San Francisco 49ers at Seattle Seahawks odds, picks and best bets

Previewing Sunday’s San Francisco 49ers at Seattle Seahawks sports betting odds and lines, with Week 16 NFL betting picks, tips and bets.

The San Francisco 49ers (12-3) visit the Seattle Seahawks (11-4) in a battle for the NFC West title Sunday with an 8:20 p.m. ET kickoff at CenturyLink Field. We analyze the 49ers-Seahawks odds and sports betting lines, while providing betting tips and advice on this Week 17 NFL matchup.

Both teams have already clinched playoff berths, but the 49ers lock up the NFC’s No. 1 seed with a win. The Seahawks can finish anywhere from the Nos. 1 through 3 seeds with a win; the loser of Sunday’s game gets the 5 seed.

In one of the better NFL games of the year, the Seahawks won the first meeting of the regular season 27-24 in overtime Nov. 11. Jason Myers’ 42-yard field goal as time expired handed the 49ers their first loss of the season.

49ers at Seahawks: Week 17 preview, betting trends and notes


Get some action on the game at BetMGM by placing a sports bet!


  • One might be surprised the home team Seahawks are NOT the favorite, but they’ve recently suffered key injuries to their defense and their running back corps — leading to the signing of RB Marshawn Lynch this week.
  • The 49ers have alternated wins and losses the last five weeks, most recently beating the visiting Los Angeles Rams 34-31 in Week 16, but failing to cover a 7-point spread.
  • An 8-point favorite, the Seahawks were stunned at home by the Arizona Cardinals 27-13 last week.
  • The 49ers are 6-1 on the road, 8-6-1 against the spread (ATS) overall, and 5-2 ATS away from home.
  • The Seahawks are a surprising 4-3 at home, 7-7-1 ATS overall and 2-5 ATS at CenturyLink Field.
  • Both teams are 8-7 against the over/under on the season.
  • 49ers QB Jimmy Garoppolo is 20-5 in 25 starts — but this is his first career start at Seattle.

49ers at Seahawks: Key injuries

49ers: WR Deebo Samuel (undisclosed), S Jaquiski Tartt (ribs), DT Julian Taylor (elbow) and DE Dee Ford (hamstring) are questionable.

Seahawks: RBs Chris Carson (hip), Rashaad Penny (knee), C.J. Prosise (arm) and LT Duane Brown (knee) are out — the three RBs are done for the year. CB Shaquill Griffin (hamstring) and DE Jadeveon Clowney (abdomen) are probable, while S Quandre Diggs (ankle) is questionable.

49ers at Seahawks: Odds, betting lines and prediction

Aug 30, 2018; Seattle, WA; Marshawn Lynch (left), when with the Oakland Raiders, and Seahawks head coach Pete Carroll (right) catch up during a 2018 game CenturyLink Field. They have rejoined forces heading into Sunday’s showdown with the 49ers. (Photo Credit: Joe Nicholson – USA TODAY Sports)

NFL odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Odds last updated Thursday at 5:45 a.m. ET.

Prediction

49ers 27, Seahawks 17

Moneyline (ML)

The 49ERS (-176) are worth a small play if you have doubts about the spread – and are afraid of the hook. The trend points to the Seahawks (+145), who have won eight straight home games vs. the 49ers, but Seattle is just not healthy and Lynch is not the answer.

New to sports betting? Every $10 wagered on the 49ers to win straight up would profit $5.68 if the 49ers win.

Against the Spread (ATS)

The 49ERS (-3.5, -106) are the STRONGEST PLAY. I’m not a fan of backing road teams, especially when they’re favored by more than 3 points. But as mentioned above, the Seahawks (+3.5, -115) are undermanned in this one – they were exposed in last week’s loss to the Cardinals, and the 49ers will take advantage in avenging the regular-season OT loss.

Over/Under (O/U)

Back the UNDER 47.5 (-115). The 49ers defense ranks eighth in allowing just 19.3 points per game, while the Seahawks allow 24.8 PPG. On the offensive side, the 49ers are second in points scored (30.2 PPG) and the Seahawks are ninth (25.6 PPG).

Want action on this game? Sign up and bet at BetMGM. For more sports betting picks and tips, visit SportsbookWire.com.

Johnny’s December record: 16-7-1. Strongest plays: 8-2.

Follow @JohnnyParlay11 and @SportsbookWire on Twitter.

Gannett may earn revenue from audience referrals to betting services.  Newsrooms are independent of this relationship and there is no influence on news coverage.

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]