Underdog Corner: 3 best NFL picks and predictions for Week 12

Assessing the NFL betting odds and lines for Week 12, with three predictions and picks for the best underdog bets to make.

NFL point-spread favorites may have wound up winning Week 11, but we were undeterred here in Underdog Corner.
We hit with the Houston Texans and Indianapolis Colts, who both wound up posting double-digit outright road wins, to notch our second straight 2-1 against-the-spread weekend and improve to a very profitable 24-9 (.727) on the season. Additionally, 20 of our 24 underdog covers have wound up winning their games outright.
Now it’s on to Thanksgiving Week and our Week 12 outlook.

NFL underdog predictions: Week 12

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 3:30 p.m. ET.

Indianapolis Colts +3.5 (-125) vs. Tampa Bay Buccaneers

Yep, we’re right back on Indy drawing points again, and that has been a profitable play this year with the Colts owning a 5-2 ATS record as an underdog.

Overall, the Horseshoes are doing just fine as well, winning five of their last six to climb back above .500 at 6-5 and join the AFC’s jumbled playoff race.

Tom Brady and the Bucs throttled the visiting Giants 30-10 Monday night to end a two-game slide, but it has been a different story on the road this season for the defending champs, who are 2-3 SU and 0-5 ATS away from Raymond James Stadium.

Go with the red-hot COLTS (+3.5) catching the field goal plus a hook at home.

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Miami Dolphins +2.5 (-108) vs. Carolina Panthers

These are two teams headed in the opposite directions, and the wrong side looks to be favored Sunday in South Beach.

The Dolphins have won and covered in three straight after a 1-7 SU, 2-5 ATS start while the Panthers are 2-6 SU/ATS after winning and covering their first three games.

Miami blitzed Lamar Jackson and the visiting Ravens into defeat two weeks ago and could do the same to Cam Newton and Carolina here. Take the DOLPHINS (+2.5) and the points and hit the Miami money line (+110) as well.

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Minnesota Vikings +3.5 (-117) at San Francisco 49ers

The Vikings are well-seasoned in close games with nine of their 10 contests so far being decided by one score or less, including five by three points or fewer.

Minnesota also is 3-2 SU and 5-0 ATS as an underdog this season.

The Niners, meanwhile, have won and covered in two straight to get back to .500 for the first time since Week 4.

However, San Fran is only 2-9 SU at home and 5-11 ATS as a favorite since the start of the 2020 season, and so the trends definitely peg the VIKINGS (+3.5) as the play here.

Also see: All Week 12 odds and lines

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