Arizona Cardinals betting odds line spread pick predictions best bets – Page 2

LA Rams at Arizona Cardinals odds, picks and predictions

Analyzing Sunday’s LA Rams at Arizona Cardinals odds and lines, with expert NFL picks and predictions.

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The LA Rams (0-1) are on the road for a divisional matchup in Week 2 facing the Arizona Cardinals (0-1). Kickoff from State Farm Stadium is at 4:05 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Rams vs. Cardinals odds, and make our expert NFL picks and predictions.

The Rams opened their season with a 26-20 OT loss at the Detroit Lions Sept. 8, failing to cover as 5.5-point underdogs. The Under (53.5) cashed.

The Cardinals lost 34-28 at the Buffalo Bills in Week 1, covering as 6.5-point underdogs. The Over (45) hit.

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Rams at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 2:05 p.m. ET.

Moneyline (ML): Rams +100 (bet $100 to win $100) | Cardinals -120 (bet $120 to win $100)
Against the spread (ATS): Rams +1 (-110) | Cardinals -1 (-110)
Over/Under (O/U): 48 (O: -110 | U: -110)

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Rams at Cardinals key injuries

Rams

G Steve Avila (knee) out
TE Davis Allen (back) out
OL Kevin Dotson (foot) questionable
CB Cobie Durant (toe) questionable
QB Jimmy Garoppolo (suspension) out
TE Tyler Higbee (knee) out
S Quentin Lake (hip) questionable
WR Puka Nacua (knee) out
OT Joe Noteboom (ankle) out

Cardinals

WR Zay Jones (suspension) out
WR Xavier Weaver (oblique) questionable

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Rams at Cardinals picks and predictions

Prediction

Cardinals 24, Rams 20

Moneyline

The Cardinals (-120) have not beaten the Rams at home in 10 years and only have 2 wins over them since 2017.

But Detroit was able to run the ball against the Rams in Week 1, and the Cardinals had a top-5 rushing offense last season, led by RB James Conner.

The Rams are down to a 3rd-string left tackle and a backup center, as Noteboom and Avila both landed on injured reserve this week along with Nacua.

It is Arizona’s home opener, which should give it a little extra juice.

The Cardinals will finally get the monkey off their back, but there are better odds with the spread.

PASS.

Against the spread

The Cardinals started the season 1-0 ATS. They built a 17-3 first-half lead last week over Buffalo, which then obliterated Miami on Thursday Night Football.

The Rams defense is not at the same level as Buffalo’s right now.

BET CARDINALS -1 (-110).

Over/Under

Between Conner and Rams RB Kyren Williams, this could be a run-heavy game, slowing down the pace.

Four of the last 5 meetings have not reached 48 total points.

BET UNDER 48 (-110).

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Arizona Cardinals at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Arizona Cardinals open the 2024 regular season on the road against the Buffalo Bills. The game kicks off Sunday at 1 p.m. ET at Highmark Stadium (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Bills odds, and make our expert NFL picks and predictions.

The Cardinals open the season with a healthy QB Kyler Murray and an improved defensive starting lineup. RB James Conner and TE Trey McBride are coming off career seasons. They are coming off a 4-win season and hope to take the next step, being competitive enough to perhaps make the playoffs.

The Bills remade their receiver room and their secondary. They have won the AFC East 4 straight years and hope to be a Super Bowl contender as QB Josh Allen leads the way.

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Cardinals at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1 p.m. ET.

Moneyline (ML): Cardinals +240 (bet $100 to win $240) | Bills -300 (bet $300 to win $100)
Against the spread (ATS): Cardinals +6.5 (-110) | Bills -6.5 (-110)
Over/Under (O/U): 47.5 (O: -105 | U: -115)

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Cardinals at Bills key injuries

Cardinals

S Joey Blount (back) questionable
TE Tip Reiman (ankle) questionable
WR Xavier Weaver (oblique) out

Bills

DE Javon Solomon (oblique) out
DE Dawuane Smoot (toe) questionable

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Cardinals at Bills picks and predictions

Prediction

Bills 30, Cardinals 24

Moneyline

The Cardinals have not won in Buffalo since 1971. They have major question marks on defense with the pass rush, and they were bad against the run last season.

However, the Cardinals were a top-five offense over the final four games of the season and could be better with the addition of rookie WR Marvin Harrison Jr.

It won’t be enough to get the upset, so the Bills should win, and you shouldn’t bet them at -300 because it isn’t worth the action.

PASS.

Against the spread

Arizona’s offense should be able to test the Bills’ new secondary. Allen has thrown 5 INTs in his last 2 season openers, which will keep the game close.

The Cardinals went 9-8 ATS in a season they were 4-13 straight up.

Arizona is likely to have a lot of high-scoring close games. This should be one of them.

BET CARDINALS +6.5 (-110).

Over/Under

Their last matchup in 2020 in Arizona had 62 total points.

Three of the Bills’ final 4 games, including the postseason, has totals of 48 or higher.

Both teams should score points.

BET OVER 47.5 (-105).

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Arizona Cardinals at Denver Broncos odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Denver Broncos odds and lines, with expert NFL picks and predictions.

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The Arizona Cardinals (0-2) and Denver Broncos (2-0) close out their preseason slate on Sunday. Kickoff from Empower Field at Mile High is at 3:30 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Broncos odds, and make our expert NFL picks and predictions.

The Cardinals have gone winless in the preseason do far, losing 16-14 at home to the New Orleans Saints and then 21-13 on the road to the Indianapolis Colts. None of their starters will play this weekend.

The Broncos are 2-0 in the preseason. They beat Indy on the road 34-30 in their preseason opener and followed it up last week with a 27-2 home win over the Green Bay Packers.

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Cardinals at Broncos odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:11 a.m. ET.

Moneyline (ML): Cardinals +150 (bet $100 to win $150) | Broncos -185 (bet $185 to win $100)
Against the spread (ATS): Cardinals +3 (-110) | Broncos -3 (-110)
Over/Under (O/U): 34 (O: -110 | U: -110)

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Cardinals at Broncos picks and predictions

Prediction

Broncos 27, Cardinals 10

Moneyline

The Cardinals won’t have any of their starters and aren’t likely to have any key rotational players playing. QB Clayton Tune will start and QB Desmond Ridder will finish the game. The Cardinals have only scored 3 points in Ridder’s playing time this preseason.

The Cardinals haven’t scored more than 14 points in the preseason and the Broncos have scored 27 or more in both.

The Broncos probably win but don’t bet the moneyline here when there is better value with the spread.

PASS.

Against the spread

The Broncos have won both preseason games by more than 3 points. The Cardinals lost last week by 8.

For the Broncos, QB Zach Wilson, a former No. 2 overall pick, will play against the Cardinals’ deep backups. He should look great.

BET BRONCOS -3 (-110).

Over/Under

The Broncos should be able to score as they have thus far in the preseason. The Cardinals should be in double digits at least, just as they have in their first 2 preseason games.

BET OVER 34 (-110).

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Arizona Cardinals at Indianapolis Colts odds, picks and predictions

Analyzing Saturday’s Arizona Cardinals at Indianapolis Colts odds and lines, with expert NFL picks and predictions.

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The second week of the preseason continues with the Arizona Cardinals on the road against the Indianapolis Colts Saturday. Kickoff from Lucas Oil Stadium is at 7 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Colts odds, and make our expert NFL picks and predictions.

The Cardinals opened the preseason with a 16-14 last-second loss to the visiting New Orleans Saints Aug. 10, covering as 3-point underdogs. The Under (38.5) cashed in.

The Colts also lost their preseason opener, falling 34-30 at home to the Denver Broncos as 1.5-point favorites Sunday as the Over (38.5) hit.

Cardinals at Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:40 a.m. ET.

Moneyline (ML): Cardinals +110 (bet $100 to win $110) | Colts -135 (bet $135 to win $100)
Against the spread (ATS): Cardinals +1.5 (-110) | Colts -1.5 (-110)
Over/Under (O/U): 36.5 (O: -110 | U: -110)

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Cardinals at Colts picks and predictions

Prediction

Cardinals 23, Colts 20

Moneyline

Neither team will play their starters this weekend. It will be a battle of backups and guys just trying to make an NFL roster.

There is never a reliable way to handicap preseason games. They are volatile.

The only way to bet the preseason is to simply take the plus odds on the moneyline on a few games and hope you hit at least half of them.

BET CARDINALS (+110).

Against the spread

Again, with games being decided late by players who largely won’t be on NFL rosters next month, there is no way to feel confident in a winning outcome, especially when no starters will play.

PASS.

Over/Under

The Cardinals only allowed 16 points last week and only scored 14, but all 14 came in the 2nd half.

The Colts allowed 34 last week. There are concerns with their defensive depth.

With no starters playing, expect both teams to be in the 20s.

BET OVER 36.5 (-110).

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New Orleans Saints at Arizona Cardinals odds, picks and predictions

Analyzing Saturday’s New Orleans Saints at Arizona Cardinals odds and lines, with expert NFL picks and predictions.

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The New Orleans Saints and Arizona Cardinals open their preseasons Saturday. Kickoff from State Farm Stadium is at 8 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around the Saints vs. Cardinals odds, and make our expert NFL picks and predictions.

The Saints are coming off a 9-8 season in 2023 in which they won 4 of their last 5 games, but did not make the postseason. They added LB Willie Gay Jr., DE Chase Young and more in the offseason.

The Cardinals went 4-13 last season, but were 3-5 in the final 8 games when QB Kyler Murray returned from an ACL tear suffered in Dec. 2022.

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Saints at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:41 a.m. ET.

Moneyline (ML): Saints -135 (bet $135 to win $100) | Cardinals +110 (bet $100 to win $110)
Against the spread (ATS): Saints -2.5 (-110) | Cardinals +2.5 (-110)
Over/Under (O/U): 37 (O: -110 | U: -110)

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Saints at Cardinals picks and predictions

Prediction

Cardinals 20, Saints 16

Moneyline

The CARDINALS (+110) had 2 come-from-behind preseason wins last year with their back-of-the-roster players.

Murray will not play, and most of their starters probably will not either.

The Saints have not said one way or another with theirs.

However, as the preseason goes, because games are decided by players late in the game who largely will not be on active NFL rosters in the regular season, there is only one way to bet preseason games — bet plus odds and hope for the best.

BET CARDINALS (+110).

Against the spread

Again, as attempting to handicap games where teams actively hold back some of their game planning and have fringe players and guys who will not be playing football next month, don’t bet the spread.

These games are too unpredictable and volatile to get any trends or read.

PASS.

Over/Under

Last preseason, 2 of the Cardinals’ preseason games (their 2 wins) had only 35 points. Their loss had 48.

Neither preseason game played Thursday had more than 20 total points.

Last year, only 9 of 16 games had over 37 points for their total.

BET UNDER 37 (-110).

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Baltimore Ravens at Arizona Cardinals odds, picks and predictions

Analyzing Sunday’s Baltimore Ravens at Arizona Cardinals odds and lines, with expert NFL picks and predictions.

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In Week 8, the Baltimore Ravens (5-2) take on the Arizona Cardinals (1-6). Kickoff from State Farm Stadium is Sunday at 4:25 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Ravens vs. Cardinals odds, and make our expert NFL picks and predictions.

The Ravens are coming off their biggest win of the season, a 38-6 blowout over the Detroit Lions as 3-point home favorites. QB Lamar Jackson passed for 357 yards with 3 touchdowns and rushed for another score.

The Cardinals lost their 4th straight game when they pushed as 10-point underdogs in a 20-10 loss at the Seattle Seahawks last Sunday. They did not score in the 2nd half for the 2nd straight game.

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Ravens at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 3 p.m. ET.

Moneyline (ML): Ravens -500 (bet $500 to win $100) | Cardinals +350 (bet $100 to win $350)
Against the spread (ATS): Ravens -9.5 (-110) | Cardinals +9.5 (-110)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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Ravens at Cardinals key injuries

Ravens

LB Odafe Oweh (ankle) questionable
S Marcus Williams (hamstring) out

Cardinals

CB Antonio Hamilton (groin) questionable
QB Kyler Murray (knee) doubtful
DL Kevin Strong (shoulder) out
S Jalen Thompson (hamstring) questionable
OL Elijah Wilkinson (neck) out

Ravens at Cardinals picks and predictions

Prediction

Ravens 28, Cardinals 13

Moneyline

The Cardinals have scored only 25 total points in their last 10 quarters of football. The Ravens have the No. 1 scoring defense at 13.9 points allowed per game and are No. 2 in total defense.

Arizona’s defense was better against Seattle last week but has allowed a 100-yard rusher in 4 of its last 5 games.

The Cardinals are abysmal in the 2nd half of games, having been outscored 104-30 this season.

The Ravens will win this game, but it isn’t worth the action at -500 odds. PASS.

Against the spread

The Cardinals have failed to cover the spread since Week 3. They are 3-3-1 ATS this season.

The Ravens have covered the spread in all 5 of their wins. Three of their 5 wins are by double digits.

If Jackson is at all close to playing the way he did last week, it will not be even close.

BET RAVENS -9.5 (-110).

Over/Under

After 4 straight games of hitting the Over, the Cardinals’ last 2 games have stayed under the projected total. Scoring points has been a problem since RB James Conner got hurt. He is on injured reserve for at least 2 more weeks, which means more struggles for QB Josh Dobbs and the offense.

The Ravens have seen the Over hit only twice this season.

BET UNDER 44.5 (-110).

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Arizona Cardinals at Seattle Seahawks odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Seattle Seahawks odds and lines, with expert NFL picks and predictions.

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The Arizona Cardinals (1-5) play their 3rd divisional road game in 4 weeks in Week 7, facing the Seattle Seahawks (3-2) Sunday. Kickoff from Lumen Field is Seattle is Sunday at 4:05 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Seahawks odds, and make our expert NFL picks and predictions.

The Cardinals have lost 3 in a row and are coming off a 26-9 road loss to the Los Angeles Rams in Week 6, failing to cover the 7.5-point spread as underdogs. The Under (47.5) hit in the loss.

The Seahawks came off their bye and lost on the road 17-13 to the Cincinnati Bengals as 3-point underdogs. The Under (45.5) cashed in. The loss snapped a 3-game winning streak they had from before their bye week.

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Cardinals at Seahawks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:15 p.m. ET.

Moneyline (ML): Cardinals +280 (bet $100 to win $280) | Seahawks -350 (bet $350 to win $100)
Against the spread (ATS): Cardinals +7.5 (-110) | Seahawks -7.5 (-110)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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Cardinals at Seahawks key injuries

Cardinals

S Budda Baker (hamstring) questionable
CB Kei’Trel Clark (hamstring) questionable
CB Antonio Hamilton (groin) out
QB Kyler Murray (knee) out
DL Kevin Strong (calf) questionable
S Jalen Thompson (hamstring) out
OL Elijah Wilkinson (neck) out
LB Josh Woods (back) questionable

Seahawks

C Evan Brown (hip) questionable
RB Zach Charbonnet (hamstring) questionable
T Jake Curhan (ankle) questionable
G Phil Haynes (calf) questionable
WR DK Metcalf (ribs, hip) questionable

Cardinals at Seahawks picks and predictions

Prediction

Seahawks 31, Cardinals 20

Moneyline

The Cardinals are winless on the road this season and have lost 3 straight. The Seahawks had won 3 in a row before their setback.

Defensively, they have decreased the yards they have allowed in every game so far this season.

The Cardinals have led at halftime in 4 of their 6 games but have been outscored 98-30 in the 2nd half of games. They have allowed 3 100-yard rushers in their last 4 games and 3 140-yard receivers in each of their last 3.

But it isn’t worth the action to bet the Seahawks on the moneyline.

PASS.

Against the spread

The Cardinals started the season 3-0 ATS but have not covered the spread in their last 3 games. In their last 3 games alone, they have been outscored 51-12 in the 2nd half.

Missing RB James Conner, who is on injured reserve, on offense gives them almost nothing. QB Josh Dobbs has 5 turnovers in his last 2 games.

Seattle’s skill players are just too talented.

BET SEAHAWKS -7.5 (-110).

Over/Under

The Cardinals had 4 consecutive games go Over the projected total before their loss to the Rams last week.

The Seahawks have scored 37 points twice.

Before scoring only 9 points last week, the Cardinals had at least 20 in 3 of their previous 4. They have allowed 31.7 points per game over their last 3.

BET OVER 44.5 (-110).

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Arizona Cardinals at Los Angeles Rams odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Los Angeles Rams odds and lines, with expert NFL picks and predictions.

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The Arizona Cardinals (1-4) and Los Angeles Rams (2-3) look to bounce back from Week 5 losses when they square off Sunday at SoFi Stadium. This rivalry game between NFC West foes is set for 4:25 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Rams odds, and make our expert NFL picks and predictions.

The Cardinals have dropped each of their last 2 games, losing to the San Francisco 49ers and Cincinnati Bengals by 19 and 14 points, respectively. They’re in last place in the NFC West at 1-4, 1 game behind the Rams, who are 2-3. QB Josh Dobbs continues to fill in for the injured Kyler Murray, while Arizona will also be without starting RB James Conner.

The Rams fell to the Philadelphia Eagles last week, 23-14, to drop their record below .500 for the 2nd time this season. They’re trying to avoid their second 2-game losing streak of the season, facing a Cardinals team that they’re 11-2 against since 2017.

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Cardinals at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10:54 p.m. ET.

Moneyline (ML): Cardinals +240 (bet $100 to win $240) | Rams -300 (bet $300 to win $100)
Against the spread (ATS): Cardinals +7 (-115) | Rams -7 (-105)
Over/Under (O/U): 47.5 (O: -110 | U: -110)

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Cardinals at Rams key injuries

Cardinals

WR Marquise Brown (illness) questionable
RB James Conner (knee) out
S Jalen Thompson (hamstring) out

Rams

LB Ernest Jones (knee) questionable
DT Larrell Murchison (knee) questionable
OL Joe Noteboom (groin) questionable

Cardinals at Rams picks and predictions

Prediction

Rams 27, Cardinals 17

Moneyline

This is the 1st time all season the Rams have been favored by more than 1 point, playing 4 of their first 5 games as underdogs to their opponents. This is a game they should win against a team that many thought would be the worst in the NFL before the season began.

However, it’s hard to feel confident enough in a Rams team that barely beat the Colts to bet them at -300 on the money line. PASS on the ML.

Against the spread

The Rams are 3-1-1 ATS this season, with their only loss coming last week against the Eagles in a 9-point defeat as 4-point underdogs. The Cardinals are a respectable 3-2 ATS and upset the Dallas Cowboys SU in Week 3, a 28-16 win, while also almost beating the Commanders and Giants in the first 2 weeks.

Arizona will be severely shorthanded without Conner, which is part of the reason the Rams look even more enticing at -7. BET RAMS -7 (-105) to cover the spread and win by at least 8 points at home, having gone 7-2-1 ATS against the Cardinals in the last 10 meetings.

Over/Under

The Over is 2-3 in the Rams’ 5 games this season but it’s 4-1 in the Cardinals’ contests thus far. Los Angeles’ offense has disappeared in the 2nd half of games this season, scoring only 1 touchdown in the 2nd half and overtime in the last 4 weeks.

Without Conner, the Cardinals’ scoring output should be lower, too. BET UNDER 47.5 (-110).

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Cincinnati Bengals at Arizona Cardinals odds, picks and predictions

Analyzing Sunday’s Cincinnati Bengals at Arizona Cardinals odds and lines, with expert NFL picks and predictions.

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In Week 5 the struggling Cincinnati Bengals (1-3) are on the road to face the Arizona Cardinals (1-3). Kickoff is Sunday at 4:05 p.m. ET at State Farm Stadium (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Bengals vs. Cardinals odds, and make our expert NFL picks and predictions.

The Bengals are coming off a 27-3 road loss to the Tennessee Titans. They were 2.5-point favorites entering the game. The Under (42) hit in the loss.

The Cardinals, after covering the spread in their first 3 games, failed to cover the 14.5-point spread in a 35-16 road loss to the San Francisco 49ers. The Over (43.5) hit for the 3rd straight game for Arizona.

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Bengals at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:55 a.m. ET.

Moneyline (ML): Bengals -160 (bet $160 to win $100) | Cardinals +135 (bet $100 to win $135)
Against the spread (ATS): Bengals -3 (-110) | Cardinals +3 (-110)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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Bengals at Cardinals key injuries

Bengals

CB Chidobe Awuzie (back) questionable
DE Trey Hendrickson (back) questionable
WR Tee Higgins (ribs) questionable
CB Cam Taylor-Britt (concussion) questionable

Cardinals

OL Will Hernandez (back) questionable
DL Jonathan Ledbetter (finger) out
LB Josh Woods (ankle) questionable

Bengals at Cardinals picks and predictions

Prediction

Cardinals 23, Bengals 17

Moneyline

The Bengals have scored only 6 combined points in 2 road games and averaged 176.5 yards per game in those 2 games.

They have averaged only 12.3 points per game and only 3 offensive touchdowns all season.

They have allowed 189.5 rushing yards a game in their road games and face a Cardinals team that has averaged 28 points and 186.5 rushing yards at home.

BET CARDINALS (+135).

Against the spread

The Cardinals are 3-1 ATS this season. The Bengals have yet to cover the spread this season, going 0-3-1 ATS so far.

They have lost 24-3 and 27-3 on the road.

But being a matchup where the Cardinals can pull off an outright win, go with the plus odds on the moneyline and PASS on the spread.

Over/Under

The Cardinals have had the Over hit in 3 of 4 games this season and in each of their last 3 contests.

The Under is 3-1 in Cincinnati’s games.

The Cardinals have not surpassed 28 points this season, and the Bengals have averaged only 12.3 per game.

BET UNDER 44.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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Arizona Cardinals at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The Arizona Cardinals (1-2) are on the road in Week 4 for their 1st divisional game of the season, taking on the San Francisco 49ers (3-0). Kickoff is Sunday afternoon at 4:25 p.m. ET at Levi’s Stadium (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. 49ers odds, and make our expert NFL picks and predictions.

The Cardinals picked up their 1st win of the season last week, defeating the Dallas Cowboys 28-16 as 12.5-point home underdogs. They lost their first 2 games of the season but have covered the spread in all 3 games.

The 49ers defeated the New York Giants 30-12 last Thursday night as 10.5-point home favorites.

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Cardinals at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:55 a.m. ET.

Moneyline (ML): Cardinals +625 (bet $100 to win $625) | 49ers -1000 (bet $1,000 to win $100)
Against the spread (ATS): Cardinals +14 (-110) | 49ers -14 (-110)
Over/Under (O/U): 43.5 (O: -110 | U: -110)

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Cardinals at 49ers key injuries

Cardinals

LB Krys Barnes (finger) questionable
WR Marquise Brown (thumb) questionable
RB Keaontay Ingram (neck) questionable
OL Paris Johnson (ankle) questionable
DL Jonathan Ledbetter (finger) out
LB Josh Woods (ankle) out

49ers

LB Dre Greenlaw (ankle) questionable
WR Jauan Jennings (shin) doubtful
RB Elijah Mitchell (knee) questionable
WR Deebo Samuel (rib, knee) questionable

Cardinals at 49ers picks and predictions

Prediction

49ers 30, Cardinals 20

Moneyline

The Cardinals have led at halftime in every game this season and scored on all 5 first-half possessions last week. They have not turned the ball over in their last 2 weeks and rushed for 222 yards against Dallas.

However, the 49ers are a better-coached team than Dallas and their defense has allowed only 53 rushing yards per game.

The 49ers defense and rushing attack will ultimately wear down Arizona’s defense and offense, but there is no money to be made on the moneyline.

PASS.

Against the spread

The Cardinals are 3-0 ATS this season with a better-than-expected defense that has 12 sacks and 23 passes defended. They are not turning the ball over, and they play with effort and intensity.

But RB Christian McCaffrey leads the NFL in rushing yards and has scored a touchdown in 12 straight games.

While the 49ers have not been great in the red zone, the Cardinals can’t expect them to go 1-for-5 in the red zone with an interception and turnover on downs like the Cowboys last week.

Arizona can, though, get pressure on 49ers QB Brock Purdy and has picked off a pass every game.

Arizona will not win but should threaten throughout.

BET CARDINALS +14 (-110).

Over/Under

The Over is 2-1 in the Cardinals’ last 2 games, and they have scored 28 points in those games.

The 49ers have scored 30 points in every game this season.

BET OVER 43.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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