San Francisco Giants at San Diego Padres odds, picks and predictions

Analyzing Friday’s San Francisco Giants at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (80-62) welcome the San Francisco Giants (69-72) to Petco Park Friday for the 1st game of a 3-game series. First pitch is set for 9:40 p.m. ET (Apple TV+). Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 4-3

The Giants beat the Arizona Diamondbacks 3-2 Thursday to avoid a sweep in that series. San Francisco lost 8-7 Tuesday and 6-4 Wednesday and has lost 4 of its last 5 games. It sits 4th in the NL West. The Giants are 29-40 on the road and 66-75 against the spread (ATS).

The Padres lost 4-3 Thursday, missing out on the sweep over the Detroit Tigers. San Diego won the prior 2 games a combined 9-5. It has won 7 of its last 11 and is 2nd in the NL West. The Padres are 39-33 at home, having won 4 of their last 6 home games, and are 72-70 ATS.

Giants at Padres projected starters

RHP Mason Black vs. RHP Michael King

Black (0-2, 7.45 ERA) makes his 5th career start and 6th appearance. He has a 1.66 WHIP, 3.3 BB/9 and 7.4 K/9 in 19 1/3 IP.

  • Last start: Loss, 5 IP, 2 ER, 4 H, 0 BB, 6 K in 4-3 home loss to the Miami Marlins Saturday
  • 2024 away stats: 0-1, 11.57 ERA (7 IP, 9 ER), 2.29 WHIP, 7.7 K/9 in 2 appearances (1 start)
  • Has never faced Padres

King (11-8, 3.17 ERA) makes his 27th start. He has a 1.21 WHIP, 3.4 BB/9 and 10.6 K/9 in 150 2/3 IP.

  • Last start: Loss, 4 1/3 IP, 2 ER, 7 H, 4 BB, 3 K in 4-1 road loss to the St. Louis Cardinals on Aug. 29
  • 2024 home stats: 3-5, 3.56 ERA (65 2/3 IP, 26 ER), 1.26 WHIP, 12.9 K/9 in 12 starts
  • Career vs. Giants: 1-1, 2.84 ERA (12 2/3 IP, 4 ER), 1.50 WHIP, 9.2 K/9 in 3 appearances (2 starts)

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Giants at Padres odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:27 a.m. ET.

  • Moneyline (ML): Giants +176 (bet $100 to win $176) | Padres -210 (bet $210 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-125) | Padres -1.5 (+104)
  • Over/Under (O/U): 7.5 (O: -122 | U: +100)

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Giants at Padres picks and predictions

Prediction

Padres 5, Giants 3

Moneyline

PASS.

There’s no value on the moneyline here. The Padres are far too expensive to play here, and the Giants, especially considering their starting option, aren’t worth a play either.

Run line/Against the spread

BET PADRES -1.5 (+105).

The Giants are among the worst road-covering teams in the MLB with a 35-33 ATS record away from home. They are 2-6 in their last 8 games and have lost 4 of those 6 by multiple runs.

The Padres have covered in 4 of King’s last 7 starts. San Diego has a major pitching advantage with Black having struggled this season. Black has allowed 4 or more ERs in 3 of his 5 appearances. Expect San Diego to score often and enough to cover here.

Back PADRES -1.5 (+105).

Over/Under

BET OVER 7.5 (-122).

The Padres have consistently gone Over this season and are 76-63-3 O/U. They are 3-2-1 O/U in their last 6 games, scoring at least 4 in 4 of their last 6.

The Giants are 71-64-6 O/U on the season and have gone Over in 3 of their last 4, allowing at least 6 in 3 of 4. Considering those trends, take OVER 7.5 (-122).

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