Denver Broncos vs. New York Giants odds predictions pick betting line spread

NFL Week 1 Can’t-Miss Parlay: 3 bets you can count on

Assessing the 3 best parlay bet options for Week 1 of the 2021 NFL season. Lock-in these wagers to maximize your payday.

The 2021 NFL season got off to a flying start Thursday night as Tom Brady and the defending-champion Tampa Bay Buccaneers outduel Dak Prescott and the Dallas Cowboys.

Even if you missed on the Cowboys cover or the over, which flew past the total in the third quarter, there remain plenty of other prime Week 1 wagering opportunities with 15 games remaining. Here’s a three-leg, can’t-miss parlay to give your NFL bankroll an opening-week boost …

Also see: Week 1 best bets

NFL can’t miss parlay: Week 1

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 8:05 a.m. ET.

Leg 1: San Francisco 49ers -8.5 (-110) at Detroit Lions

At 6-10 in 2020, the Niners only won one more game than the Lions, but the franchises have been moving in opposite directions ever since. Head coach Kyle Shanahan’s crew in San Francisco has almost all of its primary players, including QB Jimmy Garoppolo, TE George Kittle and defensive standout Nick Bosa back and healthy after enduring the league’s worst injury situation in 2020.

They’ve also added some intriguing new pieces in rookie QB Trey Lance and RB Trey Sermon, making Shanahan’s daunting offensive schemes even more dangerous and unpredictable heading into Week 1’s clean slate.

The Lions, meanwhile, downgraded quarterbacks in trading longtime starter Matthew Stafford for Jared Goff, questionably handed over the squad to a quirky and unproven head coach in Dan Campbell and didn’t do nearly enough to shore up a defense that was scorched for the most average points (32.4) and total yards (419.8) per game in 2020.

Take the reinvigorated 49ERS and don’t fret over laying the 8.5 points on the road.

Also see: 49ers-Lions picks and predictions

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Leg 2: Miami Dolphins at New England Patriots UNDER 43.5 (-110)

Two young quarterbacks, including Pats rookie Mac Jones making his first start.

Two coaching staffs who know each other very well, including Patriots-defensive-coordinator-turned-Dolphins-head-coach Brian Flores.

Two above-average defenses, including the reinforced and revitalized Pats.

Two 2020 matchups that produced totals of 32 and 34 points.

We’re going with the UNDER 43.5 (-110).

Also see: Dolphins-Patriots picks and predictions

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Leg 3: Denver Broncos -3.5 (+105) at New York Giants

Both teams finished among the league’s bottom 12 a season ago, but the Broncos look to have made the most significant offseason strides.

The Giants’ injury-wracked offense, featuring turnover-prone QB Daniel Jones and one of the league’s worst offensive lines, looks to be overmatched against an improved Denver D returning Von Miller and featuring what looks to be one of the league’s elite secondaries.

So, if new QB Teddy Bridgewater can just bring a steady hand to the team’s talented young offense, the BRONCOS shouldn’t have too much trouble covering a road spread of 3.5 points (-135).

Also see: Broncos-Giants picks and predictions

Total parlay payout

Bet $100 to win $647.14

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Denver Broncos at New York Giants odds, picks and prediction

Analyzing the Week 1 Denver Broncos at New York Giants odds and lines, with expert NFL picks, predictions and best bets.

The Denver Broncos and New York Giants meet Sunday at MetLife Stadium. Kickoff is scheduled for 4:25 p.m. ET and the game is televised on FOX. Below, we look at the Broncos vs. Giants odds and lines, and make our best NFL picks, predictions and bets.

The Broncos head to the Eastern Time Zone where they had a ton of success a season ago. Denver went 3-2 straight up and 4-1 against the spread in five trips east of the Mississippi River, while going 2-9 SU and 5-6 ATS elsewhere.

The Giants had a difficult time against AFC teams last season, going just 1-3 SU and 0-4 ATS. New York also hit the Under in all four games against AFC opponents in 2020. The G-Men are just 3-9 ATS over the last three seasons against AFC foes.

Also see: NFL team win totals

Broncos at Giants odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 12:50.m. ET.

Money line: Broncos -160 (bet $160 to win $100) | Giants +130 (bet $100 to win $130)
Against the spread (ATS): Broncos -2.5 (-135) | Giants +2.5 (+110)
Over/Under (O/U): 41.5 (O: -108 | U: -112)

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Broncos at Giants key injuries

Broncos

LB Bradley Chubb (ankle) questionable

Giants

RB Saquon Barkley (knee) questionable
TE Evan Engram (calf) out
DB Adoree’ Jackson (ankle) questionable

WIN YOUR FANTASY FOOTBALL LEAGUE!

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Use code SBW21 to take 20% OFF a new subscription. Join now!

Broncos at Giants odds, lines, predictions and picks

Prediction

Broncos 26, Giants 17

Money line

The BRONCOS (-160) are moderate favorites, and not a bad option on the money line if you just want to pick a winner and not worry about the point spread.

The Giants haven’t had a lot of success against the AFC in recent seasons, and the fact Barkley is dinged up and Engram is out does not help matters. New York could get off to a slow start yet again.

Also see: Week 1 staff picks

Against the spread

BRONCOS -2.5 (-135) is worth a small-unit play, as Denver seemed to enjoy traveling last season. Most of their best games were away from home.

QB Teddy Bridgewater makes his team debut and has a solid stable of receivers. The Giants aren’t nearly as deep. Engram would’ve been super helpful for QB Daniel Jones, but he is already ruled out. That’s bad news for the home side, and it gets worse if Barkley is ruled inactive.

Over/Under

The lean is to the OVER 41.5 (-108), ever so slightly.

The concern is with the Giants side, again, if Barkley cannot play. Bridgewater and the Broncos offense should be much better than last season, and they should do enough to inch this one Over the finish line for total bettors.

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com. Please gamble responsibly.

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