San Francisco 49ers at Seattle Seahawks odds, picks and best bets

Previewing Sunday’s San Francisco 49ers at Seattle Seahawks sports betting odds and lines, with Week 16 NFL betting picks, tips and bets.

The San Francisco 49ers (12-3) visit the Seattle Seahawks (11-4) in a battle for the NFC West title Sunday with an 8:20 p.m. ET kickoff at CenturyLink Field. We analyze the 49ers-Seahawks odds and sports betting lines, while providing betting tips and advice on this Week 17 NFL matchup.

Both teams have already clinched playoff berths, but the 49ers lock up the NFC’s No. 1 seed with a win. The Seahawks can finish anywhere from the Nos. 1 through 3 seeds with a win; the loser of Sunday’s game gets the 5 seed.

In one of the better NFL games of the year, the Seahawks won the first meeting of the regular season 27-24 in overtime Nov. 11. Jason Myers’ 42-yard field goal as time expired handed the 49ers their first loss of the season.

49ers at Seahawks: Week 17 preview, betting trends and notes


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  • One might be surprised the home team Seahawks are NOT the favorite, but they’ve recently suffered key injuries to their defense and their running back corps — leading to the signing of RB Marshawn Lynch this week.
  • The 49ers have alternated wins and losses the last five weeks, most recently beating the visiting Los Angeles Rams 34-31 in Week 16, but failing to cover a 7-point spread.
  • An 8-point favorite, the Seahawks were stunned at home by the Arizona Cardinals 27-13 last week.
  • The 49ers are 6-1 on the road, 8-6-1 against the spread (ATS) overall, and 5-2 ATS away from home.
  • The Seahawks are a surprising 4-3 at home, 7-7-1 ATS overall and 2-5 ATS at CenturyLink Field.
  • Both teams are 8-7 against the over/under on the season.
  • 49ers QB Jimmy Garoppolo is 20-5 in 25 starts — but this is his first career start at Seattle.

49ers at Seahawks: Key injuries

49ers: WR Deebo Samuel (undisclosed), S Jaquiski Tartt (ribs), DT Julian Taylor (elbow) and DE Dee Ford (hamstring) are questionable.

Seahawks: RBs Chris Carson (hip), Rashaad Penny (knee), C.J. Prosise (arm) and LT Duane Brown (knee) are out — the three RBs are done for the year. CB Shaquill Griffin (hamstring) and DE Jadeveon Clowney (abdomen) are probable, while S Quandre Diggs (ankle) is questionable.

49ers at Seahawks: Odds, betting lines and prediction

Aug 30, 2018; Seattle, WA; Marshawn Lynch (left), when with the Oakland Raiders, and Seahawks head coach Pete Carroll (right) catch up during a 2018 game CenturyLink Field. They have rejoined forces heading into Sunday’s showdown with the 49ers. (Photo Credit: Joe Nicholson – USA TODAY Sports)

NFL odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Odds last updated Thursday at 5:45 a.m. ET.

Prediction

49ers 27, Seahawks 17

Moneyline (ML)

The 49ERS (-176) are worth a small play if you have doubts about the spread – and are afraid of the hook. The trend points to the Seahawks (+145), who have won eight straight home games vs. the 49ers, but Seattle is just not healthy and Lynch is not the answer.

New to sports betting? Every $10 wagered on the 49ers to win straight up would profit $5.68 if the 49ers win.

Against the Spread (ATS)

The 49ERS (-3.5, -106) are the STRONGEST PLAY. I’m not a fan of backing road teams, especially when they’re favored by more than 3 points. But as mentioned above, the Seahawks (+3.5, -115) are undermanned in this one – they were exposed in last week’s loss to the Cardinals, and the 49ers will take advantage in avenging the regular-season OT loss.

Over/Under (O/U)

Back the UNDER 47.5 (-115). The 49ers defense ranks eighth in allowing just 19.3 points per game, while the Seahawks allow 24.8 PPG. On the offensive side, the 49ers are second in points scored (30.2 PPG) and the Seahawks are ninth (25.6 PPG).

Want action on this game? Sign up and bet at BetMGM. For more sports betting picks and tips, visit SportsbookWire.com.

Johnny’s December record: 16-7-1. Strongest plays: 8-2.

Follow @JohnnyParlay11 and @SportsbookWire on Twitter.

Gannett may earn revenue from audience referrals to betting services.  Newsrooms are independent of this relationship and there is no influence on news coverage.

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Seahawks-49ers odds: Undefeated San Francisco favored over Seattle

Previewing Monday Night Football’s Seattle Seahawks at San Francisco 49ers betting odds and lines, with NFL Week 10 matchup analysis, picks and tips.

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The undefeated San Francisco 49ers (8-0) will host the rising Seattle Seahawks (7-2) Monday night at Levi’s Stadium for an 8:15 p.m. ET kickoff. We analyze the Seahawks-49ers odds and lines while providing betting tips and advice around this key Week 10 NFL matchup.

Seahawks at 49ers: Week 10 preview, betting trends and notes


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  • Seattle has won five of its last six games but has gone just 3-3 against the spread in that span.
  • The 49ers are 5-3 ATS this season but didn’t cover the spread in two of their last three games.
  • The Seahawks have won nine of their last 10 games against the 49ers, going 7-3 ATS in those meetings. Their average margin of victory is 11.8 points per game.
  • The 49ers are 13-2 ATS in their last 15 Monday Night Football games.
  • Seattle is 0-5 ATS after covering the spread the week before.
  • The total has gone Over in six of Seattle’s last seven games against the NFC West.
  • The 49ers rank second in the NFL in rushing yards, time of possession and plays run per game.

Seahawks at 49ers: Key injuries

WR Josh Gordon could make his Seahawks debut Monday night after being claimed by Seattle off waivers from the New England Patriots; he’s recovering from a knee injury. S Quandre Diggs‘ (hamstring) status for Monday is uncertain.

49ers K Robbie Gould (quad) is doubtful. TE George Kittle (knee) is questionable.

Seahawks at 49ers: Odds, betting lines and prediction

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 2 p.m. ET.

Prediction

Seahawks 23, 49ers 21

Moneyline (?)

The Seahawks are one of the best teams in the league and this is a game ripe for an upset. As good as the 49ers have been this year, they showed a few flaws against Arizona last week against dual-threat quarterback Kyler Murray.

Russell Wilson is having an MVP season and will lift the Seahawks to victory. Bet SEATTLE to win straight up with the moneyline (+220).

Against the Spread (?)

If we’re picking the Seahawks to win straight up, you bet we’re taking them with the points, too. Seattle is a 6.5-point underdog in Week 10, which is a huge spread for a divisional matchup – even if San Francisco is at home.

Happily take the points and take the SEAHAWKS (-110) to cover the 6.5-point margin. They’re 13-3 ATS in their last 16 against the 49ers.

Over/Under (?)

The Over/Under is a tough pick this week, since the total is just 46.5 points. The Seahawks offense can go on a tear at any moment thanks to Wilson, but San Francisco’s defense is dominant.

This should be a fairly low-scoring affair with both teams managing the clock. Bet the UNDER (-110) Monday night.

Want action on this game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com.

Follow @camdasilva and @SportsbookWire on Twitter.

Gannett may earn revenue from audience referrals to betting services.  Newsrooms are independent of this relationship and there is no influence on news coverage.

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