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The Duke Blue Devils (5-2, 2-1 ACC) meet the Louisville Cardinals (6-1, 3-1) on Saturday at Cardinal Stadium in Louisville, Ky. Kickoff is scheduled for 3:30 p.m. ET (ESPN). Below, we look at Duke vs. Louisville odds from FanDuel Sportsbook. Also see: SportsbookWire’s college football picks and predictions.
The Blue Devils held a surprising 20-17 lead at halftime of their game at Florida State on Saturday, but the Seminoles outscored Duke 21-0 in the final 15 minutes for the 38-20 win. Duke failed to cover the 13.5-point number as the Over (49) cashed. After a 4-0 straight up (SU) and 3-1 against the spread (ATS) start, the Blue Devils are 1-2 SU/ATS in the past 3 games.
The Cardinals have been stewing for 2 weeks after a stunning loss at Pittsburgh as a 7-point favorite, falling 38-21. That snapped a 6-game win streak to start the season, including a signature win over Notre Dame on Oct. 7. The Cards are both 3-3-1 ATS and OU so far this season.
Duke is No. 21 and Louisville is No. 18 in the US LBM Coaches Poll powered by USA TODAY Sports.
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Duke at Louisville odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 12:38 a.m. ET.
- Moneyline (ML): Duke +172 (bet $100 to win $172) | Louisville -210 (bet $210 to win $100)
- Against the spread (ATS): Duke +4.5 (-104) | Louisville -4.5 (-118)
- Over/Under (O/U): 47.5 (O: -110 | U: -110)
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2023 betting stats
- ML: Duke 5-2 | Louisville 6-1
- ATS: Duke 4-3 | Louisville 3-3-1
- O/U: Duke 3-3-1 | Louisville 3-3-1
Duke at Louisville head-to-head
The Blue Devils and Cardinals have met just 3 previous times on the gridiron, with Louisville winning each of the outings by 10 or more points. Louisville embarrassed Duke at Wallace Wade Stadium in a Thursday night game in 2021, winning 62-22 in former coach David Cutcliffe’s final season.
The last and only time these teams met in Louisville, the Cards came away with a 24-14 win in 2016.
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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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