First look: San Francisco 49ers at Los Angeles Rams odds and lines

Looking at Xday’s VFullname at HFullname Week X NFL odds, lines and trends. Here’s what you need to know.

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After blowing out each of their opponents in Week 1, the Los Angeles Rams (1-0) and the San Francisco 49ers (1-0) will square off on Sunday afternoon at SoFi Stadium in Inglewood, Calif. Kickoff is set for 4:05 p.m. ET (FOX). Below, we look at 49ers vs. Rams odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The 49ers crushed the Pittsburgh Steelers on Sunday, cruising to a 30-7 win after jumping out to a 20-0 lead in the 1st half. QB Brock Purdy had 220 yards and 2 TDs, both to WR Brandon Aiyuk.

The Rams also made a statement in the season opener, dominating the Seattle Seahawks in a 30-13 victory. LA allowed just 12 second-half yards to the Seahawks and outscored them 23-0 in the final 30 minutes, showing the defense may be better than expected.

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49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 9:45 a.m. ET.

  • Moneyline (ML): 49ers -300 (bet $300 to win $100) | Rams +240 (bet $100 to win $240)
  • Against the spread (ATS): 49ers -7 (-110) | Rams +7 (-110)
  • Over/Under (O/U): 42.5 (O: -110 | U: -110)

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2023 betting stats

  • ML: 49ers 1-0 | Rams 1-0
  • ATS: 49ers 1-0 | Rams 1-0
  • O/U: 49ers 0-1 | Rams 0-1

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49ers vs. Rams head-to-head

The 49ers and Rams meet twice a year, sometimes 3 times if both make the playoffs. But in the last 4 seasons, the 49ers have owned the Rams in the regular season. The 49ers are 8-0 in their last 8 regular-season games against the Rams, which dates back to the 2019 season.

The Rams have 1 win since then, which came in the NFC Championship Game in January 2022, but the 49ers have had their number in regular-season meetings.

In their last 10 matchups, the 49ers are 8-2 straight-up and ATS while the Under is 6-4. The 49ers have covered the spread in 7 straight games against LA.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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