Best bets for NFL season opener as Rams open title defense against Bills

The defending champs are home underdogs against Buffalo.

It’s not often a Super Bowl champion opens the next season as an underdog in the very first game. But it’s not often the champ is playing the team favored to win the next Super Bowl as the Buffalo Bills are in 2022.

That’s what the Los Angeles Rams are up against as they ready for the Bills on Thursday night. A 2.5-point spread isn’t exactly writing them off, but they have to come into the game fired up knowing people expect them to lose fresh off a championship.

Will it matter once the opening kickoff is in the air, though? Here are a few of my favorite bets for Thursday’s action.