Underdog corner: 3 best NFL ATS picks and predictions for Week 5

Assessing the NFL betting odds and lines for Week 5, with three predictions and picks for the best ATS underdog bets to make.

After a hot start, we cooled off here in Week 4, cashing in on only one of our three weekly selections. But, hey, 9-3 after four weeks? Certainly no hanging heads here. Below, we look at the top NFL underdog ATS picks and predictions of Week 5.

Also see: All Week 5 odds and lines

NFL underdog predictions: Week 5

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 4:15 p.m. ET.

Cincinnati Bengals +3.5 (-125) vs. Green Bay Packers

QB Aaron Rodgers and the Packers have bounced back nicely from their season-opening debacle against the New Orleans Saints, by reeling off three straight wins.

The Bengals are also 3-1 and have won with a promising mix of young offensive talent, led by second-year QB Joe Burrow and rookie WR Ja’Marr Chase, along with an improved and underrated defense.

That should be more than enough to at least keep it close — and possibly even win outright — at home against a banged-up Green Bay squad which likely will be without some key offensive linemen, its best pass rusher and top cornerback.

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San Francisco 49ers +5.5 (-112) at Arizona Cardinals

QB Kyler Murray and the Cards are the league’s final unbeaten team and are coming off a huge 37-20 win over the previously undefeated Los Angeles Rams as 3.5-point road underdogs.

That, however, makes this a prime letdown spot for Arizona as it hosts an angry 49ers squad hitting the road off two straight stinging home setbacks.

Even though it likely will be rookie Trey Lance starting at QB for the Niners, they have had recent success in this NFC West series, winning three of the last four meetings.

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Buffalo Bills +2.5 (-102) at Kansas City Chiefs

K.C. is favored by less than a field goal at home Sunday night for the first time ever in a game QB Patrick Mahomes is slated to start.

That’s a giveaway right there that the wrong team might be favored in this rematch of last season’s AFC Championship Game won 38-24 by the Chiefs.

Both squads once again have top-three scoring offenses with top-level QBs, but the huge difference is defense as the Bills have surrendered the fewest points (44) and total yards (867) in the league while the Chiefs rank 31st in both categories, giving up 125 points and 1,751 yards.

With the spread under 3 points, take the Bills on the money line at +120 to earn a measure of revenge.

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San Francisco 49ers at Arizona Cardinals odds, picks and prediction

Previewing the San Francisco 49ers at Arizona Cardinals Week 16 betting odds and lines, with NFL betting picks, tips and predictions.

The Arizona Cardinals (8-6) take on the San Francisco 49ers (5-9) in one of three Saturday games in Week 16. Kickoff is Saturday afternoon at 4:30 p.m. ET at State Farm Stadium in Glendale, AZ.

Below, we preview the 49ers-Cardinals betting odds and lines and make our NFL picks and predictions.

49ers at Cardinals: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 1:40 a.m. ET.

  • Money line: 49ers +200 (bet $100 to win $200) | Cardinals -250 (bet $250 to win $100)
  • Against the spread/ATS: 49ers +5 (-110) | Cardinals -5 (-110)
  • Over/Under: 48.5 (O: -110 | U: -110)

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49ers at Cardinals: Game notes

  • San Francisco has lost three games in a row, six out of seven and has been eliminated from postseason contention. The Cardinals have won two in a row and can potentially clinch a playoff berth this weekend.
  • Cardinals QB Kyler Murray is coming off a career-high 406 passing yards in Week 15 with three passing touchdowns and a rushing touchdown. He was named NFC Offensive Player of the Week for the third time this season.
  • Arizona has collected 14 sacks in the last two weeks.
  • 49ers QB C.J. Beathard is making his first start of 2020 in place of the injured Jimmy Garoppolo and Nick Mullens. Beathard is 1-9 in his career as a starter.
  • In the Cardinals’ 24-20 season-opening win over the 49ers, QR DeAndre Hopkins had a career-high 14 receptions for 151 yards.

49ers at Cardinals: Key injuries

49ers

  • QB Nick Mullens (elbow) out
  • RB Raheem Mostert (ankle) out
  • WR Deebo Samuel (hamstring) out
  • CB Richard Sherman (calf) out
  • Jimmie Ward (concussion) questionable
  • CB Emmanuel Moseley (hamstring) questionable

Cardinals

  • LB Dennis Gardeck (knee) out
  • RB Chase Edmonds (knee, ankle) questionable
  • WR Larry Fitzgerald (groin) questionable
  • TE Dan Arnold (back) questionable
  • LB Haason Reddick (shoulder) questionable

49ers at Cardinals: Odds, betting lines, predictions and picks

Prediction

Cardinals 31, 49ers 17

Money line (?)

Arizona is playing good football again, winning two in a row after losing three straight. San Francisco has lost six of seven and is down to its third-string quarterback and does not have its top running back, receiver, pass rusher, cornerback and safety.

Beathard is making his fifth appearance against the Cardinals in his career. He has never beaten them and Arizona needs to win to stay in control of the No. 7 seed in the NFC. Take the CARDINALS (-250).

Against the spread (?)

In addition to losing six of seven games, the 49ers have failed to cover in any of those six losses. They are 5-9 ATS this season. Arizona is 7-7 ATS but has won and covered in their last two games after failing to cover the spread in five straight. They should be able to move the ball and score points on a depleted 49ers defense and maintain their playoff chances.

Take the CARDINALS -5 (-110).

Over/Under (?)

The Cardinals’ offense seems to be back on track. Their games have gone Over only five times this season but those five times have been in the last eight games. San Francisco’s games have gone Under in three of five. Arizona’s offense will be fine, but with Beathard at QB without the 49ers’ top offensive players, they will struggle.

Take UNDER 48.5 POINTS (-110).

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