San Francisco 49ers betting odds line spread pick predictions best bets – Page 2

Arizona Cardinals at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

[gambcom-standard rankid=”4141″ ]

The Arizona Cardinals (1-3) are on the road in Week 5 to face the San Francisco 49ers (2-2). Kickoff from Levi’s Stadium is at 4:05 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Cardinals vs 49ers odds, and make our expert NFL picks and predictions.

The Cardinals have lost 2 straight and are coming off their worst loss in the last 2 seasons, falling 42-14 at home to the Washington Commanders as 3.5-point favorites.

The Niners completely dominated the New England Patriots in a 30-13 home win, covering the 10.5-points spread as favorites, and sacking the Patriots 6 times.

Play our free daily Pick’em Challenge and win! Play now!

Cardinals at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 11:36 p.m. ET.

Moneyline (ML): Cardinals +280 (bet $100 to win $280) | 49ers -350 (bet $350 to win $100)
Against the spread (ATS): Cardinals +7 (-105) | 49ers -7 (-115)
Over/Under (O/U): 49 (O: -110 | U: -110)

WIN YOUR FANTASY FOOTBALL LEAGUE!
The Huddle has been turning players like you into winners for over 25 years. This season, it’s your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Save 25% off the Internet’s best-kept secret. Subscribe now!

[gambcom-standard rankid=”4132″ ]

Cardinals at 49ers key injuries

Cardinals

OL Kelvin Beachum (hamstring) questionable
TE Trey McBride (ribs) questionable
K Matt Prater (knee) questionable
DL Khyiris Tonga (knee) questionable
CB Garrett Williams (groin) out

49ers

WR Chris Conley (oblique) doubtful
WR Jacob Cowing (shoulder) questionable
DT Kalia Davis (knee) questionable
LB Demetrius Flannigan-Fowles (calf) out
DL Yetur Gross-Matos (knee) out
TE George Kittle (ribs) questionable
LB Fred Warner (ankle) questionable
CB Isaac Yiadom (thigh) questionable

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

Cardinals at 49ers picks and predictions

Prediction

49ers 31, Cardinals 27

Moneyline

In 2023, when the Cardinals lost 37-14 to the LA Rams, they bounced back with an outright road win the following week. Otherwise, they have been consistently competitive.

The 49ers have the league’s No. 2 rusher in RB Jordan Mason and the Cardinals struggle to stop the run, allowing 130 yards to the Bills, 187 to the Lions and 216 to Washington last week.

The Cardinals also struggle on 3rd down, allowing opponents to convert 45.5% of the time, and the Niners are 7th in 3rd-down offense at 44.7%.

It’s a bad matchup for Arizona, but don’t be the Niners on the M/L at that price (-350).

PASS.

Against the spread

Both teams are 2-2 ATS. The Cardinals are 0-2 ATS in their last 2 games. But the 49ers allow opponents to convert on 46% of their 3rd downs and are very average against the run (4.1 yards per attempt allowed), which will allow the Cardinals to keep up offensively.

BET CARDINALS +7 (-105).

Over/Under

The Over is 3-1 in both the Cardinals’ and the 49ers’ 1st 4 games this season.

Their last 3 meetings have had over 49 points.

The Niners have scored at least 30 twice this season and the Cardinals have allowed over 30 twice.

BET OVER 49 (-110).

[gambcom-standard rankid=”6305″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

New England Patriots at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s New England Patriots at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

[gambcom-standard rankid=”4141″ ]

The New England Patriots (1-2) visit the San Francisco 49ers (1-2) Sunday. Kickoff from Levi’s Stadium is scheduled for 4:05 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Patriots vs. 49ers odds, and make our expert NFL picks and predictions.

After winning their first game of the season, the Patriots have dropped 2 straight. They lost 24-3 as 6.5-point underdogs at the New York Jets Sept. 19. QB Jacoby Brissett went 12 of 18 for 98 yards before getting pulled for QB Drake Maye, who went 4 of 8 for 22 yards. New England had just 78 yards on the ground in the loss.

The 49ers have also dropped back-to-back games after winning their opener. They lost 27-24 as 6.5-point favorites at the LA Rams in Week 3. QB Brock Purdy went 22 of 30 for 292 yards with 3 touchdowns, all to WR Jauan Jennings who had 11 receptions for 175 yards.

Play our free daily Pick’em Challenge and win! Play now!

Patriots at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 1:35 p.m. ET.

Moneyline (ML): Patriots +425 (bet $100 to win $425) | 49ers -600 (bet $600 to win $100)
Against the spread (ATS): Patriots +10.5 (-110) | 49ers -10.5 (-110)
Over/Under (O/U): 40.5 (O: -110 | U: -110)

[gambcom-standard rankid=”4132″ ]

Patriots at 49ers key injuries

Patriots

CB Alex Austin (ankle) out
LB Anfernee Jennings (shoulder) questionable
CB Jonathan Jones (shoulder) questionable
G Mike Jordan (ankle) out
T Vederian Lowe (knee) out
G Sidy Sow (ankle) questionable
T Caedan Wallace (knee) questionable

49ers

DT Jordan Elliott (foot) questionable
LB Dre Greenlaw (Achilles) out
DT Javon Hargrave (triceps) out
S Talanoa Hufanga (ankle) questionable
RB Christian McCaffrey (Achilles) out
WR Deebo Samuel Sr. (calf) questionable
T Trent Williams (illness, toe) questionable

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

Patriots at 49ers picks and predictions

Prediction

49ers 31, Patriots 13

Moneyline

PASS.

There is no value on the 49ers (-600) to win Sunday.

Against the spread

BET 49ERS -10.5 (-110).

While underdogs have fared well both outright and ATS this season, that will not be the case in this matchup. The Niners found a lot of success last week against the Rams, leading by as many as 14 points before a 4th-quarter collapse. Against the Patriots, expect San Francisco to get back on track with a statement win.

Over/Under

BET OVER 40.5 (-110).

The 49ers will have to carry a majority of the load in order for the Over to hit. They have scored 24 or more points in 2 of 3 games this season and allowed 19 or more in all 3. With many players returning from injury this week, Purdy will have more targets and opportunities to put the ball in the end zone against a weak New England defense.

[gambcom-standard rankid=”6305″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow @seth_orlemann on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

San Francisco 49ers at LA Rams odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at LA Rams odds and lines, with expert NFL picks and predictions.

[gambcom-standard rankid=”3011″ ]

The San Francisco 49ers (1-1) are visiting the LA Rams (0-2) on Sunday afternoon in a rivalry game between NFC West foes. Kickoff from SoFi Stadium in Inglewood, Calif., is set for 4:25 p.m. ET (FOX).

Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Rams odds, and make our expert NFL picks and predictions.

The 49ers are coming off a shocking 23-17 loss to the Minnesota Vikings in Week 2, a game in which they were 4-point road favorites. RB Christian McCaffrey remains out with Achilles tendinitis, and WR Deebo Samuel will also miss this game with a calf injury.

The Rams are 0-2 for the 1st time under coach Sean McVay, with their most recent loss being a 41-10 defeat at the hands of the Arizona Cardinals. They’re arguably the most injured team in the NFL right now, missing WRs Cooper Kupp and Puka Nacua, starting linemen Jonah Jackson and Steve Avila, as well as S John Johnson III, among others.

Play our free daily Pick’em Challenge and win! Play now!

49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Friday at 6:54 p.m. ET.

Moneyline (ML): 49ers -300 (bet $300 to win $100) | Rams +240 (bet $100 to win $240)
Against the spread (ATS): 49ers -6.5 (-115) | Rams +6.5 (-105)
Over/Under (O/U): 43.5 (O: -105 | U: -115)

[gambcom-standard rankid=”3012″ ]

49ers at Rams key injuries

49ers

DE Nick Bosa (rib) probable
S Talanoa Hufanga (knee) probable
TE George Kittle (hamstring) questionable
RB Christian McCaffrey (Achilles) out
WR Deebo Samuel (calf) out
CB Charvarius Ward (hamstring/knee) questionable
LB Dee Winters (ankle) probable

Rams

OL Steve Avila (knee) out
OL Kevin Dotson (foot) probable
CB Cobie Durant (toe) probable
OL Jonah Jackson (shoulder) out
S John Johnson III (shoulder) out
WR Cooper Kupp (ankle) out
WR Puka Nacua (knee) out
CB Darious Williams (hamstring) out

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

49ers at Rams picks and predictions

Prediction

49ers 27, Rams 17

Moneyline

The 49ers are heavily favored in this game, though the ML has come down slightly to -300 after it opened at -375 on Monday. Either way, it’s not worth taking the 49ers to win outright at that number. Even with San Francisco winning 9 of the last 10 regular-season meetings against the Rams, that line is far too juiced to bet.

PASS on the ML.

Against the spread

The Rams looked completely overmatched against the Cardinals, and on paper, the 49ers are a way better team than Arizona. Injuries could be a slight concern for San Francisco in this game, but not as worrisome as the Rams’ decimated roster.

The Rams can’t stop the run and for San Francisco, that’s what’s been working best on offense with RB Jordan Mason posting back-to-back 100-yard games to open the year. The 49ers should be able to control time of possession and limit the opportunities for Los Angeles’ offense in this one.

BET 49ERS -6.5 (-115).

Over/Under

The total has dropped from 44.5 to 43.5, which is a key number. With the 49ers’ ability to run the ball and the Rams’ banged-up offense that’s missing Kupp and Nacua, this could be a lower-scoring game than we’re used to seeing from these rivals.

PASS on the total at 43.5, but if it moves back to 44.5, LEAN UNDER. The Rams could struggle to move the ball and San Francisco could shorten the game with its rushing attack.

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow @camdasilva on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

San Francisco 49ers at Minnesota Vikings odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Minnesota Vikings odds and lines, with expert NFL picks and predictions.

[gambcom-standard rankid=”3011″ ]

The Minnesota Vikings (1-0) welcome the San Francisco 49ers (1-0) to U.S. Bank Stadium Sunday. Kickoff is set for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Vikings odds, and make our expert NFL picks and predictions.

The Vikings clobbered the New York Giants on the road in Week 1, winning 28-6 and covering as 1-point favorites. In its Week 1 battle, RB Aaron Jones led the way with 94 rushing yards and a TD on 14 carries. Former top-5 pick QB Sam Darnold ended with 208 yards, 2 TDs and an INT.

The 49ers beat up the visiting New York Jets 32-19 in Week 1 action, covering as 3.5-point favorites. They used a 13-0 second quarter to pull away in the Monday Night Football showdown. The 49ers were led by RB Jordan Mason, who rushed for 147 yards and a score on 28 carries — RB Christian McCaffrey was a late scratch.

Play our free daily Pick’em Challenge and win! Play now!

49ers at Vikings odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Friday at 9:05 p.m. ET.

Moneyline (ML): 49ers -225 (bet $225 to win $100) | Vikings +185 (bet $100 to win $185)
Against the spread (ATS): 49ers -4.5 (-110) | Vikings +4.5 (-110)
Over/Under (O/U): 46.5 (O: -110 | U: -110)

[gambcom-standard rankid=”3012″ ]

49ers at Vikings key injuries

Vikings

WR Jordan Addison (ankle) out
TE T.J. Hockenson (knee) out
QB J.J. McCarthy (knee) out
T Brian O’Neill (elbow) questionable
S Harrison Smith (hip) questionable

49ers

S Talanoa Hufanga (knee) doubtful
RB Christian McCaffrey (calf) out
WR Ricky Pearsall (chest/shoulder) out

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

49ers at Vikings picks and predictions

Prediction

49ers 28, Vikings 23

Moneyline

PASS.

The 49ers (-225) are a well-coached, well-oiled machine and should be able to come out on top; however, they are too expensive to take on the moneyline.

Against the spread

BET 49ERS -4.5 (-110).

The Vikings throttled the Giants, who could be the worst team in the NFL. Darnold still had an interception and hasn’t proven he can consistently perform without turning the ball over. The 49ers have one of the best offensive lines in the NFL and should be able to find traction against a weak Vikings defensive line.

The 49ers went for over 220 rushing yards in Week 1 and are taking on a front ranked as the 30th-best unit in the NFL by PFF.com. Expect San Francisco to enforce its will in the trenches and ultimately cover. Both teams are entering 1-0 ATS.

Take 49ERS -4.5 (-110).

Over/Under

BET OVER 46.5 (-110).

There are playmakers on both sides of the ball that should do just that Sunday. The Vikings have a few superstars in Jones and WR Justin Jefferson, who both scored against the Giants. While Darnold isn’t great, he is serviceable and should be able to find his weapons.

The 49ers put up 32 points on one of the best defenses in the NFL and have the firepower to do that against a weaker Vikings side. Minnesota is 0-1 O/U due to the Giants putting up just 6 points. The 49ers are 1-0 O/U and were 12-8 O/U last season with a similar roster.

Take OVER 46.5 (-110).

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow @nathanbeighle_ on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

New York Jets at San Francisco 49ers odds, picks and predictions

Analyzing Monday’s New York Jets at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

[gambcom-standard rankid=”3011″ ]

The New York Jets and San Francisco 49ers open their regular seasons Monday at Levi’s Stadium in Santa Clara, Calif. Kickoff is scheduled for 8:20 p.m. ET (ESPN/ABC/ESPN+). Below, we analyze FanDuel Sportsbook’s lines around the Jets vs. 49ers odds, and make our expert NFL picks and predictions.

The Jets open the season on Monday Night Football for the 2nd consecutive season. They hope to have their QB Aaron Rodgers around for much longer this time around. Rodgers was acquired last offseason from the Green Bay Packers, but he lasted just 4 plays in Week 1 last season before rupturing his Achilles’ tendon.

The 49ers had the contract saga with WR Brandon Aiyuk, but the 2 sides came to an agreement for the receiver to remain in San Francisco. The off-the-field news made some forget that this still is the defending NFC champions, and they came within a whisker of winning it all.

New York went 3-2 straight up (SU) against the NFC in 2023, but it was just 1-3-1 against the spread (ATS) in those games. The Under had a slight 3-2 edge in the 5 games, too.

Not counting the Super Bowl, San Francisco was 2-3 SU and ATS in 5 games against AFC opponents in the 2023-24 season, and the total was 2-2-1 in those outings.

Play to win $5K: USA TODAY NFL Survivor pool!

Jets at 49ers odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 4:22 p.m. ET.

Moneyline (ML): Jets +176 (bet $100 to win $176) | 49ers -210 (bet $210 to win $100)
Against the spread (ATS): Jets +3.5 (-105) | 49ers -3.5 (-115)
Over/Under (O/U): 43.5 (O: -110 | U: -110)

[gambcom-standard rankid=”3012″ ]

Jets at 49ers key injuries

Jets

LB Zaire Barnes (ankle) out
OG Wes Schweitzer (hand) out

49ers

OG Aaron Banks (finger) questionable
S Talanoa Hufanga (knee) doubtful
DE Yetur Gross-Matos (knee) out
RB Christian McCaffrey (Achilles’, calf) questionable
LB Dee Winters (ankle) out

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

Jets at 49ers picks and predictions

Prediction

49ers 26, Jets 20

Moneyline

The 49ers (-210) are a little too expensive for a standalone wager, costing 2 times your potential return. However, if you were to include San Francisco as part of your multi-leg parlay, it isn’t priced out of line.

AVOID.

Against the spread

The 49ERS -3.5 (-115) are a strong play, but before you finalize your play, make sure RB Christian McCaffrey (Achilles’, calf) is officially active. If CMC were unable to go, it would change the complexion of this game dramatically, as he is not only a huge part of the run game, but he has soft hands out of the backfield, too.

All indications are that McCaffrey will be ready to go, but he missed the bulk of training camp and all of the preseason with a strained calf. The Achilles’ addition to the injury report is a little more alarming.

If McCaffrey is inactive, the Jets +3.5 (-105) would then be the play.

Over/Under

OVER 43.5 (-110) is the play, whether or not McCaffrey is unable to go. The 49ers have a solid core of receivers to move the chains either way. For the Jets, we’ll get a look at the offense with Rodgers, hopefully longer than a handful of plays. While now 40 years old, Rodgers still has plenty left in the tank, and with RB Breece Hall and WR Garrett Wilson, this could be a dangerous offense.

Play our free daily Pick’em Challenge and win! Play now!

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Kevin J. Erickson on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

San Francisco 49ers at Las Vegas Raiders odds, picks and predictions

Analyzing Friday’s San Francisco 49ers at Las Vegas Raiders odds and lines, with expert NFL picks and predictions.

[gambcom-standard rankid=”3011″ ]

The San Francisco 49ers and Las Vegas Raiders close out their preseasons Friday. Kickoff from Allegiant Stadium is at 10 p.m. ET (NFL Network). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Raiders odds, and make our expert NFL picks and predictions.

The 49ers have split their 2 preseason contests, losing 17-13 at the Tennessee Titans and then beating the visiting New Orleans Saints 16-10 Sunday.

The Raiders lost 24-23 at the Minnesota Vikings in their preseason opener and then lost 27-12 to the visiting Dallas Cowboys Saturday.

Play to win $5K: USA TODAY NFL Survivor pool!

49ers at Raiders odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:15 a.m. ET.

Moneyline (ML): 49ers -350 (bet $350 to win $100) | Raiders +260 (bet $100 to win $260)
Against the spread (ATS): 49ers -7.5 (-105) | Raiders +7.5 (-115)
Over/Under (O/U): 32.5 (O: -115 | U: -105)

[gambcom-standard rankid=”3012″ ]

49ers at Raiders picks and predictions

Prediction

Raiders 17, 49ers 13

Moneyline

The 49ers starters will play briefly. The Raiders won’t play any starters, so the Niners could jump out to a lead early.

However, the Niners have scored 29 combined points in 2 games.

That said, the only way to bet the preseason is to bet the plus odds on the moneyline underdog. Preseason is too hard to predict with back-of-roster players, practice-squadders, and guys who won’t be in the NFL in Sept. playing in the 2nd half of these games.

BET RAIDERS (+260).

Against the spread

The Raiders have lost by 1 point and by 15.

The Niners have a 4-point loss and a 6-point win.

But I say never bet the spread in the preseason. There is too much volatility and unreliability to make an informed bet.

PASS.

Over/Under

You have 2 conflicting things going on here.

The Raiders have allowed no fewer than 24 points in the preseason. The Niners haven’t scored more than 16. Neither of San Francisco’s games surpassed 30 points.

The Raiders have had 2 games with totals of at least 39.

BET UNDER 32.5 (-110).

Play our free daily Pick’em Challenge and win! Play now!

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

New Orleans Saints at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s New Orleans Saints at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

[gambcom-standard rankid=”3011″ ]

The San Francisco 49ers (0-1) welcome the New Orleans Saints (1-0) to Levi’s Stadium Sunday. Kickoff is set for 8 p.m. ET (FOX). Below, we analyze FanDuel Sportsbook’s lines around the Saints vs. 49ers odds, and make our expert NFL picks and predictions.

The 49ers, among the best teams in the NFL over the last few seasons, lost its preseason opener to the Tennessee Titans 17-13. Backup QB Joshua Dobbs passed for 146 yards and an INT. First-round draft pick WR Ricky Pearsall didn’t have a catch in the 1st preseason game.

New Orleans won its preseason opener 16-14 over the Arizona Cardinals. Starting QB Derek Carr went 2-of-6 for 12 yards.

Saints at 49ers odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:38 a.m. ET.

Moneyline (ML): Saints +100 (bet $100 to win $100) | 49ers -120 (bet $120 to win $100)
Against the spread (ATS): Saints +1.5 (-110) | 49ers -1.5 (-110)
Over/Under (O/U): 38.5 (O: -115 | U: -105)

[gambcom-standard rankid=”3012″ ]

Saints at 49ers picks and predictions

Prediction

49ers 20, Saints 17

Moneyline

BET 49ERS (-120).

The 49ers being in front of their own fans should help. The better case here is the fact the starters may get a few series which should result in points, and the backups are experienced quarterbacks in Dobbs and QB Brandon Allen.

The Saints backups are more of a wild card in QB Spencer Rattler. New Orleans may have beaten Arizona, but they were 5-of-15 on 3rd down and committed 9 penalties. Those shortcomings will be tough to overcome against San Francisco.

Given those preseason issues for New Orleans, take 49ERS (-120).

Against the spread

PASS.

Given how similar the spread and moneyline are, avoid the added risk and take the home team’s moneyline play. While not a bad option for bettors, avoid this play and look above.

Over/Under

BET UNDER 38.5 (-105).

Neither team’s 2nd unit looked overly impressive in their 1st outing. The Saints gained just 286 total yards and were not great in sustaining drives.

The 49ers scored just 13 points, and their QBs combined to go 21-of-33. San Francisco was just 4-for-11 on 3rd down as well and 0-for-2 on 4th down.

Both teams held their opponent to 17 or fewer. Given those trends, take UNDER 38.5 (-105).

Play our free daily Pick’em Challenge and win! Play now!

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow @nathanbeighle_ on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

San Francisco 49ers at Tennessee Titans odds, picks and predictions

Analyzing Saturday’s San Francisco 49ers at Tennessee Titans odds and lines, with expert NFL picks and predictions.

[gambcom-standard rankid=”3011″ ]

The San Francisco 49ers visit the Tennessee Titans as both teams open the preseason. Kickoff from Nissan Stadium is set for 7 p.m. ET (NFL+). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Titans odds, and make our expert NFL picks and predictions.

San Francisco finished atop the NFC West last year with a 12-5 record en route to a Super Bowl appearance, where the Niners lost 25-22 in OT to the Kansas City Chiefs. The 49ers are in a standoff with WR Brandon Aiyuk, the team’s leading receiver last year, who is demanding a trade.

Tennessee ended last year with a 6-11 record, finishing in last place in the AFC South. The Titans drafted OT JC Latham with the 7th overall pick in the draft. The Titans lost RB Derrick Henry to the Baltimore Ravens in free agency.

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

49ers at Titans odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 6:33 p.m. ET.

Moneyline (ML) 49ers +200 (bet $100 to win $200) | Titans -250 (bet $250 to win $100)
Against the spread (ATS): 49ers +5.5 (-110) | Titans -5.5 (-110)
Over/Under (O/U): 38.5 (O: -110 | U: -110)

[gambcom-standard rankid=”3012″ ]

49ers at Titans picks and predictions

Prediction

Titans 21, 49ers 10

Moneyline

PASS.

I like the Titans to pick up the win and cover as -250 favorites, but this heavy of a favorite is never worth the risk of betting on. Bet on the spread and/or total instead.

Against the spread

LEAN TITANS -5.5 (-110).

The Titans have expressed that most starters will play in a few drives in this game, which should give Tennessee enough of an edge to cover here when the backups take the reins.

This is a lean because neither team has great backups and because there are always unknowns in the preseason, especially with a team like Tennessee that has so many young guys.

Over/Under

BET UNDER 38.5 (-110).

Both squads are known for having very stout defensive units, and with both teams having backup QBs who have never done much in the NFL, the defenses should shine here.

With coach Mike Vrabelout the door for Tennessee, this defense may be slightly worse, but the pieces are still in place for me to have faith in this unit for this outing.

Play our free daily Pick’em Challenge and win! Play now!

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow @payton_shanks on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

Cincinnati Bengals at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Cincinnati Bengals at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

[gambcom-standard rankid=”3011″ ]

The San Francisco 49ers (5-2) welcome the Cincinnati Bengals (3-3) to Levi’s Stadium Sunday. Kickoff is set for 4:25 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Bengals vs. 49ers odds, and make our expert NFL picks and predictions.

The 49ers lost to the Minnesota Vikings 22-17 in Week 7, failing to cover as 6.5-point road favorites. San Fran has lost 2 straight games yet is 3-0 straight up and against the spread (ATS) at home. The 49ers will be without star WR Deebo Samuel. They are led by RB Christian McCaffrey, who has 11 total touchdowns on the season.

The Bengals are riding a 2-game winning streak and are coming off their bye. In Week 6, Cincinnati beat the Seattle Seahawks 17-13 at home, covering as a 3-point home favorite. It has covered in 2 straight games and is 2-3-1 ATS this season. WR Ja’Marr Chase has been the most lethal weapon for Cincinnati, totaling 556 receiving yards through 6 games.

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

Bengals at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 3:19 p.m. ET.

Moneyline (ML): Bengals +185 (bet $100 to win $185) | 49ers -225 (bet $225 to win $100)
Against the spread (ATS): Bengals +5.5 (-115) | 49ers -5.5 (-105)
Over/Under (O/U): 43.5 (O: -110 | U: -110)

[gambcom-standard rankid=”3012″ ]

Bengals at 49ers key injuries

Bengals

LB Akeem Davis-Gaither (knee) out

49ers

WR Deebo Samuel (shoulder) out
OT Trent Williams (ankle) questionable

Bengals at 49ers picks and predictions

Prediction

49ers 23, Bengals 20

Moneyline

PASS.

The 49ers have been too good at home to suggest they won’t be able to come out on top. However, they are the more banged-up side and could struggle given those injuries.

Against the spread

BET BENGALS +5.5 (-115).

The 49ers just haven’t looked like the dominant San Fran team most have been used to. The absence of Samuel is a reason why, as is the injury to Williams. Even if Williams plays, he may not be 100%, and that could loom large. The 49ers have failed to cover as 8.5-point favorites and 6.5-point favorites over the last 2 weeks, both straight-up losses as well.

The Bengals are healthy and coming off a bye. QB Joe Burrow suffered from a calf strain in the preseason which lingered and impacted his ability. He had the 2nd-most touchdowns last season and has just 7 through 6 games. Expect his health to propel the Bengals here.

Take BENGALS +5.5 (-115).

Over/Under

LEAN UNDER 43.5 (-110).

The 49ers are 3-3-1 O/U this season and 0-1-1 O/U in their last 2 games. They have scored 17 in each of the last 2 weeks after scoring 30 or more in their first 5 games of the season.

The offense has stalled, and without Samuel and with an injured Williams, that may continue. The Bengals defensive line is their strength, and it should be able to get after QB Brock Purdy.

The Bengals are 2-4 O/U and 1-3 O/U in their last 4 games. They have scored more than 20 points in just 1 of their last 4 games. Against an elite defense, they could again have issues getting in the end zone.

Take UNDER 43.5 (-110).

Play our free daily Pick’em Challenge and win! Play now!

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow @nathanbeighle_ on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

San Francisco 49ers at Minnesota Vikings odds, picks and predictions

Analyzing Monday’s San Francisco 49ers at Minnesota Vikings odds and lines, with expert NFL picks and predictions.

[gambcom-standard rankid=”3011″ ]

The San Francisco 49ers (5-1) face the Minnesota Vikings (2-4) at 8:15 p.m. ET Monday at U.S. Bank Stadium (ABC/ESPN). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Vikings odds, and make our expert NFL picks and predictions.

After scoring 30 or more points in each of their first 5 games, the 49ers were shut down by the Browns 19-17 on Oct. 15 in the worst game of QB Brock Purdy‘s career. He completed just 12 of 27 passes for 125 yards with 1 touchdown and 1 interception. The 49ers are 4-2 against the spread (ATS).

The Vikings kept hope alive for their season with a 19-13 win over the Chicago Bears. The Vikings defense knocked Bears QB Justin Fields out of the game and needed a defensive touchdown from LB Jordan Hicks to lock down the win and improve Minnesota to 2-3-1 ATS.

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

49ers at Vikings odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 10:13 p.m. ET.

Moneyline (ML): 49ers -300 (bet $300 to win $100) | Vikings +240 (bet $100 to win $240)
Against the spread (ATS): 49ers -7 (-105) | Vikings +7 (-115)
Over/Under (O/U): 43 (O: -110 | U: -110)

[gambcom-standard rankid=”3012″ ]

49ers at Vikings key injuries

49ers

LB Dre Greenlaw (hamstring) questionable
RB Christian McCaffrey (oblique) questionable
WR Deebo Samuel (shoulder) out
OT Trent Williams (ankle) doubtful

Vikings

G Ezra Cleveland (foot) out

49ers at Vikings picks and predictions

Prediction

49ers 31, Vikings 17

Moneyline

PASS.

The 49ers should win this one with relative ease — even if their injured stars don’t play or are limited. But a 1:3 ratio for return on investment is too steep a price to pay.

Against the spread

TAKE 49ERS -7 (-105).

The 49ers are the best team in the NFC and can dominate on both sides of the ball. The Vikings and QB Kirk Cousins have struggled badly in prime-time games, and without Justin Jefferson, the team is without its most dynamic player.

The 49ers are capable of blowing the doors off the Vikings, even if McCaffrey is out or limited. The Vikings are among the worst teams in the league in terms of turnovers (13), and the 49ers lead the league in giveaway/takeaway ratio (plus-8). That’s a bad combination for the Vikings.

Over/Under

TAKE OVER 43 (-110).

The 49ers have scored 30 or more points in 5 of 6 games and have a good chance of doing that against Minnesota’s risk-taking, blitz-happy defense. Big plays will be available to the 49ers offense if the line can pick up Minnesota’s blitzes.

San Francisco has outscored its opponents 41-6 in the 1st quarter this season and 106-54 in the 1st half. If the Vikings get behind, they will become 1-dimensional and could end up passing 40 or more times. That should help give them enough points to do their part to get this score Over.

Play our free daily Pick’em Challenge and win! Play now!

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]