on Sunday, cruising to a 30-7 win after jumping out to a 20-0 lead in the 1st half. QB Brock Purdy had 220 yards and 2 TDs, both to WR Brandon Aiyuk.

The Rams also made a statement in the season opener, dominating the Seattle Seahawks in a 30-13 victory. LA allowed just 12 second-half yards to the Seahawks and outscored them 23-0 in the final 30 minutes, showing the defense may be better than expected.

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49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 9:45 a.m. ET.

Moneyline (ML): 49ers -300 (bet $300 to win $100) | Rams +240 (bet $100 to win $240)
Against the spread (ATS): 49ers -7 (-110) | Rams +7 (-110)
Over/Under (O/U): 42.5 (O: -110 | U: -110)

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2023 betting stats

ML: 49ers 1-0 | Rams 1-0
ATS: 49ers 1-0 | Rams 1-0
O/U: 49ers 0-1 | Rams 0-1

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49ers vs. Rams head-to-head

The 49ers and Rams meet twice a year, sometimes 3 times if both make the playoffs. But in the last 4 seasons, the 49ers have owned the Rams in the regular season. The 49ers are 8-0 in their last 8 regular-season games against the Rams, which dates back to the 2019 season.

The Rams have 1 win since then, which came in the NFC Championship Game in January 2022, but the 49ers have had their number in regular-season meetings.

In their last 10 matchups, the 49ers are 8-2 straight-up and ATS while the Under is 6-4. The 49ers have covered the spread in 7 straight games against LA.

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First look: San Francisco 49ers at Los Angeles Rams odds and lines

Looking at Sunday’s San Francisco 49ers at Los Angeles Rams Week 8 NFL odds, lines and trends. Here’s what you need to know.

It’s only Week 8, but the Los Angeles Rams (3-3) and San Francisco 49ers (3-4) will square off for the 2nd time this season Sunday. Kickoff from SoFi Stadium will be at 4:25 p.m. ET (FOX). Below, we look at 49ers vs. Rams odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The 49ers have lost 2 games in a row, falling at the Atlanta Falcons in Week 6 and at home to the Kansas City Chiefs Sunday. The Chiefs made the win look easy, too, winning 44-23 thanks to 30 second-half points. The 49ers acquired RB Christian McCaffrey last week and he played Sunday in a somewhat of a limited role — 8 carries for 38 yards and 2 receptions for 24 yards. Expect him to get more touches against the Rams.

Los Angeles is coming off a bye for this division matchup at home. In the Rams’ last game, they beat the Carolina Panthers 24-10 in L.A. to snap a 2-game losing streak. The Rams lost their first meeting with the 49ers 24-9 back in Week 4 in Santa Clara. Los Angeles ranks 28th in points per game (17.3) this season.

Also see: All Week 8 odds and lines

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49ers at Rams odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 2:30 p.m. ET.

Moneyline (ML): 49ers -135 (bet $135 to win $100) | Rams +110 (bet $100 to win $110)
Against the spread (ATS): 49ers -2.5 (-110) | Rams +2.5 (-110)
Over/Under (O/U): 42.5 (O: -112 | U: -108)

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2022 betting stats

ML: 49ers 3-4 | Rams 3-3
ATS: 49ers 3-4 | Rams 2-4
O/U: 49ers 2-5 | Rams 1-5

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49ers vs. Rams head-to-head

There’s no question which team has owned this rivalry in recent years. The 49ers have won 7 of the last 8 meetings dating back to 2019, including their most recent meeting in Week 4. San Francisco has won 7 straight regular-season meetings, too.

The Rams’ only win against the 49ers in their last 8 attempts was in the NFC title game in January behind a 20-17 victory at home. The 49ers are a perfect 6-0 ATS in the last 6 meetings of this series, with the total going Under in 5 of those 6 games.

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What do the Rams need to do to beat the 49ers for the first time since 2018?

The 49ers have the Rams’ number recently. How can LA change that?

The last thing standing between Matthew Stafford and his first Super Bowl appearance is the San Francisco 49ers. For the Los Angeles Rams, this is a problem.

The Rams haven’t beaten their in-state NFC West rival since 2018. San Francisco is 6-0 against Los Angeles, sweeping the regular season home-and-home series in each of the last three years. The Niners’ dominance in that stretch has taken on several forms. They’ve won low-scoring affairs (20-7 in 2019) and shootouts (34-31 later that season). Most recently, San Francisco punched its playoff ticket by overcoming a 17-0 deficit in a Week 18 overtime win.

That leaves a difficult puzzle for Rams coach Sean McVay to decipher. Los Angeles is a 3.5-point favorite at home, but history suggests his team will fail to live up to those modest expectations. So what does he have to do to stop the surge of a Niners team that’s feasted on opponent’s miscues to rally to the NFC Championship game this winter?

First look: San Francisco 49ers at Los Angeles Rams odds and lines

Looking at Sunday’s San Francisco 49ers at Los Angeles Rams conference championship NFL odds, lines and trends. Here’s what you need to know.

The San Francisco 49ers and Los Angeles Rams battle in the NFC Championship Game with a trip to Super Bowl LVI on the line. Kick-off from SoFi Stadium for the NFC West foes is set for Sunday at 6:30 p.m. ET. Below, we look at the 49ers vs. Rams odds and lines; check back for our NFL picks and predictions.

The 49ers stunned the Green Bay Packers with a 13-10 victory in the Divisional Round Saturday despite not scoring a single offensive touchdown. They won with strong special teams play including a blocked field goal at the end of the first half and a blocked punt that was returned for a touchdown with just under 5 minutes remaining as they capitalized on the Packers’ miscues.

San Francisco has won four games in a row, including three elimination games as underdogs against the Rams, Dallas Cowboys and Packers.

Also see: Conference Championship odds and lines

The Rams pulled off an upset of their own Sunday against the Tampa Bay Buccaneers with a 30-27 road victory. They led 27-3 at one point in the third quarter but allowed the Bucs to score 24 unanswered points to tie the game with 42 seconds remaining.

However, QB Matthew Stafford hit WR Cooper Kupp for a 44-yard gain with 5 seconds left and PK Matt Gay drilled a 30-yard field goal to win it for the Rams. They’ve won back-to-back games since losing to the 49ers in Week 18.

49ers at Rams odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:36 a.m. ET.

Money line: 49ers +145 (bet $100 to win $145) | Rams -180 (bet $180 to win $100)
Against the spread (ATS): 49ers +3.5, -115 (bet $115 to win $100) | Rams -3.5, -105 (bet $105 to win $100)
Over/Under (O/U): 46.5, O: -108 (bet $108 to win $100) | U: -112 (bet $112 to win $100)

Also see: Betting 101

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2021 betting stats:

ML: 49ers 12-7 | Rams 14-5
ATS: 49ers 11-8 | Rams 10-9
O/U: 49ers 8-11 | Rams 10-8-1

49ers at Rams head-to-head

This will be the third meeting between the Rams and 49ers this season. The 49ers won both games in the regular season, including a miraculous overtime victory in Week 18 after erasing a 17-point deficit with an incredible comeback.

The 49ers have now won six games in a row against the Rams, sweeping them the last three seasons. The 49ers are 7-3 straight up and ATS in their last 10 against the Rams.

The Over/Under is split 5-5 in those 10 games but the total has gone Over just once in their last three meetings. San Francisco has had L.A.’s number in recent years, despite often being the underdogs.

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First look: San Francisco 49ers at Los Angels Rams odds and lines

Looking at Sunday’s San Francisco 49ers at Los Angels Rams Week 18 NFL odds, lines and trends. Here’s what you need to know.

The San Francisco 49ers (9-7) visit the Los Angeles Rams (12-4) for a regular-season finale Sunday in Week 18. Kickoff is scheduled for 4:25 p.m. ET at SoFi Stadium. Below, we look at the 49ers vs. Rams odds and lines; check back for our NFL picks and predictions.

San Francisco can clinch its second postseason appearance in three seasons with a win or tie against the Rams or a loss or tie by the New Orleans Saints (8-8), who play at the Atlanta Falcons (7-9) Sunday, also at 4:25 p.m. ET.

The Rams, who already wrapped up a playoff berth, win the NFC West with a win or tie vs. the 49ers or a loss or tie by the Arizona Cardinals (11-5), who host the Seattle Seahawks (6-10) Sunday at 4:25 p.m. ET.

The 49ers beat the visiting Houston Texans 23-7 Sunday. Rookie QB Trey Lance, starting in place of injured QB Jimmy Garoppolo (thumb), threw for 249 yards with 2 second-half touchdowns and the defense tossed a shutout in the second half as the 49ers covered as 14-point favorites.

The Rams rallied for a 20-19 victory at the Baltimore Ravens in Week 17. L.A., which won its fifth in a row, trailed 16-7 with 4:42 to go in the third quarter before scoring 2 touchdowns in the fourth for the win. QB Matthew Stafford and WR Odell Beckham Jr. hooked up for a 7-yard TD pass with 57 seconds to go for the winning score — the Rams missed the ensuing two-point conversion attempt.

Also see: All Week 18 odds and lines

49ers at Rams odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 8 a.m. ET.

Money line: 49ers +190 (bet $100 to win $190) | Rams -240 (bet $240 to win $100)
Against the spread (ATS): 49ers +5.5, -112 (bet $112 to win $100) | Rams -5.5, -108 (bet $108 to win $100)
Over/Under (O/U): 44.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)

Also see: Betting 101

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2021 betting stats:

ML: 49ers 9-7 | Rams 12-4
ATS: 49ers 8-8 | Rams 8-8
O/U: 49ers 7-9 | Rams 8-7-1

49ers at Rams head-to-head

The 49ers lead the all-time series 74-67-3, including 1-0 in the postseason, a 30-3 rout at home in the 1989-90 NFC Championship Game.

San Francisco took the first meeting of the season, cruising to a 31-10 home victory in Week 10 as a 3.5-point underdog.

The 49ers have actually won the last five in this series. They swept both games last season with a 24-16 home win in Week 6 as 2.5-point underdogs and a 23-20 squeaker in Week 12 as 5-point road ‘dogs.

The underdog is 5-0 ATS in the last five, while the Under is 4-1.

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