San Francisco 49ers betting odds line spread pick predictions best bets – Page 7

San Francisco 49ers at Seattle Seahawks odds, picks and prediction

Analyzing Sunday’s San Francisco 49ers at Seattle Seahawks odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (6-5) are on the road against the Seattle Seahawks (3-8) in Week 13 for a classic NFC West rivalry game. Kickoff is 4:25 p.m. ET at Lumen Field. Below, we look at the 49ers vs. Seahawks odds and lines, and make our best NFL picks, predictions and bets.

The 49ers have won three games in a row and four of their last five. They have scored 30 or more points while averaging 170 rushing yards across the four victories. Their one hiccup in the last five was a 31-17 loss to the Cardinals where they only mustered 39 rushing yards.

The Seahawks are a mess. They have lost three in a row and six of their last seven games. Since QB Russell Wilson returned from injured reserve they have scored a total of 28 points combined in three games. Wilson still has not won a home game this season.

49ers at Seahawks odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 8:30 p.m. ET.

Money line: 49ers -175 (bet $175 to win $100) | Seahawks +140 (bet $100 to win $140)
Against the spread (ATS): 49ers -3.5 (+100) | Seahawks +3.5 (-120)
Over/Under (O/U): 45.5 (O: -108 | U: -112)

49ers at Seahawks key injuries

49ers

LB Dre Greenlaw (groin) out
WR Deebo Samuel (groin) out
RB Trey Sermon (ankle) out
LB Fred Warner (hamstring) doubtful
LB Marcell Harris (concussion) questionable

Seahawks

G Damien Lewis (elbow) doubtful
RB Rashaad Penny (hamstring) questionable
RB Alex Collins (abdomen) questionable
RB Travis Homer (calf) questionable

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49ers at Seahawks odds, lines, predictions and picks

Prediction

Seahawks 24, 49ers 23

Money line

Wilson’s finger injury was supposed to take four to eight weeks to recover and we enter the seventh week since he suffered the injury. It’s been clear that he’s not been 100% in the three games since he’s returned.

However, even with the struggles at home this season, the Seahawks beat the 49ers once this season and have done so 14 of the last 16 times they have played each other.

Rivalry games are always weird. With Samuel out and their linebackers banged up, this is the perfect week for an upset.

Take the SEAHAWKS (+140).

Against the spread

The Seahawks are 5-6 ATS this season but have failed to cover the spread in the three games since Wilson’s return.

The 49ers started the year 1-5 ATS but are 4-1 ATS in their last five games.

However, expecting the outright Seattle win, take the SEAHAWKS +3.5 (-120).

Over/Under

The Seahawks have only had one game this season hit the Over, an overtime game in Week 2.

The 49ers have had four of their last six games go Over the projected total.

This is the game the Seahawks come alive a little.

Take OVER 45.5 (-108).

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Underdog Corner: 3 best NFL picks and predictions for Week 13

Assessing the NFL betting odds and lines for Week 13, with three predictions and picks for the best underdog bets to make.

We were 1-2 here last week in Underdog Corner, hitting on the Miami Dolphins and coming up short with the Indianapolis Colts and Minnesota Vikings.
It was only our third losing week of the season, though, as our against-the-spread record stands at 25-11 (.694). A full 21 of those 25 underdog ATS winners have won outright as well.
That established, it’s on to our three selections for lucky Week 13.

NFL underdog predictions: Week 13

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 4:30 p.m. ET.

New Orleans Saints +4.5 (-110) vs. Dallas Cowboys

The Cowboys still have a two-game lead atop the NFC East but have dropped three of their last four contests and continue to battle COVID issues with head coach Mike McCarthy out for this Thursday night road game.

The struggle also is real for the Saints, who have lost four straight since a Halloween upset of the defending-champion Tampa Bay Buccaneers. But New Orleans’ health fortunes finally appear to be on the upswing with Taysom Hill set to take the reins at quarterback, and stud RB Alvin Kamara likely to play for the first time since Week 9.

Additionally, New Orleans has been one of the league’s best with 12-4 ATS/11-5 SU records as an underdog since 2018, so we’re banking on the SAINTS (+4.5) to keep it close in the Week 13 opener.

Los Angeles Chargers +3.5 (-120) at Cincinnati Bengals

The Bengals have put together back-to-back double-digit wins to move to 7-4. But their other two-game win streaks this season have been followed by losses, and we could easily see that happening again with the whole city still celebrating the Bengals’ first season sweep of the hated Pittsburgh Steelers since 2009.

The up-and-down Chargers, meanwhile, were stymied in a 28-13 road loss to the Denver Broncos on Sunday to fall to 6-5.

The Bolts, though, have performed better as underdog (6-4 ATS) than favorite (7-9) over the last two seasons, so we’ll take CHARGERS (+3.5) catching the field goal-and-the-hook Sunday.

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Seattle Seahawks +3.5 (-120) vs. San Francisco 49ers

These are two NFC West rivals trending in completely different directions with the Niners having won and covered in four of their last five while the 3-8 Seahawks have dropped six of seven since beating the host 49ers 28-21 in Week 4.

But we’re banking on one last stand from Russell Wilson and Co., who have won 13 of the last 15 meetings (10-5 ATS) against San Francisco, who will be without injured do-it-all WR Deebo Samuel in this one.

Take the SEAHAWKS (+3.5) and the points at home.

Also see: All Week 13 odds and lines

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Minnesota Vikings at San Francisco 49ers odds, picks and prediction

Analyzing Sunday’s Minnesota Vikings at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

Two teams that looked dead in the water a couple of weeks ago – the Minnesota Vikings (5-5) and San Francisco 49ers (5-5) – meet up with a potential playoff spot at stake at 4:25 p.m. ET Sunday at Levi’s Stadium. Below, we look at the Vikings vs. 49ers odds and lines, and make our best NFL picks, predictions and bets.

The Vikings haven’t been above .500 all season, but coming off wins over the Chargers and Packers, Minnesota is playing some of its best ball of the season and, as things currently stand, are in possession of the second wild-card spot.

After dropping four straight in late September and October, the 49ers have won two straight in blowout fashion, including a 31-10 upset over the Rams and a 30-10 beatdown of the Jaguars.

The 49ers are the only NFC team other than Minnesota with a record of 5-5, which places San Francisco as the third wild card team.

Also see: All Week 12 odds and lines

Vikings at 49ers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 2:15 p.m. ET.

Money line: Vikings +140 (bet $100 to win $140) | 49ers -175 (bet $175 to win $100)
Against the spread (ATS): Vikings +3.5 (-120) | 49er -3.5 (+100)
Over/Under (O/U): 49.5 (O: -110 | U: -110)

Vikings at 49ers key injuries

Vikings

DE Everson Griffen (personal) out
DT Dalvin Tomlinson (COVID-list) out
S Camryn Bynum (ankle) questionable

49ers

DT Maurice Hurst (calf) doubtful
RB Elijah Mitchell (finger) questionable

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Vikings at 49ers odds, lines, predictions and picks

Prediction

49ers 27, Vikings 24

Money line

The Vikings are really good at keeping games close. Eight of their nine games (including all five of their losses) have come by seven points or less. The 49ers have overcome numerous injuries to win three of their last four by 11, 21 and 20 points.

Like so many Minnesota games, this could come down to the last possession to determine a winner and, while either team could just as easily win, I’m leaning toward a late score that wins it for the 49ERS (-175)

Against the spread

There hasn’t been a blowout loss against the Vikings all season because they’re the only team in the NFL that has had a lead of seven points or more in every game this season. If they can make it 10 in a row, it could set the tone for the game because the 49ers aren’t a team built to erase a big deficit.

That’s why this one should stay close. There are plenty who will take the Vikings straight up. I’m much more comfortable hedging my bet and taking the VIKINGS +3.5 (-120)

Over/Under

The Vikings have scored 27 or more points in their last three games and four of their last five. The 49ers have scored 30 or more in each of their last three wins.

That helps explain why the Over/Under is so high (49.5 points). It’s there for a reason because that is the type of ball both teams are playing.

Take the OVER 49.5 (-110)

Also see: Bet Slippin’ Podcast: NFL Week 12 picks and predictions

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Underdog Corner: 3 best NFL picks and predictions for Week 12

Assessing the NFL betting odds and lines for Week 12, with three predictions and picks for the best underdog bets to make.

NFL point-spread favorites may have wound up winning Week 11, but we were undeterred here in Underdog Corner.
We hit with the Houston Texans and Indianapolis Colts, who both wound up posting double-digit outright road wins, to notch our second straight 2-1 against-the-spread weekend and improve to a very profitable 24-9 (.727) on the season. Additionally, 20 of our 24 underdog covers have wound up winning their games outright.
Now it’s on to Thanksgiving Week and our Week 12 outlook.

NFL underdog predictions: Week 12

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 3:30 p.m. ET.

Indianapolis Colts +3.5 (-125) vs. Tampa Bay Buccaneers

Yep, we’re right back on Indy drawing points again, and that has been a profitable play this year with the Colts owning a 5-2 ATS record as an underdog.

Overall, the Horseshoes are doing just fine as well, winning five of their last six to climb back above .500 at 6-5 and join the AFC’s jumbled playoff race.

Tom Brady and the Bucs throttled the visiting Giants 30-10 Monday night to end a two-game slide, but it has been a different story on the road this season for the defending champs, who are 2-3 SU and 0-5 ATS away from Raymond James Stadium.

Go with the red-hot COLTS (+3.5) catching the field goal plus a hook at home.

Miami Dolphins +2.5 (-108) vs. Carolina Panthers

These are two teams headed in the opposite directions, and the wrong side looks to be favored Sunday in South Beach.

The Dolphins have won and covered in three straight after a 1-7 SU, 2-5 ATS start while the Panthers are 2-6 SU/ATS after winning and covering their first three games.

Miami blitzed Lamar Jackson and the visiting Ravens into defeat two weeks ago and could do the same to Cam Newton and Carolina here. Take the DOLPHINS (+2.5) and the points and hit the Miami money line (+110) as well.

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Minnesota Vikings +3.5 (-117) at San Francisco 49ers

The Vikings are well-seasoned in close games with nine of their 10 contests so far being decided by one score or less, including five by three points or fewer.

Minnesota also is 3-2 SU and 5-0 ATS as an underdog this season.

The Niners, meanwhile, have won and covered in two straight to get back to .500 for the first time since Week 4.

However, San Fran is only 2-9 SU at home and 5-11 ATS as a favorite since the start of the 2020 season, and so the trends definitely peg the VIKINGS (+3.5) as the play here.

Also see: All Week 12 odds and lines

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San Francisco 49ers at Jacksonville Jaguars odds, picks and prediction

Analyzing Sunday’s San Francisco 49ers at Jacksonville Jaguars odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (4-5) face the Jacksonville Jaguars (2-7) on the road Sunday in Week 11. Kickoff is 1 p.m. ET at TIAA Bank Stadium. Below, we look at the 49ers vs. Jaguars odds and lines, and make our best NFL picks, predictions and bets.

The 49ers picked up their first win at Levis Stadium in over a year when they defeated the Los Angeles Rams 31-10 Monday. QB Jimmy Garoppolo threw both his touchdown passes to WR Deebo Samuel who finished with 133 total yards, while S Jimmie Ward returned from injury to intercept two passes, returning one for a touchdown.

The Jaguars lost 23-17 to the Indianapolis Colts in Week 10. QB Trevor Lawrence completed only 16 of 35 passes for 162 yards. The Jaguars have averaged only 11 points per game in their last three contests and Lawrence has not thrown a touchdown pass in consecutive games.

Also see: All Week 11 odds and lines

49ers at Jaguars odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 10 a.m. ET.

Money line: 49ers -290 (bet $290 to win $100) | Jaguars +225 (bet $100 to win $225)
Against the spread (ATS): 49ers -6.5 (-110) | Jaguars +6.5 (-110)
Over/Under (O/U): 45.5 (O: -105 | U: -115)

49ers at Jaguars key injuries

49ers

RB Elijah Mitchell (rib, finger) doubtful
DT Maurice Hurst (calf) out
RB JaMycal Hasty (ankle) out

Jaguars

RB James Robinson (heel, knee) questionable

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49ers at Jaguars odds, lines, predictions and picks

Prediction

49ers 20, Jaguars 16

Money line

The 49ers have been wildly inconsistent. They’ve scored over 30 points in three of their four wins and scored under 20 points in three of their five losses. San Francisco is 3-1 on the road.

The Jaguars have won both of their last “home” games, although one of them was in London, England. However, they continue to struggle on offense and have not scored more than 21 points in any game.

The line is almost not worth a bet on the 49ers, but betting the Jaguars is risky business. San Francisco looked like a team ready to make some noise in the NFC wild-card race last week.

Take the 49ERS (-290).

Against the spread

The 49ers are 3-6 ATS this season but had covered the spread in three of their four wins. They are 2-5 ATS as favorites.

The Jaguars covered the spread in three of their last four games despite their offensive struggles.

Take the JAGUARS +6.5 (-110).

Over/Under

Only two of the Jaguars’ nine games this season have hit the Over, and they’re the only two games that would have gone Over this week’s projected total.

The 49ers have seen three of their last four games go Over the projected total. Two of their four wins went Over the projected total.

Jacksonville’s defense is playing better as of late and their offense still struggles, so take UNDER 45.5 (-115).

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Los Angeles Rams at San Francisco 49ers odds, picks and prediction

Analyzing Monday’s Los Angeles Rams at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Los Angeles Rams (7-2) are on the road to visit the San Francisco 49ers (3-5) for Monday Night Football in Week 10. Kickoff from Levi’s Stadium will be at 8:15 p.m. ET. Below, we look at the Rams vs. 49ers odds and lines, and make our best NFL picks, predictions and bets.

The Rams are coming off their second loss of the season as they fell to the Tennessee Titans at home in lopsided fashion last Sunday night. The Rams had won four in a row coming into that game, all by at least nine points, but the Titans gave the Rams offense a lot of trouble and held them to only 16 points.

The 49ers have had a really disappointing season up to this point, dropping five of their last six games after starting the year 2-0. They were crushed 31-17 by the Arizona Cardinals in Week 9 despite the Cards being without both QB Kyler Murray and WR DeAndre Hopkins. QB Jimmy Garoppolo remains the starter but the 49ers are only 17th in scoring this season.

Rams at 49ers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 8:35 a.m. ET.

Money line: Rams -190 (bet $190 to win $100) | 49ers +155 (bet $100 to win $155)
Against the spread (ATS): Rams -3.5 (-108) | 49ers +3.5 (-112)
Over/Under (O/U): 50.5 (O: -108 | U: -112)

Rams at 49ers key injuries

Rams

WR Robert Woods (knee) out
C Brian Allen (elbow) questionable
OLB Von Miller (ankle) questionable
CB Darious Williams (ankle) questionable
WR Ben Skowronek (thigh) questionable

49ers

DT Maurice Hurst (calf) out
DB Jimmie Ward (quad) questionable
CB Josh Norman (rib) questionable
S Tavon Wilson (foot) out
RB JaMycal Hasty (ankle) out

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Rams at 49ers odds, lines, predictions and picks

Prediction

Rams 31, 49ers 21

Money line

The 49ers are trending in the wrong direction, and fast. Their only wins have come against the Detroit Lions, Philadelphia Eagles and Chicago Bears, while also losing last week to the Murray-less Cardinals. The Rams looked out of sorts against the Titans but don’t expect another performance like that from the offensive line tonight.

So long as the Rams can contain WR Deebo Samuel and keep DE Nick Bosa off of QB Matthew Stafford, they’ll win this game.

Bet the RAMS (-190) to win outright.

Against the spread

The 49ers are a paltry 2-6 against the spread this season and have only covered once in their last six games. The Rams have lost their last four games to the 49ers but Robert Saleh is no longer in San Francisco and he was a thorn in Sean McVay’s side, so I expect a better offensive performance tonight.

The Rams will bounce back from last week’s loss to the Titans and get off to a strong start against the 49ers. Bet the RAMS -3.5 (-108) to cover.

Over/Under

The Over has been a solid pick for both of these teams this season. The total has gone Over five times for each team and with the Rams offense playing well all year, I think it’s a good bet again on Monday night.

Seeing as the Over has hit in each of the 49ers’ last four games and in five of the Rams’ nine contests this year, I like the OVER 50.5 (-108).

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Arizona Cardinals at San Francisco 49ers odds, picks and prediction

Analyzing Sunday’s Arizona Cardinals at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (7-1) will face the San Francisco 49ers (3-4) for the second time this season. After facing one another in Arizona in Week 5, they take their matchup to Santa Clara. Kick-off for Sunday’s game is 4:25 p.m. ET at Levi’s Stadium. Below, we look at the Cardinals vs. 49ers odds and lines, and make our best NFL picks, predictions and bets.

The Cardinals hope to rebound from their first defeat of the season, a 24-21 loss to the Green Bay Packers. QB Kyler Murray nearly led them to a game-winning 99-yard touchdown drive but threw an end-zone interception with 12 seconds left in the game.

The 49ers snapped a four-game losing streak in Week 8 with a 33-22 win over the Chicago Bears.

In his second game back from injury, QB Jimmy Garoppolo passed for 322 yards and rushed for a pair of touchdowns, and they got 137 rushing yards and a score from RB Elijah Mitchell.

Cardinals at 49ers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 11:15 p.m. ET.

Money line: Cardinals +135 (bet $100 to win $135) | 49ers -170 (bet $170 to win $100)
Against the spread (ATS): Cardinals +3.5 (-125) | 49ers -3.5 (+102)
Over/Under (O/U): 44.5 (O: -115 | U: -105)

Cardinals at 49ers key injuries

Cardinals

DE J.J. Watt (shoulder) out
DT Rashard Lawrence (calf) out
WR A.J. Green (COVID-19) doubtful
QB Kyler Murray (ankle) questionable
WR DeAndre Hopkins (hamstring) questionable

49ers

S Jimmie Ward (quadriceps) out
RB Elijah Mitchell (rib) questionable
WR Deebo Samuel (calf) questionable
DE Dee Ford (back, concussion) questionable

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Cardinals at 49ers odds, lines, predictions and picks

Prediction

Cardinals 20, 49ers 16

Money line

The Cardinals defeated the 49ers 17-10 in Week 5. The Cardinals have the No. 4-ranked scoring offense and also allow the fourth-fewest points in the league.

Potentially looking at a game without their starting quarterback and top receiver, the defense will have to carry the offense unless Murray is able to play. He will be a game-time decision.

The 49ers will get back TE George Kittle but could be without their leading receiver and rusher, so it will come down to which defense is better.

Arizona’s defense is better.

Take the CARDINALS (+135).

Against the spread

The Cardinals are 6-2 ATS this season and a perfect 4-0 ATS on the road. This is only the second time they have been underdogs this season, although they began the week favored this week.

The 49ers are 2-5 ATS and 0-3 ATS at home.

Expecting the outright Cardinals victory, you can take them with points to spare. Take the CARDINALS +3.5 (-125).

Over/Under

While the Cardinals average 30.8 points per game, only three of their games this season have gone Over the projected total.

With the Cardinals possibly going without Murray, Hopkins and Green, they will have to slow the game down, while the defense will continue to play at a high level.

Take UNDER 44.5 (-108).

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San Francisco 49ers at Chicago Bears odds, picks and prediction

Analyzing Sunday’s San Francisco 49ers at Chicago Bears odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (2-4) come off their bye to face the Chicago Bears (3-4) on the road in Week 8. They kick off their game Sunday at 1 p.m. ET at Soldier Field. Below, we look at the 49ers vs. Bears odds and lines, and make our best NFL picks, predictions and bets.

The 49ers have lost four straight games after a 2-0 start. They have struggled to take care of the football as they have turned the ball over nine times in the four losses. They have been inconsistent offensively, twice gaining more than 440 yards and twice gaining fewer than 300.

The Bears have lost their last two games and have struggled offensively. They rank 30th in the NFL averaging just 14.4 points per game. Rookie QB Justin Fields has thrown only two touchdown passes and has six interceptions.

49ers at Bears odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 10:30 a.m. ET.

Money line: 49ers -205 (bet $205 to win $100) | Bears +165 (bet $100 to win $165)
Against the spread (ATS): 49ers -3.5 (-112) | Bears +3.5 (-108)
Over/Under (O/U): 39.5 (O: -108 | U: -112)

49ers at Bears key injuries

49ers

DE Dee Ford (concussion) doubtful
LT Trent Williams (ankle, elbow) questionable
S Jaquiski Tartt (knee) out

Bears

OLB Khalil Mack (foot) out
S Tashaun Gipson (hip) questionable
DL Akiem Hicks (groin) questionable

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49ers at Bears odds, lines, predictions and picks

Prediction

49ers 24, Bears 17

Money line

The 49ers should win this game. Their defense has questions against the pass, but Fields has not been able to exploit anyone. The Bears offense struggles. They have scored 14 or fewer points in four of their seven games. They have four games with fewer than 280 total yards.

The 49ers have had time to prepare an offensive plan with their Week 7 bye and the 49ers are 24-11 when QB Jimmy Garoppolo starts in his career.

Take the 49ERS (-205).

Against the spread

Only the Washington Football Team has a worse record against the spread than the 49ers’ 1-5 ATS mark.

The Bears, even with their offensive struggles, are 3-4 ATS this season.

However, with a fairly even spread on both sides.

I know there isn’t a lot of love for Garoppolo, but he does give the 49ers a better shot of winning.

Take the 49ERS -3.5 (-112).

Over/Under

Six of the Bears’ seven games have stayed Under the projected total.

The 49ers are 3-3 O/U this season.

I expect the 49ers to play better than they did last week and for the Bears to continue to struggle to score points.

This is the lowest O/U total in the league this week. Take OVER 39.5 (-108).

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Indianapolis Colts at San Francisco 49ers odds, picks and predictions: Player prop bets

Analyzing the Indianapolis Colts at San Francisco 49ers Week 7 matchup and offering up expert picks and predictions on the top player prop bets.

The Indianapolis Colts (2-4) stop by Levi’s Stadium to play the San Francisco 49ers (2-3) on Sunday Night Football in Week 7. Kickoff is scheduled for 8:20 p.m. ET. Below, we look at the Colts vs. 49ers prop bet odds and lines, and make our best NFL picks, predictions and bets.

Indy handled business last weekend by crushing the Houston Texans 31-3 as 11.5-point home favorites. Colts RB Jonathan Taylor rushed for 145 yards on just 14 carries with two rushing TDs. QB Carson Wentz completed 11-of-20 passes for 223 yards and a 2 TD:0 INT ratio.

San Francisco had a bye Week 6 and announced earlier this week QB Jimmy Garoppolo will be starting vs. the Colts Sunday after rookie QB Trey Lance was ruled out with a knee injury.

Colts at 49ers prop bet picks and predictions

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 7:30 a.m. ET.

49ers RB Elijah Mitchell UNDER 62.5 rushing yards (-118)

If San Francisco’s offense is going to have success on Sunday Night Football then it’ll most likely have to come through the passing game.

According to Football Outsiders, Indy’s defense has the best rushing DVOA in the NFL and the Colts have played against formidable ground games. In fact, three of Indy’s opponents are in the top-10 of offensive rushing DVOA: Seattle Seahawks, Tennesee Titans and Baltimore Ravens.

Furthermore, the Colts give up the third-fewest fantasy points per game to opposing running backs and the 10th-fewest yards per rush. Also, Indy’s defense has two top-tier players in its front seven, including former 49ers DT DeForest Buckner and LB Darius Leonard.

On top of that, Mitchell’s rushing prop is bloated in the first place. Mitchell is a rookie dealing with injuries and has only played in three games, one of which he ran for more than 62.5 yards.

The team that Mitchell gained more than 62.5 rushing yards against was the Detroit Lions, who are ranked 26th by Football Outsiders in defensive rushing DVOA.

Colts RB Jonathan Taylor Anytime Touchdown scorer (-105)

After failing to hit paydirt in his first three games, Taylor has scored five combined TDs in the last three contests. The difference in my opinion between Taylor’s production early and lately is Wentz getting comfy in his new surroundings and realizing Taylor is his best skill position player.

Moreover, Indy announced this week that WR T.Y. Hilton is sidelined with an injury for this game and the weather forecast is predicting a rainy, windy night in San Francisco.

Wentz having fewer receiving options combined with Taylor having the second-most receiving yards for the Colts and the weather conditions grounding both teams’ aerial attacks equals more Taylor reps in this game.

At nearly even money, I love the value in Jonathan Taylor‘s Anytime Touchdown prop (-105).

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

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Indianapolis Colts at San Francisco 49ers odds, picks and prediction

Analyzing Sunday’s Indianapolis Colts at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Indianapolis Colts (2-4) will take on the rested San Francisco 49ers (2-3) on the road in the featured Sunday night game in Week 7. kickoff is 8:20 p.m. ET at Levi’s Stadium. Below, we look at the Colts vs. 49ers odds and lines, and make our best NFL picks, predictions and bets.

The Colts, after losing their first three games of the season, have won two of their last three, and the one loss was in overtime against the Baltimore Ravens. They have scored at least 25 points in three straight games. QB Carson Wentz is heating up after dealing injuries to both ankles. He now has nine touchdown passes and only one interception this season, and RB Jonathan Taylor is averaging 5.4 yards per carry for 472 yards and four scores through six games.

The 49ers won their first two games of the season, only to drop their next three. They are coming off their bye week and get QB Jimmy Garoppolo back in the starting lineup after Trey Lance made his first NFL start in Week 5 in a 17-10 loss to the Arizona Cardinals.

Colts at 49ers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 9:00 a.m. ET.

Money line: Colts +155 (bet $100 to win $155) | 49ers -190 (bet $190 to win $100)
Against the spread (ATS): Colts +3.5 (-110) | 49ers -3.5 (-110)
Over/Under (O/U): 42.5 (O: -112 | U: -108)

Colts at 49ers key injuries

Colts

OL Braden Smith (thumb, foot) out
CB Rock Ya-Sin (ankle) out
S Julian Blackmon (Achilles) out
WR T.Y. Hilton (quad) questionable

49ers

QB Trey Lance (knee) out
DT Javon Kinlaw (knee) out
LT Trent Williams (elbow, ankle) doubtful
LB Marcell Harris (thumb) questionable

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Colts at 49ers odds, lines, predictions and picks

Prediction

49ers 27, Colts 21

Money line

The 49ers are just a different team with Garoppolo in the lineup. They are 24-10 in the regular season when he starts, and the one time he was healthy for a full season, he took them to the Super Bowl. Their defensive front will give Wentz problems.

Plus, coming off the bye, the 49ers have had extra time to prep and are playing at home, although they are 0-2 there this season.

Take the 49ERS (-190).

Against the spread

The Colts are 4-2 ATS this season, while the 49ers are 1-4 ATS. However, the 49ers are physical up front defensively, while the Colts will be missing one of their starting interior linemen, which will challenge the Colts’ rushing attack.

The 49ers will apply pressure to Wentz and Garoppolo, if he doesn’t get hurt again, keeps the 49ers offense on schedule.

Take the 49ERS -3.5 (-110).

Over/Under

With the Colts having scored 25 points or more in each of their last three games and the 49ers showing the ability to put points on the board – 41 against the Lions and 28 against the Packers, we can expect to see some points.

It won’t be a shootout in the 30s, but we can expect both teams to be in the 20s this weekend. Take OVER 42.5 (-112).

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

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