The Arizona Cardinals (7-1) will face the San Francisco 49ers (3-4) for the second time this season. After facing one another in Arizona in Week 5, they take their matchup to Santa Clara. Kick-off for Sunday’s game is 4:25 p.m. ET at Levi’s Stadium. Below, we look at the Cardinals vs. 49ers odds and lines, and make our best NFL picks, predictions and bets.
The Cardinals hope to rebound from their first defeat of the season, a 24-21 loss to the Green Bay Packers. QB Kyler Murray nearly led them to a game-winning 99-yard touchdown drive but threw an end-zone interception with 12 seconds left in the game.
The 49ers snapped a four-game losing streak in Week 8 with a 33-22 win over the Chicago Bears.
In his second game back from injury, QB Jimmy Garoppolo passed for 322 yards and rushed for a pair of touchdowns, and they got 137 rushing yards and a score from RB Elijah Mitchell.
Cardinals at 49ers odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 11:15 p.m. ET.
- Money line: Cardinals +135 (bet $100 to win $135) | 49ers -170 (bet $170 to win $100)
- Against the spread (ATS): Cardinals +3.5 (-125) | 49ers -3.5 (+102)
- Over/Under (O/U): 44.5 (O: -115 | U: -105)
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Cardinals at 49ers key injuries
Cardinals
- DE J.J. Watt (shoulder) out
- DT Rashard Lawrence (calf) out
- WR A.J. Green (COVID-19) doubtful
- QB Kyler Murray (ankle) questionable
- WR DeAndre Hopkins (hamstring) questionable
49ers
- S Jimmie Ward (quadriceps) out
- RB Elijah Mitchell (rib) questionable
- WR Deebo Samuel (calf) questionable
- DE Dee Ford (back, concussion) questionable
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Cardinals at 49ers odds, lines, predictions and picks
Prediction
Cardinals 20, 49ers 16
Money line
The Cardinals defeated the 49ers 17-10 in Week 5. The Cardinals have the No. 4-ranked scoring offense and also allow the fourth-fewest points in the league.
Potentially looking at a game without their starting quarterback and top receiver, the defense will have to carry the offense unless Murray is able to play. He will be a game-time decision.
The 49ers will get back TE George Kittle but could be without their leading receiver and rusher, so it will come down to which defense is better.
Arizona’s defense is better.
Take the CARDINALS (+135).
Against the spread
The Cardinals are 6-2 ATS this season and a perfect 4-0 ATS on the road. This is only the second time they have been underdogs this season, although they began the week favored this week.
The 49ers are 2-5 ATS and 0-3 ATS at home.
Expecting the outright Cardinals victory, you can take them with points to spare. Take the CARDINALS +3.5 (-125).
Over/Under
While the Cardinals average 30.8 points per game, only three of their games this season have gone Over the projected total.
With the Cardinals possibly going without Murray, Hopkins and Green, they will have to slow the game down, while the defense will continue to play at a high level.
Take UNDER 44.5 (-108).
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