NFL Week 1 Can’t-Miss Parlay: 3 bets you can count on

The 2021 NFL season got off to a flying start Thursday night as Tom Brady and the defending-champion Tampa Bay Buccaneers outduel Dak Prescott and the Dallas Cowboys.

Even if you missed on the Cowboys cover or the over, which flew past the total in the third quarter, there remain plenty of other prime Week 1 wagering opportunities with 15 games remaining. Here’s a three-leg, can’t-miss parlay to give your NFL bankroll an opening-week boost …

Also see: Week 1 best bets

NFL can’t miss parlay: Week 1

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 8:05 a.m. ET.

Leg 1: San Francisco 49ers -8.5 (-110) at Detroit Lions

At 6-10 in 2020, the Niners only won one more game than the Lions, but the franchises have been moving in opposite directions ever since. Head coach Kyle Shanahan’s crew in San Francisco has almost all of its primary players, including QB Jimmy Garoppolo, TE George Kittle and defensive standout Nick Bosa back and healthy after enduring the league’s worst injury situation in 2020.

They’ve also added some intriguing new pieces in rookie QB Trey Lance and RB Trey Sermon, making Shanahan’s daunting offensive schemes even more dangerous and unpredictable heading into Week 1’s clean slate.

The Lions, meanwhile, downgraded quarterbacks in trading longtime starter Matthew Stafford for Jared Goff, questionably handed over the squad to a quirky and unproven head coach in Dan Campbell and didn’t do nearly enough to shore up a defense that was scorched for the most average points (32.4) and total yards (419.8) per game in 2020.

Take the reinvigorated 49ERS and don’t fret over laying the 8.5 points on the road.

Also see: 49ers-Lions picks and predictions

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Leg 2: Miami Dolphins at New England Patriots UNDER 43.5 (-110)

Two young quarterbacks, including Pats rookie Mac Jones making his first start.

Two coaching staffs who know each other very well, including Patriots-defensive-coordinator-turned-Dolphins-head-coach Brian Flores.

Two above-average defenses, including the reinforced and revitalized Pats.

Two 2020 matchups that produced totals of 32 and 34 points.

We’re going with the UNDER 43.5 (-110).

Also see: Dolphins-Patriots picks and predictions

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Leg 3: Denver Broncos -3.5 (+105) at New York Giants

Both teams finished among the league’s bottom 12 a season ago, but the Broncos look to have made the most significant offseason strides.

The Giants’ injury-wracked offense, featuring turnover-prone QB Daniel Jones and one of the league’s worst offensive lines, looks to be overmatched against an improved Denver D returning Von Miller and featuring what looks to be one of the league’s elite secondaries.

So, if new QB Teddy Bridgewater can just bring a steady hand to the team’s talented young offense, the BRONCOS shouldn’t have too much trouble covering a road spread of 3.5 points (-135).

Also see: Broncos-Giants picks and predictions

Total parlay payout

Bet $100 to win $647.14

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