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The San Francisco Giants (23-25) and Pittsburgh Pirates (22-26) meet Tuesday to open a 3-game series. First pitch from PNC Park is set for 6:40 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Pirates odds and make our expert MLB picks and predictions for the best bets.
Season series: Giants lead 2-1
San Francisco beat the Colorado Rockies 4-1 Sunday, covering as a -209 home favorite Sunday. The Rockies opened with a run in the 1st, but that was it and the Giants plated 3 in the 5th and 1 in the 6th en route to the win. The Giants have won 4 consecutive games and have scored at least 10 runs in 2 of their last 3 wins.
Pittsburgh escaped with a 3-2 win at the Chicago Cubs Sunday, covering as a +115 underdog. RHP Mitch Keller picked up the win, pitching 6 innings of 2-run ball on 2 hits and 3 walks with 3 K’s. 2B Nick Gonzales‘ 2-run single gave the Bucs a 3-1 lead in the top of the 5th and 3 Pirates relievers shut down the Cubs the final 3 innings after Chicago cut the deficit to 3-2 in the 6th. Pittsburgh took 3 of 4 at Wrigley, only losing Saturday.
Giants at Pirates projected starters
RHP Logan Webb vs. LHP Martin Perez
Webb (4-4, 3.03 ERA) makes his 11th start. He has a 1.35 WHIP, 2.6 BB/9 and 7.1 K/9 through 59 1/3 innings.
- Last start: Win, 6 IP, 0 ER, 3 H, 3 BB, 5 K in 4-1 home victory vs. Los Angeles Dodgers Wednesday
- Career vs. Pirates: 1-1, 2.84 ERA (12 2/3 IP, 4 ER), 12 H, 3 BB, 13 K in 2 starts; last faced Bucs in 2022
Perez (1-3, 4.86 ERA) makes his 10th start. He has a 1.50 WHIP, 2.5 BB/9 and 7.2 K/9 through 50 innings.
- Last start: Loss, 5 IP, 9 ER, 11 H, 1 BB, 4 K in 10-2 loss at Milwaukee Brewers Wednesday
- Career vs. Giants: 1-1, 2.33 ERA (19 1/3 IP, 5 ER), 11 H, 3 BB, 14 K across 3 starts
- 2024 vs. Giants: 1 road start, no-decision, 6 IP, 0 ER, 4 H, 2 BB, 4 K in 4-3 Pirates win in 10 innings April 27 — game was tied 1-1 after 9
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Giants at Pirates odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:37 a.m. ET.
- Moneyline (ML): Giants -136 (bet $136 to win $100) | Pirates +116 (bet $100 to win $116)
- Run line (RL)/Against the spread (ATS): Giants -1.5 (+125) | Pirates +1.5 (-150)
- Over/Under (O/U): 7.5 (O: -118 | U: -104)
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Giants at Pirates picks and predictions
Prediction
Giants 6, Pirates 5
Moneyline
LEAN GIANTS (-136).
San Francisco has won 4 straight games and is 6-2 in its last 8 overall. The Giants are also 5-1 in their last 6 matchups vs. the Pirates, including 3-0 in the last 3 games in Pittsburgh.
This is only a lean because the Giants are just 8-15 on the road this season and because both teams have been similarly hot recently.
Run line/Against the spread
While the moneyline lean is with the Giants, consider backing Pittsburgh +1.5 (-150) as I’m predicting a 1-run game.
Expect a tightly contested contest. The Pirates are 3-1 in their last 4 games and are a very similar team to the Giants in terms of overall record.
Pittsburgh is 27-21 ATS this season and is 3-1 ATS in its last 4 games.
Over/Under
BET OVER 7.5 (-118).
The Over has hit in 2 of San Francisco’s last 3 overall and is 6-4 in its last 10 games. For Pittsburgh, the Over is 6-3-1 in its last 10 and is 2-0-1 in its last 3 home games.
The Over also hit in 2 of the 3 head-to-head meetings in Pittsburgh just last month.
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