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The undefeated San Francisco 49ers (8-0) will host the rising Seattle Seahawks (7-2) Monday night at Levi’s Stadium for an 8:15 p.m. ET kickoff. We analyze the Seahawks-49ers odds and lines while providing betting tips and advice around this key Week 10 NFL matchup.
Seahawks at 49ers: Week 10 preview, betting trends and notes
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- Seattle has won five of its last six games but has gone just 3-3 against the spread in that span.
- The 49ers are 5-3 ATS this season but didn’t cover the spread in two of their last three games.
- The Seahawks have won nine of their last 10 games against the 49ers, going 7-3 ATS in those meetings. Their average margin of victory is 11.8 points per game.
- The 49ers are 13-2 ATS in their last 15 Monday Night Football games.
- Seattle is 0-5 ATS after covering the spread the week before.
- The total has gone Over in six of Seattle’s last seven games against the NFC West.
- The 49ers rank second in the NFL in rushing yards, time of possession and plays run per game.
Seahawks at 49ers: Key injuries
WR Josh Gordon could make his Seahawks debut Monday night after being claimed by Seattle off waivers from the New England Patriots; he’s recovering from a knee injury. S Quandre Diggs‘ (hamstring) status for Monday is uncertain.
49ers K Robbie Gould (quad) is doubtful. TE George Kittle (knee) is questionable.
Seahawks at 49ers: Odds, betting lines and prediction
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 2 p.m. ET.
Prediction
Seahawks 23, 49ers 21
Moneyline (?)
The Seahawks are one of the best teams in the league and this is a game ripe for an upset. As good as the 49ers have been this year, they showed a few flaws against Arizona last week against dual-threat quarterback Kyler Murray.
Russell Wilson is having an MVP season and will lift the Seahawks to victory. Bet SEATTLE to win straight up with the moneyline (+220).
Against the Spread (?)
If we’re picking the Seahawks to win straight up, you bet we’re taking them with the points, too. Seattle is a 6.5-point underdog in Week 10, which is a huge spread for a divisional matchup – even if San Francisco is at home.
Happily take the points and take the SEAHAWKS (-110) to cover the 6.5-point margin. They’re 13-3 ATS in their last 16 against the 49ers.
Over/Under (?)
The Over/Under is a tough pick this week, since the total is just 46.5 points. The Seahawks offense can go on a tear at any moment thanks to Wilson, but San Francisco’s defense is dominant.
This should be a fairly low-scoring affair with both teams managing the clock. Bet the UNDER (-110) Monday night.
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