After a hot start, we cooled off here in Week 4, cashing in on only one of our three weekly selections. But, hey, 9-3 after four weeks? Certainly no hanging heads here. Below, we look at the top NFL underdog ATS picks and predictions of Week 5.
Also see: All Week 5 odds and lines
NFL underdog predictions: Week 5
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 4:15 p.m. ET.
Cincinnati Bengals +3.5 (-125) vs. Green Bay Packers
QB Aaron Rodgers and the Packers have bounced back nicely from their season-opening debacle against the New Orleans Saints, by reeling off three straight wins.
The Bengals are also 3-1 and have won with a promising mix of young offensive talent, led by second-year QB Joe Burrow and rookie WR Ja’Marr Chase, along with an improved and underrated defense.
That should be more than enough to at least keep it close — and possibly even win outright — at home against a banged-up Green Bay squad which likely will be without some key offensive linemen, its best pass rusher and top cornerback.
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San Francisco 49ers +5.5 (-112) at Arizona Cardinals
QB Kyler Murray and the Cards are the league’s final unbeaten team and are coming off a huge 37-20 win over the previously undefeated Los Angeles Rams as 3.5-point road underdogs.
That, however, makes this a prime letdown spot for Arizona as it hosts an angry 49ers squad hitting the road off two straight stinging home setbacks.
Even though it likely will be rookie Trey Lance starting at QB for the Niners, they have had recent success in this NFC West series, winning three of the last four meetings.
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Buffalo Bills +2.5 (-102) at Kansas City Chiefs
K.C. is favored by less than a field goal at home Sunday night for the first time ever in a game QB Patrick Mahomes is slated to start.
That’s a giveaway right there that the wrong team might be favored in this rematch of last season’s AFC Championship Game won 38-24 by the Chiefs.
Both squads once again have top-three scoring offenses with top-level QBs, but the huge difference is defense as the Bills have surrendered the fewest points (44) and total yards (867) in the league while the Chiefs rank 31st in both categories, giving up 125 points and 1,751 yards.
With the spread under 3 points, take the Bills on the money line at +120 to earn a measure of revenge.
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