Carolina Panthers betting odds line spread pick predictions best bets – Page 5

Buffalo Bills at Carolina Panthers odds, picks and prediction

Analyzing Friday’s Buffalo Bills at Carolina Panthers odds and lines, with expert NFL picks, predictions and best bets.

The Buffalo Bills (2-0) and Carolina Panthers (1-1) wrap up their preseason schedule Friday. Kickoff from Bank of America Stadium is scheduled for 7 p.m. ET. Below, we analyze Tipico Sportsbook‘s lines around the Bills vs. Panthers odds, and make our best NFL picks, predictions and bets.

The Bills throttled the visiting Denver Broncos 42-15 last weekend, playing the starters for most of the 1st quarter. But the run game continued to be impressive well after the 1st unit was out of there, showing some tremendous organizational depth.

Coach Sean McDermott confirmed early this week that most of his 1st-team players will not play Friday in Charlotte, including star QB Josh Allen.

The Panthers were on the short end of a 20-10 loss at New England after joint practices with the Patriots last week. The only touchdown came via pick-6 from DB Tae Hayes, too.

Carolina made headlines this week, officially naming QB Baker Mayfield as the starter, while also announcing rookie QB Matt Corral (foot) suffered a long-term injury. Mayfield is expected to play into the 2nd quarter Friday, with QBs Sam Darnold and PJ Walker finishing up.

Bills at Panthers odds

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 4:01 p.m. ET.

Money line (ML): Bills +220 (bet $100 to win $220) | Panthers -280 (bet $280 to win $100)
Against the spread (ATS): Bills +6.5 (-115) | Panthers -6.5 (-105)
Over/Under (O/U): 39.5 (O: -117 | U: -103)

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Bills at Panthers picks and predictions

Prediction

Panthers 22, Bills 16

Money line

The Panthers (-280) will use the 1st-team offense well into the 2nd quarter, while the Bills (+220) will take a low-key approach to this preseason finale, using mostly reserves.

The advantage is to the home side, but you can’t risk nearly 3 times your potential return on a favorite in a preseason game.

AVOID.

Against the spread

The PANTHERS -6.5 (-105) are worth playing lightly, as the starters on offense should feature well into the 2nd quarter in front of the home fans. Coach Matt Rhule will give us a glimpse of what to expect from the Panthers, and it might be a little better than the regular season, since they’ll be facing a Bills team using mostly reserves.

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Over/Under

The UNDER 39.5 (-103) is the way to go here, as no Allen means the offense is likely to be a little slower for Buffalo. Of course, that wasn’t the case at home against Denver last week even after Allen exited.

Still, the Panthers offense managed just a field goal last weekend, and it is still a work in progress.

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Carolina Panthers at New England Patriots odds, picks and prediction

Analyzing Friday’s Carolina Panthers at New England Patriots odds and lines, with expert NFL picks, predictions and best bets.

The New England Patriots (0-1) welcome the Carolina Panthers (1-0) to Gillette Stadium Friday. Kickoff is scheduled for 7 p.m. ET. Below, we analyze Tipico Sportsbook‘s lines around the Panthers vs. Patriots odds, and make our best NFL picks, predictions and bets.

The Patriots didn’t give 2nd-year QB Mac Jones any plays in their opening preseason loss to the New York Giants. After ending the 1st quarter up 7-3, the Patriots eventually lost 23-21.

The combination of Jones, QB Bailey Zappe and QB Brian Hoyer will be what New England goes with in Week 1. Fans may get a better glimpse at the running back committee they’re destined to use as well.

The Panthers, who have a quarterback competition on their hands, beat the Washington Commanders. RB Christian McCaffrey did not play.

In the 23-21 victory last week, QB Baker Mayfield and QB Sam Darnold both got a series with the former going 4-for-7 for 45 yards and the latter going 2-for-3 for 16 yards and a touchdown. A report Thursday said Mayfield would be named the starter for Week 1.

Panthers at Patriots odds

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 2:44 p.m. ET.

Money line (ML): Panthers +133 (bet $100 to win $133) | Patriots -160 (bet $160 to win $100)
Against the spread (ATS): Panthers +3.5 (-130) | Patriots -3.5 (+105)
Over/Under (O/U): 40.5 (O: -103 | U: -117)

Panthers at Patriots picks and predictions

Prediction

Panthers 24, Patriots 20

Money line

BET PANTHERS (+115).

The Panthers have been in a heated quarterback battle, and I wouldn’t be shocked if they opted to play Darnold and Mayfield for the entirety of the first half. On the other hand, Jones may be too valuable to give multiple series to.

Even the Patriots backfield, which is a 3-headed monster, should see limited time.

The Panthers played well in the first quarter against Washington, jumping out to a 10-0 lead while the Giants beat the Patriots at Gillette and took a 10-7 lead into the half.

Carolina has more figuring out to do with its first string than New England, and in turn, I think it’ll want to see what it is working with. Against Washington, its top players thrived, and I expect the same on Friday evening.

Against the spread

PASS.

If you feel more comfortable playing Carolina +3.5, then by all means go that route, but I would suggest the plus-money play on the money line instead given the value.

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Over/Under

LEAN OVER 40.5 (-103).

Both teams went over this amount in their first preseason matchup with both teams totaling 44 points on identical 23-21 scores.

The Panthers are expected to name Mayfield their starter, which could mean more time on the field for Darnold. Similarly, fans should get to see Jones in action. The stars should be able to aid the scoring.

Given the scuffle that went on in a joint practice, the teams should be primed to give a little added effort which could also help the game keep a high pace. Nonetheless, betting NFL overs was a solid option in Week 1 and that should keep up as the preseason progresses.

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Carolina Panthers at Washington Commanders odds, picks and prediction

Analyzing Saturday’s Carolina Panthers at Washington Commanders preseason odds and lines, with expert NFL picks, predictions and best bets.

The Carolina Panthers and Washington Commanders meet in their preseason opener Saturday. Kickoff from FedEx Field is scheduled for 1 p.m. ET. Below, we analyze Tipico Sportsbook‘s lines around the Panthers vs. Commanders odds, and make our best NFL picks, predictions and bets.

The Panthers acquired QB Baker Mayfield from the Cleveland Browns to come in and compete with QB Sam Darnold for the starting job. Both quarterbacks are expected to see action Saturday in D.C. Rookie QB Matt Corral is also expected to debut.

Like the Panthers, the Commanders have 3 capable QBs in Carson Wentz, Taylor Heinicke and Sam Ehlinger, and all are expected to see some snaps against Carolina. The level of play on offense for both sides could be good.

Panthers at Commanders odds

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 11:07 p.m. ET.

Money line (ML): Panthers +125 (bet $100 to win $125) | Commanders -155 (bet $155 to win $100)
Against the spread (ATS): Panthers +2.5 (+105) | Commanders -2.5 (-130)
Over/Under (O/U): 37.5 (O: +100 | U: -120)

Panthers at Commanders picks and predictions

Prediction

Panthers 19, Commanders 13

Money line

The PANTHERS (+125) are likely to keep oft-injured RB Christian McCaffrey on the sidelines, but they have 2 NFL starting QBs in Mayfield and Darnold, and both are likely to see at least a handful of series. That gives the visitors the edge, although Washington’s defense is fierce.

For the Commanders (-155), Wentz has had a woeful training camp with his new team, and it is going to be a work in progress this preseason to get him hitting on all cylinders before Week 1.

Against the spread

The PANTHERS +2.5 (+105) is the play, although playing ATS vs. ML really makes no sense unless you strongly believe there is going to be a tie. Just play the money line.

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Over/Under

The UNDER 37.5 (-120) is the way to go.

While these teams are each deep at the QB position, these teams still are among the lowest ranked overall clubs in the NFL. The Washington defense will make things particularly difficult on the Carolina offense, and the Panthers D isn’t too shabby, either. Expect many field goals, not so many touchdowns.

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Tampa Bay Buccaneers at Carolina Panthers odds, picks and prediction

Analyzing Sunday’s Tampa Bay Buccaneers at Carolina Panthers odds and lines, with expert NFL picks, predictions and best bets.

The Tampa Bay Buccaneers (10-4) travel to meet the Carolina Panthers (5-9) for a Week 16 game Sunday at Bank of America Stadium. Kickoff is scheduled for 1 p.m. ET. Below, we look at the Buccaneers vs. Panthers odds and lines, and make our best NFL picks, predictions and bets.

The Buccaneers are coming off a stunning 9-0 loss to the New Orleans Saints at home last Sunday night, although they’re still 4-1 SU/ATS across the past five outings.

The Panthers are in freefall, losing four straight games while also going 0-4 ATS. All four of those games were with QB Cam Newton back under center. The Over has cashed in five in a row for Carolina, with the defense allowing 27 or more points in each of the past four outings.

Buccaneers at Panthers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10 a.m. ET.

Money line: Buccaneers -550 (bet $550 to win $100) | Panthers +400 (bet $100 to win $400)
Against the spread (ATS): Buccaneers -10.5 (+100) | Panthers +10.5 (-120)
Over/Under (O/U): 43.5 (O: -108 | U: -112)

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Buccaneers at Panthers key injuries

Buccaneers

WR Jaelon Darden (reserve/COVID) out
CB Jamel Dean (illness/non-COVID) questionable
WR Mike Evans (hamstring) out
WR Breshad Perriman (reserve/COVID) questionable
LB Jason Pierre-Paul (shoulder) doubtful
CB Richard Sherman (Achilles) questionable
S Antoine Winfield Jr. (foot) out

Panthers

C Pat Elflein (reserve/COVID) out
OT Cam Erving (calf) questionable
WR DJ Moore (hamstring) questionable

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Buccaneers at Panthers odds, lines, predictions and picks

Prediction

Buccaneers 29, Panthers 13

Money line

The Buccaneers (-550) are furious after getting blanked at home last week by the mediocre Saints, and they’ll likely take out their aggressions on the poor Panthers (+400).

However, PASS, as risking more than five times your return is just too much, especially with Evans joining WR Chris Godwin (knee) and RB Leonard Fournette (hamstring) on the shelf. Returning WR Antonio Brown is the de facto WR1, and he could be rusty after returning from suspension. If the Panthers D can slow TE Rob Gronkowski, they have a puncher’s chance.

Against the spread

The BUCCANEERS -10.5 (+100) are warranted being at least 10 points better than the skidding Panthers +10.5 (-120), although I don’t like all of the injuries on the offensive side of the ball for Tampa. As such, go lightly.

Over/Under

The lean is to the UNDER 43.5 (-112) in this NFC South battle. Again, the Bucs are racked with injuries on offense, but the Panthers defense has still been unable to stop anyone lately. It will be close. A small-unit bet is warranted, but don’t get carried away.

Also see: All Week 16 odds and lines

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Carolina Panthers at Buffalo Bills odds, picks and prediction

Analyzing Sunday’s Carolina Panthers at Buffalo Bills odds and lines, with expert NFL picks, predictions and best bets.

The Carolina Panthers (5-8) travel to face the Buffalo Bills (7-6) in a Week 15 matchup Sunday. Kickoff is scheduled for 1 p.m. ET. Below, we look at the Panthers vs. Bills odds and lines, and make our best NFL picks, predictions and bets.

The Panthers are skidding, dropping three in a row while failing to cover each. The defense has been an issue, allowing 27 or more points in each of the losses, and the Over has hit in four consecutive games for Carolina.

The Bills dropped a 33-27 overtime heartbreaker at Tampa Bay last week, which was like losing twice. The Bills erased a late 27-10 deficit to force overtime, but couldn’t stop the Bucs in OT. Buffalo enters on a 2-5-1 ATS slide.

Panthers at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 2:25 p.m. ET.

Money line: Panthers +470 (bet $100 to win $470) | Bills -700 (bet $700 to win $100)
Against the spread (ATS): Panthers +10.5 (-105) | Bills -10.5 (-115)
Over/Under (O/U): 44.5 (O: -105 | U: -115)

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Panthers at Bills key injuries

Panthers

CB A.J. Bouye (foot) out
WR DJ Moore (hamstring) questionable
OG Michael Jordan (hamstring) questionable
OG John Miller (ankle) questionable

Bills

WR Emmanuel Sanders (knee) doubtful
DT Star Lotulelei (toe) questionable

Panthers at Bills odds, lines, predictions and picks

Prediction

Bills 29, Panthers 13

Money line

The Bills (-700) are going to snap back on track with a win over head coach Sean McDermott’s old team, but you can’t lay seven times your potential winnings on a team that is just one game over .500. Don’t do it.

PASS.

Against the spread

The BILLS -10.5 (-115) are 2-1-1 ATS as a double-digit favorite this season, and they’re 2-1 SU/ATS against three NFC opponents.

Buffalo is 6-1-1 ATS in the past eight against teams with a losing record, so expect the Bills to finally pull it together and put a performance together worthy of a playoff team.

Over/Under

The UNDER 44.5 (-115) hit in Buffalo’s most recent home game, but blustering, wintry conditions played a huge part in its 14-10 loss to New England on Monday night in Week 13.

The temperature will be around freezing with winds of 13-16 mph, but not too terribly for this time of year in western New York.

The Under is 5-2 in the past seven at home for the Bills and 4-1 in the past five against teams with a losing record. The Panthers’ offense has been mediocre, and the Bills’ D should shut them down for a convincing win.

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Carolina Panthers at Miami Dolphins odds, picks and prediction

Analyzing Sunday’s Carolina Panthers at Miami Dolphins Week 12 odds and lines, with expert NFL picks, predictions and best bets.

The Carolina Panthers (5-6) visit the Miami Dolphins (4-7) on Sunday for a Week 12 matchup at Hard Rock Stadium in Miami Gardens, Fla. Kickoff is scheduled for 1 p.m. ET. Below, we look at the Panthers vs. Dolphins odds and lines, and make our best NFL picks, predictions and bets.

The Panthers were unable to follow up their 34-10 upset at the Arizona Cardinals two weeks ago with a win at home in Week 11. Carolina fell to the Washington Football Team by a 27-21 score in QB Cam Newton’s first start since re-signing with the team.

The Dolphins head into this one with a three-game win streak, averaging 21.0 points per game (PPG) while allowing 12.0 PPG during the impressive run. They’re 3-0-1 ATS in the previous four outings while hitting the Under in four straight.

Also see: All Week 12 odds and lines

Panthers at Dolphins odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 1:32 a.m. ET.

Money line: Panthers -130 (bet $130 to win $100) | Dolphins +105 (bet $100 to win $105)
Against the spread (ATS): Panthers -2.5 (-108) | Dolphins +2.5 (-112)
Over/Under (O/U): 41.5 (O: -112 | U: -108)

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Panthers at Dolphins key injuries

Panthers

OG John Miller (ankle) out

Dolphins

S Brandon Jones (ankle, elbow) questionable
TE Adam Shaheen (knee) out

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Panthers at Dolphins odds, lines, predictions and picks

Prediction

Panthers 22, Dolphins 18

Money line

The PANTHERS (-130) aren’t priced too high if you just want to play them straight up and not worry about the points.

Against the spread

The PANTHERS -2.5 (-108) are a little cheaper if you think they can win by a field goal. This one is going to be a super close defensive battle. The Dolphins have looked good on defense lately, and the Panthers rank second in total yards per game allowed (288.7) and first against the pass (174.2).

Over/Under

The UNDER 41.5 (-108) is a low number, but points are going to be at a premium here. Each team has been playing strong defensively lately, and you can expect that to continue in South Florida Sunday.

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Underdog Corner: 3 best NFL picks and predictions for Week 12

Assessing the NFL betting odds and lines for Week 12, with three predictions and picks for the best underdog bets to make.

NFL point-spread favorites may have wound up winning Week 11, but we were undeterred here in Underdog Corner.
We hit with the Houston Texans and Indianapolis Colts, who both wound up posting double-digit outright road wins, to notch our second straight 2-1 against-the-spread weekend and improve to a very profitable 24-9 (.727) on the season. Additionally, 20 of our 24 underdog covers have wound up winning their games outright.
Now it’s on to Thanksgiving Week and our Week 12 outlook.

NFL underdog predictions: Week 12

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 3:30 p.m. ET.

Indianapolis Colts +3.5 (-125) vs. Tampa Bay Buccaneers

Yep, we’re right back on Indy drawing points again, and that has been a profitable play this year with the Colts owning a 5-2 ATS record as an underdog.

Overall, the Horseshoes are doing just fine as well, winning five of their last six to climb back above .500 at 6-5 and join the AFC’s jumbled playoff race.

Tom Brady and the Bucs throttled the visiting Giants 30-10 Monday night to end a two-game slide, but it has been a different story on the road this season for the defending champs, who are 2-3 SU and 0-5 ATS away from Raymond James Stadium.

Go with the red-hot COLTS (+3.5) catching the field goal plus a hook at home.

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Miami Dolphins +2.5 (-108) vs. Carolina Panthers

These are two teams headed in the opposite directions, and the wrong side looks to be favored Sunday in South Beach.

The Dolphins have won and covered in three straight after a 1-7 SU, 2-5 ATS start while the Panthers are 2-6 SU/ATS after winning and covering their first three games.

Miami blitzed Lamar Jackson and the visiting Ravens into defeat two weeks ago and could do the same to Cam Newton and Carolina here. Take the DOLPHINS (+2.5) and the points and hit the Miami money line (+110) as well.

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Minnesota Vikings +3.5 (-117) at San Francisco 49ers

The Vikings are well-seasoned in close games with nine of their 10 contests so far being decided by one score or less, including five by three points or fewer.

Minnesota also is 3-2 SU and 5-0 ATS as an underdog this season.

The Niners, meanwhile, have won and covered in two straight to get back to .500 for the first time since Week 4.

However, San Fran is only 2-9 SU at home and 5-11 ATS as a favorite since the start of the 2020 season, and so the trends definitely peg the VIKINGS (+3.5) as the play here.

Also see: All Week 12 odds and lines

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Washington Football Team at Carolina Panthers odds, picks and prediction

Analyzing Sunday’s Washington Football Team at Carolina Panthers odds and lines, with expert NFL picks, predictions and best bets.

The Washington Football Team (3-6) visit the Carolina Panthers (5-5) on Sunday for a Week 11 game at Bank of America Stadium in Charlotte. Kickoff is scheduled for 1 p.m. ET. Below, we look at the Washington vs. Panthers odds and lines, and make our best NFL picks, predictions and bets.

Washington is coming off its most impressive showing of the season, a 29-19 win over the defending Super Bowl-champion Tampa Bay Buccaneers last week. That snapped an 0-4 SU/ATS run. The Under is 4-0 in the past four for WFT.

The Panthers won 34-10 at Arizona last week as seven-point underdogs, and Carolina is now 2-1 SU/ATS across the past three. QB Cam Newton will make the start, taking over for QB P.J. Walker, who started last week in place of the injured QB Sam Darnold (scapula).

Also see: All Week 11 odds and lines

Washington at Panthers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 9:30 a.m. ET.

Money line: Washington +145 (bet $100 to win $145) | Panthers -180 (bet $180 to win $100)
Against the spread (ATS): Washington +3.5 (-117) | Panthers -3.5 (-103)
Over/Under (O/U): 42.5 (O: -117 | U: -103)

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Washington at Panthers key injuries

Washington

WR Curtis Samuel (groin) questionable
TE Ricky Seals-Jones (hip) out

Panthers

No notable injuries to report

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Washington at Panthers odds, lines, predictions and picks

Prediction

Panthers 24, Washington 19

Money line

PANTHERS (-180) is not terribly out of line if you just want to back Newton and the home team without worrying about laying the points.

Against the spread

The PANTHERS -3.5 (-103) welcome Newton back under center, and welcome former head coach Ron Rivera to town. There are all kinds of interesting storylines in this game, and Washington +3.5 (-117) is riding high after an upset of the Bucs last week, too.

I think the crowd is going to be electric in Charlotte with Cam making his first start with the team since re-signing, and they’ll hold off Washington. Three-and-a-hook is not a great spread, so play it lightly. I actually like the money line much better in what should be a close game.

Over/Under

The OVER 42.5 (-117) is the lean, ever so slightly. The Panthers offense is averaging just 20.5 PPG, ranking 21st in the NFL this season. And the defense is yielding just 19.3 PPG, which is sixth in the NFL. This defense is nasty, and will give QB Taylor Heinicke and the Washington offense trouble. But Cam and the Panthers should be able to do enough, and WFT likely will score late to inch this one over the finish line.

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Carolina Panthers at Arizona Cardinals odds, picks and prediction

Analyzing Sunday’s Carolina Panthers at Arizona Cardinals odds and lines, with expert NFL picks, predictions and best bets.

The Carolina Panthers (4-5) face the Arizona Cardinals (8-1) on the road Sunday in Week 10. Kickoff at State Farm Stadium is set for 4:05 p.m. ET. Below, we look at the Panthers vs. Cardinals odds and lines, and make our best NFL picks, predictions and bets.

The Panthers have lost five of their last six games following a 3-0 start to the season. They have weathered injuries to RB Christian McCaffrey and now QB Sam Darnold, who suffered a fractured scapula and was placed on injured reserve. QB Cam Newton signed with the team this week but will not start this week as the team has opted to roll out QB P.J. Walker under center.

Arizona is the top seed in the NFC but is dealing with injuries of their own. QB Kyler Murray and WRs DeAndre Hopkins and A.J. Green were out in Week 9, but QB Colt McCoy led them to a 31-17 win over the San Francisco 49ers. They have the second-ranked scoring offense in the NFL (30.8 points per game) and the third-best scoring defense (17.2 points per game allowed).

Panthers at Cardinals odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 8:12 a.m. ET.

Money line: Panthers +330 (bet $100 to win $330) | Cardinals -450 (bet $450 to win $100)
Against the spread (ATS): Panthers +8.5 (-108) | Cardinals -8.5 (-112)
Over/Under (O/U): 43.5 (O: -105 | U: -115)

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Panthers at Cardinals key injuries

Panthers

DE Brian Burns (ankle) questionable
CB Rashaan Melvin (hand) out
QB Sam Darnold (shoulder) injured reserve

Cardinals

RB Chase Edmonds (ankle) out
OL Justin Pugh (calf) out
QB Kyler Murray (ankle) questionable
WR DeAndre Hopkins (hamstring) questionable
S Budda Baker (knee) questionable
WR Rondale Moore (neck) questionable
DE Jordan Phillips (groin) questionable

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Panthers at Cardinals odds, lines, predictions and picks

Prediction

Cardinals 30, Panthers 12

Money line

PASS on the money line. The Cardinals are going to take care of business and it isn’t worth the money to gain so little. Carolina allows the second-fewest yards per game in the league (293.1) but they do not have the offense to keep up with the Cardinals, especially with Walker at quarterback. They are turnover-prone and the Cardinals are one of the top defenses in the league in creating takeaways.

Against the spread

The Cardinals are 7-2 ATS this season, while the Panthers are 4-5 ATS and 2-2 ATS on the road.

Six of the Cardinals’ eight wins have been by at least 12 points. They have scored over 30 points seven times and allowed 20 or fewer seven times.

The only way the Panthers keep this game close is by not turning the ball over, creating multiple turnovers and using the run game to slow the game down. Short of all those things happening, the Cardinals are the way to go.

Take the CARDINALS -8.5 (-112).

Over/Under

Only two of the Panthers’ games this season have gone Over the projected total this season. Four of the Cardinals’ nine games have.

The Panthers have not cracked 20 points in their last three outings and in two of them, they scored 6 or fewer points. The Cardinals will get around the 30 points they have been scoring. The question is whether the Panthers can score more than 13 points against this Arizona defense.

Take UNDER 43.5 (-115).

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

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New England Patriots at Carolina Panthers odds, picks and prediction

Analyzing Sunday’s New England Patriots at Carolina Panthers odds and lines, with expert NFL picks, predictions and best bets.

Winners of two straight, the New England Patriots (4-4) are on the road against the Carolina Panthers (4-4). They face one another Sunday at 1 p.m. ET at Bank of America Stadium. Below, we look at the Patriots vs. Panthers odds and lines, and make our best NFL picks, predictions and bets.

The New England defense picked off QB Justin Herbert twice, with S Adrian Phillips returning one for a touchdown, while K Nick Folk make four field goals in a 27-24 win over the Los Angeles Chargers. Rookie QB Mac Jones has not turned the ball over the last two games.

The Panthers snapped a four-game losing streak last week with a 19-13 win over the Atlanta Falcons. The defense held Atlanta to 213 yards of offense and picked off QB Matt Ryan twice in the win.

Patriots at Panthers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 11:25 p.m. ET.

Money line: Patriots -190 (bet $190 to win $100) | Panthers +155 (bet $100 to win $155)
Against the spread (ATS): Patriots -3.5 (-105) | Panthers +3.5 (-115)
Over/Under (O/U): 41.5 (O: -105 | U: -115)

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Patriots at Panthers key injuries

Patriots

K Nick Folk (knee) questionable
WR N’Keal Harry (knee) questionable
LB Dont’a Hightower (ankle) questionable
G Shaq Mason (abdomen) questionable
TE Jonnu Smith (shoulder) questionable

Panthers

QB Sam Darnold (concussion, shoulder) questionable
G Pat Elflein (hamstring) questionable

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Patriots at Panthers odds, lines, predictions and picks

Prediction

Patriots 21, Panthers 17

Money line

The Patriots are 3-0 on the road this season. Jones is taking care of the football, while the Panthers have been in a tailspin.

QB Sam Darnold has not had a passing touchdown in his last two games. The Panthers are No. 2 in total defense and allow the fifth-fewest points in the league.

But Jones will continue to be effective and to protect the football.

Take the Patriots (-190).

Against the spread

Both teams are 4-4 ATS this season, but the Pats have covered the spread in their last two games, while the Panthers, before their win over the Falcons last week, had failed to cover the spread in four straight games.

The Pats are 2-3 ATS as a favorite.

I expect this to be close and come down to the wire.

Take the PATRIOTS -3.5 (-105).

Over/Under

The Patriots have had each of their last four games hit the Over.

Only two of the Panthers’ games this season have not gone Under the projected total.

This will be a defensive battle between two top-10 defensive teams.

Take UNDER 41.5 (-115).

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow Jess Root on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

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